AAAS talk: Bioinformatics for Biologists

1www.Digital-World-Biology.com

Bioinformatics for Biologists

Sandra PorterDigital World [email protected]

Bio-Linkwww.bio-link.org

mailto:[email protected]

www.Digital-World-Biology.com

Bioinformatics = databases & software Bioinformatics = databases & software for working with biological informationfor working with biological information

Acquire Analyze VisualizeStore


Who are most programs designed to serve?


Who uses bioinformatics?

Biology is an information-rich science


Bioinformatics in industry

Did you hear about that paper?

Instrument Run

Search PubMeddownload paper

Go to GenBankdownload sequences

Align sequences with company data

Try to clone gene

Design PCR primers

Sequence cloned gene

Make constructs for expression, sequence constructs

Use microarrays / transcriptome sequencingto look at effects of construct & ligand

look at structures, ligand binding

General

• Find information - in databases (>1300)• Analyze data• Prepare and interpret graphs• Use multiple kinds of software• Work with databases • Need practical skills for working with

computers and the internet



Begin with molecular structures

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Investigating Influenza: How might antigenic drift affect immunity?

Ab

Hemagglutinin

Which residues contact the Ab?


Genetic variation & pharmacogenomics


Our course at ACC

Structures

Sequences

Variation

Gene expression

AAAS talk: Bioinformatics for Biologists

Education

Transcript of AAAS talk: Bioinformatics for Biologists