A2E Agenda:
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Transcript of A2E Agenda:
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A2E Agenda:A2E Agenda:• Enzyme Function Worksheet/Activity (In IB 3406)• Brief Aquaporin Structure and Function Overview• Lab Presentations• Group Discussion of Aquaporin Readings• Aquaporin Revisited
Reminder: Bring a food sample tomorrow (soy, papaya, or corn are best) if you’d like
to test it tomorrow!
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Comparing Your ModelsComparing Your Models
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Comparing Comparing Your ModelsYour Models
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Biological Functions of Biological Functions of Aquaporins:Aquaporins:
What do your
kidneys do?!?
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Some Biological Functions Some Biological Functions of Aquaporinsof Aquaporins
Mammals have two Mammals have two kidneys, each supplied kidneys, each supplied
with LOTS of blood with LOTS of blood flow; as a result, all flow; as a result, all
blood is filtered blood is filtered ~every 30 minutes~every 30 minutes
Our kidneys can excrete Our kidneys can excrete urine 4X as urine 4X as
concentrated (1,200 concentrated (1,200 mosm/L) as our blood!mosm/L) as our blood! Image: The Biology Project
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Functional Unit = the Functional Unit = the Nephron (single Nephron (single
long tubule with a long tubule with a ball of capillariesball of capillaries
Kidneys are Kidneys are compacted bundles compacted bundles of nephrons (~1.3 of nephrons (~1.3
million) all draining, million) all draining, eventually, into the eventually, into the
ureterureterImage: The Biology Project
Some Biological Functions Some Biological Functions of Aquaporinsof Aquaporins
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What does Antidiuretic What does Antidiuretic Hormone (ADH) do?Hormone (ADH) do?
Note that Antidiuretic Hormone (ADH) is also known as vasopressin.
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So should the cells lining the collecting ducts in your kidneys become more or less
permeable to water in response to ADH? How might they control this
permeability?
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Revisiting Revisiting Aquaporin:Aquaporin: Use your understanding of protein Use your understanding of protein structure to construct a model structure to construct a model (drawing) of what a water channel in a (drawing) of what a water channel in a cell membrane would look like, and cell membrane would look like, and how it would orient itself in a plasma how it would orient itself in a plasma membrane. membrane.
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Structure Structure of of
PhenylalaPhenylalanine and nine and
TryptophaTryptophann
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GlycerolGlycerol