A traditional Chinese medicine used in modern science Flavonoids.
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Transcript of A traditional Chinese medicine used in modern science Flavonoids.
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A traditional Chinese medicine used in modern science
Flavonoids
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IntroductionFlavonoids are nearly ubiquitous in plants and are
consumed regularly with the human dietCertain plants and spices containing flavonoids have been
used for thousands of years in traditional Eastern medicineThey are usually subdivided into
flavanols anthocyanidins flavones flavanones chalcones
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The flavonoids display
a remarkable array of biochemical and
pharmacological
actions
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Direct effect on mitochondrial calcium uniporter
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effects of several of the most naturallyabundant flavonoids on mitochondrial Ca2+ uptake in
permeabilizedHeLa cells
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Concentration dependence of the activation of mitochondrial Ca2+
uptake by several natural flavonoids
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Reversible activation of mitochondrial Ca2+ uptake by kaempferol
in permeabilized cells
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Inhibition by Ru360 of themitochondrial Ca2+ uptake induced bykaempferol and SB202190
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Effect of the absence of ATP in the activation of mitochondrialCa2+ uptake by genistein or SB202190
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attenuate apoptosis andprotein oxidation in neuronal cell
lines
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Scavenging effects of flavones on reactive oxygen species generated
by GO
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Effect of flavone pretreatment on apoptosis in neuronal cells exposed to oxidative stress
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Effect of flavone pretreatment on the Bcl-2- and Bax-protein levels
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Effect of flavone pretreatment on the phosphorylation of Bcl-2 and
Bax proteins
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Effect of flavone pretreatmenton protein carbonyl formation
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Antioxidant Activity
flavonoids,as a dietary antioxidants, possess the potential to scavenge and quench various radicals and ROS
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As a antioxidant,flavonoids can function as below
Metal chelator
scavengers of ROS
chain-breaking antioxidants
quenchers of the formation of singlet
oxygen
LOO· + FL-OH LOOH + FL-O·
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Effect of flavonoids on lipid peroxidation
suppress lipid peroxidation
Flavonoids
Enzymatic lipid peroxidation
Nonenzymaticlipid peroxidation
Impairment oflipid peroxidation
Cytochome P450
Free radical species
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The illustrations above are only parts of the functions of flavonoids,which I think will be connective to my research on brain ischemia and reperfusion.
In addition,the flavonoids also possess anti-inflammatory,antiallergic,hepatoprotective,
antithrombotic, antiviral, and anticarcinogenic activities
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Thank you !Thank you ! Lin LinLin Lin
2005.6.10.2005.6.10.