A REVIEW ON HYDROXYETHYL CELLULOSES

Prepared by: Guided by:

Mr. Jiten B. Patel Mr. Nishant Upadhyay

M.Pharm(2nd Sem) Assit. Pro. M.pharm

BMCP(215),Surat

General description

1. Nonproprietary Names BP: Hydroxyethylcellulose PhEur: Hydroxyethylcellulose USP-NF: Hydroxyethyl Cellulose

2. Synonyms Cellosize HEC; Cellulose hydroxyethyl ether; Cellulose 2-

hydroxyethyl, Cellulose hydroxyethylate

3. Chemical Name 2-hydroxyethyl ether

5. Structural Formula

R is H or [—CH2CH2O—]mH where m is a common integralnumber of cellulose derivatives.

6. Functional Category Coating agent; Thickening agent; Suspending agent; Tablet binder; Viscosity-increasing agent.

7. Applications in Pharmaceutical Formulation Thickening agent in ophthalmic and topical formulations, Used as a binder and film-coating agent for tablets, It is present in lubricant preparations for dry eye, contact lens care,

and dry mouth, Hydroxyethyl cellulose is also widely used in cosmetics.

8. Description Hydroxyethyl cellulose occurs as a white, yellowish-white or grayish-white, odorless and tasteless, hygroscopic powder.

10. Typical Properties Density (bulk) 0.35–0.61 g/cm3 for Cellosize; 0.60 g/cm3 for Natrosol. Melting point Softens at 135–140ºC; decomposes at about 280ºC. Solubility Hydroxyethyl cellulose is soluble in hot or cold water. Practically insoluble in acetone, ethanol (95%), ether, toluene.

In some polar organic solvents, such as the glycols, hydroxyethyl cellulose either swells or is partially soluble.

11. Method of Manufacture

14. SafetyNontoxic and Nonirritant material.

A purified form of

cellulose

Sodium hydroxide

Swollen alkali

cellulose

Ethylene oxide

A series of hydroxyethyl cellulose ethers.

Comparison of HEC with other polymer

1. In Buccal patches of miconazole nitrate

•HEC is more hydrophilic and has high polymer dissolution whereas HPMC has slow erosion rate.

•HEC is showing greater drug release than SCMC, chitosan, and HPMC but less then PVA.

• HEC (1.5% w/w) solutions.

 

Hydroxyethylcellulose (HEC, 1.5, 2%, w/v), The rank order of permeation appeared to be: HPMC > HPC ≥ Na alg. > MC > HEC > Carb. 934 ≥ NaCMC > PF-127

> PVA.  HEC shows good mucoadhesive properties, but Na CMC shows better

then HEC.

2. piroxicam formulated in gel forms Prepared by using different polymer like HPMC, HPC, HEC, Carbopol 934 etc.

3. Deoxycholate-hydrogels Drug release profile Drug permeation profile

4. Delayed release tablet using HEC as a gel forming matrix

Three sub type of HEC on the bases of viscosity:• CM-L4 (14 cps)• CM-L3 (27 cps)• CM-L2 (95 cps)

5. Mucoadhesive, syringeable drug delivery systems for controlled application of metronidazole

Hydroxyethylcellulose (HEC; 3 and 5%, w/w)

In formulations containig 5% (w/w) HEC or carbopol, the amount of free water is decreased and followed by swelling in comperision to 3%(w/w) HEC or Carbopol.

Increasing concentrations of HEC

Increased formulation mucoadhesive bond strength. Increased hardness, compressibility and adhesiveness.

6.Comparative evaluation of rate of hydration and matrix erosion of HEC and HPC and study of drug release from their matrices

50% drug release, for HEC(4.8 h)and for HPC(6.5 h)

Conclusion

In the present study we evaluated HEC widely used as Coating agent; Thickening agent Suspending agent; Tablet binder; Viscosity-increasing agent, Easily available, Nontoxic and Nonirritant material. HEC has high polymer dissolution and greater drug release capability. HEC shows good mucoadhesive properties as compare to other polymer. HEC shows better result within 1.5-3%w/w after that decreased formulation mucoadhesive bond strength, Increased hardness, compressibility and adhesiveness.

Reference:

Hand book of pharmaceutical excipients, volume 6, pages 311-313,Raymond C Rowe,Paul J shesky,Marian E Quinn

International Journal of Pharmaceutics, Volume 264, Issues 1–2, 2 October 2003, Pages 1-14Noha A Nafee, Fatma A Ismail, Nabila A Boraie, Lobna M Mortada

International Journal of Pharmaceutics, Volume 276, Issues 1–2, 19 May 2004, Pages 11-28M.A Attia, I El-Gibaly, S.E Shaltout, G.N Fetih

International Journal of Pharmaceutics, Volume 151, Issue 2, 26 May 1997, Pages 223-233David S Jones, A.David Woolfson, Andrew F Brown

Journal of Controlled Release, Volume 49, Issue 1, 10 November 1997, Pages 71-79David S Jones, A.David Woolfson, Andrew F Brown, Michael J O'Neill

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