A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel...

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© 1995 Nature Publishing Group http://www.nature.com/nsmb

Transcript of A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel...

Page 1: A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

© 1995 Nature Publishing Group http://www.nature.com/nsmb

Page 2: A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

© 1995 Nature Publishing Group http://www.nature.com/nsmb

Page 3: A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

© 1995 Nature Publishing Group http://www.nature.com/nsmb

Page 4: A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

© 1995 Nature Publishing Group http://www.nature.com/nsmb

Page 5: A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

© 1995 Nature Publishing Group http://www.nature.com/nsmb

Page 6: A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

© 1995 Nature Publishing Group http://www.nature.com/nsmb

Page 7: A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

© 1995 Nature Publishing Group http://www.nature.com/nsmb

Page 8: A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

© 1995 Nature Publishing Group http://www.nature.com/nsmb


Selective Multiplication of Dihydrofolate Reductase Genes in … · 2002-12-14 · The rate of dihydrofolate reductase synthesis in the AT- 3000 line of methotrexate-resistant murine

Selective Multiplication of Dihydrofolate Reductase Genes in … · 2002-12-14 · The rate of dihydrofolate reductase synthesis in the AT- 3000 line of methotrexate-resistant murine

Early dihydrofolate reductase gene amplification events in CHO ...

Early dihydrofolate reductase gene amplification events in CHO ...

US005916895A United States Patent [19] [11] Patent Number ......N0~5,770,601,WhiChiSacontinuatiOII-irl-partofapplication and/or a dihydrofolate reductase inhibitor, and methods of

US005916895A United States Patent [19] [11] Patent Number ......N0~5,770,601,WhiChiSacontinuatiOII-irl-partofapplication and/or a dihydrofolate reductase inhibitor, and methods of

THE JOURNAL OF Vol. No. 21, Issue of May 27, Biolom, Inc in … · 2001-06-27 · THE JOURNAL OF BIOLOGICAL. ... Dihydrofolate reductase (DHFR; EC 1.5.1.3) ... Drosophila Dhfr amplification

THE JOURNAL OF Vol. No. 21, Issue of May 27, Biolom, Inc in … · 2001-06-27 · THE JOURNAL OF BIOLOGICAL. ... Dihydrofolate reductase (DHFR; EC 1.5.1.3) ... Drosophila Dhfr amplification

ANTI-CANCER DRUGS · Mechanism of action: MTX is structurally related to folic acid and acts as an antagonist of the vitamin by inhibiting mammalian dihydrofolate reductase (DHFR),

ANTI-CANCER DRUGS · Mechanism of action: MTX is structurally related to folic acid and acts as an antagonist of the vitamin by inhibiting mammalian dihydrofolate reductase (DHFR),

Transcription Initiation from Dihydrofolate Reductase

Transcription Initiation from Dihydrofolate Reductase

Trimethoprim Resistance of Dihydrofolate Reductase Variants from Clinical …aac.asm.org/content/57/10/4990.full.pdf · 2017-12-16 · Trimethoprim Resistance of Dihydrofolate Reductase

Trimethoprim Resistance of Dihydrofolate Reductase Variants from Clinical …aac.asm.org/content/57/10/4990.full.pdf · 2017-12-16 · Trimethoprim Resistance of Dihydrofolate Reductase

Site-Specific Bioconjugation of a Murine …...Site-Specific Bioconjugation of a Murine Dihydrofolate Reductase Enzyme by Copper(I)-Catalyzed Azide-Alkyne Cycloaddition with Retained

Site-Specific Bioconjugation of a Murine …...Site-Specific Bioconjugation of a Murine Dihydrofolate Reductase Enzyme by Copper(I)-Catalyzed Azide-Alkyne Cycloaddition with Retained

Regulation of dihydrofolate reductase gene expression and E2F ...

Regulation of dihydrofolate reductase gene expression and E2F ...

Discovery of Selective Toxoplasma gondii Dihydrofolate … · 2019-01-29 · Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis

Discovery of Selective Toxoplasma gondii Dihydrofolate … · 2019-01-29 · Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis

SELECTIVE INHIBITORS OF DIHYDROFOLATE …...series of selective inhibitors of dihydrofolate reductase with the synthesis of 2,4-diamino-5-phenoxypyrimidine, and Gertrude Elion synthesized

SELECTIVE INHIBITORS OF DIHYDROFOLATE …...series of selective inhibitors of dihydrofolate reductase with the synthesis of 2,4-diamino-5-phenoxypyrimidine, and Gertrude Elion synthesized

Tech Help: Email: tech@biovision.com | Toll Free: 800.891 ......Dihydrofolate Reductase Inhibitor Screening Kit K247 100 Assays C EZDetect Aldo-keto Reductase Activity Assay Kit K847

Tech Help: Email: [email protected] | Toll Free: 800.891 ......Dihydrofolate Reductase Inhibitor Screening Kit K247 100 Assays C EZDetect Aldo-keto Reductase Activity Assay Kit K847

dihydrofolate reductase-thymidylate synthase of Leishmania major

dihydrofolate reductase-thymidylate synthase of Leishmania major

Dihydrofolate Reductase Gene Amplification and Possible ... · THE JOURNAL. OF BIOLOGICAL CHEMISTRY Vol. 257, No. 24, Issue of December 25, pp. 15079-15086, 1982 Printed in U.S.A.

Dihydrofolate Reductase Gene Amplification and Possible ... · THE JOURNAL. OF BIOLOGICAL CHEMISTRY Vol. 257, No. 24, Issue of December 25, pp. 15079-15086, 1982 Printed in U.S.A.

Novel Dihydrofolate Reductase Inhibitors. Structure- Based versus Diversity-Based Design and High- Throughput Synthesis and Screening Pierre C. Wyss, Paul.

Novel Dihydrofolate Reductase Inhibitors. Structure- Based versus Diversity-Based Design and High- Throughput Synthesis and Screening Pierre C. Wyss, Paul.

Southern Mozambique Europe PMC Funders Group . Author ...researchonline.lshtm.ac.uk/8221/1/Differential Effect of...dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps),

Southern Mozambique Europe PMC Funders Group . Author ...researchonline.lshtm.ac.uk/8221/1/Differential Effect of...dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps),

INTELLECTUAL DISABILITY GENE PANEL - Pronto …...DHCR7 118 88 270400 Smith-Lemli-Opitz syndrome DHFR 57 32 613839 Megaloblastic anemia due to dihydrofolate reductase deficiency DHTKD1

INTELLECTUAL DISABILITY GENE PANEL - Pronto …...DHCR7 118 88 270400 Smith-Lemli-Opitz syndrome DHFR 57 32 613839 Megaloblastic anemia due to dihydrofolate reductase deficiency DHTKD1

Original Article Novel Potent Inhibitors of Plasmodium vivax ... · selected parthenin like compounds with P. vivax and mammalian dihydrofolate reductase revealed the involvement

Original Article Novel Potent Inhibitors of Plasmodium vivax ... · selected parthenin like compounds with P. vivax and mammalian dihydrofolate reductase revealed the involvement

CENTER FOR DRUG EVALUATION AND RESEARCH...1992/08/07  · dihydrofolate reductase (DHFR) and also directly inhibits the folate-dependent enzymes of de novo purine and thymidylate synthesis.

CENTER FOR DRUG EVALUATION AND RESEARCH...1992/08/07  · dihydrofolate reductase (DHFR) and also directly inhibits the folate-dependent enzymes of de novo purine and thymidylate synthesis.

Targeting plant DIHYDROFOLATE REDUCTASE with antifolates ... · role in the folate pathway by catalysing the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate

Targeting plant DIHYDROFOLATE REDUCTASE with antifolates ... · role in the folate pathway by catalysing the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate