A NOVEL LOW-COST MINIATURE PROBE FOR ORAL DIAGNOSIS
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Transcript of A NOVEL LOW-COST MINIATURE PROBE FOR ORAL DIAGNOSIS
A NOVEL LOW-COST
MINIATURE PROBE FOR ORAL DIAGNOSIS
Thair Takesh, Afarin Anbarani, Jessica Ho, Vania Firmalino,
Petra Wilder-Smith
Beckman Laser Institute University of California, Irvine
Ron Liang: College of Optical Sciences, University of Arizona, Tucson
Background• More than 526,481 incident cases annually.
• 6th most lethal form of cancer.
• 150,000 new cases and >10,000 deaths annually in US.
• Advanced lesions outnumbered localized lesions more than 2:1 of all
oral cancers
• Five-year survival rate is 75%, 16% for those with metastasis.
• Clinical problems: Specialist, Invasive with functional and esthetic
implications, sampling, Field cancerization, Poor patient compliance
• Gold standard treatment is surgical biopsy.
• New techniques are required.
Goals
(1) Design and construct a low cost mini-probe for smart phones that combines high resolutionpolarized white light images (pWLI) and auto fluorescence imaging (AFI).
(2) Test probe design, ergonomics and functionality .
Materials and MethodsImaging Probe
Optical concept of the proposed mobile phone imaging device for oral cancer screening. All components in black are built-in components in mobile phone, others inside the red box are components in the intra oral imaging probe.
Materials and Methods• 15 human subjects in full compliance with UCI IRB-
approved protocol 2002-2805.
• 10 subjects with healthy oral mucosa and 5 subjects with leukoplakia.
• 6 standard oral sites imaged in each subject.
• 3 dual-modality images recorded for each site.
Materials and Methods • Clinicians and subjects evaluated the device’s
– ease and comfort of use
– size and shape-compatibility with the mouth
– weight
– imaging speed
– clarity and color of images
– resolution and magnification
– detection of differences between healthy and diseased oral mucosa
ResultsHigh-resolution pWLI mapped mucosal color, texture and vascularity at levels of high resolution.
ResultsAFI images of healthy oral tissues showed a characteristic strong green AFI signal.
ResultsAFI images of pathological oral mucosa showed areas of dark reddish-brown signal.
Results
• AFI signal differed minimally between subjects for any 1 specific imaging location.
• AFI signal differed in intensity and variability between each of the 6 imaging locations in the same subject and
between subjects.
Conclusion• Effective design and appropriate for clinical use.
• recorded data in subjects with healthy and pathological oral mucosa.
• Observed site specific AFI characteristics.
• Healthy tissues were differentiated from pathological ones.
• Next steps:
- Re optimize intra-oral imaging probe.
- Developing image processing software.
- Clinical validation studies.
• We gratefully acknowledge funding from NIH: award # 1UH2EB022623-01
Thank you