1

Dr. Brielmann

Dear student and parents/guardians,

Welcome to Chemistry!

This packet contains

1. A syllabus

2. A student survey

to be completed in class

3. A safety contract

The safety contract must be signed and returned to me by tomorrow; students cannot begin lab

work until it is signed and returned.

Thanks in advance for your cooperation,

Dr. Brielmann

Homework (5 points): Please have on your desk tomorrow, and each day

1. A 3 ring binder with this packet inserted (please do not use pockets).

2. A scientific calculator

3. A pen or pencil

4. Your completed homework: for tomorrow: this is your signed safety contract.

5. Read the story “How I got hooked on chemistry” which is in this packet.

2

Chemistry

Dr. Brielmann

Syllabus

Introduction

Welcome to chemistry! I look forward to working with you this school year. The purpose of this

handout is to summarize the goals, content, grading policy, and class expectations for this school

year.

What is everything made out of?

That is the essential question for this course- the same question that the we all naturally ask as

we look at the world around us. Finding the answers to this question is both challenging and

rewarding. For a few of you, opening your mind to the world of chemistry may change the course

of your life, as it did for me. For all of you this course will help you to understand the world

around you.

Content

Here are the chapters we will cover. Each chapter will last for 1-2 weeks, and most chapters will

be tested individually.

1. Introduction to

Chemistry

2. Data

3. Matter

4. The Atom

5. Electrons

6. The Periodic Table

7. Chemical Bonding

8. Chemical Reactions

9. The Mole

10. Gases

11. Solutions.

12. Energy

13. Reaction Rates

14. Equilibrium

15. Acids and Bases

The System

At the beginning of each of the 15 chapters shown above, each student will receive a packet

to be inserted in your 3-ring binders. It includes everything you need for the chapter- labs,

worksheets, and slides. You will also receive a textbook that you may keep at home for

evening homework. At the end of the chapter you will be tested, and your notebook will be

collected.

Class Rules

1. Notebook open at the bell, homework out

2. Listen while others are speaking

3. Respect each other

4. No ipods, cellphones, food, or drink in classroom.

These rules are in place to help promote a friendly, hard-working classroom environment.

3

Grading Policy

This class uses a “pure points” system: your grade will be determined by the points

accumulated from homework, tests, and lab reports. For, example, you might earn 90 points

on a 100 point exam, and 5 points on a 10 point quiz. Your average at that point would be 95

points out of a possible 110 total points for an “average” of 86%. Your grade can be accessed

on PowerSchool through the GHS website, also available on the chemistryadventure website.

During any type of testing, there will be no communications in any form with any other

student(s). Should such communications take place, the student(s) will receive a grade of

zero on the test.

What to bring to class

1. An up to date 3 ring binder with chapters and homework.

2. A scientific calculator

3. A pen or pencil

Common Issues

1. Late to class

Students who are late to class without a pass will receive a minor point deduction

on their next test. Three tardies will result in detention.

2. Arriving unprepared.

Students who do not have a binder, calculator, and a pencil will receive a minor

point deduction on their next test. Daily homework is worth 5-10 points.

3. Ipods and cellphones visible in class

Ipods and cellphones will be confiscated if seen, and delivered to the student

affairs center. You will be permitted to use internet capable devices such as

iphones only when specifically requested by the teacher.

4. Lab Groups of more than 2

To receive credit for a lab experiment your group must be no more than 2

students.

4. Absences

Unexcused absences are treated in accordance with the student handbook.

Students are responsible for making up lost work and will still have to take each

test. Makeups are available for students with a score of less than 70%.

5. Homework from other classes

Will be confiscated if students work on it in class unless specifically instructed

otherwise.

6. Students not seated or not in assigned seats

Please remain seated in your assigned seat unless instructed otherwise

7. Unsafe laboratory practices

This is a serious offense and will result in immediate removal from class and

detention.

4

Homework

There will be a moderate amount of homework assigned and posted to the right of the

chalkboard, and on the chemistryadventure website most days. Please have it in your open

binder on your desk completed at the beginning of class each day for grading. Most

assignments will be checked at the beginning of the class the next school day for credit. No

credit will be given for late homework. Keep up with the homework and the tests will likely

go well.

L1, Honors

Read

L1, Honors

Problems

Conceptual

Chemistry

Read

Conceptual

Chemistry

Problems

1. Introduction to

Chemistry 1-11, 46-53, p. 31: 1

p. 53:

1,2,4,5,7,11,12

2. Data 12-18, 55-

58, 63

p. 14: 1-3

p. 31: 6,7,8,9,10,

32, 35, 36, 37,

38

p. 59: 1-3

p. 63: 1,

2,3,4,5,6

3. Matter 22-27

4. The Atom 74-88

234-235

p. 89:

1,2,3,4,5,6,7,8

p. 236: 1,2

5. Electrons 90-98 p. 99: 1-11

6. The Periodic Table 116-122;

124-131;

132-141

Optional:

142-147

p. 122: 1-14

1-13

7. Chemical Bonding 158-165

166-175

176-179

190-198

199-207

Honors

only: p.

208-213

p. 165: 1-13

p. 175: 1-10

p. 180: 1-8

p. 198:

1,3,5,6,7,11,12,14

p. 207:1-13

Honors only: 1-11

8. Chemical Reactions

9. The Mole 100-101

224-233-

236-238

p. 102:1-4

p. 103: 1-3

p. 228: 1-4

p. 229: 1-5

p. 230: 1-4

p. 233: 1-13

5

p. 239: 1,2

10. Gases

11. Solutions.

12. Energy 38-45; 60 p. 45:

1,2,3,5,6,12

p. 61: 1-4

13. Reaction Rates

14. Equilibrium

15. Acids and Bases

1. Introduction to Chemistry

2. Data

3. Matter

4. The Atom

5. Electrons

6. The Periodic Table

7. Chemical Bonding

8. Chemical Reactions

9. The Mole

10. Gases

11. Solutions.

Textbook

The honors and level one classes are based on the textbook Chemistry (Holt Publishers), and

the Conceptual Chemistry classes use the book Conceptual Chemistry. They will be handed

out on the first day, and students may keep them at home for evening homework

assignments. A set of class textbooks will be available. Students are fiscally responsible for

the textbooks, which must be returned at the end of the school year in good shape.

Absences and Makeup Tests

If you are absent from class it is your responsibility to find out what you missed and make

up any missing work. Daily and weekly lessons and homework are posted in class, and on the

chemistryadventure website; this is where to find out what you missed. Contact me if you

have missed class- you will still have to take the test.

All students must take each test regardless of the number of absences. Even if you had

multiple absences, give the test your best effort- at the very least it will help guide you for

the makeup test. A makeup test is available to all students; scores will be averaged. To help

invite your best effort on the first attempt, the makeup test is designed to be more

challenging than the first test.

Fiscal Responsibility

6

Students are fiscally responsible for instructional equipment including laboratory materials

and the textbooks.

Ipods and Cellphones

The school policy will be enforced- cell phones and ipods are not allowed in the classroom.

They will be confiscated if they are seen at any time in the classroom.

Media Privacy

Occasionally there may be photographs or videos taken of us in the classroom. Although

these are usually popular for the students and are good for the class morale, it is important

for each student to know that their right not to be photographed or videotaped is important

and will be respected. Additionally, any photos or videos that are taken in the classroom will

never be shared outside the classroom. Each student was mailed a media privacy form at the

beginning of the year. Please let me know if you prefer not to be photographed or

videotaped.

In the News

We will begin each day of class with an In The News presentation by a member of the class

highlighting any chemical discoveries that were made recently. These are brief

presentations that are emailed to me the day before each presentation. For examples see

the “In the news” section at chemadventure.com. Use the presentation I provide on the first

day as a model for your own presentations.

Final Note to students/Parents/Guardians

Please contact me whenever you wish. I prefer to communicate by email

(brielmannh@guilford.k12.ct.us).

Again, welcome to the world of chemistry. I look forward to working and learning and exploring with

you this year.

Dr. Brielmann

(Dr. B.)

How to submit an “In the News” Presentation

Create your in the news presentation using Wix or a similar website, and email an

invitation to me at brielmannh@k12.ct.us

7

Lab Safety Contract

You and your parent must read and sign this contract before performing any experiments.

1. The science laboratory can provide you with the exciting opportunity to do science. However,

remember at all times that the laboratory is a place for serious work. Fooling around or disruptive

behavior will result in removal from the laboratory.

2. Always prepare for an experiment by reading the directions for the experiment before you

come to the laboratory. Follow the directions carefully and intelligently, noting all precautions.

Note the MSDS (Material Safety Data Sheets) precautions for each chemical. Do not add to, omit

or change any of the directions unless your teacher instructs you to do so.

3. Know the location of the Chemical Safety Policy and the MSDS. These include handling

precautions, disposal techniques and other pertinent information as noted on the MSDS for each

chemical.

4. Do only the experiments assigned or approved by your instructor. Unauthorized experiments

are prohibited.

5. Read the label to be sure of the contents and information provided by the MSDS. Do not use

any chemicals stored in unlabeled bottles.

6. Throw all solids and paper to be discarded into the chemical waste jar or other location

directed by the teacher. Discard chemical waste as per MSDS instructions. Follow directions for

recycling products of your experiments per directions from your instructor.

7. Never discard matches, filter paper or any other slightly soluble solids in the sink. Please clean

the sink at the end of each lab.

8. Know the location of the eye wash, hood, blanket station, and the laboratory evacuation exit

procedure. In the rectangle on the other side of this page, diagram the lab area noting the

locations of all safety equipment, exits, fire alarms, etc. Note the location of the Chemical Safety

Plan and MSDS envelope for experiments.

9. When working with corrosive materials, goggles, gloves and lab aprons must be worn throughout

the lab period until ALL your classmates have completed the lab and the chemicals are safely

stored. The rule for goggles is simple: If the instructor has them on, you should have them on, even

if you have completed your experiment.

10. Do not touch chemicals with your hands.

Important addition: The internet, and YouTube in particular, may contain extremely hazardous

videos that include explosions, fire and even bombs. Parents, please monitor your children

carefully to be sure they never attempt to perform any at-home experiments- they can lead to

severe injury or death.

8

11. If acid or another corrosive chemical is gets in your eyes, wash with water for at least 15

minutes. Notify your instructor immediately.

12. Never taste a chemical solution.

13. No food (including candy or gum) or drink is allowed in the laboratory.

14. Sports cap drink bottles may be allowed (at teacher’s discretion) but may not be used during

laboratory activities using chemicals. Never have a water bottle at a lab station.

15. When observing the odor of a substance, do not hold your face directly over the container.

Fan a little of the vapor toward you by sweeping your hand over the top of the container.

16. Allow ample time for hot glass to cool. Remember that hot glass looks like cool glass.

17. Report any accident, even a minor injury, to your instructor.

18. Long hair must be tied back securely.

19. Never return unused material to stock bottles. Do not put any object into a reagent bottle

except the dropper with which it may be equipped.

20. Keep your apparatus and work area organized. Avoid spillage, but if you do spill something,

clean it up immediately using proper technique. Put your own equipment into your drawer and/or

return any special apparatus to its proper place at the end of the period.

21. During clean-up time, attend to your assigned area duties. All duties must be completed before

leaving the laboratory. Wash hands thoroughly with soap at the conclusion of each lab.

22. Respect your equipment and fellow laboratory workers.

23. Handle all spring-loaded and projectile devices with extreme caution to prevent accidental

release or discharge.

24. Back packs and book bags must be stored under your table or on your chair out of the aisles to

accommodate proper egress from the lab/classroom.

25. Students are not to work in a laboratory unless an instructor is present. All student

experiments are to be done under the direct supervision of an instructor.

26. Open toe shoes/sandals and loose fitting clothing or jewelry are not permitted during

specifically designated laboratory activities. Your instructor will notify you in advance of the

activity.

27. Science department regulation states that safety goggles (flexible plastic with ventilating

ports for chemical splash and glass breakage standard) must be worn by all students, teachers and

9

visitors in the laboratory during work periods including clean-up time in accordance with State

Statute.

Science Department Policy and State Statute:

“Any person who is working, teaching, observing, supervising, assisting or engaging in any work,

activity or study in a public or private elementary or secondary school laboratory or workshop

where the process used tends to damage the eyes or where protective devices can reduce the risk

of injury to the eyes concomitant with such activity shall wear an eye protective device of

industrial quality in the manner in which such device was intended to be worn.”

In order to maintain a safe working environment, teachers are required to remove from the

classroom any student out of compliance.

I HAVE READ THE ATTACHED SAFETY RULES AND HAVE BEEN PRESENT WHEN THEY WERE

DISCUSSED IN CLASS OR DIRECTLY WITH MY SCIENCE TEACHER.

_____ YES, I HAVE ALLERGIES/SENSITIVITIES:

Print Name ______________________

Student Signature _____________________Period ______________________

Instructor _________________________ Date _______________________

I HAVE READ AND DISCUSSED THE LABORATORY SAFETY RULES WITH MY CHILD.

Parent Signature __________________________ Date _______________

10

Name______________________________ Period_________

Chemistry Dr. Brielmann

Student survey

Parent/guardian names:________________________ ___________________

Your email address (please write neatly):_______________________________

What Science courses have you recently taken?

Year____________________ Course ________________Teacher________

Year____________________ Course ________________Teacher________

Please fill out the following table:

Very Interested

Interested

neutral

Not interested

Definitely

not interested

I am concerned about the environment

I am concerned about meeting America’s future energy needs

I am curious about hydrogen as an energy source

I would like to know how a battery works

I would like to learn about nuclear power

I am considering a career in medicine

I would like to learn about the chemistry of steroids

I like to watch stuff explode

Do you have internet access at home? Yes / No. Can you access the internet at school? Yes / no

Do you have interned access on your cell phone? (It’s ok if you do)

What do you plan to do after high school?

What colleges or universities are you applying to?

Tell me a little about yourself.

11

Notebook Check

Throughout the school year your notebook will be checked weekly to help keep you organized, and

to keep you from falling behind. This notebook will be a valuable reference in college, and I

encourage you to hold on to it. It is critical, however that you do not share it with any students who

may be later taking this course. Aside from the fact that it is considered cheating, it means they

will not get the opportunity to discover any of the concepts and ideas for themselves.

Your notebook will generally be collected on Fridays, and will be returned on Mondays. It will also

be randomly collected during the year to help you keep it up to date, and for periodic grading of

labs and worksheets. Please do your best to keep everything organized and follow these rules-

1. Make the front page your notebook check page, always. Reinforce the 3 holes.

2. Insert chapters, tests, and all class handouts chronologically: chapter 1 on top, chapter 15

at the end.

3. Do not use pockets. Everything must be punched and in the binder.

4. Complete all assigned worksheets and slides for credit.

5. Have the notebook opened to your completed homework assignment at the beginning of

each class to receive credit.

On the following page is your schedule for notebook checks. Please keep it at the front of your

notebook so I can find it easily.

12

Notebook Check Schedule: Please make this the first page in your notebook, always. Reinforce each

of the 3 holes.

Date Score Comments

13

Chemistry Chapter 1: Introduction to Chemistry

How I got Hooked on Chemistry

In 1979 I took a course at the University of Connecticut called Advanced Organic Chemistry. Our

Professor was Sam Huang, who gave us instructions on the first day and then we rarely saw him

again. We were told we had to complete three experiments:

1. Identify an unknown pure chemical sample

2. Purify and identify 2 unknown chemicals in a mixture

3. Create a new chemical

He gave each of us a vial with a liquid or a powder in it. We had three weeks to identify it. Mine was

a shiny white solid. Under a magnifying glass it appeared as flat white plates. It melted sharply at

212 degrees Celsius. A big clue was discovered when I placed it under ultraviolet light- it glowed

with a bright blue color. With this information I was able to correctly identify the solid as

Anthracene, a constituent of coal.

Next, he gave each of us another vial. We were told it was a mixture of two chemicals. We had

three weeks to separate and identify them. This time the vial had a dull

white powder in it. I watched as my lab partners set up complex

chromatography and distillation devices and began tedious separations of

their mixtures. Ugh. Under a magnifying glass two distinct crystals could

be identified- needles and plates. It took a couple days, but I was able to

separate my mixture using a pair of tweezers and the magnifying glass, and identify each sample.

Finally, we had the rest of the semester to make a new chemical. I got so excited about this one

that I skipped spring break and spent it at the library. Yes, I had become a science nerd, big time.

It was my first time reading real accounts of chemical research and I found it fascinating. Here

people were creating chemicals to treat cancer, make bulletproof plastics, all sorts of projects

…but what really interested me was the field of natural products- the study of natural, not man-

made, chemicals. I found a research paper where the individual chemical that creates the main

flavor of pineapples and strawberries was created in the lab. It was called furaneol, and I decided

I would make my own version of it with a slight chemical change designed to give it a sweeter taste.

The initial experiments were a disaster. There were chemicals I needed that weren’t in the

stockroom. My lab partners were goofing off while I was working with dangerous

chemicals. And soon the deadline was approaching, but in the end I managed to

make a small amount of a white solid, and the spectroscopic data matched the

chemical structure. I realized that with enough effort any chemical one could

imagine could eventually be made, and it seemed to me this was a powerful tool. I

changed my major from biology to chemistry, and two years later I had my first

job making chemicals designed to study cancer.

In this class each of you will be given a similar opportunity to explore, imagine, and create using the

chemical skills and knowledge from this class. In your first hands-on experiment you will be asked

to create an artistic design using some safe, simple ingredients. By the time this class is near

complete you will be ready to identify unknown samples and safely perform your own initial chemical

research in a field of your choice.

Our first chapter: Introduction to chemistry, will follow the following tentative schedule:

Day 1: Introduction to Chemistry

Introductions, hand out packet, water into wine demonstration, whoosh bottle

demonstration, class picture, class rules.

Anthracene

O

OH OH

furaneol

14

Homework: Get safety agreement signed by parents. Read “How I got hooked on

chemistry”. Bring in 3 ring binder, pencil, and calculator

Day 2: Chemical Rainbow Lab

Notebook check, Homework check.

Homework: Complete chemical rainbow lab. Prepare for notebook check

Day 3 :Activity: The Periodic Table of Our Class

Notebook check, homework check, distribute class pictures.

Homework: Work on Periodic Table of our Class Posters; due date to be assigned in

class. Complete Unit 1 Slideshow assignment on Chemistryadventure.com

Day 4: Slideshow: Introduction to Chemistry

Notebook check, collect Periodic Table of Our Class Posters.

Homework: Complete Introduction to chemistry worksheet (WS 1.1) and Introduction

to chemistry worksheet (WS 1.2)

Day 5: Review

Homework: Complete how to ace your first chemistry test worksheet; study for test.

Day 6: Test- Introduction to Chemistry

15

Day 1: insert flammability lab

Name: ___________________________________Period: _____ Lab1.1

The Periodic Table of Our Class

30 Points

Introduction: One of the biggest scientific discoveries occurred during the time of our civil war,

when it was eventually determined that the universe consists of only about one hundred elements,

and that they exhibit highly organized, periodic behavior. For example, elements number 2, 10, and

18 are inert and stable, while elements 3, 11 and 19 ignite when placed in water. Your task is to

discover a similar periodicity for the students in this class.

As an added challenge, three dimensional tables earn five bonus points.

Directions: A form will be passed around in class to gather information about each student, and

each of you will get a copy. Use this information to create an informative periodic table or our

class.

Grading will be based on:

10 points neatness: a superior poster has the same level of neatness as the periodic table in

our classroom

10 points clarity: Obvious patterns exist throughout the table. The key is clear and brief,

and like the periodic table, all organization is “global”, not “local”. This means that the

patterns are throughout all rows and columns , not within each row and column. Ask me if you

still aren’t clear.

10 points utility: A great class periodic table quickly shows obvious trends. For rectangular

tables, the corners should show extremes. For example, one corner may show the oldest,

most quiet student, and the opposite corner is the youngest, loudest student.

This assignment must be completed and turned in on the date assigned.

1. You are an element. Fill in the information below and copy it on to the board. Name Element

Name

Element

Symbol

(Capitalize

first letter

Age in

days

(16

years

=5840;

17

years =

6205

Height

in

inches

Astrological

Sign

Choose one:

Boring

Nerd

Interesting

fascinating

Wild child

How

loud

are

you?

Quie

t

Mode

rate

Loud

Reall

y

loud

How

smart

are

you?

Brain

dead

Not

smart

Smart

Really

smart

Brillian

t

Favorite

musical

style

Rock

Punk

Grunge

Rap

Hip hop

Other:

Dr. B Beeenium Be 18,396 67 taurus nerd mode

rate

smart rock

16

3. Based on this information create a periodic table of our class. Note that the periodic table

shows patterns for both rows and columns. Be sure to refer to the scoring guide and directions

while creating your periodic table of the class.

17

Name ____________________________ Period_____________ lab 1.2

Chemical Rainbow Experiment 14 Points

Objective; Use the materials listed below to create a visually stunning display that shows as many

layered colors as possible. Be sure to provide a repeatable procedure so that anyone in the class

could repeat your experiment.

This is our first chemistry laboratory experiment. It is designed to let you discover that

1. Chemistry is fun!

2. A good experimental procedure can be repeated by anyone

3. Understanding physical properties such as solubility, density, and viscosity allow us to

predictably manipulate chemicals.

You will receive one point for each separate layer of color, and five points for a repeatable

procedure. The effort and reproducibility of your lab report (this paper) are also worth 5 points.

The group that creates the largest number of separate layers gets 5 bonus points. There may be

additional bonus points for creating other solutions- listen to the instructions.

Materials (May vary)

Corn syrup

Shampoo

Strawberry syrup

Corn oil

Mineral oil

Water

Sugar

salt

graduated cylinders

Food coloring

Clear cups

Watch glasses

Here are things we tried, and the results:

We tried: Results:

Here is our final repeatable procedure to create a _____-layer rainbow (create a clear numbered

list):

18

Discussion

Solubility is the ability of one solution to dissolve in another.

Example: Oil is insoluble in water

Density is the mass of a substance for a given volume

Example: Water has a density of 1 gram per milliliter; air is much less dense (0.001

g/mL)

Viscosity is the resistance of a substance to flow.

Example: Honey has a greater viscosity than water.

Questions

1. Give an example of two substances in your experiment that are form an insoluble mixture

(2 layers): ______________ and ____________. The sample with greater density

is_________.

2. In this experiment, how does the density of your substance affect the results?

_____________________________________________________________________

____

3. Is it possible for samples with a big difference is density to be soluble in each

other?_______

4. Two samples that are insoluble in each other can be made to form two layers, at least for

a while, if they have a large difference in solubility/density/viscosity (circle one).

Score: ____/4 layers + ____/5 for repeatable procedure + ___ bonus points + _____/4

questions= ________/14 points

19

1

Introduction to

Intro video

20

21

22

23

24

25

18

10. The big question: What is everything made out of?

2. W

hat

is

chem

istr

y?7

. The scientific m

ethod

1. W

hy

is c

hem

istr

y aw

esom

e?

4. What do chemists do? 5. What do chemists look like?3. What is matter?

6. B

ranches of ch

emistry

8. Quantitative and Qualitative data 9. Precision vs. accuracy

10. The big question: What is everything made out of?

9. Precision vs. accuracy

Marie Curie1903, 1911radioactivity

Irene Curie1935

neutron

Barbara McClintock1983 DNA

Dorothy Crowfoot Hodgkin1964B12

Richard Schrock 2005 catalysts

NameThat

scientistEnd Unit 1

26

WS1.1

Name_____________________________Period____________

What is Chemistry? Worksheet

Introduction: For this school year we will be investigating chemistry

together. Perhaps we should start by thinking about the word.

chemistry

What thoughts does it bring to mind?

One place to get a feel for a real world definition is to Google it. One of the first things that

comes up is, well, dating sites. Chemistry seems to imply a proper mixing of things, which is nice.

Others who have had exposure to it before think of strange topics like the mole, and labs where

mixing things creates strange colors and smells.

Hopefully by now you have learned by now that chemistry is the study of matter. This means

chemists such as yourself want to know not only what everything is made out of (our essential

question for the year), but also how to mix things together to create new substances. The mixing

part is fun, but finding out what everything is made out of can also be exciting. For example, a

natural products chemist in 1962 isolated an extract from a simple pine tree (the pacific yew) that

contained the chemical taxol, now used extensively for the treatment of many forms of cancer.

The word chemical also seems to have two definitions- the one that scientists use, and the way

everyone else thinks about it. We will always use the scientific definitions, but it would be

unrealistic not to consider other viewpoints. Scientists consider be a chemical to a pure substance.

Any pure substance. Water, for example. But out in the world, most people think of chemicals as

substances that are BAD for you.

Please answer these questions to the best of your ability.

1. What is chemistry?

2. What do chemists do?

3. List 10 chemicals:

1.

2.

3.

4.

5.

6.

7.

8.

9.

10

27

28

WS1.2

Name___________________________________Period____________

Introduction to Chemistry Worksheet

Xiaozhang Zheng (his American friends call him Zang) is a friend of mine that worked

for Neurogen, a small biotech company in Branford, Connecticut. Unfortunately they

went out of business in 2008. He is a chemist that was part of a team working to

develop a new pill for relieving pain. As of 2008 this medicine is in phase II clinical

trials. The medicine is known currently as MK-2295, and it works in a brand new

way, by docking into a receptor known at TRPV1.

Here is your at-home homework assignment. Use the internet to answer these

questions.

1. Describe the purpose of each of the FDA (US Food and Drug Administration) phases for

experimental drug clinical trials:

Phase I:

Phase II:

Phase III:

Launch:

2. What is the status of MK-2295?

Hint- you may want to try the following websites:

http://clinicaltrials.gov/ct2/show/NCT00387140?term=mk+2295&rank=1

and

http://clinicaltrialsweb.blogspot.com/2008/03/caution-recommended-following-study-

on.html

On a typical day my friend Zang arrives to work in the morning, has a cup of tea, and does a

computer search for any important scientific updates that relate to his field. Then he goes into the

lab and checks on any chemical reactions that have run overnight to see if they are complete. To do

this he will pull out a small sample (an aliquot) and have them analyzed on some instruments in a

nearby lab. Then he will start some new chemical reactions to make some more research drugs for

testing. Those that are complete he will take over to a nearby building where they will be tested on

some animal cell lines to see if they are effective, and safe. As the reactions are cooking he will

prepare some stock aqueous solutions that he routinely uses during the day. Before he leaves at the

end of the day he will draw some of the molecules he is planning for the next day on his computer

and the computer will predict whether those compounds are likely to be safe, effective, and

whether anyone else has made them before.

29

Use your class notes to answer the following questions:

1. When is Zang acting as

A. A computational chemist?

B. A medicinal or organic chemist?

C. An inorganic chemist?

D. A biochemist?

E. An analytical chemist?

2. Which data is Zang likely to consider more important, the predictions from his computer, or the

results of his animal cell lines? Why?

3. Is there any time during Zang’s research when he is not working with matter? Provide an

example.

4. Give an example of a time when Zang is involved in a science that is more applied (less basic) than

chemistry.

5. What is an aliquot?

6. Draw the OHEC cycle for the scientific method, and include an example from Zang’s work for

each step that shows the scientific method in action.

7. When testing his chemical Zang will compare his reaction mixture to authentic samples of both

his starting material and his desired product to be sure things are going according to plan. Which

sample acts as a positive control?

Which sample acts as a negative control?

30

Name___________________________________ Period___________ howtoaceit1

How to Ace your First Chemistry Test

Test 1 Unit 1: Introduction to Chemistry

In this our first unit we were introduced to the world of chemistry. We began by asking ourselves

what chemistry is, and what chemists do. As an example we showed how small chemicals can make

large differences in color during the “water into wine” demonstration. We created a “Periodic Table

of Our Class” to show how properties may be categorized. We also performed a solubility lab to

introduce ourselves to observing and comparing the physical properties of some liquids. We then

explored the branches of chemistry, and how chemistry fits in with the other sciences.

We wrapped things up by reviewing a brief version of the scientific method, and the difference

between accuracy and precision. In unit 2 we will explore data- how it is collected, and how it is

analyzed.

I’m sure you would all like to ace your first chemistry exam. Here’s how.

1. Test yourself on the topics below.

2. Review this packet in its entirety. Be familiar with each of the 10 topics that were

covered in the powerpoint presentation.

3. Write down what you don’t know yet. If you don’t know something, ask a friend or ask me.

4. If you are missing anything it may be available on the class website:

http://www.chemadventure.com

note that the in-class material may be more recent than the website. This exam is

based on in-class material.

Topics:

1. What is chemistry?

Chemistry is____________________

2. What is matter?

Matter is_____________________

3. Branches of chemistry: organic, inorganic, analytical, medicinal, forensic,

Physical

a. organic:

Organic chemistry is____________________

b. inorganic:

Inorganic chemistry is___________________

c. analytical:

Analytical chemistry deals with____________________

d. medicinal:

Medicinal chemistry deals with___________________

e. forensic:

Forensic chemists are all about__________________

f. physical:

31

A physical chemist is only concerned with_____________________

In a physical change, ____________________________________

4. The Scientific Method (OHEC):

5. Controls- negative and positive

Negative controls ________________________. Example:_____________

Positive controls _____________________________

A control is a __________________________________

6. Pure vs. applied science

1.___________2.___________ 3.__________ 4. ___________ 5.__________

7. Qualitative and quantitative data

Easy: Quantitative data involves_____________

8. Accuracy and precision

Accuracy:___________________ Precision:_______________

9. Safety in the lab: where is the safety equipment?

10. What are meant by the terms solubility, viscosity, and density, and what how do they influence

the mixing of solutions?

11. About how many elements are there, and what sort of periodic behavior do they have?

12. Level 1 only: You are responsible for the material covered in the “in the news”

presentations. You should also be familiar with the work of

Marie Curie :

Irene Curie :

Dorothy Hodgkin :

Barbara McClintock:

and Richard Schrock.

Finally, for all students: Consider the positive and negative impact of chemistry on

society.

32

Additional topics 2008

13. Use words to complete the following chemical equations

Methanol + ____________ ____________ + ______________

Propanol + _____________ ___________ + ______________

Magnesium + __________ _______________________

14. A yellow and a red solution are slowly combined. They form 2 fairly distinct layers with

the red layer on the bottom. However when stirred they form one orange layer. What is

going on in terms of density, viscosity, and solubility?

Density:

Viscosity:

Solubility:

15. What is wrong with this chemical symbol:

HB