A Graph-Based Recovery and Decomposition of Swanson’s Hypothesis using Semantic Predications
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Transcript of A Graph-Based Recovery and Decomposition of Swanson’s Hypothesis using Semantic Predications
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A Graph-Based Recovery and Decomposition of Swanson’s Hypothesis using Semantic
Predications
Delroy Cameron, Olivier Bodenreider, Hima Yalamanchili, Tu Danh, Sreeram Vallabhaneni, Krishnaprasad Thirunarayan,
Amit P. Sheth and Thomas C. Rindflesch
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Experiment 1:Run Final
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Primary Association 1: Platelet Aggregation (path#1)Dietary Fish Oil->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome
Epoprostenol
Raynaud Syndrome
DISRUPTS
DISRUPTS
Platelet Aggregation
DFO/EPA/FOD/FO
CAUSES
STIMULATES TREATS
Epoprostenol = Prostacyclin (PGI2)
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Supplementary Association: Platelet Aggregation (path 1a)
DFO/EPA/
FOD/FO
Dietary Fish Oil->PRODUCES->Prostaglandin (PGI3)-> INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome
Epoprostenol
Raynaud Syndrom
e
Platelet Aggregation
Prostaglandin I3
ISA
CONVERTS_TO
DISRUPTS CAUSES
Prostaglandin
ISA
DISRUPTS
DISRUPTS
DISRUPTS
ISA
STIMULATES
CONVERTS_TO
TREATS
Epoprostenol = Prostacyclin (PGI2)Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Secondary Association: Platelet Aggregation (path 1.1)Prostaglandin (PGE1)->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome
Alprostadil
Raynaud Syndrome
DISRUPTS
DISRUPTS
Platelet Aggregation
DFO/EPA/FOD/FO
CAUSES
INTERACTS_WITH
Alprostadil = Prostaglandin (PGE1)
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Secondary Association: Platelet Aggregation (path 1.2)Prostacyclin (PGI2)->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome
Epoprostenol
Raynaud Syndrome
DISRUPTS
DISRUPTS/INHIBITS_MAN/PREVENTS_MAN
Platelet Aggregation
DFO/EPA/
FOD/FOCAUSES
TREATSSTIMULATES
Epoprostenol = Prostacyclin (PGI2)
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Secondary Association: Platelet Aggregation (path 1.3)Nifedipine->ISA-CCB->INHIBITS->platelet activation->ASSOCIATED_WITH->Raynaud Syndrome
Epoprostenol
Raynaud Syndrome
DISRUPTS
DISRUPTS
Platelet Aggregation
DFO/EPA/FOD/FO
CAUSES
TREATSSTIMULATES
Nifedipine
DISRUPTSTREATS
Calcium Channel Blocker
ISA
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Primary Association 2: Blood Viscosity (path#2)Dietary Fish Oil->INHIBITS->Blood Viscosity->CAUSES ->Raynaud Syndrome
Raynaud Syndrome
DFO/EPA/
FOD/FO
Ketanserin
TREATSDISRUPTS
Epoprostenol
TREATS
Blood Viscosity
DISRUPTS
STIMULATES DISRUPTS
CAUSES
Epoprostenol = Prostacyclin (PGI2)
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Supplementary Association: Blood Viscosity (path 2a)
Dietary Fish Oil->INHIBITS->triglyceride->ISA->Blood Lipid->AFFECTS->Blood Viscosity->CAUSES ->Raynaud Syndrome
Raynaud Syndrome
DFO/EPA/
FOD/FO
Blood ViscosityDISRUPTS CAUSES
ISA
Essential Fatty Acid
ISA
Triglyceride
INHIBITS
AFFECTS
Lipid
ISA
ISA
Fatty Acid
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Secondary Association: Blood Viscosity (path 2.1)Prostacyclin (PGI2)->AUGMENTS->Erythrocyte Deformability->INHIBITS->Blood Viscosity-> CAUSES ->Raynaud Syndrome (in vitro)
Epoprostenol
Raynaud Syndrome
AFFECTS/DISRUPTS
DFO/EPA/
FOD/FOCAUSES
TREATSSTIMULATES
Epoprostenol = Prostacyclin (PGI2)
Blood Viscosity
Ketanserin
TREATSDISRUPTS
DISRUPTS
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Secondary Association: Blood Viscosity (path 2.2)Ketanserin->INHIBITS->serotonin->AUGMENTS->Erythrocyte Deformability->INHIBITS->Blood Viscosity-> CAUSES ->Raynaud Syndrome
Raynaud Syndrome
AFFECTS/DISRUPTS
DFO/EPA/
FOD/FOCAUSESBlood
Viscosity
Ketanserin
TREATSDISRUPTS
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Primary Association: Vascular Reactivity (path#3)Dietary Fish Oil->INHIBITS->Vascular Reactivity->CAUSES->Raynaud Syndrome
Epoprostenol
Raynaud Syndrome
AFFECTS_MAN
INHIBITS_MAN
Vascular Reactivity
DFO/EPA/
FOD/FOCAUSES
AFFECTS_MAN TREATS
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Supplementary Association: Vascular Reactivity (path 3a, 3b)Dietary Fish Oil-> PRODUCES->Prostaglandin (PGI3)->CAUSES->vasodilation->INHIBITS->Raynaud Phenomenon
Epoprostenol
Raynaud SyndromeINHIBITS_MAN Vascular
Reactivity
DFO/EPA/
FOD/FOCAUSES
AFFECTS_MAN
Dietary Fish Oil-> PRODUCES->Prostaglandin (PGI3)->INHIBITS ->vasoconstriction->CAUSES->Raynaud Phenomenon
Prostaglandin I3
CONVERTS_TOINHIBITS_MAN
INHIBITS_MANISA
TREATS
TREATS
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Secondary Association: Vascular Reactivity (path 3.2)Prostacyclin (PGI2)->CAUSES->vasodilation->INHIBITS ->Raynaud Phenomenon
Epoprostenol
Raynaud Syndrome
AFFECTS_MAN
INHIBITS_MAN
Vascular Reactivity
DFO/EPA/
FOD/FOCAUSES
AFFECTS_MAN TREATS
Epoprostenol = Prostacyclin (PGI2)
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Secondary Association: Vascular Reactivity (path 3.3)Nifedipine->ISA-CCB->INHIBITS->platelet activation->ASSOCIATED_WITH->Raynaud Syndrome
Raynaud Syndrome
Vascular Reactivity
DFO/EPA/FOD/FO
CAUSES
Nifedipine
INHIBITS_MANTREATS
Calcium Channel Blocker
ISA
AFFECTS_MAN
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Experiment 2:Run Final
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Primary Association: Platelet Aggregation (path#1)
Epoprostenol
Raynaud Syndrome
DFO/EPA/FOD/FO
PRODUCES
LOCATION_OF
Platelet Aggregation
TREATSEndothelial
Cells
STIMULATES
Dietary Fish Oil->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Supplementary Association: Platelet Aggregation (path 1a)
DFO/EPA/
FOD/FO
Epoprostenol
Raynaud Syndrome
Prostaglandin I3
ISA
Platelet Aggregation
STIMULATESTREATS
CONVERTS_TO
Dietary Fish Oil->PRODUCES->Prostaglandin (PGI3)-> INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
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Primary Association: Blood Viscosity (path#2)
Raynaud Syndrome
DFO/EPA/
FOD/FO
Ketanserin
AFFECTS
Epoprostenol
TREATS
Blood ViscosityDISRUPTS
STIMULATESDISRUPTS
CAUSES
TREATS
Dietary Fish Oil = EPA/FOD/FOEPA – Eicosapentaenoic AcidFOD – Fish Oil – dietaryFO – Fish Oils
Dietary Fish Oil->INHIBITS->Blood Viscosity->CAUSES ->Raynaud Syndrome
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Epoprostenol
STIMULATES TREATS
DFO
Prostaglandin (PGI3)
CONVERTS_TO
INHIBITS
RS
Platelet aggregation
CAUSES
p1
p2
Epoprostenol
STIMULATES TREATS
DFOCONVERTS_TO
INHIBITS
RS
Platelet aggregation
CAUSES
p1
p2
ISA
Prostaglandin (PGI3)
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Corpus
Semantic Predication Extractor (SemRep)
Predications Graph
Subgraph
Background KnowledgeSemantic Associatio
n Generator