A genomic perspective on human well-being · 2017. 11. 13. · Cole et al. Psychoneuroendocrinol...
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A genomic perspective on human well-being Steve W. Cole, Ph.D. UCLA School of Medicine Division of Hematology-Oncology
Transcript of A genomic perspective on human well-being · 2017. 11. 13. · Cole et al. Psychoneuroendocrinol...
A genomic perspective on human well-being
Steve W. Cole, Ph.D.
UCLA School of Medicine Division of Hematology-Oncology
Lonely
Integrated
Social isolation
78 131
Inflammation
Immunoglobulin G1 production Type I interferon antiviral response
Cole et al. Genome Biology 2007
Low SES Social loss / bereavement Post-traumatic stress Cancer diagnosis Social threat Loneliness Social instability Chronic stress Low social rank Caregiving for seriously ill Anxiety
Early life adversity
Cole et al. PNAS 2011 Powell et al. PNAS 2013
Heidt et al. Nature Medicine 2014 Cole et al. PNAS 2015
Irwin & Cole, Nature Reviews Immunology 2011
Lonely
Integrated
How not to live
How should we live?
How often do you feel happy? How often do you feel satisfied?
Life has direction and meaning?
Grow and become a better person?
Hedonic Eudaimonic
Fredrickson et al. PNAS 2013
FOS FOSB FOSL1 FOSL2 JUN JUNB JUND NFKB1 NFKB2 REL RELA RELB
Eudaimonic
Hedonic
IL1A IL1B IL6 IL8 TNF PTGS1 PTGS2
IGJ IGLL1 IGLL3
GBP1 IFI16 IFI27 IFI27L1 IFI27L2 IFI30 IFI35 IFI44 IFI44L IFI6 IFIH1 IFIT1 IFIT1L IFIT2 IFIT3 IFIT5
IFITM1 IFITM2 IFITM3 IFITM4P IFITM5 IFNB1 IRF8 IRF2 IRF7 MX1 MX2 OAS1 OAS2 OAS3 OASL
Favorable
Adverse
Fredrickson et al. PNAS 2013
Hedonic Eudaimonic
Hedonic
Eudaimonic
Fredrickson et al. PNAS 2013 Cole et al. Psychoneuroendocrinol 2015
Fredrickson et al. PLOS One 2015 Kitiyama et al. Psychoneuroendocrinol 2016
Nelson et al. Psychoneuroendocrinol 2017 Moeini et al. in preparation 2017
Amygdala
Ventral Striatum
Dutcher, Bower, Eisenberger, et al. in prep 2017 Eisenberger & Cole, Nature Reviews Neuroscience 2012
-0.3
-0.2
-0.1
0
0.1
0.2
0.3
-2 -1 0 1 2
r=-.71
VSac.va.on
Proinfl
ammatoryRN
A(lo
g 2)
-0.3
-0.2
-0.1
0
0.1
0.2
0.3
-2 -1 0 1 2
r=+.11
Amygdalaac.va.on
Proinfl
ammatoryRN
A(lo
g 2)
Goetz et al. Psychological Bulletin 2010 Porges Int J Psychophysiology 2001
Porges Psychophysiology 1995
-0.14-0.12-0.10-0.08-0.06-0.04-0.020.000.020.040.060.080.100.120.14
Control
World
Other
Self
∆ C
TRA
gen
e ex
pres
sion
lo
g 2 [
proi
nfla
mm
ator
y –
(inte
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ant
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*
Nelson-Coffey et al. Psychoneuroendocrinol 2017
ControlTrackac'vi'es
x4weeksn=35
Other3kindacts/day
x4weeksn=33
World3kindacts/day
x4weeksn=45
Self3kindacts/day
x4weeksn=42
155healthyadultsUCRiversidecommunity
Creswell et al. BBI 2012 Antoni et al. Biological Psychiatry 2012
Black et al. Psychoneuroendocrinol 2013 Bower et al. Psychoneuroendocrinol 2014
Irwin et al. JNCI Monographs 2014 Bower et al. Cancer 2015
Laudenslager et al. J Behav Med 2016 Antoni et al. Psychoneuroendocrinol 2016
Fredrickson et al. PNAS 2013 Cole et al. Psychoneuroendocrinol 2015
Fredrickson et al. PLOS One 2015 Kitiyama et al. Psychoneuroendocrinol 2016
Nelson et al. Psychoneuroendocrinol 2017 Moeini et al. in preparation 2017
Collado-Hidalgo et al. BBI 2006 Sloan et al. Cancer Res 2010
Powell et al. PNAS 2013 Eyre et al. Pharmacopsychiatry 2017
Ben-Eliyahu et al. Clin Cancer Res 2017 Capitanio et al. in preparation 2017
Collaborators John Cacioppo, Louise Hawkley, Bob Rose Greg Miller, Edith Chen John Sheridan, Nicole Powell Barbara Fredrickson, Karen Grewen Sonja Lyubomirsky, Nelson-Coffey, Megan Fritz Naomi Eisenberger, Janine Dutcher, Mona Moieni Shinobu Kitayama, Satoshi Akutsu, Yukiko Uchida
Support NCI CA116778, CA110793, CA109298 NIAID AI33259, AI36554, AI49135, AI52737 NIA AG107265, AG033590, AG034679 JSPS KAKENHI 25285113 MacArthur Foundation HopeLab Foundation Norman Cousins Center
Those only are happy (I thought) who have their minds fixed on some object other thantheir own happiness, on the happiness of others, on the improvement of mankind.
– John Stuart Mill, in Autobiography, 1909
and healthy
^
Whatisgood?
Whatisbad?
-0.12-0.10-0.08-0.06-0.04-0.020.000.020.040.060.080.100.12
T1 T2
CTRA
gen
ecompo
site(z-score) World
OtherSelfControl
Return Nelson-Coffey et al. Psychoneuroendocrinol 2017
hRp://www.newyorker.com/tech/elements/a-beRer-kind-of-happiness
How to make more eudaimonia?
