A Facile Synthesis of New Tetrahydropyrido[4,3-d]pyrimidine Derivatives.
1
2006 Fused pyrimidine derivatives R 0515 A Facile Synthesis of New Tetrahydropyrido[4,3-d]pyrimidine Derivatives. — Pyrimidine derivatives (IV) are synthesized by reaction of 1-benzylpiperidin-2-one with different nitriles in the presence of triflic anhydride. The methylthio-substituted derivative (IVc) can be further elaborated to dimethoxy or dicarbonyl derivatives ac- cording to the literature. — (HERRERA, A.; MARTINEZ-ALVAREZ*, R.; CHIOUA, R.; ALMY, J.; Tetrahedron Lett. 47 (2006) 31, 5463-5465; Dep. Quim. Org., Fac. Cienc. Quim., Univ. Complutense, E-28040 Madrid, Spain; Eng.) — S. Adam 46- 199
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Transcript of A Facile Synthesis of New Tetrahydropyrido[4,3-d]pyrimidine Derivatives.
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2006
Fused pyrimidine derivativesR 0515 A Facile Synthesis of New Tetrahydropyrido[4,3-d]pyrimidine Derivatives. —
Pyrimidine derivatives (IV) are synthesized by reaction of 1-benzylpiperidin-2-one with different nitriles in the presence of triflic anhydride. The methylthio-substituted derivative (IVc) can be further elaborated to dimethoxy or dicarbonyl derivatives ac-cording to the literature. — (HERRERA, A.; MARTINEZ-ALVAREZ*, R.; CHIOUA, R.; ALMY, J.; Tetrahedron Lett. 47 (2006) 31, 5463-5465; Dep. Quim. Org., Fac. Cienc. Quim., Univ. Complutense, E-28040 Madrid, Spain; Eng.) — S. Adam
46- 199
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