Biosampling Case Children with Leukemia (Acute Lymphocytic and
A Case Study Of A Man With Leukemia
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Transcript of A Case Study Of A Man With Leukemia
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A Case Study Of A Man With Leukemia
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A Chromosomal Translocation is Discovered
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PDGFR-beta null mutants are embryonically lethal
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PDGFR alpha and beta have different downstream consequences
AngiogenesisLymphocytesMetabolism
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The PDGF receptor can activate many Different Pathways
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The ETV6-PDGFRB fusion causes constitutive dimerization
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Chronic Myelomonocytic Leukemia (CMML)Is a Cancer of the Monocytes
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Sources
• http://genesdev.cshlp.org/content/8/16/1888.full.pdf+html• http://ac.els-cdn.com/0092867494903220/1-s2.0-009286749
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• http://www.cancer.gov/cancertopics/pdq/treatment/mds-mpd/HealthProfessional/page2
• http://clincancerres.aacrjournals.org/content/16/12/3094.full• http://www.sciencedirect.com/science/article/pii/S00256196
11612378#
• http://www.cancer.org/cancer/leukemia-chronicmyelomonocyticcmml/detailedguide/leukemia-chronic-myelomonocytic-diagnosed
• http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003794