A Case of Orbital Apex Syndrome
-
Upload
stanley-medical-college-department-of-medicine -
Category
Health & Medicine
-
view
2.894 -
download
1
description
Transcript of A Case of Orbital Apex Syndrome
![Page 1: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/1.jpg)
An interesting case of Vision loss
S. KarthikeyanProf. P. Vijayaraghavan’s Unit
M5Special Thanks: Prof K.S. Chenthil.,IMCU
![Page 2: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/2.jpg)
On 18/9/10
30yr male Mr. Srinivasan,admitted in surgery dept.
c/o pain abdomen 2 days Diagnosed and treated as Acute pancreatitisImaging and biochemical analysis supportingDeveloped AKI – 3 cycles of HD doneTransferred to IMCU on 25/9/10
![Page 3: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/3.jpg)
25/9/10 In IMCU loss of vision in rt eye noted -2 d complete painless no reddening/watering drooping of eye lid +No h/o floaters No h/o diplopiaNo h/o traumaNo h/o similar symptoms in other eye
![Page 4: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/4.jpg)
No h/o sugg.of other cranial nerve involvement
No h/o difficulty in using the limbs No h/o disturbance in sensory modalitiesNo h/o involuntary movementsNo h/o headache/ blurring of vision/projectile
vomitingNo h/o altered sensorium
![Page 5: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/5.jpg)
h/o fever -3 days continuous low grade no rigors/chillsh/o abdominal pain+ diffuse/dull aching not radiating no agg./relieving factors intensity over past 3 daysh/o abdominal distension+ over past 3 days
![Page 6: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/6.jpg)
h/o vomiting -7 days back 5-6 episodes/d non-bilious lasting for 2 days h/o constipation- 5 days h/o passing flatus+ No h/o passing bulky stools No h/o hematemesis/bleeding PR/melena No h/o jaundice No h/o cough/ shortness of breath No h/o polyuria/polyphagia No h/o nasal/ear discharge No h/o leg swelling/facial puffiness h/o loss of appetite+ No h/o loss of weight
![Page 7: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/7.jpg)
Past h/o: no similar episodes not a known HT/DM/ BA/PTBPersonal h/o: smoker 2 yrs alcoholic 7 yrs mixed dietFamily h/o: no similar illness in family
![Page 8: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/8.jpg)
GE: conscious/oriented
Febrile temp-101F
no pallor/icterus/cyanosis/clubbing/ pedal edema JVP /hydration fair/no lymphadenopathy
R –Eye : Ptosis+ /no reddening/no tenderness/no proptosis L—Eye : Normal
VITALS: Pulse 105/min B.P 110/70 mmHg
![Page 9: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/9.jpg)
CVS: S1S2+ No murmur
RS: NVBS
Abdomen: soft, non tender, no shifting dullness BS+/sluggish
![Page 10: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/10.jpg)
CNS: HMF: Conscious oriented speech- Normal Memory-Intact GCS: 15/15 Pupils:
RIGHT LEFT
5mm—Dilated , not reacting to light
2mm—Reacting to light
![Page 11: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/11.jpg)
CRANIAL NERVES:
NO: RIGHT LEFT
1 N N
2 No PR/PL N
3,4,6 Palsy N
5 N N
7,8 N N
9,10,11,12 N N
![Page 12: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/12.jpg)
MOTOR SYSTEM: NADSENSORY SYSTEM: NADGAIT & COORDINATION: NormalCFT: NormalSPINE & CRANIUM: Normal No e/o meningeal signs
![Page 13: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/13.jpg)
PROBLEMS: Alcoholic
Pain abdomen
AKI– On HD
Fever
R– 2,3,4,6 cranial nerve involvement
![Page 14: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/14.jpg)
DDs :
Purtscher’s Retinopathy
Cavernous sinus thrombosis
Superior orbital fissure syndrome
Orbital Apex syndrome
![Page 15: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/15.jpg)
Purtscher’s Retinopathy:
rare complication of acute
pancreatitis
occlusion of posterior retinal artery by granulocytes
sudden loss of vision
3,4,6 not involved
![Page 16: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/16.jpg)
CAVERNOUS SINUS THROMBOSIS:
Unilateral 24– 48 hrs bilateral
can occur in pancreatitis due to dehydration
chemosis/redness+
proptosis+
blurring of vision +
sudden vision loss rare
3,4,6 cr.nerves involved
5 cr.nerve involvement characteristic
![Page 17: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/17.jpg)
Superior orbital fissure Syndrome:
3,4,6 cranial nerves involved
2,cranial nerve not involved
![Page 18: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/18.jpg)
Orbital Apex syndrome:
2,3,4,6 cr. nerves involved
5,cr. nerve not involved
![Page 19: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/19.jpg)
Diagnosis : Acute pancreatitis
AKI
Orbital apex syndrome
? Infective etiology—Orbital cellulitis ? Sepsis
![Page 20: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/20.jpg)
![Page 21: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/21.jpg)
![Page 22: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/22.jpg)
Investigations CBC Hb 13.5 g/dl TC 14,500 DC P60 L40 ESR 10/25 Plt 1 Lakh PCV 40
18/9 21/9
25/9 27/9 30/9
12,500 13,OOO 14,500 14,000 13,500
P60 L40 P62 L38 P58 L42 P60 L40 P60 L40
![Page 23: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/23.jpg)
RFT
Intake/output
18/9 20/9 22/9 25/9 27/9 29/9 30/9
UREA 120 180 150 130 100 70 60
CREAT 3.2 5.O 4.5 4.0 3.0 2.0 1.4
18/9 20/9 22/9 25/9 27/9 29/9 30/9
INTAKE 2500 1500 1500 1500 1500 2000 2000
OUTPUT 500 200 500 700 1100 1500 1700
![Page 24: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/24.jpg)
RBS/ Urine ketones:
Sr.ELECTROLYTES:
18/9 20/9 22/9 25/9 27/9 29/9
RBS 450 375 400 300 200 150
URINEKETONES
+ + + + + --
18/9 22/9 25/9 27/9
Na 140 135 138 140
K 4.0 3.5 4.0 4.0
Ca 10 ----- ----- 9.5
![Page 25: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/25.jpg)
LFT:T.Bilurubin– 1.0 mg/dlDirect --- 0.4 mg/dlSGOT--- 90 IU/LSGPT---85 IU/LSAP----100 IU/L
LIPID PROFILE--Normal
![Page 26: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/26.jpg)
Sr .Amylase/Lipase:
ABG: Metabolic Acidosis with compensatory respiratory Alkalosis with anion gap
18/9 20/9 23/9 25/9 27/9
Amylase 1873 1200 500 200 50
Lipase 1100 800 750 500 300
![Page 27: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/27.jpg)
ECG: WNL
CXR—L Sided pleural effusion USG Abdomen 25/9: Pancreas obscured Fatty liver+ ascites + CT Abdomen: Bulky pancreas+
![Page 28: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/28.jpg)
![Page 29: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/29.jpg)
![Page 30: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/30.jpg)
Fever profile:
Smear Mp/Mf :Blood Widal : NegativeMSAT :Dengue IgG/M:
Blood c/s:Urine c/s: Negative Swab from CV catheter:Nasal swab c/s: HIV ELISA: NegativeVDRL:
![Page 31: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/31.jpg)
Ophthal opinion: Gen. Arteriolar narrowing+ Ghost vessels+ Cherry red spot + Disc –temporal pallor + Imp: s/o CRAOENT : Sugg. DNENeuromedicine opinion: ?Orbital apex syndrome Sugg. MRI
![Page 32: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/32.jpg)
![Page 33: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/33.jpg)
R- Maxillary sinusitis with ? # medial wall of maxilla
![Page 34: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/34.jpg)
![Page 35: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/35.jpg)
Hyperglycemia/ketones+/Acidosis
CT--R- Maxillary sinusitis with ? # medial wall of maxilla[ ! EROSION ]
Fundus s/o CRAO [!Vascular invasion] ?MUCORMYCOSIS
![Page 36: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/36.jpg)
Nasal swab for KOH mount: hyphal elements+ sugg.fungal c/sDNE : Nasal crust for HPE
MRI Brain with Orbital cuts:
In posterior part of orbit
T1– Hypointensity +T2—Hyperintensity+
Brain normal
![Page 37: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/37.jpg)
![Page 38: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/38.jpg)
![Page 39: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/39.jpg)
FINAL DIAGNOSIS:
CHRONIC ALCOHOLISMACUTE PANREATITISAKIKETOACIDOSIS RHINO ORBITAL MUCORMYCOSIS
![Page 40: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/40.jpg)
ACUTE PANCREATITIS AND KETO-ACIDOSIS:
Ketonemia/ketonuria usually not a feature of Acute pancreatitis POSSIBLE ASSOCIATIONS:Pre-existing DM with Acute PancreatitisAcute on Chronic Pancreatitis:
DM 2 to chronic pancreatitis ̊�Super imposed on acute episodeCan develop ketoacidosis
![Page 41: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/41.jpg)
Contd…
Alcoholic ketoacidosis with superimposed Acute pancreatitis
“Pancreatic ketoacidosis” Ref: U.M.Kabadi et al Post graduate Journal
of Medicine VA MEDICAL CENTER PHOENIX ARIZONA
![Page 42: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/42.jpg)
“PANCREATIC KETOACIDOSIS”
Acute pancreatitis
Lipase
Peripheral fat breakdown
Ketosis/acidosis
![Page 43: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/43.jpg)
Initial treatment:
NPOInj Meropenam 1g i.v tid
Inj Pantoprazole 40 i.v. bd
Inj Tramadol i.m sos
Inj Paracetamol i.m sos
![Page 44: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/44.jpg)
Fluid management:
IVF ---OUTPUT + 600 mlClear fluids orally after 2 days
Inj Insulin HA 5U/hr in NS
Inj Insulin HA 10U In 500ml DNS maintenance
Inj HA s.c. 5U tds after starting oral
![Page 45: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/45.jpg)
MANAGEMENT:Inj. Inj.Amphotericin B i.v – 1.5mg/kg/d over 8-12 hrs
![Page 46: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/46.jpg)
MUCORMYCOSIS“ZYGOMYCOSIS”Serious, uncommonAggressive, lethally invasive mycosisETIOLOGY: Order--Mucorales Genus--Mucor Rhizopus Rhizomucor Absidia
![Page 47: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/47.jpg)
Pathogenesis: Non-pathogenic/Environmental
Spores inhaled—Airway deposition {normally don’t germinate}
Blood sugar/Acidemia Iron overload
Germinate to hyphae
Blood vessel/neural invasion Tissue necrosis
![Page 48: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/48.jpg)
Clinical manifestations:
Rhino-orbital-Cerebral
Pulmonary
Gastrointestinal
Cutaneous
![Page 49: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/49.jpg)
Rhino-orbital-Cerebral Mucormycosis:
Clinical manifestations:Symptoms of sinusitis+Ocular muscle palsy+Sudden loss of vision-retinal artery
invasionProptosis /ptosisBlack Eschar– Palatal involvementCavernous sinus thrombosisBrain abcess/Phlegmon
![Page 50: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/50.jpg)
Pulmonary mucormycosis:
Neutropenia-predisposing factor
Severe pneumonia
Cavitation develops rapidly
High mortality
![Page 51: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/51.jpg)
Gastrointestinal mucormycosis:Occurs in PEM patients
Presents as Perforated viscus
High mortalityCutaneous mucormycosis:
CommonIn sites of trauma
Self limiting area of tissue necrosis
![Page 52: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/52.jpg)
Lab features:Abnormalties reflect predisposing conditions
MicroscopyBiopsy DIAGNOSTICCulture & Sensitivity
STAINS USED:Gomori-methanamine silver,PAS
![Page 53: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/53.jpg)
Management:Reversal of underlying conditionSurgical debridementAnti fungal therapy:Inj.Amphotericin B i.v – 1.5mg/kg/d, can be
stepped upLIPOSOMAL PREPARATIONS:
AmBisome– 15-20mg/kg/dAbelcet—15mg/kg/d
![Page 54: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/54.jpg)
RECENT ADVANCES:Posaconazole –new triazoleCan be used in amphotericin failure Prophylaxis in immunocompromised
FOLLOW UP:Therapy may be required for 3 months after
Clinical stabilisationLab studies,scans,X-rays yield normal results
Follow upto 1 yr necessary
![Page 55: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/55.jpg)
Carry home points
Ketonemia/ketonuria usually not a feature of Acute Pancreatitis
Pancreatitic ketoacidosis – a rare possibility,still can be considered
Mucormycosis is common on ketoacidosisCan be under-reported as SINUSITISTreatment should be aggressive
![Page 56: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/56.jpg)
References :
Harrison’s Principles of Int.Medicine,17 Edition
Kanski’s text book of ophthalmology
‘eMedicine’
Journal
‘Mucormycosis a complication of critical care’ by William A. Agger, MD; Dennis G. Maki, MD Arch Intern Med. 1978;138(6):925-927 ‘ACUTE PANCREATITIS BY RENAL CORTICAL NECROSIS AND CEREBRAL MUCORMYCOSIS’ by C. L. Aszkanazy Dolman and J. A. Herd *From the Departments of Pathology, Vancouver General Hospital and University of British Columbia
Can Med Assoc J. 1959 October 1; 81(7): 562–564.
![Page 57: A Case of Orbital Apex Syndrome](https://reader033.fdocuments.in/reader033/viewer/2022061211/5492e4eeb47959834a8b45aa/html5/thumbnails/57.jpg)
THANK YOU