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Transcript of 98 P 7 T G Áp A ¦ T251… · 244 7 T G Á p A P e 98 P 7 T G Á p A ¦ T ° @ ç p A ½ 1 Ä / ö...
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ISO 9001 2008
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29.5% 55.5%
SPF
SCI 279 Non SCI 45
358
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1. Methods for clinical
investigation
2. Clinical cancer research
3. Genomics and medicine
4. Infectious diseases and
pathogen-host interaction
5.
-- B
–e
2009
11
--
“Gain-
of-function of mutated C-CBL tumour
suppressor in myeloid neoplasms”
(Nature) Vol 460, 904-908 (13 Aug
2009)
“Uncertainty and Anxiety During
the Diagnostic Period for Women With
Suspected Breast Cancer”
CANCER NURSING 2009 Annual
Research Award
98 3 13 3 14
3
245
98
98
98
A
98
8 19
A
B
C
-
OECD GLP (Good Laboratory Practice)
2009
ISO / IEC 17025
TAF ILAC MRA
( )
8 00~12 00
246
98
2
1.
2. Galectins
3.
4.
47
2009
--
3
10 12
8 12
34
98 10 14~10 16
(1) (2) Galectins (3)
Galectins
247
1
CZRPG86053
98 3
GMP
85
17
3 15
25
98
( )
99
(Association for
Assessment and Accreditation of Laboratory
Animal Care, AAALAC)
248
2
98 10
1
BMRP
(FISH)
Real-time PCR
genomic DNA
total RNA
300
100
6
(FISH)
(TMA)
real-time PCR
direct sequencing
EGFR
k-ras mutation HPV EBV C-kit
100
4,306
DNA
RNA
249
3
1.
98 69%
52%
50% 66.7%
65%
2.
98 7
279 7 105
12 132
12
3.
12
PI
1 Proteomic differential displays before and after Tai Chi Chuan exercise
2 Proteomic analysis for the Platelet Proteins of Patients with Major Depression
3Prognostic, Biological, and Potential Therapeutic Implications of Gene Amplification-
Driven Skp2 overexpression in Myxofibrosarcoma
4Proteomic Analysis of Amniotic Fluid in Pregnancies with Edwards Syndrome
Fetuses
5 Angiogenesis Proteomic Profiling in Osteoarthritic Knee
6Pretreatment serum proteome to predict virological response in hepatitis C genotype
1b patients treated with 24-week pegylated interferon plus ribavirin
Follistatin Induced Differentiation of Mouse Embryonic Stem Cells Toward
7 Endoderm Through Enhanced G-protein Alpha 12 Signaling Pathway Revealed by
Quantitative Proteome Analysis Using SILAC Labeling
8Large-scale Proteomic Analysis of Human Wharton’s Jelly Mesenchymal Stem Cells
by SDS-PAGE combined with NanoLC-MS/MS
9Targetome of Inactive Glycogen Synthase Kinase-3β Prevention of Glucocorticoid-
induced Bone Loss
10Calcium-binding Protein S100A9 Mediates Osteoblasts Apoptosis and Severity of
Osteonecrosis of Femoral Head
11 Proteomic Approach to Search Serum Biomarkers for Osteogensesis Imperfect
12Functional Discrepancy and Adjustment of Different Human Mesenchymal Stem
Cells Based on Proteomic Differential Displays
250
4.
12 8 2
PI
Yang KD, Chang WC, Chuang H, Wang PW, Liu RT, Yeh SH. Increase
of complement factor H along with decrease of factor B determined by
1 proteomic differential displays as a biomarker of Tai Chi Chuan exercise.
Clinical Chemistry 2010;56:127-131. (SCI IF = 5.579, CMRPG880251
CMRPF870501)
Yang KD, Chang JC, Chuang H, Liang HM, Kuo HC, Lee YS, Hsu TY,
2Ou CY. Gene-gene and gene-environment interactions on IgE production
in prenatal stage. Allergy 2009 Nov 25 [Epub ahead of print].
(SCI IF = 6.204, CMRPG850353 CMRPG850373 CMRPG880251)
Chen RF, Wang L, Cheng JT, Chuang H, Chang JC, Liu JW, Lin IC,
Yang KD. Combination of CTLA-4 and TGFbeta1 gene polymorphisms
3 associated with dengue hemorrhagic fever and virus load in a dengue-2
outbreak. Clinical Immunology 2009;131:404-409. (SCI IF = 3.606,
CMRPG83038)
Lo LH, Huang TL, Shiea J. Acid hydrolysis followed by Matrix-
Assisted Laser Desorption Ionization Mass Spectrometry for rapid
4diagnosing of serum protein biomarkers in patients with major
depression. Rapid Communications in Mass Spectrometry
2009;23:589-598. (Corresponding author, SCI IF = 2.772,
CMRPG840521 CMRPG83038)
Yu HR, Kuo HC, Sheen JM, Wang L, Lin IC, Wang CL, Yang KD.
A unique plasma proteomic profiling with imbalanced fibrinogen
5 cascade in patients with Kawasaki disease. Pediatric Allergy and
Immunology 2009;20:699-707. (SCI IF = 2.723, CMRPG860031
CMRPG83038)
Kang HY, Huang HY, Hseh CY, Li CF, Shyr CR, Tsai MY, Chuang YC,
Huang KE. Activin A enhances prostate cancer cell migration via
6 activation of androgen receptor and is overexpressed in metastatic
prostate cancer. Journal of Bone and Mineral Research
2009;24:1180-1193. (SCI IF = 6.443, CMRPG83038)
Wei YC, Li CF, Yu SC, Chou FF, Fang FF, Eng HL, Uen YH, Tian YF,
Wu JM, Li SH, Huang WW, Li WW, Huang HY. Ezrin overexpression
7 in gastrointestinal stromal tumors: an independent adverse prognosticator
associated with the non-gastric location. Modern Pathology
2009;22:1351-1360. (SCI IF = 4.678, CMRPG880251)
251
5.
1)
2)
3)
Huang HY, Li SH, Yu SC, Chou FF, Tzeng CC, Hu TH, Uen YH, Tian
YF, Wang YH, Fang FM, Huang WW, Wei YC, Wu JM, Li CF.
8Homozygous deletion of MTAP gene as a poor prognosticator in
gastrointestinal stromal tumors. Clinical Cancer Research
2009;15:6963-6972. (SCI IF = 6.488, NSC 94-2320-B-182A-005
NSC 95-2320-B-182A-007 -MY2 CMRPG880251)
Functional recovery of collagenase-induced muscle injury by human
9 umbilical cord mesenchymal stem cells. Submitted to Journal of
American Pathology.
Decreased complement component C3 and vitamin D-binding protein
10 display as serum biomarkers for osteogenesis imperfect. Submitted to
Arthritis and Rheumatism.
PI
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