9. absorption of food

emtabUlIsemtabUlIs1- esckþIefþIm :famBl nigemtabUlIs : 2- KøIkUlIs3- KøIkUEsnemtabUlIsnigkMNkKúøykUs4- vdþsuIRTikGasuIt5- kardwknaMeGLicRtugnigpUsVrIlkmµGuksuItkmµ5- kardwknaMeGLicRtugnigpUsVrIlkmµGuksuItkmµ6- lIBItemtabUlIs7- eGtaNulemtabUlIs8- GamINUGasuItemtabUlIs9- nuyekøGUTItemtabUlIs10- karrMlay nigkarRsUbsmasFatuGaharHeng Savoeun/2009 1

Heng Savoeun/2009 2

karrMlayGahar

Ù smasZatuGaharRtUv:ner[bcMedaysmµPaBGg´suImy¨agNa EdlvaGacRtUv:nRsUbykenA~geBaHev[ntUc

Ù RbEvgéneBaHev[ntUcTaMgmUlCaGñkTTYlxusRtUvsMrabdMeNIrkarRsUbenHÙ RbEvgéneBaHev[ntUcTaMgmUlCaGñkTTYlxusRtUvsMrabdMeNIrkarRsUbenH

Ù mYyEpñkZMénsmasZatuGaharRtUv:nRsUbenA~gduodenum(30cm)

nig jejunum(120cm )

Heng Savoeun/2009 3

karrMlayGahar

Heng Savoeun/2009 4

Ù karrMlayGahar KWrYmTaMgkarkatbMEbkGaharedayemkanic nigGg´suIm RBmTaMgkarRsUbykplitplbMEbkpgEdr

karrMlayGahar

Ù bnÞab´BIkarbMEbkGaharCatUc>edayemkanictamkarTMBarmk dMeNIrkarkatedayGg´suIm k¾bnþtamry;karlayGaharCamYyGgsuIm

Ù Gg´suImsMrab´rMlayGahar KWCa hydrolaseEdleRbImUelKulTwk

Heng Savoeun/2009 5

GuIRdUlIs nigkarRsUbyksmasPaKGahar

Heng Savoeun/2009 6

kabUGuIRdatÙGg´suIm EdlTTYlxusRtUv~gkarbMEbkenHdUcCaamylo-1,6-α

glucosidase,

isomaltase, maltase,isomaltase, maltase,

lactasenig saccharase

zitenA~g mucosacell

Heng Savoeun/2009 7

karxVH disaccharidase naMeTArkCMgWrakÙ karrMxanénkarrMlay nigkarRsUbykkabUGuIRdat RtUv:nRtLbmkrkkarbnæyskmµPaB rWk¾karxVHTaMgRsugéndisaccharidase

ÙebIsindisaccharideminRtUv:nrMlayenaH vak¾minRtUv:nRsUbykEdr ehIyvaZøak´eTA~geBaHev[nZMÙ enATIenaHvabg,eGaymanCMgWrakGUsµÚ‘osmotic diarrhoe) ehIynigkarbeJ©jxüledaysarel|Igén:ketrI~geBaHev[nnigkarbeJ©jxüledaysarel|Igén:ketrI~geBaHev[n

ó karxVH lactasebNþaleGay lactose minRtUv:nbMEbk ehIyk¾minRtUv:nRsUbyk rYcvabg,eGaymanCMgWrak eRBaHza ;1- mUlehtusMBaZGUsµÚ enaH lactose rkSaTwkenA~geBaHev[n2- :k´etrI~geBaHev[nbMElg lactose eTACasarZatuBul

Heng Savoeun/2009 8

RbB½n§dwkCBa¢ÚnyfaRbePT RtUv)an TamTarsMrab;karRsUbykmU:NUsakarIt

Ù GuicsUsepSg> dUcCa KøúykUs RPuctUs nigkaLaktUs RtUv:nRsUbykedayel|}nxusKñaEdlmann&yza reb[bdwkCJ¢ÚnsMerceTAedayeyagtamTMrg´mUelKuló D-glucose RtUv:nRsUbyk cMENkÉ L-glucose minRtUv:nRsUbykeTRsUbykeT

Ù kardwkCJ¢ÚnmUNUsakarItskmµ RbRBwtþeTAEt~gvtþmanrbsGuIyuugsUdüÚm

Ù mUNUsakarItEdlRtUvdwkCJ¢Ún nigGuIy¨ugsUdüÚm :npþMúKñaedaybeg,ItCakuMepøcCamYymUelKulGñkyYr‘carrier molecule’ enAEpñkxagRbehagrbsmucosacell

Heng Savoeun/2009 9

RbB½n§dwkCBa¢ÚnyfaRbePT RtUv)an TamTarsMrab;karRsUbykmU:NUsakarIt

Ù edaysarkMhab´sUdüÚmenAkñúg mucosacell TabEdlCalTÆplénskmµPaBrbs Na+ / K+-ATPase EdlzitenAEpñkxagQamenaHsUdüÚmk¾GachUrtambeNþayCMraleGLicRtUKImI‘electroche-

mical gradient) kattamPñascUleTAkñúg mucosacell

RBmTaMgykeTACamYynUvmU¨NUsakarIt EdlenAEk|renaHÙ clnkarénkardwkCJ¢ÚnenH eZVIkarrhUtdlza kMhabsUdüÚmkñúgRBmTaMgykeTACamYynUvmU¨NUsakarIt EdlenAEk|renaHÙ clnkarénkardwkCJ¢ÚnenH eZVIkarrhUtdlza kMhabsUdüÚmkñúgekasika RtUv:nrkSaeGayenATabtamry;karbUmsUdüÚm-kalsüÚmEdlGaRs&ynwg ATP

Ù dMeNIrkarenHnwgminRbRBwtþeTAeT[teT ebIsinskmµPaBrbsvaRtUv:nbgÁak´edaysarZatubgÁak´ dUcCa ouabain(RbECgCamYy K+

edIm|Icab´ykkEnøgcgP©ab´’

Heng Savoeun/2009 10

clnkarénkarCBa¢ÚnKøúykUsskmµTI2(second active glucose transport) enAkøúgeBaHevon

EpñkxagsrésQam ~gekasikamucosa GJ©aj RbehageBaHev[n

•GlucosetransportercgP¢ab´KøúykUsnigsUdüÚmCakuMepøcenAxagRbehag eBaHev[nkuMepøcenAxagRbehag eBaHev[n•CMralkMhab´rvagsUdüÚm~gRbehag nig~gekasikanaMeTArkzamBlesrIsMrab´kardwkCJ¢ÚnKøúykUsRcasCMralkMhab´


xøaj;Ù xøaj´‘triacylglycerine, kUelesþrulk¾dUc vItamIn A, D, E nig K

Edlrlaykñúgxøaj´’ Edl:nTTYlykCamYyGahar RtUv:neZVIeGayGacRsUbyk:nedaykarbMEbk k¾dUc emulgation enAkñúgRbehageBaHev[nÙ bnÞabBIkarRsUbykeTAkñúg mk mankarsMerceLIgÙ bnÞabBIkarRsUbykeTAkñúg mucosacellmk mankarsMerceLIgnUvkarsagsg´CazµIénxøaj´kñúgTMrg´mYysmRsbsMrabkardwkCJ¢ÚnkñúgQam


triacylglycerine énGaharRtUvbMEbkeday lipase

énlMEBgÙ karbMEbkxøaj´enAkñúgRbehageBaHev[nRtUv:nkatalIsedayGgsuIm

lipase eTACabMENkduM>Ù karrMlay triacylglycerine beg,It:n β-monoacylglycerine nigGasuItxøaj´Ù vtþmanénGasuItTwkRbmat sMrabkarbeg,ItmicelleKWsMxanNassMrabkarRsUbykénkUelesþrul nigvItamInrlaykñúgxøaj´

Ù vtþmanénGasuItTwkRbmat sMrabkarbeg,It KWsMxanNassMrabkarRsUbykénkUelesþrul nigvItamInrlaykñúgxøaj´

Ù micelle TaMgGsekItmaneLIgenAb¨HnwgGJ©ajénmucosacell EdlkEnøgenaHRtUv:nERbZatu nigZatupSMepSg>énmicelle RtUv:nRsUbykmþgmYy>


karRsUbykxøaj;


karsMeyaKeLIgvijén triacylglycerine k¾dUc kardak;pþúMKñaén chylomicrone sMerceLIg

enAkñúg mucosal celle

Ù karRsUbykGasuItxøaj´ monoacylglycerine, kUelesþrul nigvItamInrlaykñúgxøaj´cUleTAkñúg mucosal cellsMerceTAtamry;karsayPaygaykarsayPaygay

1- β-monoacylglycerideEdl:nRsUbykmkBIRbehageBaHev[nGacRtUvrgRbtikmµeGEsÞrkmµpÞalCamYyGasuItxøaj´kñúgTMrgskmµ ‘acyl-CoA’

2- sMrab´clnkareGEsÞrkmµeLIgvijkñúgmucosacellmankarsMeyaKtriacylglycerine ecjBI α-glycerophosphatenigacyl-CoA


karbMEbk nigkarsMeyaKén triacylglycerine

kñúgeBaHevonlymph pathlumen


CIvsMeyaK nigkarbeBa©jén chylomicrone kñúgmucosal cell énEs,kGn§Wlrbs; duodenum

chylomicroneekIteLIgenA~gmucosacellén duodenum

Ù triacylglycerineEdl:nbMEbk~geBlRsUbyk sMercnUvkarsMeyaKeLIgvijedaykarpþMúén cholesterol triacylglycerine nigphosphoglyceride CamYy apolipoprotein AI, AII nig B48

Ù kEnøgénkarpþúMenHKW golgi-body énmucosacellÙ kEnøgénkarpþúMenHKW golgi-body énmucosacell

Ù ecjBI golgi-bodyKW chylomicroneRtUv:nrkSaTuk~gsecretegranular rYck¾RtUv:nbeJ©jeTA~gextracellular

roomtamreb[bexocytosis

Ù enAkEnøgenaHvak¾:nRbmUlpþúMKñaenA~gpøÚvcUlén lymph rbseBaHev[n rYck¾eTAdl lymph vessel


karrMlayRbUetGuInÙ karbMEbkRbUetGuInRbRBwtþeTACaeRcIndMNakénA~gRkBH nigeBaHev[ntUc edaysar«TÆiBlrbs proteinase nig peptidase

Ù ~gRkBH RbUetGuInTTYlnUvkarbMEbkCaelIkdMbUgeday pepsin

Ù vamancMnYnRbEhl10PaKryénsm¬&nÆbuibTIt RtUv:nkatpþacEdleZVIeGayRbUetGuIndacĆakg´>

Ù bnÞabmkenA~geBaHev[n nig k¾dUcÙ bnÞabmkenA~geBaHev[n trypsin nig chymotrypsink¾dUcpeptidase epSg>eT[tEdlmanenA~glMEBgnigrMGileBaHev[nkatpþac´rhUtdlGamINUGasuIt nigbuibTItxøI>EdlGacRtUvRsUbedayEs|kRsTabésþIgéneBaHev[g ehIyenA~gmucosal cell k¾mankatpþac´buibTItxøITaMgenaHeTACaGamINUGasuItbnþeT[t


karrMlayRbUetGuIn nigkarRsUbykGamINUGasuIt nigoligopeptide


PaBsauMGkmµ (passive immunity)

Ù cMeBaHmnusSeBjv&y Es|kRsTab´esþIgéneBaHev[nCaZmµta minGnujatieGayRbUetGuInRCabqøgkat:neT

Ù enHKWCakarkarBarxøÜnRbqaMgTlnwgkarcUlénRbUetGuInxageRkA EdlGacbg,eGaymankareqøIytbnUvRbB&nÆsuaM‘immune)

Ù cMeBaHTarkeTIbnwgekIt Es|kRsTab´esþIgéneBaHev[n ‘mucosal cell’GacTajykRbUetGuIntamdMeNIr pinocytosisGacTajykRbUetGuIntamdMeNIr pinocytosis

Ù enAelImUldðanenH antibodyénmþayEdlmanvtþmanenA~gTwkedaHdMbUgRtUv:ncMlgeTAeGayTark

ehtuenH stVeTIbnwgekItk¾mansarZatusauM‘immune substance)

EdlenA~g:øsµarbs´vaminTan´manenAeLIy→ PaBsauMGkmµ‘passive immunity)


rYsxøaMgRbqaMgnwgRbUetGuIn

Ù karekIneLIgénkarRCabqøgkat´Es|kRsTab´esþIgéneBaHev[n GacbNþalmkBICMgWmYycMnYn nigCamUlehtusMrab´

karrYsxøaMgRbqaMgnwgRbUetGuInGahar


oligopeptide

RtUvRsUbykedayRbB½n§dwknaMEdlGaRs½y H+

Ù GMBIclnkarénkarRsUbykGamINUGasuIt nigbuibTIt eKdwgza;

Õ vaRbRBwtþeTAtamry;dMeNIrkarskmµEdlmann&yza RcasCMralkMhab´Õ mYyEpñkZMénRbUetGuInGahar minRtUv:nTTYlyk~gTMrgCaGamINUGasuItesrIeT BiessRtUv:nTTYlyk~gTMrgDIbuibTIt nigRTIbuibTItsuItesrIeT BiessRtUv:nTTYlyk~gTMrgDIbuibTIt nigRTIbuibTItehIyk¾GacCa tetrapeptideEdredaymucosal cell

→ eRBaHeK:nrkeXIjza kMhab´rbsDIbiubTIt nigRTIbuibTItenA~gRbehagén duodenumeKWBI5eTA10dgZMCagkMhabrbsGamINUGasuIt esrI dUcenH el|}nRsUbDIbiubTIt nigRTIbuibTIt KW el]nCagel|}nRsUb GamINUsuIt


clnkarénkarRsUbyk peptide

rW peptideantibiotic eday mucosacell

kardwkCJ¢Ún RbRBwtþeTA

→ edayehtuenH eKGacyl:nza buibTItEdlRtUv:nRsUbykRtUv:nkatpþac´enAxag~gekasikaCaGamINUGasuItesrI

→ bnÞab´mkRtUv:nbeJ©jBIkEnøgenaH eTA~gEv¨nTVarezøIm

kardwkCJ¢Ún RbRBwtþeTAR:sCMralkMhab´Calk¡N; protonecotransport


9. absorption of food

Food

Transcript of 9. absorption of food