119

8 Referências Bibliográficas

AL-GHAIS, S. M.; AHMAD, S.; ALI, B. Differential inhibition of xenobiotic-metabolizing carboxylesterases by organotins in marine fish. Ecotoxicology and Environmental Safety, v. 46, n. 3, p. 258-264, Jul 2000. ISSN 0147-6513. Disponível em: < <Go to ISI>://000088855600004 >. ALBERTSSON, E. et al. Proteomic analyses indicate induction of hepatic carbonyl reductase/20 beta-hydroxysteroid dehydrogenase B in rainbow trout exposed to sewage effluent. Ecotoxicology and Environmental Safety, v. 68, n. 1, p. 33-39, Sep 2007. ISSN 0147-6513. Disponível em: < <Go to ISI>://000249674200004 >. ALMEIDA, A. C. M. Geocronologia de compostos organicos de estanho e de alguns metais de relevância ambiental. Estudo de caso: Baía de Guanabara. 2003. (PhD thesis ). Departamento de Química, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro. AMADOR, E. S. Baía de Guanabara e ecossistemas periféricos: homem e natureza. Reproarte Gráfica e Editora Ltda, 1997. 539. AMIARD, J.-C. et al. Metallothioneins in aquatic invertebrates: Their role in metal detoxification and their use as biomarkers. Aquatic Toxicology, v. 76, n. 2, p. 160-202, 2006. AMIARD, J. C.; BERTHET, B. Fluctuations of cadmium, copper, lead and zinc concentrations in field populations of the Pacific Oyster Crassostrea gigas in the bay of Bourgneuf (Atlantic coast, France). Annales de l'Institut Océanographique, v. 72, p. 195-207, 1996. ANDRADE JÚNIOR, D. R.; SOUZA, R. B. S., S.A.S.; ANDRADE, D. R. Os radicais livres de oxigênio e as doenças pulmonares. Jornal Brasileiro de Pneumologia, v. 31, n. 1, p. 60-68, 2005. ASARE, G. A. et al. Evaluation of serum metallothionein-1, selenium, zinc, and copper in Ghanaian type 2 diabetes mellitus patients. International Journal of Diabetes in Developing Countries, v. 33, p. 86-95, 2013. ATSDR. Toxicological profile for selenium. Department of health and human services, P.H.S.: Agency for Toxic Substances and Disease Registry. , 2003.

120

______. Toxicological profile for copper- draft for public comment. . DEPARTMENT OF HEALTH AND HUMAN SERVICES, P. H. S.: Agency for Toxic Substances and Disease Registry . , 2004. ______. Toxicological profile for zinc- Atlanta. . DEPARTMENT OF HEALTH AND HUMAN SERVICES, P. H. S.: Agency for Toxic Substances and Disease Registry., 2005. AVELAR, W. E. P. et al. The marine mussel Perna perna (Mollusca, Bivalvia, Mytilidae) as an indicator of contamination by heavy metals in the Ubatuba Bay, Sao Paulo, Brazil. Water Air and Soil Pollution, v. 118, n. 1-2, p. 65-72, Feb 2000. ISSN 0049-6979. Disponível em: < <Go to ISI>://000085313800006 >. BAINY, A. C. D. How to evaluate the safety chemical substances in aquatic environments. Ciência e Cultura, n. 45, p. 10 -11, 1993. BAINY, A. C. D. et al. In vivo effects of metals on the acetylcholinesterase activity of the Perna perna mussel’s digestive gland. Biotemas, v. 19, p. 35-39, 2006. BAIRD, C. Química Ambiental. 2. Porto Alegre: Bookman, 2002. 622. BALOGH, L. M.; ATKINS, W. M. Interactions of glutathione transferases with 4-hydroxynonenal. Drug and Metabolism Reviews, v. 43, n. 2, p. 165-178, 2011. - . . et al. n ent ati n and i availa ilit eav metals in sediments m ite i a u (Guanabara Bay/S.E. Brazil). Journal of Coastal Research, v. 20, n. 0, p. 0749-0208, 2005. BARAJ, B.; NIENCHESKI, L. F.; CORRADI, C. Trace metal content trend of mussel Perna perna (Linnaeus, 1758) from the Atlantic Coast of Southern Brazil. Water Air and Soil Pollution, v. 145, n. 1, p. 205-214, May 2003. ISSN 0049-6979. Disponível em: < <Go to ISI>://000182709500015 >. BARATA, C.; SOLAYAN, A.; PORTE, C. Role of B-esterases in assessing toxicity of organophosphorus (chlorpyrifos, malathion) and carbamate (carbofuran) pesticides to Daphnia magna. Aquatic Toxicology, v. 66, n. 2, p. 125-139, Feb 10 2004. ISSN 0166-445X. Disponível em: < <Go to ISI>://000220007000002 >. BARREIROS, A. L. B. S.; DAVID, J. M.; DAVID, J. P. Oxidative stress: Relations between the formation of reactive species and the organism's defense. Quimica Nova, v. 29, n. 1, p. 113-123, Jan-Feb 2006. ISSN 0100-4042. Disponível em: < <Go to ISI>://000235520700021 >. BARRET, A. J.; RAWLINGS, N. D.; WOESSNER, J. F. Handbook of proteolytic enzymes. London: Academic Press, 2004. Barret, A.J.;

121

Rawlings, N.D.; Woessner, J.F. (2004). Handbook of proteolytic enzymes. London: academic press. BASTOS, F. F. Melatonina, Isoenzimas de Glutationa S- tranferases e Estresse Oxidante em Pacu (Piaractus mesopotamicus). 2010. 97 f. PhD Biociências nucleares, Universidade do Estado do Rio de Janeiro BASTOS, F. F. et al. Melatonin affects conjugation of 4-hydroxynonenal with glutathione in liver of pacu, a hypoxia-tolerant fish. Fish Physiology and Biochemistry, v. 39, p. 15-19, 2013. BAT, L. et al. Copper, Zinc, Lead and Cadmium Concentrations in the Mediterranean Mussel Mytilus galloprovincialis Lamarck,1819 From the Sinop Coast of the Black Sea. Tr. J. of Zoology, v. 23, p. 321-326, 1999. BEBIANNO, M. J.; NOTT, J. A.; LANGSTON, W. J. Cadmium Metabolism in the Clam Ruditapes decussata - the Role of Metallothioneins. Aquatic Toxicology, v. 27, n. 3-4, p. 315-333, Dec 1993. ISSN 0166-445X. Disponível em: < <Go to ISI>://A1993MT91000007 >. BELLOTTO, V. R. et al. Biomonitoramento ativo de metais traço e efeito biológico em mexilhões transplantados para área de influência de efluente de indústria de beneficiamento de aço-fase. Brazilian Journal of Aquatic Science Technology, v. 9, n. 2, p. 33-37, 2005. BEUTLER, E. Red Cell Metabolism: a Manual of Biochemical Methods. 2nd. New York: Grune and Stratton, 1975. 546. BEYNON, R. J.; BOND, S. Proteolytic enzymes: a practical approach. Oxford: Oxford University Press, 1989. BIZERRIL, C. R. S. F. Peixes Marinhos do Estado do Rio de Janeiro. Rio de Janeiro: Fundação de Estudos do Mar – Femar, Secretaria de Estado de Meio Ambiente e Desenvolvimento Sustentável do Estado do Rio de Janeiro, 2001. 234. BORNSCHEUER, U. T. Microbial carboxyl esterases: classification, properties and application in biocatalysis. FEMS Microbiol. Ver., v. 733, p. 1-9, 2002. BORNSCHEUER, U. T.; KAZLAUSKAS, R. J. Phospholipases. In: (Ed.). Hydrolases in organic synthesis regio-and stereoselective biotransformations. Weinheim: Wiley-VCH, 1999. BRASIL. Portaria nº. 685/98. Aprova o Regulamento Técnico: Princípios Gerais para o Estabelecimento de Níveis Máximos de Contaminantes Químicos em Alimentos e seu Anexo: Limites máximos de tolerância para contaminantes inorgânicos. Complementa e faz algumas modificações no Decreto Lei nº 55.871, de 26 de março de 1965., 1998.

122

______. Boletim Estatístico da Pesca e Aquicultura. Ministério da Pesca e Agricultura 2009. 101. BRITO, N. M. et al. validação de métodos analíticos: Estratégia e discussão. Pesticidas: Revista de Ecotoxicologia e Meio Ambiente, v. 13, p. 129-146, 2003. BROWN, R. J. et al. Differential sensitivity of three marine invertebrates to copper assessed using multiple biomarkers. Aquatic Toxicology, v. 66, n. 3, p. 267-278, Feb 25 2004. ISSN 0166-445X. Disponível em: < <Go to ISI>://000189100800004 >. BRYMAN, A.; CRAMER, D. Quantitative data analysis with IBM SPSS Statistics 17, 18 and 19: A guide for social scientists.: Hove: Psychology Press. . . 2011. BUONOCORE, G.; GROENENDAAL, F. Anti-oxidant strategies. Seminars in Fetal & Neonatal Medicine, v. 12, n. 4, p. 287-295, Aug 2007. ISSN 1744-165X. Disponível em: < <Go to ISI>://000248028200007 >. BURLANDO, B.; BERTI, E.; VIARENGO, A. Effects of seawater pollutants on protein tyrosine phosphorylation in mussel tissues. Aquatic Toxicology, v. 78, p. S79-S85, Jun 1 2006. ISSN 0166-445X. Disponível em: < <Go to ISI>://000238130600011 >. CANESI, L. et al. Heavy metals and glutathione metabolism in mussel tissues. Aquatic Toxicology, v. 46, n. 1, p. 67-76, Jun 1999. ISSN 0166-445X. Disponível em: < <Go to ISI>://000080201500007 >. CANLI, M.; ATLI, G. The relationships between heavy metal (Cd, Cr, Cu, Fe, Pb, Zn) levels and the size of six Mediterranean fish species. Environmental Pollution, v. 121, n. 1, p. 129-136, 2003. ISSN 0269-7491. Disponível em: < <Go to ISI>://000179435000016 >. CARDOSO, A. G. A. et al. Metal distribution in sediments from the Ribeira Bay, Rio de Janeiro - Brazil. Journal of the Brazilian Chemical Society, v. 12, n. 6, p. 767-774, Nov-Dec 2001. ISSN 0103-5053. Disponível em: < <Go to ISI>://000172077900012 >. CARVALHO, C. E. V. et al. Distribuição de Metais Pesados em Mexilhões (Perna perna, L.) da Ilha de Santana, Macaé, Brasil Ecotoxicology and Environmental Restoration, v. 4, n. 1, p. 1-5, 2001. CATHARINO, M. et al. Biomonitoring of Hg, Cd, Pb and other elements in coastal regions of Sao Paulo State, Brazil, using the transplanted mussel Perna perna (Linnaeus, 1758). Journal of Radioanalytical and Nuclear Chemistry, v. 278, n. 3, p. 547-551, Dec 2008. ISSN 0236-5731. Disponível em: < <Go to ISI>://000261262500003 >.

123

CENSI, P. et al. Heavy metals in coastal water systems. A case study from the northwestern Gulf of Thailand. Chemosphere, v. 64, n. 7, p. 1167-1176, Aug 2006. ISSN 0045-6535. Disponível em: < <Go to ISI>://000240157100015 >. CHAHINIAN, H. et al. Distinction between esterases and lipases: a Kinetic study with vinyl ester and TAG. Lipids, v. 37, n. 7, p. 653-662, 2002. CHASE, M. E. et al. Gulfwatch: Monitoring spatial and temporal patterns of trace metal and organic contaminants in the Gulf of Maine (1991-1997) with the blue mussel, Mytilis edulis L. Marine Pollution Bulletin, v. 42, n. 6, p. 491-505, Jun 2001. ISSN 0025-326X. Disponível em: < <Go to ISI>://000169801900019 >. CHAVES, E. S. Determinação de elementos traço em diesel e biodiesel por espectrometria de emissão atômica em chama e por espectrometria de massa com plasma indutivamente acoplado com introdução da amostra por vaporização eletrotérmica. 2008. 145 (PhD thesis). Departamento de Química, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro. CHEUNG, V. V.; DEPLEDGE, M. H.; JHA, A. N. An evaluation of the relative sensitivity of two marine bivalve mollusc species using the Comet assay. Marine Environmental Research, v. 62, p. S301-S305, 2006. ISSN 0141-1136. Disponível em: < <Go to ISI>://000238957800195 >. CHOU, C. L. et al. Distribution of contaminants in biota and sediments in the Musquash Estuary, Atlantic Canada, marine protected area site initiative and contaminant exclusion zone. Marine Pollution Bulletin, v. 48, n. 9-10, p. 884-893, May 2004. ISSN 0025-326X. Disponível em: < <Go to ISI>://000221395200018 >. COGO, A. J. D. et al. Utilização de enzimas do estresse oxidativo como biomarcadoras de impactos ambientais. Natureza online, v. 7, n. 1, p. 37-42, 2009. COLLINS, C. H.; BRAGA, G. L.; BONATO, P. S. Introdução a Métodos Cromatográficos. 6th. Campinas: Unicamp, 1995. 279. CONCEIÇÃO, G. Distribuição de elementos-traço em sedimentos superficiais do Rio Itajaí-Mirim em Santa Catarina. 2004. 108 (MSc). Engenharia Ambiental, Universidade Regional de Blumenau, Blumenau. COSTA, M.; PAIVA, E.; MOREIRA, I. Total mercury in Perna perna mussels from Guanabara Bay - 10 years later. Science of the Total Environment, v. 261, n. 1-3, p. 69-73, Oct 16 2000. ISSN 0048-9697. Disponível em: < <Go to ISI>://000089587200007 >.

124

COSTA, W. M. V. et al. Hydrogen peroxide-induced carbonylation of key metabolic enzymes in Saccharomyces cerevisiae: The involvement of the oxidative stress response regulators Yap1 and Skn7. Free Radical Biology and Medicine, v. 33, n. 11, p. 1507-1515, Dec 1 2002. ISSN 0891-5849. Disponível em: < <Go to ISI>://000179434500009 >. CREED, J.; PIRES, D.; FIGUEIREDO, M. Biodiversidade Marinha da Baía da Ilha Grande. Brasília: Ministério do Meio Ambiente – MMA: 416 p. 2007. CRUPKIN, A. C.; MENONE, M. L. Changes in the activities of glutathione-S-transferases, glutathione reductase and catalase after exposure to different concentrations of cadmium in Australoheros facetus (Cichlidae, Pisces). . Ecotoxicology and Environmental Contamination, v. 8, n. 1, p. 21-25, 2013. CURTIUS, A. J. et al. Evaluating trace element contamination in mariculture activities. Partial results of a case study carried out in the coastal region of Santa Catarina, Brazil. Quimica Nova, v. 26, n. 1, p. 44-52, Jan-Feb 2003. ISSN 0100-4042. Disponível em: < <Go to ISI>://000180855000010 >. DAMASCENO, D. C. et al. Oxidative stress and diabetes in pregnant rats. Animal Reproduction Science, v. 72, n. 3-4, p. 235-244, Aug 15 2002. ISSN 0378-4320. Disponível em: < <Go to ISI>://000177464400009 >. DAME, R. F. Organismic level processes. Ecology of marine bivalves: an ecosystem approach. New York: CRC Press: 35-74 p. 1996. DAUTERMAN, W. C. Metabolism of toxicans: phase II reactions. . In: HODGSON, E.; LEVI, P.E. (Eds). Introduction to BiochemicalToxicology. Connecticut: Appleton & Lange., p. 113-132, 1994. DE LIMA, D.; ROQUE, G. M.; DE ALMEIDA, E. A. In vitro and in vivo inhibition of acetylcholinesterase and carboxylesterase by metals in zebrafish (Danio rerio). Marine Environmental Research, v. 91, p. 45-51, Oct 2013. ISSN 0141-1136. Disponível em: < <Go to ISI>://000327924700007 >. DO AMARAL, M. C. R. et al. Bioaccumulation and depuration of Zn and Cd in mangrove oysters (Crassostrea rhizophorae, Guilding, 1828) transplanted to and from a contaminated tropical coastal lagoon. Marine Environmental Research, v. 59, n. 4, p. 277-285, May 2005. ISSN 0141-1136. Disponível em: < <Go to ISI>://000226354600001 >. EL GHAZI, I. et al. Quantification of Metallothionein-like Proteins in the Mussel Mytilus galloprovincialis Using RP-HPLC Fluorescence Detection. Environ. Sci. Technol., v. 37, p. 5739-5744, 2003.

125

ELLMAN, G. L. Tissue Sulfhydryl Groups. Archives of Biochemistry and Biophysics, v. 82, n. 1, p. 70-77, 1959. ISSN 0003-9861. Disponível em: < <Go to ISI>://A1959WE02900008 >. EPA. Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisories, v. 2. Risk Assessment and Fish Consumption Limits. EPA 823-B-94-004. In: HEINEN, J. M. (Ed.). Water Quality Criteria, Uptake, Bioaccumulation, and Public Health Considerations for Chemicals, 1996. ERK, M. et al. Evaluation of different purification procedures for the electrochemical quantification of mussel metallothioneins. Talanta, v. 57, n. 6, p. 1211-1218, Jul 19 2002. ISSN 0039-9140. Disponível em: < <Go to ISI>://000177110700021 >. ESCARTÍN, E.; PORTE, C. The use of cholinesterase and carboxylesterase activities from Mytilus galloprovincialis in pollution monitoring. Environmental Toxicology and Chemistry, v. 16, n. 10, p. 2090-2095, 1997. ESTEVES, F. A. Fundamentos de Limnologia. Rio de Janeiro: Interciência, 1988. 574. FAO/WHO. Food consumption and exposure assessment of chemicals. Report of a FAO/WHO consultation, 10-14 February. Geneva, Switzerland. 1997. ______. Evaluation of certain food additives and contaminants for lead and methylmercury. In: Report of the Joint FAO/WHO Expert Committee on Food Additives, 53rd. Technical Report Series 896. Geneva, Switzerland. 1999. ______. Evaluation of certain food additives and contaminants for cadmium and methylmercury. In: Report of the Joint FAO/WHO Expert Committee on Food Additives, 55th. Technical Report Series 901. Geneva, Switzerland. 2000. FARKAS, A. et al. Metal pollution as health indicator of lake ecosystems. International journal of occupational medicine and environmental health, v. 14, n. 2, p. 163-170, 2001. FERNANDES, F. C. et al. Distribuição mundial e o impacto de sua introdução no Brasil. In: RESGALLA JR, C.;WEBER, L. I., et al (Ed.). O mexilhão Perna perna (L.): biologia, ecologia e aplicações. Rio de Janeiro: Interciência, 2008. p.26-30. FERNANDEZ, B. et al. Antioxidant responses in gills of mussel (Mytilus galloprovincialis) as biomarkers of environmental stress along the Spanish Mediterranean coast. Aquatic Toxicology, v. 99, n. 2, p. 186-197, Aug 15

126

2010. ISSN 0166-445X. Disponível em: < <Go to ISI>://000280510700009 >. FIFIELD, F. W.; HAINES, P. J. Environmental Analytical Chemistry. Wiley-Blackwell, 2000. 512. FILHO, D. W. et al. Seasonal changes in antioxidant defenses of the digestive gland of the brown mussel Perna perna. Aquaculture, v. 203, p. 149-158, 2001. FISTAROL, G. O. et al. Environmental and Sanitary Conditions of Guanabara Bay, Rio de Janeiro. Frontiers in Microbiology, v. 6, p. 1232, 2015. FITZPATRICK, P. J. et al. Assessment of a glutathione S-transferase and related proteins in the gill and digestive gland of Mytilus edulis (L.), as potential organic pollution biomarkers. Biomarkers, v. 2, n. 1, p. 51-56., 1997. FÖRSTNER, U. Contaminated Sediments. Berlin: SpringerVerlag, 1989. 157. FOWLER, S. W. Biological transfer and transport process. CRC Press, 1982. 65. FREIRE, M. M. et al. Biomarcadores na avaliação da saúde ambiental dos ecossistemas aquáticos. Oecologia brasiliensis, v. 12, n. 3, p. 347-354, 2008. FURLAN, E. F. Vida útil dos mexilhões Perna perna cultivados no litoral norte de São Paulo: aferiação dos parâmetros físico-químicos e microbiológicos. 2004. 95 (MSc). Ciência e Tecnologia de Alimentos, Escola Superior de Agricultura Luiz de Queiroz, Piracicaba. GAITANAKI, C. et al. Various stressors rapidly activate the p38-MAPK signaling pathway in Mytilus galloprovincialis (Lam.). Molecular and Cellular Biochemistry, v. 260, n. 1-2, p. 119-127, May 2004. ISSN 0300-8177. Disponível em: < <Go to ISI>://000221121000015 >. GALVAO, P. et al. Estimating the Potential Production of the Brown Mussel Perna perna (Linnaeus, 1758) Reared in Three Tropical Bays by Different Methods of Condition Indices. Journal of Marine Biology, p. 11p, 2015. GALVÃO, P. M. A. Metais Pesados (Cd, Mn, Fe, Ni, Cu, Z, Pb, Cd) em sedimentos e material particulado em suspensão no baixo rio Paraíba do Sul: Uma descrição após contaminação por rejeitos da produção de papel e celulose. 2003. 87 (BSc). Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro.

127

GARCIA DE ARAÚJO, W. A.; ASSIS JUNIOR, F. I.; SOBREIRA, G. F. Fundamentos e métodos para análises de aminoácidos. Nutritime, v. 4, n. 2, p. 395-404, 2007. GARCIA, J. S.; DE MAGALHAES, C. S.; ARRUDA, M. A. Z. Trends in metal-binding and metalloprotein analysis. Talanta, v. 69, n. 1, p. 1-15, Mar 15 2006. ISSN 0039-9140. Disponível em: < <Go to ISI>://000235510000001 >. GARCIA-SEVILLANO, M. A. et al. Biological response of free-living mouse Mus spretus from Doana National Park under environmental stress based on assessment of metal-binding biomolecules by SEC-ICP-MS. Analytical and Bioanalytical Chemistry, v. 404, n. 6-7, p. 1967-1981, Oct 2012. ISSN 1618-2642. Disponível em: < <Go to ISI>://000309348400035 >. GARRIGUES, P. et al. The Impacts Cluster of the European Commission. In: I Workshop of Biological Effects of Environmental pollution in The Marine Coastal Ecosystems (BEEP). 2002. 165-178 Universidade de Pau, Pau. GE-HEALTHCARE. 2D Electrophoresis: principles and methods. uppsala, sweden: Ge-Healthcare, 2004. GEORGE, S. G. Heavy-Metal Detoxication in the Mussel Mytilus-Edulis - Composition of Cd-Containing Kidney Granules (Tertiary Lysosomes). Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology, v. 76, p. 53-57, 1983. GERET, F.; COSSON, R. P. Induction of specific isoforms of metallothionein in mussel tissues after exposure to cadmium or mercury. Arch. Environ. Contam. Toxicol., v. 42 , p. 36-42, 2002. GERET, F. et al. Metal compartmentalization and metallothionein isoforms in mussels from the Mid-Atlantic Ridge; preliminary approach to the fluid–organism relationship. . Cah. Biol. Mar., v. 39, p. 291-293, 1998. GETZ, E. B. et al. A comparison between the sulfhydryl reductants tris(2-carboxyethyl)phosphine and dithiothreitol for use in protein biochemistry. Analytical Biochemistry, v. 273, n. 1, p. 73-80, Aug 15 1999. ISSN 0003-2697. Disponível em: < <Go to ISI>://000082252300009 >. GHEZZI, P.; BONETTO, V. Redox proteomics: Identification of oxidatively, modified proteins. Proteomics, v. 3, n. 7, p. 1145-1153, Jul 2003. ISSN 1615-9853. Disponível em: < <Go to ISI>://000184507200006 >. GIARRATANO, E.; AMIN, O. A. Heavy metals monitoring in the southernmost mussel farm of the world (Beagle Channel, Argentina). Ecotoxicology and Environmental Safety, v. 73, p. 1378-1384, 2010.

128

GIL, E. S. Controle físico-químico de qualidade de medicamentos. 2nd. São Paulo: Pharmabooks, 2007. GINÉ-ROSIAS, M. F. A espectrometria de massas com fonte de plasma ICP-MS. 1st. Piracicaba: CPG-CENA-USP, 1999. 118. GOMES, F. C. et al. Metal concentrations, fluxes, inventoris and chronologies in sediments from Sepetiba and Ribeira Bays: A comparative study. . Marine Pollution Bulletin, v. 59, p. 123-133, 2009. GOMES, F. C. et al. Metal concentrations, fluxes, inventoris and chronologies in sediments from Sepetiba and Ribeira Bays: A comparative study. Marine Pollution Bulletin, v. 59, p. 123-133, 2009. GONCALVES, J. F. et al. N-acetylcysteine prevents memory deficits, the decrease in acetylcholinesterase activity and oxidative stress in rats exposed to cadmium. Chemico-Biological Interactions, v. 186, n. 1, p. 53-60, Jun 7 2010. ISSN 0009-2797. Disponível em: < <Go to ISI>://000278801500008 >. GONZÁLEZ-FERNÁNDEZ, M. et al. Metal-binding molecules in the organs of Mus musculus by size-exclusion chromatography coupled with UV spectroscopy and ICP-MS. Analytical and Bioanalytical Chemistry, v. 390, p. 17-28, 2008. GONZALEZ-FERNÁNDEZ, M. et al. Size characterization of metal species in liver and brain from free-living (Mus spretus) and laboratory (Mus Musculus) mice by SEC-ICP-MS: Application to environmental contamination assessment. Journal of Analytical Atomic Spectrometry, v. 26, p. 141-149, 2011. GORE, M. G. Spectrophotometry and Spectrofluorimetry. 2nd. Oxford University Press, 2000. 368. GOURGOU, E. et al. Hyperthermia-induced Hsp70 and MT20 transcriptional upregulation are mediated by p38-MAPK and JNKs in Mytilus galloprovincialis (Lamarck); a pro-survival response. Journal of Experimental Biology, v. 213, p. 347-357, 2010. GUANABARA, P. D. B. D. Instituto Baía de Guanabara: As Praias. http://baiadeguanabara.org.br/site/?page_id=4813 2015. HABIG, W. H.; PABST, M. J.; JAKOBY, W. B. Glutathione S-Transferases - First Enzymatic Step in Mercapturic Acid Formation. Journal of Biological Chemistry, v. 249, n. 22, p. 7130-7139, 1974. ISSN 0021-9258. Disponível em: < <Go to ISI>://A1974U808400011 >. HALLIWELL, B.; GUTTERIDGE, J. M. C. Free Radicals in Biology and Medicine. 3rd. Oxford: Oxford University Press, 2007.

129

HAMED, M. A.; EMARA, A. M. Marine molluscs as biomonitors for heavy metal levels in the Gulf of Suez, Red Sea. Journal of Marine Systems, v. 60, n. 3-4, p. 220-234, May 2006. ISSN 0924-7963. Disponível em: < <Go to ISI>://000238331500003 >. HAMER, B. et al. Effect of hypoosmotic stress by low salinity acclimation of Mediterranean mussels Mytilus galloprovincialis on biological parameters used for pollution assessment. Aquatic Toxicology, v. 89, n. 3, p. 137-151, Sep 17 2008. ISSN 0166-445X. Disponível em: < <Go to ISI>://000260203700001 >. HARDIVILLIER, Y. et al. Metal influence on metallothionein synthesis in the hydrothermal vent mussel Bathymodiolus thermophilus. Comp. Biochem. Physiol. C Toxicol. Pharmacol. , v. 143, p. 321-332, 2006. HAUSER-DAVIS, R. A. et al. Disruption of zinc and copper interactions with A beta(1-40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy? . Metallomics, v. 7, p. 743-747, 2015. HAUSER-DAVIS, R. A. et al. A novel report of metallothioneins in fish bile: SDS-PAGE analysis, spectrophotometry quantification and metal speciation characterization by liquid chromatography coupled to ICP-MS. Aquatic Toxicology, v. 116, p. 54-60, Jul 15 2012. ISSN 0166-445X. Disponível em: < <Go to ISI>://000304290900008 >. HAUSER-DAVIS, R. A. et al. First-time report of metalloproteinases in fish bile and their potential as bioindicators regarding environmental contamination. Aquatic Toxicology, v. 110-111, p. 99-106, 2012. HE, X. Q.; CHEN, M. G.; MA, Q. Activation of Nrf2 in defense against cadmium-induced oxidative stress. Chemical Research in Toxicology, v. 21, n. 7, p. 1375-1383, Jul 2008. ISSN 0893-228X. Disponível em: < <Go to ISI>://000257860700012 >. HE, X. Q. et al. Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association. Toxicological Sciences, v. 98, n. 1, p. 298-309, Jul 2007. ISSN 1096-6080. Disponível em: < <Go to ISI>://000247601800028 >. HEATH, A. G. Water Pollution and Fish Physiology. Boca Raton, Florida: Lewis, 1991. HENRIQUES, M. B. et al. Estimativa do tempo de recuperação de um banco natural do mexilhão Perna perna (Linnaeus, 1758) na Baía de Santos, Estado de São Paulo. Holos Environment, v. 1, n. 12, p. 85-100, 2001.

130

HEUKESHOVEN, J.; DERNICK, R. Simplified Method for Silver Staining of Proteins in Polyacrylamide Gels and the Mechanism of Silver Staining. Electrophoresis, v. 6, n. 3, p. 103-112, 1985. ISSN 0173-0835. Disponível em: < <Go to ISI>://A1985AEZ0100001 >. HEUSSEN, C.; DOWDLE, E. B. Electrophoretic Analysis of Plasminogen Activators in Polyacrylamide Gels Containing Sodium Dodecyl-Sulfate and Copolymerized Substrates. Analytical Biochemistry, v. 102, n. 1, p. 196-202, 1980. ISSN 0003-2697. Disponível em: < <Go to ISI>://A1980JG14100032 >. HUBER, P. C.; ALMEIDA, W. P.; DE FATIMA, A. Glutathione and related enzymes: Biological roles and importance in pathological processes. Quimica Nova, v. 31, n. 5, p. 1170-1179, 2008. ISSN 0100-4042. Disponível em: < <Go to ISI>://000259122200046 >. HUGGETT, R. J. et al. Biomarkers. Biochemical, physiological, and histological markers of anthropogenic stress. 1st. Boca Raton: Lewis Pub, 1992. 347. HUMMEL, K. M. et al. Anomalous estimation of protease molecular weights using gelatin-containing SDS-PAGE. Analytical Biochemistry, v. 233, n. 1, p. 140-142, Jan 1 1996. ISSN 0003-2697. Disponível em: < <Go to ISI>://A1996TR13600019 >. HUNG, D. Q.; NEKRASSOVA, O.; COMPTON, R. G. Analytical methods for inorganic arsenic in water: a review. Talanta, v. 6, n. 2, p. 269-277, 2004. IBAMA. INSTITUTO BRASILEIRO DO MEIO AMBIENTE E DOS RECURSOS NATURAIS RENOVÁVEIS - IBAMA. Estatística da pesca 2006 Brasil: grandes regiões e unidades da federação. Brasília, DF: 2008. 174. IBGE. Censo Demográfico 2000. 2000. IKEDA, Y.; GODOI, S. S.; CACCIARI, P. L. Um estudo de séries temporais de corrente na Baía da Ilha Grande. Instituto Oceanográfico de São Paulo, São Paulo, p. 24, 1989. IKEM, A.; EGIEBOR, N. O. Assesment of trace elements in canned fishes (mackerel, tuna, salmon, sardines and herrings) marketed in Georgia and Alabama (United States of America) . Journal of Food Composition and Analysis , v. 18, p. 771-787, 2005. IMAMURA, S. et al. Recent topics of candidate antigens for immunological control of ixodid ticks. Acta Scientiae Veterinariae., v. 35, n. 1, p. 1-16, 2007.

131

ITOH, Y. et al. Plasma membrane-bound tissue inhibitor of metallopeptidases (TIMP)-2 specifically inhibits matrix metallopeptidase 2 (gelatinase A) activated on the cell surface. J. Biol Chem, v. 273, p. 24360-24367, 1998. JARQUE, S. et al. Seasonal variations of gene expression biomarkers in Mytilus galloprovincialis cultured populations: temperature, oxidative stress and reproductive cycle as major modulators. Science of The Total Environment, v. 499, n. 15, p. 363-372, 2014. JARVIS, K. E.; GRAY, L. A.; HOUK, R. S. Handbook of Inductively Couple Plasma Mass Spectrometry. New York: Blackie, 1992. 380. JEBALI, J. et al. Comparative study of the bioaccumulation and elimination of trace metals (Cd, Pb, Zn, Mn and Fe) in the digestive gland, gills and muscle of bivalve Pinna nobilis during a field transplant experiment. Journal of Trace Elements in Medicine and Biology, v. 28, n. 2, p. 212-217, 2014. ISSN 0946-672X. Disponível em: < <Go to ISI>://000335706000017 >. JI, Y. et al. Biochemical responses of freshwater fish Carassius auratus to polycyclic aromatic hydrocarbons and pesticides. Water Science and Engineering, v. 5, n. 2, p. 145-154, 2012. JORDÃO, C. P. et al. Distribution of heavy metals in environmental samples near smelters and mining areas in Brazil. . Environmental technology, v. 20, n. 5, p. 489-498, 1999. JOZEFCZAK, M. et al. Glutathione is a key player in metal-induced oxidative stress defenses. International Journal of Molecular Sciences v. 13, p. 3145-3175, 2012. JUNIOR, R. G. D. L. et al. Evaluation of heavy metals in fish of the Sepetiba and Ilha Grande Bays, Rio de Janeiro, Brazil. Environmental Research, v. 89, n. 2, p. 171-179, Jun 2002. ISSN 0013-9351. Disponível em: < <Go to ISI>://000176452500008 >. KAGI, J. H. R. Overview of Metallothionein. Methods in Enzymology, v. 205, p. 613-626, 1991. ISSN 0076-6879. Disponível em: < <Go to ISI>://A1991HG71800069 >. KEHRIG, H. A.; MALM, O.; I, M. Mercury in a widely consumed fish Micropogonias furnieri (Demarest, 1823) from four main Brazilian estuaries. Science of the Total Environment, v. 213, n. 1-3, p. 263-271, Jun 10 1998. ISSN 0048-9697. Disponível em: < <Go to ISI>://000074162000029 >. KEHRIG, H. A. et al. Bioconcentration and Biomagnification of Methylmercury in Guanabara Bay, Rio De Janeiro. Quimica Nova, v. 34,

132

n. 3, p. 377-U209, 2011. ISSN 0100-4042. Disponível em: < <Go to ISI>://000289857500003 >. KJERFVE, B. et al. Oceanographic characteristics of an impacted coastal bay: Baia de Guanabara, Rio de Janeiro, Brazil. Continental Shelf Research, v. 17, n. 13, p. 1609-+, Nov 1997. ISSN 0278-4343. Disponível em: < <Go to ISI>://000071276000004 >. KLEINER, D. E.; STETLERSTEVENSON, W. G. Quantitative Zymography - Detection of Picogram Quantities of Gelatinases. Analytical Biochemistry, v. 218, n. 2, p. 325-329, May 1 1994. ISSN 0003-2697. Disponível em: < <Go to ISI>://A1994NH77400014 >. KOVENDAN, K. et al. Expression of metallothionein in liver and kidney of freshwater fish Cyprinus carpio var. communis (Linn) exposed to arsenic trioxide. . American Journal of Scientific and Industrial Research, v. 4, p. 1-10, 2013. KUPAI, K. et al. Matrix metalloproteinase activity assays: Importance of zymography. Journal of Pharmacological and Toxicological Methods, v. 61, n. 2, p. 205-209, Mar-Apr 2010. ISSN 1056-8719. Disponível em: < <Go to ISI>://000282624500018 >. LACERDA, L. D.; PFEIFFER, W. C.; FISZMAN, M. Níveis naturais de metais pesados em sedimentos marinhos da Baía da Ribeira, Angra dos Reis. Ciência e Cultura, v. 34, n. 7, p. 921-924, 1981. LACERDA, L. D.; SOUZA, C. M. M.; PESTANA, M. H. D. Trace metals geochemical associations in sediments of a non-contaminated estuary. . Ciência e cultura., v. 41, p. 301-304, 1989. LAMPARELLI, C. C. Bivalve Perna perna (Linnaeus, 1758) como amostrador biológico das condiçoes ecológico-sanitárias de águas costeiras. 1987. 193 (MSc). Instituto de Ciências Biológicas, Universidade de São Paulo LAVRADAS, R. T. et al. Metal, metallothionein and glutathione levels in blue crab (Callinectes sp.) specimens from southeastern Brazil. Ecotoxicology and Environmental Safety, v. 107, p. 55-60, Sep 2014. ISSN 0147-6513. Disponível em: < <Go to ISI>://000342122000008 >. LEBER, T. M.; BALKWILL, F. R. Zymography: A single-step staining method for quantitation of proteolytic activity on substrate gels. Analytical Biochemistry, v. 249, n. 1, p. 24-28, Jun 15 1997. ISSN 0003-2697. Disponível em: < <Go to ISI>://A1997XE30600004 >. LEHNINGER, A. L.; NELSON, D. L.; COX, M. M. Princípios de Bioquímica. Sarvier, 1995.

133

LEONARD, S. S.; HARRIS, G. K.; SHI, X. L. Metal-induced oxidative stress and signal transduction. Free Radical Biology and Medicine, v. 37, n. 12, p. 1921-1942, Dec 15 2004. ISSN 0891-5849. Disponível em: < <Go to ISI>://000225652600002 >. LEVINE, R. L. et al. Determination of Carbonyl Content in Oxidatively Modified Proteins. Methods in Enzymology, v. 186, p. 464-478, 1990. ISSN 0076-6879. Disponível em: < <Go to ISI>://A1990MC42000049 >. LI, B. et al. Butyrilchonesterase, paraoxonase, and albumin esterase, but no carboxylesterase, are present in human plasma. Biochemical Pharmacology, v. 70, p. 1673-1684, 2005. LI, Y. Q. et al. Cadmium Accumulation and Metallothionein Biosynthesis in Cadmium-Treated Freshwater Mussel Anodonta woodiana. Plos One, v. 10, n. 2, Feb 3 2015. ISSN 1932-6203. Disponível em: < <Go to ISI>://000348822600050 >. LIMA, V. F.; MERÇON, F. Metais pesados no ensino de química. Química nova na escola, v. 33, n. 4, p. 199-205, 2011. LIÑÁN-CABELLO, M. A. et al. Effects of carotenoids and retinol in oocytes maturation of crayfish Cherax quadrucarinatus. Aquaculture Research, v. 35, p. 905-911, 2004. LINDE, A. R. et al. Metallothionein and heavy metals in brown trout (Salmo trutta) and European eel (Anguilla anguilla): A comparative study. Ecotoxicology and Environmental Safety, v. 44, n. 2, p. 168-173, Oct 1999. ISSN 0147-6513. Disponível em: < <Go to ISI>://000083242700005 >. LINOA, A. S. et al. Metal bioaccumulation in consumed marine bivalves in Southeast Brazilian coast. Journal of Trace Elements in Medicine and Biology, v. 34, p. 50-55, 2016. LOBINSKI, R.; CHASSAIGNE, H.; SZPUNAR, J. Analysis for metallothioneins using coupled techniques. Talanta, v. 46, p. 271-289, 1998. LUSHCHAK, V. I. Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions. . Hindawi Publishing Corporation Journal of Amino Acids, p. 26 2012. MACFARLANE, G. R.; BURCHETT, M. D. Cellular distribution of copper, lead and zinc in the grey mangrove, Avicennia marina (Forsk.) Vierh. Aquatic Botany, v. 68, n. 1, p. 45-59, Sep 2000. ISSN 0304-3770. Disponível em: < <Go to ISI>://000089142900004 >. MACFARLANE, G. R.; SCHREIDER, M.; MCLENNAN, B. Biomarkers of heavy metal contamination in the red fingered marsh crab, Parasesarma

134

erythodactyla. Archives of Environmental Contamination and Toxicology, v. 51, n. 4, p. 584-593, Nov 2006. ISSN 0090-4341. Disponível em: < <Go to ISI>://000241263000015 >. MACHADO, B. V. Z.; DA SILVA, R. M. L. C. F. Análise da influência da Baía de Guanabara na Qualidade da Água das Praias Oceâncias Adjacentes através da Modelagem Computacional. 2010. (BSc). Engenharia Ambiental, UFRJ/ Escola Politécnica, Rio de Janeiro. MACKAY, E. A. et al. Complete amino acid sequences of five dimeric and four monomeric forms of metallothionein from edible mussel Mytilus edulis. European Journal of Biochemistry, v. 218, p. 183-194, 1993. MAIA, C. B.; ALMEIDA, A. C. M.; MOREIRA, F. R. Avaliação do Teor de Chumbo em Mexilhões da Espécie Perna perna na Região Metropolitana da Cidade do Rio de Janeiro. . J. Braz. Soc. Ecotoxicol., v. 1, n. 2, p. 195-198, 2006. MANZONI, G. C. Cultivo de mexilhões Perna perna: evolução da atividade no Brasil e avaliação econômica da realidade de Santa Catarina. 2005. 264 (PhD). Centro de Aqüicultura, Universidade Estadual Paulista , Jaboticabal, São Paulo. MAO, H.; WANG, D. H.; YANG, W. X. The involvement of metallothionein in the development of aquatic invertebrate. Aquatic Toxicology, v. 110, p. 208-213, 2012. MARQUES, H. L. A. Criação comercial de mexilhões. São Paulo: Nobel, 1998. 109. MARQUES, L. A. Criação comercial de mexilhões. Nobel, 1997. 113. MARTINS, P. A. P. Determinação da razão isotópica 87Sr/86Sr por ICP-MS no sistema solo-vinho. 2012. 32 (MSc). Instituto Superior de Agronomia Universidade Técnica de Lisboa, Lisboa. MELENDEZ, L. B. et al. Determinação de Metalotioneínas e Fitoquelatinas utilizando a técnica de HPLC-ICP-MS. Rev. Virtual Quim, v. 4, n. 6, p. 612-622, 2012. MELO, G. J. Poluição química das águas. IX Congresso brasileiro de geoquímica. Belém: 2003. MICHALKE, B. The coupling of LC to ICP-MS in element speciation - Part II: Recent trends in application. Trac-Trends in Analytical Chemistry, v. 21, n. 3, p. 154-165, Mar 2002. ISSN 0165-9936. Disponível em: < <Go to ISI>://000175624100014 >.

135

MIEIRO, C. L. et al. Metallothioneins failed to reflect mercury external levels of exposure and bioaccumulation in marine fish - Considerations on tissue and species specific responses. Chemosphere, v. 85, n. 1, p. 114-121, Sep 2011. ISSN 0045-6535. Disponível em: < <Go to ISI>://000295307800016 >. MILLER, G. G. et al. In vitro toxicity and interactions of environmental contaminants (Arochlor 1254 and mercury) and immunomodulatory agents (lipopolysaccharide and cortisol) on thymocytes from lake trout (Salvelinus namaycush). Fish & Shellfish Immunology, v. 13, n. 1, p. 11-26, Jul 2002. ISSN 1050-4648. Disponível em: < <Go to ISI>://000177264200002 >. MILLER, J. C.; MILLER, J. N. Statistics for analytical chemistry. Londres: Ellis Horwook PTR Prentice Hall, 1994. MONSERRAT, J. M. et al. Pollution biomarkers in estuarine animals: Critical review and new perspectives. Comparative Biochemistry and Physiology C-Toxicology & Pharmacology, v. 146, n. 1-2, p. 221-234, Jul-Aug 2007. ISSN 1532-0456. Disponível em: < <Go to ISI>://000248881200021 >. MONTASER, A. Inductively Coupled Plasma Mass Spectrometry. 1st. USA: Wiley-VCH, 1998. 1004. MONTEIRO, D. A. Efeitos do inseticida organofosforado Metil Paration (Folisuper 600 BR®) sobre biomarcadores do estresse oxidante no teleósteo de água doce matrinxã Brychon cephalus (GÜNTHER, 1869) e o papel da suplementação de selênio na dieta. 2006. (MSc). Ciências Fisiológicas, Universidade Federal de São Carlos, São Carlos. MORAES, C. S. et al. Métodos experimentais no estudo de proteínas. Instituto Oswaldo Cruz, 2013. 86. MOREIRA, F. R.; MOREIRA, J. C. Os efeitos do chumbo sobre o organismo humano e seu significado para a saúde. Rev Panam Salud Publica, v. 15, n. 2, p. 119-129, 2004. MORGAN, E. W. et al. Purification and Characterization of 2 Rat-Liver Microsomal Carboxylesterases (Hydrolase-a and Hydrolase-B). Archives of Biochemistry and Biophysics, v. 315, n. 2, p. 495-512, Dec 1994. ISSN 0003-9861. Disponível em: < <Go to ISI>://A1994PV82900040 >. MORTATTI, J.; PROBST, J. L. Hidrogeoquímica de bacias de drenagem. Piracicaba: CENA/USP, 1998. 232. MOTTA, T. C. S. Metalotioneínas em Tilápias Oreochromis niloticus, (Linnaeus, 1758): dinâmica de formação e desintoxicação avaliada através de bioensaios com o emprego de marcadores isotópicos de

136

111Cd e 65Cu. 2012. 134 (PhD). Centro de Energia Nuclear na Agricultura, Univesidade de São Paulo, Piracicaba. MOURGAUD, Y. et al. Metallothionein concentration in the mussel Mytilus galloprovincialis as a biomarker of response to metal contamination: validation in the field. Biomarkers, v. 7, n. 6, p. 479-490, 2002. MUBIANA, V. K. et al. Temporal and spatial trends in heavy metal concentrations in the marine mussel Mytilus edulis from the Western Scheldt estuary (The Netherlands). Hydrobiologia, v. 540, p. 169-180, 2005. NAJIMI, S. et al. Use of Acetylcholinesterase in Perna perna and Mytilus galloprovincialis as a Biomarker of Pollution in Agadir Marine Bay (South of Morocco). Bulletin of Environmental Contamination and Toxicology, v. 58, p. 901-908, 1997. NEURATH, H. The diversity of proteolytic enzimes. In: BEYON, R. J. e BOND, J. S. (Ed.). Proteolytic Enzymes a practical approach. Oxford: IRL Press, 1989. p.1-13. NICHOLSON, S.; LAM, P. K. S. Pollution monitoring in Southeast Asia using biomarkers in the mytilid mussel Perna viridis (Mytilidae : Bivalvia). Environment International, v. 31, n. 1, p. 121-132, Jan 2005. ISSN 0160-4120. Disponível em: < <Go to ISI>://000226278900013 >. NILIN, J. Biomarcadores em estudos ambientais: a vigília dos bivalves na ria de Aveiro (Portugal) e no rio Ceará (Brasil). 2012. 154 (Doutorado). Instituto de Ciências do Mar, Universidade Federal do Ceará NRIAGU, J. O.; PACYNA, J. M. Quantitative Assessment of Worldwide Contamination of Air, Water and Soils by Trace-Metals. Nature, v. 333, n. 6169, p. 134-139, May 12 1988. ISSN 0028-0836. Disponível em: < <Go to ISI>://A1988N345500048 >. NUNES, B. The Use of Cholinesterases in Ecotoxicology. Reviews of Environmental Contamination and Toxicology, Vol 212, v. 212, p. 29-59, 2011. ISSN 0179-5953. Disponível em: < <Go to ISI>://000289755300002 >. OAKESHOTT, M. et al. Evolutionary genetics of Drosophila esterases. Genetics. v. 90, p. 239-268, 1993. OLIVEIRA, M. R. Investigação da contaminação por metais pesados da água e do sedimento de corrente nas margens do Rio São Francisco e tributários, a jusante da Represa da Ceming, no município de Três Marias, Minas Gerais. 2007. 149 f. PhD Geociências, Universidade Federal de Minas Gerais

137

OLIVEIRA RIBEIRO, C. A. et al. Bioaccumulation and the effects of organochlorine pesticides, PAH and heavy metals in the Eel (Anguilla anguilla) at the Camargue Nature Reserve, France. . Aquatic Toxicology, v. 74, p. 53 - 69, 2005. OVISSIPOUR, M. et al. Kinetics of quality changes in whole blue mussel (Mytilus edulis) during pasteurization. Food Research International, v. 53, p. 141-148, 2013. PEREIRA, E. et al. The contribution of heavy metal pollution derived from highway runoff to Guanabara Bay sediments: Rio de Janeiro / Brazil. Anais da Academia Brasileira de Ciências, v. 79, n. 4, p. 739-750, 2007. PETERSON, G. L. A. Simplification of the protein assay method of Lowry et al. which is More Generally Applicable Analytical Biochemistry, v. 83, p. 346-356, 1977. PETES, L. E.; MENGE, B. A.; HARRIS, A. L. Intertidal mussels exhibit energetic trade-offs between reproduction and stress resistance. Ecological Monographs, v. 78, n. 3, p. 387-402, 2008. PFEIFFER, W. C. et al. Metais pesados no pescado da Baía de Sepetiba, Estado do Rio de Janeiro, RJ. Ciência e Cultura, v. 37, n. 2, p. 297-302, 1985. PHYTIAN, S. J. Esterases. In: (Ed.). Biotechnology-Series. Weinheim: Wiley-VCH, 1998. p.193-241. PINHEIRO, F. M. et al. Assessing the Impacts of Organotin Compounds in Ilha Grande Bay, (Rio de Janeiro, Brazil): Imposex and a Multiple-Source Dispersion Model. Journal of Coastal Research, v. 39, p. 1383 - 1388, 2004. PUENTE, X. S. et al. Human and mouse proteases: a comparative genomic approach. Nature Reviews Genetics, v. 4, p. 544-588, 2003. PURINA, I. et al. Concentrations of metallothionein in the bivalve molluscs Anodonta spp. and Unio spp. from Latvian lakes with different anthropogenic pressure. Web of Conferences, v. 1, 2013. PYTHAROPOULOUA, S. et al. Translational responses and oxidative stress of mussels experimentally exposed to Hg, Cu and Cd: One pattern does not fit at all. Aquatic Toxicology, v. 105, p. 157-165, 2011. RABESTEIN, D. L.; GUEVREMONT, R.; EVANS, C. A. Glutathione and its metal-complexes. In: H. Siegel, (Ed.), Metal Ions in Biological Systems. . New York: Marcel Dekker, 1985.

138

RAINBOW, P. S. Phyisology, physicochemistry and metal uptake: a crustacean perspective. Marine Pollution Bulletin, v. 31, n. 1-3, p. 55-59, 1995. RAMALHO, J. F. G. P.; SOBRINHOS, N. M. B. A.; VELLOSO, A. C. X. Contaminação da microbacia de Caetés com metais pesados pelo uso de agroquímicos. Pesquisa agropecuária brasileira, v. 35, n. 7, p. 1289-1303, 2000. RAMSAK, A.; SCANCAR, J.; HORVAT, M. Evaluation of Metallothioneins in Blue Mussels (Mytilus galloprovincialis) as a Biomarker of Mercury and Cadmium Exposure in the Slovenian waters (Gulf of Trieste): A Long-term Field Study. ACTAADRIATICA, v. 53, n. 1, p. 71 - 86, 2012. RASPOR, B. et al. Is the digestive gland of Mytilus galloprovincialis a tissue of choice for estimating cadmium exposure by means of metallothioneins? . Science of the Total Environment, v. 333 n. 1-3, p. 99-108, 2015. ISSN 0048-9697. RASPOR, B. et al. Assessment of metal exposure of marine edible mussels by means of biomarker. In: Klaassen C., editor. Metallothionein IV. Basel (Switzerland): Birkhauser, p. 629- 632, 1999. RASPOR, B.; PAVICIC, J.; BRANICA, M. Cadmium-Induced Proteins from Mytilus galloprovincialis - Polarographic Characterization and Study of their Interaction with Cadmium. Marine Chemistry, v. 28, p. 199-214, 1989. REGOLI, F.; NIGRO, M.; E, O. Lysosomal and antioxidant responses to metals in the Antarctic scallop Adamussium colbecki. . Aquatic Toxicology, v. 40, p. 375-392, 1998. REISCHL, E. et al. Distribution, adaptation and physiological meaning of thiols from vertebrate hemoglobins. . Comp Biochem Physiol C Toxicol Pharmacol, v. 146, n. 1-2, p. 22-53, 2007. RESGALLA JR., C. R.; WEBER, L. I.; CONCEIÇÃO, M. B. O mexilhão Perna perna (L.): biologia, ecologia e aplicações. Rio de Janeiro (RJ). Interciência, 2008. 324. RICHETTI, S. K. et al. Acetylcholinesterase activity and antioxidant capacity of zebrafish brain is altered by heavy metal exposure. NeuroToxicology, v. 32, p. 116-122, 2011. ROCHA, F. R. P.; TEIXEIRA, L. S. G. Estratégias para aumento de sensibilidade em espectrofotometria UV-VIS. Química Nova, v. 27, n. 5, p. 807-812, 2004.

139

ROESIJADI, G.; KIELLAND, S.; KLERKS, P. Purification and Properties of Novel Molluscan Metallothioneins. Archives of Biochemistry and Biophysics, v. 273, p. 403-413, 1989. ROMANI, R. et al. Increased acetylcholinesterase activities in specimens of Sparus auratus exposed to sublethal copper concentrations. . Chemico-Biological Interactions, v.145, p.321-329, . , 2003. ROVER JUNIOR, L. et al. Sistema antioxidante envolvendo o ciclo metabólico da glutationa associado a métodos eletroanalíticos na avaliação do estresse oxidante. . Química nova, v. 24, n. 1, p. 112-119, 2001. RUEGG, M.; METZGER, V.; SUSI, H. Computer Analyses of Characteristic Infrared Bands of Globular Proteins. Biopolymers, v. 14, n. 7, p. 1465-1471, 1975. SÁENS, L. A. et al. Biochemical biomarkers and metals in Perna perna mussels from mariculture zones of Santa Catarina, Brazil. Ecotoxicology and Environmental Safety, v. 73, p. 796-804, 2010. ’ M. . et al. n exp su e m di ies a et l lineste ase activity in zebrafish (Danio rerio) tissues: distinct susceptibility of tissues to iron overload. Fish Physiology and Biochemistry, v. 37, n. 3, p. 573-581, 2011. SANTOVITO, G.; BOLDRIN, F.; IRATO, P. Metal and metallothionein distribution in different tissues of the Mediterranean clam Venerupis philippinarum during copper treatment and detoxification. Comparative Biochemistry and Physiology, v. Part C 174-175, p. 46-53, 2015. SARKARS, A. et al. Molecular Biomarkers: their significance and application in marine pollution monitoring. Ecotoxicology, v. 15, n. 4, p. 333-340, 2006. SATOH, T. Toxicological implications of esterases- From molecular structures to functions. Toxicology and Applied Pharmacology, v. 207, p. S11-S18, 2005. SATOH, T.; HOSOKAWA, M. The mammalian carboxylesterases: from molecules to functions. . Annu Rev Pharmacol Toxicol, v. 38, p. 257-288, 1998. SCHEEFFER, M. Uma avaliação do controle industrial do programa de despoluição da Baía de Guanabara: O caso das 55 indústrias prioritárias. 2001. (Master's). ENgenharia, UFRJ, Rio de Janeiro. SCHLENK, D. Necessity of defining biomarkers for use in ecological risk assessments . Marine Pollution Bulletin, v. 39, n. 1-12, p. 48-53, 1999.

140

SCHMIDT, W.; POWER, E.; QUINN, B. Seasonal variations of biomarker responses in the marine blue mussel (Mytilus spp.). Marine Pollution Bulletin, v. 74, n. 1, p. 50–55, 2013. SEIXAS, T. G. et al. DISTRIBUIÇÃO DE SELÊNIO EM ORGANISMOS MARINHOS DA BAÍA DE GUANABARA/ RJ. Quimica Nova, v. 30, n. 3, p. 554-559, 2007. SEMMLER, M. G. M. C. Biomonitoração de Hg, Cd, Pb e outros elementos em áreas costeiras do estado de São Paulo por meio do mexilhão transplantado Perna perna (Linnaeus, 1758). 2007. 140 (PhD). Instituto de Pesquisas Energéticas e Nucleares, Universidade de São Paulo, São Paulo. SETTLE, F. Handbook of Instrumental Techniques for Analytical Chemistry. New Jersey: Prentice Hall, 1997. 866. SEVCIKOVA, M. et al. Metals as a cause of oxidative stress in fish: a review. Veterinarni Medicina, v. 56, p. 537-546, 2011. SHAUMLOFFEL, D. Precolumn isotope dilution analysis in nanoHPLC-ICP-MS for absolute quantification of sulfur-containing peptides. Analytical Chemistry, v. 79, p. 2859-2868, 2007. SIGNORINI, S. R. A study of the circulation in bay of Ilha grande and bay of Sepetiba. Part I. A survey of the circulation based on experimental field data. Boletim do Instituto de Oceanografia, v. 29, n. 1, p. 41-55, 1980. SILVA, A. A. D.; GONÇALVES, R. C. Espécies reativas do oxigênio e as doenças respiratórias em grandes animais. Ciência Rural, v. 40, n. 4, p. 994-1002, 2010. SIMES, D. C.; BEBIANNO, M. J.; MOURA, J. J. G. Isolation and characterisation of metallothionein from the clam Ruditapes decussatus. Aquatic Toxicology, v. 63, n. 307-318, 2003. SKOOG, D. A.; HOLLER, F. J.; NIEMAN, T. A. Principles of Instrumental Analysis. 5th. Philadelphia: Harcourt Brace College, 1998. SKOOG, D. A.; HOLLER, F. J.; NIEMAN, T. A. Princípios de Análise Instrumental. 5th. Porto Alegre: Bookman, 2002. 836. SNOEK-VAN BEURDEN, P. A. M.; VON DEN HOFF, J. W. Zymography techniques for the analysis of matrix metalloproteinases and their inhibitors. Biotechniques, v. 38, n. 1, p. 73-83, 2005. SOLÉ, M. et al. Esterase activities and lipid peroxidation levels in offshore commercial species of the NW Mediterranean Sea. Marine Pollution Bulletin v. 52, p. 1708-1716, 2006.

141

SOUZA, V. M. Bioindicadores animais de metais poluentes. 2010. 67 (MSc). Ecologia e Produção Sustentável, Pontifícia Universidade Católica de Goiás SREEDEVI, P. et al. Chemosphere, v. 24, n. 1, p. 29-36, 1992. STEGEMAN, J. J. Cytocrome P450 Forms in Fish. In: (Ed.). Handbook of Experimental Pharmacology: Springer-Verlag Berlin Heidelberg, v.105, 1993. STORELLI, M. M.; STORELLI, A.; MARCOTRIGIANO, G. O. Heavy metals in mussels (Mytilus galloprovincialis) from the Ionian Sea, Italy. Journal of Food Protection, v. 63, n. 2, p. 273-276, 2000. STOREY, K. B. Oxidative stress: animal adaptations in nature. Brazilian Journal of Medical and Biological Research, v. 29, n. 12, p. 1715-1733, 1996. SUN, P. et al. An investigation of heavy metal contamination of marine animals in Shantou harbor. Journal of Tropical Oceanography, v. 23, p. 56-62, 2004. SZEFER, P. et al. Distribution and coassociations of trace elements in soft tissue and byssus of Mytilus galloprovincialis relative to the surrounding seawater and suspended matter of the southern part of the Korean Peninsula. Environmental Pollution, v. 129, n. 2, p. 209-228, May 2004. ISSN 0269-7491. Disponível em: < <Go to ISI>://000220279400005 >. TAKESHITA, S. et al. Elevated serum levels of matrix metalloproteinase-9 (MMP-9) in Kawasaki disease. Clinical & Experimental Immunology, v. 125, n. 2, p. 340-344, 2001. TASTET, L.; SHAUMLOFFEL, D.; LOBINSKI, R. ICP-MS-assisted proteomics approach to the identification of selenium-containing proteins in selenium-rich yeast. Journal of Analytical Atomic Spectrometry, v. 23, p. 309-317, 2008. TENÓRIO-DAUSSAT, C. L. et al. Evaluation and standardization of different purification procedures for fish bile and liver metallothionein quantification by spectrophotometry and SDS-PAGE analyses. Talanta, v. 120, p. 491-497, 2014. TROEBERG, L.; NAGASE, H. Zymography of metalloproteinases. Current Protocols in Protein Science, v. 21, p. 2115-2133, 2003. TSANGARIS, C. et al. Multiple biomarkers of pollution effects in caged mussels on the Greek coastline. Comparative Biochemistry and

142

Physiology Part C: Toxicology & Pharmacology v. 151, n. 3, p. 369-378, 2010. UVED. Chimie de L'environnement. 2015. Disponível em: < http://www.cima.ualg.pt/piloto/UVED_Geochimie/UVED/site/html/2/2-3/2-3-3/2-3-3-5.html >. VAN DER OOST, R.; BEYER, J.; VERMEULEN, N. P. E. Fish bioaccumulation and biomarkers in environmental risk assessment: a review. . Environmental Toxicology and Pharmacology, v. 13, n. 2, p. 57-149, 2003. VIARENGO, A. et al. Metallothionein as a tool in biomonitoring programmes. Biomarkers, v. 4, p. 455-166, 1999. VIARENGO, A. et al. The use of biomarkers in biomonitoring: a 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms. Comparative Biochemistry and Physiology part C: Toxicology and Pharmacology, v. 146, n. 3, p. 281-300, 2007. VIARENGO, A. et al. A simple spectrophotometric method for metallothionein evaluation in marine organisms: an application to Mediterranean and Antarctic molluscs. Marine Environmental Research v. 44, n. 1, p. 69-84, 1997. VIEIRA, C. E. et al. Integrated biomarker response index using a Neotropical fish to assess the water quality in agricultural areas. Neotropical Ichthyology, v. 12, n. 1, p. 153-164, 2014. VIJAYAVEL, K.; BALASUBRAMANIAN, M. P. Changes in oxygen consumption and respiratory enzymes as stress indicators in an estuarine edible crab, Scylla serrata, exposed to naphthalene. Chemosphere v. 63, p. 1523-1531, 2006. VIOQUE-FERNÁNDEZ, A.; ALMEIDA, E. A.; LÓPEZ-BAREA, J. Esterases as pesticide biomarkers in crayfish (Procambarus clarkii, Crustacea): Tissue distribution, sensitivity to model compounds and recovery from inactivation. Comparative Biochemistry and Physiology Part C, v. 145, p. 404-412, 2007. VOET, D.; VOET, J. G. Bioquímica. 4. Porto Alegre: Artmed, 2013. WAALKES, M. P.; HARVEY, M. J.; KLAASSEN, C. D. Relative in vitro affinity of hepatic metallothionein for metals. Toxicology Letters, v. 20, p. 33-39, 1984. WAGENER, A. L. R. et al. Hydorcarbons in sediments of a chronically contaminated bay: the challenge of source assignment. Marine Pollution Bulletin, v. 64, p. 284-294, 2012.

143

WALKER, C. H. et al. Principles of Ecotoxicology. Londres: Taylor & Francis, 1996. WALLNER-KERSANACH, M.; BIANCHINI, A. Metais traço em organismos: monitoramento químico e de efeitos biológicos. In: BAPTISTA NETO, J. A. E. A. (Ed.). Poluição marinha. Rio de Janeiro: Interciência, 2008. cap. 9, p.237-283. WANG, W. X.; DEI, R. C. H. Factors affecting trace element uptake in the black mussel Septifer virgatus. Marine Ecology Progress Series, v. 186, p. 161-172, 1999. WELZ, B.; SPERLING, M. Atomic absortion spectroscopy . 3rd. Wiley-VCH, 1999. 965. WHEELOCK, C. E. et al. Applications of Carboxylesterase Activity in Environmental Monitoring and Toxicity Identification Evaluations (TIEs). Reviews of Environmental Contamination and Toxicology, v. 195, p. 117-178, 2008. WHEELOCK, C. E. et al. Applications of Carboxylesterase Activity in Environmental Monitoring and Toxicity Identification Evaluations (TIEs). Reviews of Environmental Contamination and Toxicology, p. 117-178, 2008. WHEELOCK, C. E.; SHAN, G.; OTTEA, J. Overview of carboxylesterases and their role in the metabolism of insecticides. . Journal of Pesticide Science, v. 30, p. 75-83, 2005. WHITAKER, J. R. Introduction to the hydrolases. In: (Ed.). Principles of enzymology for the food sciences. New York: Marcel Dekker, Inc., 1994. p.387-389. WHO. Joint FAO/WHO food standards programme codex committee on contaminants in foods. p. 1-90, 2011. WHO, W. H. O. Biomarkers and Risk Assessment: Concepts and Principles. International Programme on Chemical Safety. Environmental Health Criteria v. 155, 1993. WILHELM-FILHO, D. et al. Effect of different oxygen tensions on weight gain, feed conversion and antioxidant status in piapara, Leporinus elongatus (Valenciennes, 1847). . Aquaculture, v. 244, n. 1-4, p. 349-357, 2005. WILSON, K.; WALKER, J. Principles and Techniques of Biochemistry and Molecular Biology. 7th. United States: Cambridge University Press, 2010.

144

YABE, M. J. S.; OLIVEIRA, E. O. Metais pesados em águas superficiais como estratégia de caracterização de bacias hidrográficas. Química nova, v. 21, n. 5, p. 551-556, 1998. ZHANG, J. et al. Effects of chronic exposure of 2,4-dichlorophenol on the antioxidant system in liver of freshwater goldfish Carassius auratus. Chemosphere v. 55, p. 167-174, 2004.