7.ANTIVIRAL DRUGS
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Transcript of 7.ANTIVIRAL DRUGS
BYBY
Dr. Dr. SAMINATHAN KAYAROHANAMSAMINATHAN KAYAROHANAM
M.PHARM, M.B.A, PhDM.PHARM, M.B.A, PhD
ANTIVIRAL DRUGS
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NUM CONTENT SLIDE
1 1 INTRODUCTION TO VIRUS 4
2 2 THE STRUCTURE OF VIRUSES 5-7
3 3 VIRUSES SIZE COMPARISON BETWEEN E.COLI 8
4 4 TYPE OF VIRUS (RNA VIRUS) (DNA VIRUS) 9,10
5 5 CLASSIFICATION OF ANTIVIRAL DRUGS 11
6 6 MECHANISM OF ANTIVIRAL AGENTS 12
7 7 MECHANISM OF SELECTED ANTIVIRAL AGENTS 13-15
8 8 HIGHLY ACTIVE ANTIRETROVIRAL (HIV) THERAPY (HAART)
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9 9 DRUGS USED TO PREVENT HIV FROM REPLICATING
10 10 TOXIC EFFECT OF PROTEASE INHIBITORS/ANTIVIRAL DRUG
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3 Con…
LEARNING OUTCOME
1. Describe and understand the virus and structure of virus.
2. Able to understand the types of viruses.
3. List the classification of drugs used to treat virus infections.
4. Abele to demonstrate the general mechanism of antivirus drugs.
5. Describe the adverse drug reaction of antiviral drugs.
6. Able to understand the antivirus available drugs and dose in the market.
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1.INTRODUCTION TO VIRUS
Virion size range is ~10-400 nm
All virions contain a nucleocapsid which is composed of nucleic acid (DNA or RNA) and a protein coat (capsid)
Some viruses consist only of a nucleocapsid, others have additional components
Envelopes• virions having envelopes
= enveloped viruses• virions lacking envelopes
= naked viruses
Dr.K.Saminathan.M.Pharm, M.B.A, Ph.D
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2.THE STRUCTURE OF VIRUSES
Con…
CYTOMEGALOVIRUS
Many viruses that infect humans and other animals are enveloped.
Envelopes form when viral glycoproteins and oligosaccharides associate with the plasma membrane of the host cell.
All envelopes have a phospholipid bilayer.
Dr.K.Saminathan.M.Pharm, M.B.A, Ph.D
2.VIRAL ENVELOPES
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Envelopes vary in:SizeMorphologyComplexityComposition
Con…Dr.K.Saminathan.M.Pharm, M.B.A, Ph.D
2.GENOMIC PACKAGING
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Genome packaging has an important role in the infection.
Viral genomes are packaged in one of three ways:• Directly in the capsid-inner side of the
protein coat• Enclosed in special proteins-nucleic acid
binding protein• Enclosed in proteins from the host cell
Con…Dr.K.Saminathan.M.Pharm, M.B.A, Ph.D
20
HYPERSENSITIVITY REACTIONS TO ABACAVIR
SOME ADVERSE EFFECTS OF THE HIV PROTEASE INHIBITORS
Con…Dr.K.Saminathan.M.Pharm, M.B.A, Ph.D
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ADVERSE REACTIONS OF EFAVIRENZ
ADVERSE REACTIONS OF NUCLEOSIDE ANALOGS
Con…Dr.K.Saminathan.M.Pharm, M.B.A, Ph.D
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ADMINISTRATION, METABOLISM, AND TOXICITY OF ZIDOVUDINE (AZT) DIDANOSINE
Con…Dr.K.Saminathan.M.Pharm, M.B.A, Ph.D