7.3 Homeostasis

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    7.3 Maintenance of thebody at rest, and in

    activity

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    Syllabus objectives

    Discuss the concept of homeostasis and its importance

    in maintaining the body in a state of dynamic

    equilibrium during exercise, including the role of the

    hypothalamus and the mechanisms of

    thermoregulation.

    Explain the principle of negative feedback in

    maintaining systems within narrow limits.

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    Understand that cardiac muscle is myogenic and describelectrical activity of the heart, including the roles of the s(SAN), the atrioventricular node (AVN) and the bundle of Hisuse of electrocardiograms (ECGs) can aid the diagnosis of

    disease (CVD) and other heart conditions.

    Explain how variations in ventilation and cardiac output enableof oxygen to tissues and the removal of carbon dioxide from thow the heart rate and ventilation rate are controlled and thcardiovascular control centre and the ventilation centre.

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    Syllabus objectives Describe how to investigate the effects of exercise on

    and breathing rate using data from spirometer traces.

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    Definition the maintenance of a constant internal environment.

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    How is homeostasis achieved?

    Negative feedback mechanism

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    Components of a negative feedback mech

    The detectors are specialised cells either in the brain or in other organs, suc

    The effectors are organs such as the skin, liver and kidneys. Informatio

    detectors and effectors via

    the nerves of the nervous system, or via hormones (the endocrine system), o

    The outcome is an incredibly precisely regulated internal environment.

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    Homeostasis in action control of body temp

    Heat may be transferred between an animal and the envconvection, radiation and conduction, and the body losevaporation

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    ThermoregulationThe regulation of body temperature, known as thermoregulation

    consists of a heat loss centre

    and a heat gain centre

    temperature-sensitive nerve cells(neurones) are situated, anddetect changes in thetemperature of the blood flowingthrough the brain.

    The thermoregulation centre ofthe hypothalamus also receivesinformation via sensory nervesfrom temperature-sensitivereceptors located in the skin andin many internal organs.

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    How The hypothalamus communicates with tthe body

    via the autonomic nervous system.

    For example, when the body temperature is lower than normathe heat gain centre inhibits activity of the heat loss centre, ansends impulses

    to the skin,

    To hair erector muscles,

    To sweat glands and elsewhere, that decrease heat loss (such as by causi

    vasoconstriction of skin capillaries) and increase heat production (causing shivering, and enhanced brown fat respiration, f

    example).

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    The role of the skin in temperature regu

    l f ill i i l i h

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    role of capillaries in regulating heatloss through the skin

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    role of the sweat glands in regulating hethrough the skin

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    role of the hair in regulating heat lossthrough the skin

    H t i i ti l ti f di

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    Homeostasis in action regulation of cardia

    The heart beats rhythmically throughout life, withoutfrom the momentary relaxation between beats.

    The heart beat is myogenic in origin.

    The heart beat originates in a structure in the muscle of thright atrium, called the sino-atrial node (SAN), also known apacemaker.

    Muscle fibres radiating out from the SAN conduct impulses to t

    both atria, triggering atrial systole (contraction).

    Then a second node, the atrio-ventricular node, situated at thright atrium picks up the excitation and passes it to the vent

    modified muscle fibres, called the Purkinje fibres.Ventricular systole is then triggered.

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