65 year-old female with Alzheimer’s disease
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65 year-old female with Alzheimer’s disease
Lananh Nguyen, M.D.Division of Neuropathology
University of Pittsburgh Medical Center
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An autopsy was performed. Identify the structures arrow.
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An autopsy was performed. Identify the structures arrow.
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Hippocampus
Thalamus
Corpus callosumCaudate, tail
Lateral geniculate nucleus
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Note the atrophy in the brain with the Alzheimer’s disease.
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Normal Severe atrophy
library.med.utah.edu
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What microscopic pathology is in abundance in Alzheimer’s disease (AD)?
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What microscopic pathology is in abundance in Alzheimer’s disease (AD)?
• Neuritic plaques • Neurofibrillary tangles• Amyloid plaques
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What stains would you use to evaluate microscopic pathology in Alzheimer’s disease (AD) for these features?
• Neuritic plaques • Neurofibrillary tangles• Amyloid plaques
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What stains would you use to evaluate microscopic pathology in Alzheimer’s disease (AD) for these features?
• Neuritic plaques : Bielchowsky stain• Neurofibrillary tangles: Phosphorylated tau stain• Amyloid plaques: Beta amyloid stain
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What “body” would you expect to see in the hippocampus of a person with AD
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• Hirano bodies
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Where in the hippocampus can you find these bodies?
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Where in the hippocampus can you find these bodies?
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• CA1 region of the hippocampus
CA4
CA1
CA2CA3
Dentate gyrus
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What are the 4 most common genes linked to AD?
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• Amyloid precursor protein mutation (causative gene)• Presenilin 1 and Presenilin 2 mutations (causative gene)• Apolipoprotein E4 (risk gene)