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6/19/07 CURRICULUM VITAE Name: Hugh A. Tilson Date and Place of Birth : July 24, l946, Plainview, Texas Citizenship: United States Education: l968 - B.A., Physiological Psychology, Texas Technological University, Lubbock, Texas l972 - Ph.D., Psychopharmacology, University of Minnesota, Minneapolis, Minnesota Brief Chronology of Employment: l968 - l97l USPHS Trainee in Psychopharmacology, University of Minnesota, Dr. Travis Thompson, Director; Dr. Sheldon Sparber, Advisor. l972 - l973 Research Associate with Professor Richard Rech, Department of Pharmacology, Michigan State University, East Lansing, Michigan. l972 - l973 Lecturer, Behavioral and Pharmacological Effects of Psychotomimetics; Principles of Behavioral Pharmacology to advanced students in veterinary school, Michigan State University. l973 - l976 Senior Research Scientist, Pharmacology Department, Bristol Laboratories, Syracuse, New York. l973 - l976 Adjunct Associate Professor, Department of Psychology, Syracuse University, Syracuse, New York. l973 - l976 Lecturer, Brain Mechanisms Involved in Basic Reinforcement Processes; Principles of Neurotransmission, Syracuse University. l976 - l977 Pharmacologist, Laboratory of Environmental Toxicology, National Institute of Environ- mental Health Sciences, Research Triangle Park, North Carolina. l977 - 1988 Pharmacologist, Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. l978 - 1984 Adjunct Associate Professor, Department of Zoology, North Carolina State University, Raleigh, North Carolina. 1982 - Date Adjunct Associate Professor, Toxicology Program, University of North Carolina. 1986 - Date Adjunct Professor, Neurobiology Program, University of North Carolina, Chapel Hill, North Carolina. 1988 - 1989 Pharmacologist, Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park,

Transcript of 6/19/07 · Web viewDeveloping Countries, New Delhi, India, November 24-28, 1991. Invited speaker,...

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6/19/07

CURRICULUM VITAE

Name: Hugh A. Tilson

Date and Place of Birth : July 24, l946, Plainview, Texas

Citizenship: United States

Education:

l968 - B.A., Physiological Psychology, Texas Technological University, Lubbock, Texas l972 - Ph.D., Psychopharmacology, University of Minnesota, Minneapolis, Minnesota

Brief Chronology of Employment:

l968 - l97l USPHS Trainee in Psychopharmacology, University of Minnesota, Dr. Travis Thompson, Director; Dr. Sheldon Sparber, Advisor.

l972 - l973 Research Associate with Professor Richard Rech, Department of Pharmacology, Michigan State University, East Lansing, Michigan.

l972 - l973 Lecturer, Behavioral and Pharmacological Effects of Psychotomimetics; Principles of Behavioral Pharmacology to advanced students in veterinary school, Michigan State University.

l973 - l976 Senior Research Scientist, Pharmacology Department, Bristol Laboratories, Syracuse, New York.

l973 - l976 Adjunct Associate Professor, Department of Psychology, Syracuse University, Syracuse, New York.

l973 - l976 Lecturer, Brain Mechanisms Involved in Basic Reinforcement Processes; Principles of Neurotransmission, Syracuse University.

l976 - l977 Pharmacologist, Laboratory of Environmental Toxicology, National Institute of Environ-mental Health Sciences, Research Triangle Park, North Carolina.

l977 - 1988 Pharmacologist, Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

l978 - 1984 Adjunct Associate Professor, Department of Zoology, North Carolina State University, Raleigh, North Carolina.

1982 - Date Adjunct Associate Professor, Toxicology Program, University of North Carolina. 1986 - Date Adjunct Professor, Neurobiology Program, University of North Carolina, Chapel Hill,

North Carolina. 1988 - 1989 Pharmacologist, Laboratory of Molecular and Integrative Neuroscience, National

Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. 1989 - 2000 Director, Neurotoxicology Division, Environmental Protection Agency, Research

Triangle Park, North Carolina. 2000- 2005 Assistant Laboratory Director for Multimedia Research, Research Coordination and

Planning Branch, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina.

2005- Acting National Program Director, Human Health Research Program, Office of Research and Development

2007- National Program Director, Human Health Research Program, Office of Research and Develop-ment

Societies:

Society of the Sigma Xi. American Association for the Advancement of Science. New York Academy of Sciences (1982-1988). American Society for Pharmacology and Experimental Therapeutics. Behavioral Teratology Society (Secretary, l982 - l984).

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North Carolina Society of Toxicology (President, 1996-1997). North Carolina Society of Neuroscience (President 1988-1989). International Union of Pharmacology (Section on Toxicology). Society of Toxicology (Nominating Committee, 1989-1990; Membership Committee, 1995-1997). Neurotoxicology Specialty Section, Society of Toxicology (President, 1986-1987). International Neurotoxicology Association (Scientific Committee, 1991-1993).

Awards and Honors:

Psi Chi (Honorary Society). Phi Kappa Phi (Honorary Society). Who's Who in America. Sigma Xi. National Institute of Health Training Fellowship (1968-1972). US EPA Bronze Medal for Commendable Service (1991)-Neurotoxicity Testing Guidelines. US EPA Scientific and Technology Achievement Award (1993). US EPA Bronze Medal for Commendable Service (1994)-Principles of Neurotoxicology Risk

Assessment. US EPA Bronze Medal for Commendable Service (1995)-Fuels/Fuel Additives. Publisher’s Award (Society of Toxicology)-Best paper in Toxicology and Applied Pharmacology (1996). US EPA Science and Technology Achievement Award (1996). US EPA Bronze Medal for Commendable Service (1997)-IPCS Collaborative Study to Validate Neurotoxicological Screening Tests.US EPA Silver Medal for Commendable Service (2000)-Neurotoxicology Risk Assessment Guidelines.US EPA Science and Technology Achievement Award (2002).US EPA Bronze Medal for Commendable Service (2003)-Reference Dose and Reference

Concentration Process Technical Panel US EPA NHEERL Teamwork Award (2003) Production of NHEERL’s Implementation Plan for

Human Health Research.US EPA Bronze Medal for Commendable Service (2004)-Computational Toxicology Steering

Group.US EPA Bronze Medal for Commendable Service (2005)- Organization of Scientific Program for

External Review of the Endocrine Disrupting Chemical Orogram.

Research Interests :

Children’s Health Issues.Integrated Health and Ecological Risk Assessment.

US Environmental Protection Agency:

Chairman, HERL Promotion Review Board, 1989-2000.Member, Ad-hoc Working Group, Neurotoxicity Testing Guidelines.Member, Developmental Neurotoxicity Guidelines Workgroup.Member, Ad-hoc Working Group on Neurotoxicity Risk Assessment Guidelines.Chairman, HERL Committee on Quality/Quantity of Publications.Member, Risk Assessment Forum Technical Panel Document on Cholinesterase Inhibitors.Scientific Advisor, EPA/UNC Toxicology Research Program (1992-1998).Member, Guideline Harmonization Workgroup.HERL Endocrine Disruptors Steering Committee.Developmental Reproduction Toxicity Testing Workgroup, 1993-1994.NHEERL Organizational Task Force.Senior Author, Neurotoxicity Risk Assessment Guidelines.Human Resource Council (Alternate), 1996 to 1998.EPA Representative, Interagency Coordinating Committee on the Validation of Alternative Methods, 1997-1998.Member, ORD FQPA 10x Task Force.Member, ORD RFD/RFC Technical Panel.

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Member, ORD Human Health Research Strategy Document Steering Committee and Editor, Human Health Research Strategy Document.Member, ORD Endocrine Disruptor Strategic Plan Working Group.Member, ORD Computational Toxicology Steering Committee; Editor, A Framework for a Research Program on Computational Toxicology at ORD.Member, NHEERL Endocrine Disruptor Research Steering Committee.Lead Author, Harmonization Section of the ORD Human Health Multi-Year Plan.Co-Author, Conditions Research Section of the ORD Ecological Research Multi-Year Plan.NHEERL representative to the EPA Multimedia Research Coordination Team and Co-Chair, Human Health Working Group (2002-2003). Co-Chair, Ecology Research Working Group (2004).Member, Ecological Research Working Group (2000-2005)Member, Endocrine Disruptor Working Group (2000 to 2005). Member, NHEERL Human Health Implementation Steering Committee.Editor, NHEERL Human Health Implementation Research Strategy.Member, ORD Asthma Research Steering Committee.Member, ORD Management Multi-Year Plan Goal 3 Team.Member, ORD Science Council.

Editorial Boards :

Associate Editor, NeuroToxicology, l978-2004.Member, Editorial Board, Neurotoxicology and Teratology, l978-1990.Member, Editorial Board, Toxicology and Applied Pharmacology, 1985-1995.Associate Editor, Toxicology and Applied Pharmacology, 1995-2002.Member, Editorial Board, Reviews on Environmental Health, 1990-1998.Member, Editorial Advisory Board for Toxicology Methods, 1990-2002.Member, Editorial Board, Environmental Health Perspectives, 1993-1999.

Committee and Consultant Appointments:

Member, Project Advisory Group, Project to Standardize and Validate Methods and Procedures in Behavioral Teratology, National Center for Toxicological Research, Jefferson, Arkansas,

1978-1986.

Consultant, Organization for Economic Co-operation and Development (OECD), Ad Hoc Expert Group on Neurotoxicology, April, l982.

Consultant, WHO International Program on Chemical Safety (IPCS), Working Group on Methods for the Integrated Evaluation of Risks for Progeny Associated with Prenatal Exposures to Chem-icals, Leningrad, USSR, l983

Consultant, WHO IPSC Working Group on "Methods in Neurobehavioral Toxicology, Moscow, USSR, l984.

Consultant, Research Program, U. S. Army Medical Bioengineering Research and Development Laboratory, l982-1984.

Ad Hoc Reviewer, National Science Foundation Psychobiology Program.

Ad Hoc Reviewer, Environmental Protection Agency (to 1989).

Ad Hoc Reviewer, March of Dimes.

Consultant, IPCS Environmental Document on Acrylamide, Carshalton, Surrey, England, December 2-7, 1984.

Steering Committee, IPCS/WHO Collaborative Study to Validate a Neurobehavioral Testing Battery, 1987-1995

Co-Principal Investigator, Interagency Cooperative Agreement with Food and Drug Adminis- tration, Studies on Neurobiological Effects of Aspartame, 1987-1989

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Consultant, WHO International Program on Chemical Safety, Organizing Committee for Development of Protocol for the Assessment of Chemicals for Neurobehavioral Toxicity,

Prague, Czechoslovakia, May 25 - June 1, l987Member, Federal Insecticide, Fungicide and Rodenticide (FIFRA) Scientific Advisory Panel Sub-

panel for Environmental Protection Agency Neurotoxicity Guidelines, Washington, DC, October 15-16, 1987.

Member, Ad Hoc review committee for National Institute of Aging for neuroscience and behavioral proposals on "Development of Biomarkers of Aging", Washington, D.C., November

4-6, 1987.

Member, NIEHS Coordinating Committee on Aids, 1987

Member, Ad Hoc review panel for the Swedish Work Environment Fund, Neurotoxicology Section, 1987-1988.

Member, NIH Coordinating Committee on Alzheimer's Disease, 1988-1989.

Consultant, Task Force on Environmental Cancer and Heart and Lung Disease, Working Group on Neurotoxicology - Effects of Pesticides on Human Health, 1988.

Member, Ad hoc review panel for National Institute of Health Study Section, August 30 - September 1, 1989.

Member, Center for Alternatives to Animal Testing, 1990.

Chairman, Interagency Committee on Neurotoxicology, September 1989-1995..

Consultant, National Research Council, Draft Document on Neurotoxicology, March, 1990.

Member, External Advisory Group, NASA Specialized Centers for Research and Training, The University of Texas Health Science Center at San Antonio, May 1990-1992.

Member, FCCSET Subcommittee on Brain and Behavioral Sciences, 1990-1995.

Member, External Advisory Committee to the Environmental Health Center at the University of Rochester, May 1991-1993.

Executive Secretary, Working Party on Neurotoxicology, FCCSET Subcommittee on Risk, June 1991-1993.

Connsultant, Task Group Meeting on Environmental Health Criteria (EHC) and a Health and Safety Guide (HSG) for Methyl Ethyl Ketone, Geneva, September 9-13, 1991.

Ad hoc Member, Toxicology Study Section II, National Institutes of Health, June 1993.

Participant, WHO/IPCS, Workshop on Biomarkers, October 11-15, 1993, Adelaide, Australia.

Consultant, WHO/IPCS, Planning Meeting on Application of Biomarkers, October 18-19, 1993, Adelaide, Australia.

Technical Advisory Team, Whistler Mercury Conference, EPRI, November 30-December 1, 1993.

Steering Committee, Symposium on Alternatives in the Assessment of Toxicity: Theory and Practice. Edgewood Proving Ground, Maryland, May 24-26, 1994.

Consultant, Scientific Oversight Committee concerning potential health effects of Pfiesteria piscimorte, State of North Carolina, Department of the Environment, 1994.

Consultant, Environmental Health Sciences Center, Department of Community Medicine, Mt. Sinai Medical Center, October 5, 1994.

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Full Member, Toxicology Study Section II. National Institutes of Health, 1994-1998.

Consultant, Review of Neurotoxicology In Vitro Grant Proposals, Center for Alternative Animal Testing, Baltimore, MD, September 26, 1994.

Consultant, Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Rutgers University, Piscataway, NJ, 1995-1996.

Consultant, IPCS/WHO Working Group on In Vitro Procedures in Neurotoxicology, Research Triangle Park, NC, December 4-8, 1995.

Member, ad hoc Scientific Review Committee for Research Centers in Basic and Clinical Studies of Environmental Hazards, Department of Veterans Affairs, March, 1996.

Member, ILSI Risk Science Institute’s Working Group to develop strategy on age- related differences in susceptibility to chemical toxicants. Washington, DC, July 16-17, 1996.

Consultant, Chemical Industry Institute for Toxicology, Science Review Panel, 1996-1998.

Consultant, National Resources Defense Council, Document Review, 1997.

External Advisory Committee, Center for Children’s Environmental Health, Mississippi State University, College of Veterinary Medicine, 1998.

Society of Toxicology Media Resource Specialist, 1998-2000.

Consultant, Document review, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, 1998.

Consultant, Air Force Office of Scientific Research, Grant Review, June, 1998.

Subject Matter Expert, Joint Service Integration Group, Department of Defense, August, 1998.

Consultant, US Army Medical Research and Material Command, Grant Proposal Review, June, 1998.

Subject Matter Expert, Criteria Document Evaluation of Airborne Exposure Limits for Vx. US Army Center for Health Promotion and Preventive Medicine. Aberdeen Proving Ground, MD, October 14, 1998.

Consultant, Site Visit Team, VA Environmental Hazards Research Centers, Department of Veteran Affairs, November, 1998.

Consultant, University of Medicine and Dentistry of New Jersey, NIEHS Center Grant, Piscataway, NJ, December 7-8, 1998.

Member, Food and Drug Administration’s Senior Biomedical Research Service CredentialsCommittee, 1998-present.

Consultant, WHO/IPCS Steering Committee to Rewrite Criteria Document on Neurotoxicology, Geneva, Switzerland, January 25-28, 1999.

Consultant, Assessment of Document “Evaluation of Airbourne Exposure Limits for Sulfur Mustard. Occupational and General Population Exposure Criteria,” Department of the Army,

September 2, 1999.

Consultant, Use of Genomic and Proteomic Information in Risk Assessment, British Toxicological Society, September, 2003.

Invited Lectures and Papers:

Chair and invited participant, Workshop on "Biological Concomitants of Hallucinogens," Winter Conference on Brain Research, Steamboat Springs, CO, January, l974.

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Invited paper, “Adaptive Changes in Behavior After Chronic Administration of Various Psycho- active Drugs”, American Association for the Advancement of Science, San Francisco, CA, l974.

Invited presentation, "The Effects of a-MT and p-CPA on Behavioral Effects of d-Amphetamine Administered Repeatedly to Rats Responding on a Continuous Avoidance Schedule," Winter

Conference on Brain Research, Steamboat Springs, CO, January 23-29, l975.

Invited participant, at Symposium on "Relevance of the Animal Psychopathological Model to the Human," New York, NY, March 10-12, l974.

Invited participant, Comparative Behavioral Pharmacology Section of the Gordon Conference on Catecholamines, Proctor Academy, Andover, NH, July 12-14, l975.

Invited participant, Workshop on "The Use of the Dystrophic Chicken Model as a Drug Screen," New York, NY, May 15, l976.

Invited participant, Symposium on the "Effects of Prenatal and Postnatal Toxic Exposure on Behavioral Development," American Psychological Association Convention, San Francisco, CA, August 12, 1977.

Invited paper, "The Effect of Parachloroamphetamine on the Intake of Ethanol, Saccharin, Food, and Water," Medical-Scientific Conference of National Council on Alcoholism, San Diego, CA, May, l977.

Invited paper, "Behavioral Toxicologic Effects of Polybrominated Biphenyl (PBB) Compounds in Rodents, Department of Health, Education and Welfare Committee to Coordinate Toxicology and Related Programs, Bethesda, MD, July l8, l977.

Invited paper, "Behavioral Toxicological Effects of Polybrominated Biphenyls (PBBs) in Rats and Mice," Workshop on Polybrominated Biphenyls, East Lansing, MI, October, l977.

Invited presentation, "Effects of Polybrominated and Polychlorinated Compounds on Behavior and Neurological Functioning”, Workshop on Behavioral and Neurotoxic Effects of Environmental Agents, Winter Conference on Brain Research, Steamboat Springs, CO, January, l978.

Invited discussant, "Neurobehavioral Changes with PBB Exposure: Clinical and Laboratory Obser-vations," Conference of the Combined Clinical Staff of the National Institutes of Health concerning the Health Consequences of Halogenated Hydrocarbons, Bethesda, MD, March, 1978.

Invited speaker, "Neurobehavioral Effects of Halogenated Hydrocarbons in Rodents," CNS Section, Pharmacology Department Seminar Series, Virginia Commonwealth University, Richmond, VA,

January, 1979.

Invited speaker, "A Strategy for the Development of Behavioral Tests to be used in Neurotoxicology: An Example Using Acrylamide," Biological Sciences Seminar Series, Virginia Commonwealth

University, Richmond, VA, January, l979.

Invited speaker, "Test Methods for Definition of Effects of Toxic Substances on Behavior and Neuromotor Functions," Workshop at the Southwest Foundation for Research and Education, San

Antonio, TX, April 2-4, l979.

Invited speaker, "The Neurotoxicology of Acrylamide-Evidence for Alterations in Brain Dopamine Function," The Graduate School, Graduate Center for Toxicology, University of Kentucky,Lexington, KY, April 12, l980.

Invited lecturer , “Neurotoxicology”, Graduate Student Neurotoxicology Course, George Washington University Medical Center, Department of Pharmacology, Washington, DC, March 30, l98l.

Invited participant, “Neurotoxicity of Solvents”, Conference on Neurotoxicity of Organic Solvents co-sponsored by the Environmental Protection Agency and Johns Hopkins University School of Medicine, Raleigh, NC, June 26-27, l98l.

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Invited participant, "Behavioral and Teratological Research in Neurotoxicology," Fall Symposium ofMid-Atlantic Chapter, Society of Toxicology, New York, NY, November 7, l98l.

Invited speaker, "The Neurotoxicity of Acrylamide," University of Cincinnati and Institute of Environ-mental Health, Cincinnati, OH, January l9-20, l982.

Invited speaker, "Neurotoxicity of Triethyl Lead", Satellite Symposium on Environmental Neuro-toxicology-Assessment of Nervous System and Behavioral Dysfunction, Dusseldorf, Germany, March 29-3l, l982.

Invited speaker, "Sites of Chlordecone-Induced Tremor," Department of Pharmacology Seminar Series, University of Georgia Medical College, Augusta, GA, January 24-25, l983.

Invited participant, US-USSR Workshop on Physical Factors, Raleigh, NC, June 2l-23, l983.

Invited speaker, "Developmental Effects of Triethyl Lead", Behavioral Teratology Symposium,Teratology Society Meeting, Atlantic City, NJ, June 26, l983.

Invited speaker, "Mechanism of Action of Organochlorine-induced Tremor and Hyperexcitability in Rats:, Food and Drug Administration Seminar, Washington, DC, March 5, l984.

Invited lecturer, "Developmental Neurotoxicology and Teratology", University of North Carolina, Chapel Hill, NC, April 2, l984.

Invited participant, "Effects of 5,5-diphenylhydantoin on Tremor and Hyperreflexia of Rats Exposed to Organochlorine Insecticides and Permethrin", Third International Conference on Neurotoxicology of Selected Chemicals: Pyrethroids and Neuroactive Pesticides, Little Rock, AR, September 9-11, l984.

Invited participant, "The Use of Pharmacological Agents in Neurotoxicology", International Workshop on Experimental Models of Treatment Effects on Central Nervous System Function and Behavior:

A multi-disciplinary Analysis. Commission of the European Communities Committee on Medical and Public Health Research and the Instituto di Sanita, Rome, Italy, September 23-27, l984.

Invited speaker, "Neurobehavioral Techniques in Toxicology", Ciba-Geigy Corporation, Basel, Switzerland, October l, l984.

Invited speaker, "Neurochemical Correlates of DDT-induced Neurotoxicity", Medical College of Virginia, Department of Pharmacology, Richmond, VA, February l9, l985.

Invited speaker, "Experiments that Attempt to Correlate Neurochemical and Neurobehavioral Effects: Problems and Examples", Department of Psychology, North Carolina State University, Raleigh, NC, March 29, l985.

Invited participant, "Neurobehavioral Toxicology: A Systematic Approach to the Study of the Nervous System," Department of Toxicology, Hoffman-LaRoche, Nutley, NJ, April l6, l985.

Invited speaker, "Organochlorine-induced Tremor and its Relationship to Neurological Disease," Sym-posium on the Use of Organochlorine Insecticides in Neurobiology, American Society for Pharmacology and Experimental Therapeutics, San Diego, CA, August l8-22, l985.

Invited participant, Symposium on MPTP: A Parkinsonian Syndrome Producing Neurotoxin, Bethesda, MD, June 10-11, 1985.

Invited participant, Symposium and Workshop on Design Considerations in Screening for Behavioral Teratogens, Cincinnati, OH, September 3-6, 1985.

Invited speaker, Symposium on Predicting Neurotoxicity and Behavioral Dysfunction from Preclinical Toxicologic Data, Washington, DC, September 30-October 1, 1985.

Invited participant, Symposium on Neurobehavioral Methods in Safety Assessment of Chemicals and Drugs, Dusseldorf, Federal Republic of Germany, December 16-19, 1985.

Invited speaker, "Neurobehavioral Techniques in Toxicology", National Food Institute, Institute of

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Toxicology, Síborg, Denmark, December l3, l985.

Invited speaker, "Colchicine-Induced Hippocampal Damage and Neurobehavioral Function", Symposium on Neurotoxic Chemicals as Probes and Models of Neurological Disorders. Jointmeeting of the American Society of Pharmacology and Experimental Therapeutics and Society of , Toxicology, Baltimore MD, August 17, 1986.

Invited speaker, "Animal Models of Neurological Disease: Alzheimer's", Glaxo Pharmaceutical Co., Research Triangle Park, NC, December 13, 1986.

Invited speaker, "Intradentate Colchicine as a Model of Alzheimer's Disease", Pharmacology Section, Burroughs-Wellcome, Research Triangle Park, NC, March 24, 1987.

Invited speaker, "Colchicine as a Model of Cognitive Dysfunction", CNS Section, Medical College of Virginia, Richmond, VA, April 28, 1987.

Invited speaker, "Cytotoxicants as Models of Neurological Disease", Annual Retreat, Behavioral and Neuropharmacology Research Training Program, University of Minnesota, Minneapolis, MN, April 29-May 1, 1987.

Invited speaker, "Neurobehavioral Effects of Aspartame", Conference on the Biological Effects of Phenylalanine, Washington, DC, May 8-10, 1987.

Invited speaker, "The Role of the Dentate Gyrus in Cognitive Behavior of the Rat", Cognitive Dysfunction in Children and Adults: Clinical and Basic Science Issues, Little Rock, AR, September

28- October 2, 1987.

Invited speaker, "Role of the Dentate Gyrus in Working and Reference Memory", Department of Psychology, University of North Carolina, Chapel Hill, NC, November 3, 1987.

Presidential Address, "Compensatory Changes in Cholinergic Function Following Damage to the Dentate Gyrus by Colchicine", North Carolina Society for Neuroscience, Raleigh, NC, November 3,

1987.

Invited speaker, "Experiments on the Neurobiological Effects of Aspartame", Food and DrugAdministration, Washington, DC, February 8, 1988.

Invited participant, Workshop on Neurotoxicological Assessment, Health Effects Institute, Cambridge, Massachusetts, December 11, 1987.

Invited speaker, "Compensatory Changes in Hippocampal Cholinergic Function following Destructionof Dentate Gyrus Granule Cells with Colchicine", XI European Congress of Perinatal Medicine, Rome, Italy, April 10-13, 1988.

Invited speaker, "Cholinergic Modulation of Colchicine-Induced Cognitive Deficits in Rats", Symposium on Behavioral Toxicology, Second Meeting of the European Behavioral

Pharmacology Society, Athens, Greece, August 31-September 3, 1988.

Invited speaker, "Compensatory Cholinergic Changes in the Hippocampus following Intradentate Administration of Colchicine", Conference on Behavioral Pharmacology: A Case Study of anEmerging Discipline, Minneapolis, MN, October 13-15, 1988.

Invited speaker, "Animal Neurobehavioral Test Battery in NTP Assessment," Third International

Symposium on Neurobehavioral Methods in Occupational and Environmental Health, Washington, DC, December 12-15, 1988.

Invited participant, "Developmental Neurotoxicology of Polychlorinated Biphenyls: Animal Data," Workshop on Quantitative and Qualitative Comparability of Human and Animal Developmental Neurotoxicity, US Environmental Protection Agency, Williamsburg, VA, April 11-13, 1989.

Invited speaker, "Colchicine-Induced Models of Cognitive Dysfunction and their Possible Application in Aging," First Biennial Medical Update, Bari, Italy, April 26-29, 1989.

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Invited speaker, "Behavioral Indices of Neurotoxicity, VIII International Symposium of the Society of Toxicologic Pathologists, Cincinnati, OH, May 21-25, 1989.

Invited speaker, "Neurotoxicology at the Environmental Protection Agency", Chevron Environmental Health Center, San Francisco, CA, March 1-2, 1990.

Invited speaker, "Compensatory Cholinergic Changes in the Hippocampus Following Experimentally-Induced Neurodegeneration". University of North Carolina Neurobiology Colloquium, ChapelHill, NC, March 22, 1990.

Invited speaker, "Evolution of Neurotoxicology at the Environmental Protection Agency," Ohio Regional Chapter of the Society of Toxicology, Cincinnati, OH, May 5, 1990.

Invited speaker, "Functional Aspects of Developmental Neurotoxicity", 8th Biennial Meeting of the International Society for Developmental Neuroscience, Bal Harbour, FL, June 16-22,

1990.

Invited speaker, "Neurochemical Substrates of Learning and Memory: Role of the Cholinergic System”, University of Wisconsin, Topics in Toxicology: Neurotoxicology in the EnvironmentalToxicology Center, Madison, WI, August 8-9, 1990.

Invited speaker, "Problems in Laboratory Experimentation in Neurobehavioral Toxicology and Teratology." 17th Collegium Internationale Neuro-Psychopharmacologicum, Kyoto, Japan,October 10-14, 1990.

Invited speaker, "Compensatory Cholinergic Mechanisms following Experimentally InducedNeurodegeneration," Department of Pharmacology and Neurology, University of Mississippi,

Oxford, MS, September 24, 1990.

Invited speaker, "The Role of Behavioral Studies in Assessing the Risk of Chemicals," International Symposium on Toxicology, Beijing, China, October 16-19, 1990.

Invited speaker, "Compensatory Cholinergic Changes in the Hippocampus following Experimentally-

Induced Degeneration by Colchicine", Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, January 21-22, 1991.

Invited speaker, "Neurotoxicology Research at the Health Effects Research Program", NationalCapital Area Chapter Society of Toxicology, Washington, DC, January 24, 1991.

Invited speaker, "Neurotoxicology and Risk Assessments", Environmental Health Conference, Regional Environmental Center for Central and Eastern Europe, Budapest, Hungary, February25-28, 1991.

Invited speaker, "Neurobehavioral Methods Used in Neurotoxicology", National Institute on Drug Abuse Technical Review Meeting on Assessing Neurotoxicity of Drugs of Abuse, Washington,DC, May 20-21, 1991.

Invited speaker, "Study Design Considerations in Developmental Neurotoxicity", Neurobehavioral Teratology Society Symposium on Design and Analysis Issues in Developmental Neurotoxicology, Boca Raton, FL, June 22, 1991.

Invited speaker, "Comparison of Screening Approaches", Third International NeurotoxicologyAssociation, Salsomaggiore Terme, Italy, July 1-5, 1991.

Invited speaker, "Compensatory Changes in the Hippocampus following Intradentate Colchicine",International Minisymposium: Limbic System and Hippocampus. Dusseldorf, September 3-5, 1991.

Invited speaker, "Compensatory Changes in the Brain following Neurotoxic Insult", ToxicologyTraining Program, Rutgers University, Piscataway, NJ, October 9, 1991.

Invited speaker, "Developmental Neurotoxicity and Regulatory Issues", Mid-Atlantic Chapter of the

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Society of Toxicology, Langhorn, PA., October 10, 1991.

Invited speaker, "Compensatory Changes in Cholinergic Second Messenger Mechanism FollowingIntra- dendate Infusion of Colchicine", Symposium on Environmental Neural Toxicology, Societyof Environmental Toxicology and Chemistry, Seattle, WA, November 3-7, 1991.

Invited speaker, "Approaches to Screening Neurotoxic Agents", Second Congress of Toxicology in Developing Countries, New Delhi, India, November 24-28, 1991.

Invited speaker, "Cholinesterase Inhibitors: Ongoing and Proposed Research Needs", Cholinesterase Methodologies Workshop, Arlington, VA, December 4-5, 1991.

Invited speaker, "Neurotoxicology and Regulatory Aspects", International Council on Metals and the Environment, Workshop on Neurotoxicology, Raleigh, NC, December 17, 1991.

Invited lecturer, "Developmental Neurotoxicology - Theory and Fact", Andrea Hunter MemorialLecture, East Carolina University, Medical School Faculty, Greenville, NC, April 1, 1992.

Invited Speaker, "Compensatory Changes in the Hippocampus of Rats Following ExperimentalNeurodegeneration with Colchicine", Department of Pharmacology, East Carolina University,Greenville, NC, April 1, 1992.

Invited speaker, "Compensatory Changes in the Hippocampus Following Intradentate Infusionof Colchicine", Symposium on Role of Receptors and their Regulatory Effectors inNeurotoxicity, sponsored by the American Society of Pharmacology and Experimental

Therapeutics, Annaheim, CA, April 8, 1992.

Invited speaker, "Compensatory Changes in the Hippocampus Following Experimentally-Induced Neurodegeneration with Colchicine", Department of Pharmacology, Michigan State University, East Lansing, MI, April 28, 1992.

Invited speaker, "Compensatory changes in the Hippocampus following Experimentally-Induced Neurodegeneration", Instituto di Scienze Pharmacologiche, Universita' di Milano, Milan, Italy, May 7, 1992.

Invited speaker, "Risk Assessment of Pesticides", Toxicology Seminar, University of Pavia, Pavia, Italy, May 8, 1992.

Invited speaker, "Measures of Neurotoxicology", Conference on Application of Toxicology toRisk Assessment, Dayton, OH, May 19-21, 1992.

Invited speaker, "Behavioral Toxicology Case Studies," Conference on Toxicological Interpretation of Neurobehavioral Data, Rochester, NY, June 22-24, 1992.

Invited speaker, "Behavioral Manifestations of Neurotoxicity," Neurotoxicology Symposium:Mechanisms of Neuronal Function,: Effects of Neurotoxicants, and Practical Aspects of Neuro-toxicity Testing, Madison, WI, September 16-18, 1992.

Invited speaker, "Compensatory Changes in the Hippocampus Following Experimentally-Induced Neurodegeneration with Colchicine”, University of Kentucky, Lexington, KY, October 17-19,

1992.

Invited speaker, "Excitatory Amino Acid System Neurotoxicity," Symposium on Biochemical and Neuro chemical Bases of Behavioral Toxicity, Society of Toxicology, New Orleans, LA., March 14-18, 1993.

Invited speaker, "Behavioral Consequences in Second Messenger Systems Following Neurotoxicants," Symposium on Behavioral and Psychological Consequences of Alterations in Second Messenger Systems, Fourth International Neurotoxicology Association, Elsinore, Denmark, June 6-11, 1993.

Invited speaker, "Excitatory Amino Acid Neurotoxicity", American College of Toxicology, New Orleans, LA, October 3-6, 1993.

Invited speaker, "Neurotoxicity of Endogenous Transmitters", North Carolina Society of Toxicology, Research Triangle Park, NC, October 27, 1993.

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Invited speaker, "Neural Targets of Environmental Toxins", American Society of Neurochemistry, Albuquerque, NM, March 5-9, 1994.

Invited speaker, "The Concern for Developmental Neurotoxicology: Is It Justified and What is Being Done About It"? Symposium on Preventing Child Exposure to Environmental Hazards: Research and Policy Issues, Washington, DC, March 18-19, 1994.

Invited speaker, "Neurotoxicity of Indoor Air Pollutants", Eleventh ORNL Life Sciences Symposium: Indoor Air and Human Health Revisited, Knoxville, TN, March 28-31, 1994.

Invited participant, Workshop on "Risk Assessment for Neurobehavioral Toxicity", Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC), Rochester, NY, June12-17, 1994.

Invited speaker, "Neurotoxicity from the Viewpoint of Regulatory Agencies", Symposium on "Serotonin Neurotoxicity: Criteria and Methods," Chicago, IL, July 30-August 3, 1994.

Invited speaker, "Non-carcinogenic Effect of PCBs". California Environmental Protection Agency, October 16-18, 1994.

Invited discussant, "Neurotoxicity Issues in In-Door Air Research", Workshop on Animal Models of Nervous System Susceptibility to In-Door Air Contaminants, Chapel Hill, NC, October 19-21,

1994.

Invited speaker, "Neurotoxicology - Issues and Future Plans", Colloquium on Neurotoxicologic Evaluation of Chemicals, Palo Alto, CA, September 15-16, 1994.

Invited participant, "Cellular and Molecular Effects of Methylmercury Neurotoxicity", Twelfth International Neurotoxicology Conference, Neurotoxicity of Mercury: Indicators and Effects of Low-level Exposure, Hot Springs, AR, October 30-November 2, 1994.

Invited speaker, "Evaluation and Current Status of Neurotoxicology Risk Assessment", Third l Annual Arkansas Toxicology Symposium, Little Rock, AR, November 10-11, 1994.

Invited speaker, "Neurotoxicity Risk Assessment", Fifth International Symposium on Neuro- behavioral Methods and Effects in Occupational and Environmental Health, Cairo, Egypt,

December 3-7, 1994.

Invited speaker, "Environmental Impacts on the Nervous System", Symposium on Environmental Toxicology at the University of California-Davis, February 13, 1995.Invited speaker, "Neurotoxicity Risk Assessment", CIIT, Research Triangle Park, NC, February

17, 1995.

Invited speaker, "Neurotoxicity Risk Assessment Guidelines", The Toxicology Forum, Washington, DC, February 20-22, 1995.

Invited speaker, "The Neurotoxicity of Polychlorinated Biphenyls and Related Chemicals", The Academy of Medicine in New Jersey and Robert Wood Johnson Medical School Lecture,

iscataway, NJ, March 20, 1995.

Invited speaker, "The Neurochemical Toxicity of the Polychlorinated Biphenyls" 5th International Symposium on Environmental Neurotoxicology, Dusseldorf, Germany, September 11-15, 1995.

Invited participant, Developmental Neurotoxicology Workshop, National Institute of Environ- mental Health Sciences, Research Triangle Park, NC, September 7-11, 1995.

Invited participant, "EPA Risk Assessment Guidelines: Where to From Here?" Society for RiskAnalysis and CIIT, Raleigh, NC, October 9, 1995.

Invited speaker, "An Overview of Polychlorinated Biphenyl Neurotoxicity", Thirteenth International Neurotoxicology Conference, Hot Springs, AR, October 29-November 1, 1995.

Invited panel discussion leader, "Research Needs in PCB Neurotoxicology", Thirteenth International

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Neurotoxicology Conference, Hot Springs, AR, October 29-November 1, 1995.

Invited participant, NIEHS Workshop on Research Objectives, Research Triangle Park, NC, November 9, 1995.

Invited speaker, "An Overview of EPA's Neurotoxicity Risk Assessment Guidelines", National Capital Area Society of Toxicology, Washington, DC, December 14, 1995.

Invited participant, Workshop on Neurobehavioral Testing, IPCS/WHO Collaborative Study, Capri, Italy, June 10-15, 1995.

Invited participant, The NIEHS/US EPA Workshop on Research Priorities for New Risk Assessment Guidelines. NIEHS, Research Triangle Park, NC, April 11-12, 1996.

Invited speaker, "The Neurotoxicity of the PCBs-Epiphenomenon?", Department of Pharmacology, Texas A&M University, College Station, TX, May 6, 1996.

Invited speaker, “Neurotoxicity Risk Assessment at the EPA”, Toxicology Forum, Aspen, CO,

June 8-12, 1996.

Invited participant, Acute Cholinesterase Risk Assessment Workgroup, Washington, DC, July 29-30, 1996. Invited speaker, “Developmental Neurotoxicology of Endocrine Disruptors and Pesticides”,

Children’s Environmental Health Research Conference, Washington, DC, February 21-23, 1997

Invited participant, “Neurotoxicity Risk Assessment Guildelines” workshop on EPA’s Risk Assessment Guidelines, Regional Chapter of the Society of Toxicology, Cincinnati, OH,

March 9-13, 1997.

Invited speaker, “Neurochemical Effects of Polychlorinated Biphenyls - Structure-ActivityRelationships”, Department of Physiology and Pharmacology, Bowman Gray School of Medicine,Winston-Salem, NC, April 3, 1997.

Jacob Hoosima Memorial Lecture, “The Neurotoxicity of Polychlorinated Biphenyls”, International Neurotoxicology Association, Szeged, Hungary, June 29-July 4, 1997.

Invited participant, Framework for Human Health Risk Assessment Colloquium, Arlington,VA., September 29-30, 1997.

Invited speaker, “Neurotoxicity of Environmental Chemicals and Their Mechanism of Action”, International Congress for Toxicology, Paris, France, July 5-10, 1998.

Invited speaker, “Neurotoxicity Risk Assessment”, Conference on Issues and Applications in Toxicology and Risk Assessment, Wright-Patterson Air Force Base, April 24-28, 1998.

Keynote speaker, “Developmental Neurotoxicity of Polychlorinated Biphenyls”, International Behavioral Neuroscience Society, Richmond, Virginia, June 11-14, 1998.

Invited participant, Expert Consultation Meeting: Development of a Guidance Document in Neurotoxicity, Organization of Economic Cooperation and Development, Niagara Falls, NY,

March 30-31, April 1, 1998.

Invited speaker, “Neurotoxicology Risk Assessment Guidelines: Developmental Neurotoxicology”, Henry Stewart Conference, Washington, DC, January 18-19, 1999.

Invited participant, Workshop on “Issues in Neurobehavioral Endpoints in Risk Assessment”, Conference on Topics in Toxicology and Risk Assessment, Dayton, OH, April 12-15, 1999.

Invited participant, Pest Management Regulatory Agency (Canada) Neurotoxicity Training Conference, Ottawa, Canada, April 27- 28, 1999.

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Invited speaker, “Developmental Neurotoxicology Studies”, International Conference on “Environmental Influence on Children: Brain, Development, and Behavior”, New York,

NY, May 24-25, 1999.

Invited speaker, “The Role of Developmental Neurotoxicology Studies in Risk Assessment”, 18th International Symposium on Toxicologic Pathology of the Nervous System, Washington, DC, June 13-17, 1999.

Invited speaker, “Roundtable: Do the EPA Developmental Neurotoxicity Guidelines Detect

Human Developmental Neurotoxicity?” Seventeenth International Neurotoxicology Conferenc, Little Rock, AR, October 17-20, 1999.

Invited speaker, “Neurotoxicity of Polychorinated Biphenyls,” Annual Meeting of the Argentina

Society of Neurochemistry, Cordoba, Argentina, October 4-6, 1999. Invited Speaker, “Risk Assessment at the Environmental Protection Agency,” Colloquium of

Faculty and Students, University Nacional de Rosario, Rosario, Argentina, October 4, 1999.

Invited Speaker, “Neurotoxicity of Mixtures and How to Evaluate Them,” Faculty of the Department of Clinical Biochemistry and Pharmacology, University Nacional de Rosario, Rosario, Argentina, October 4, 1999.

Invited Participant, “Epidemiology in the Twenty-First Century Workshop,” Research Triangle Park, NC, October 31-Nov 2, 1999.

Invited Participant, “Toxicogenomics and the Risk Assessment of Chemicals for the Protection of Human Health”, IPCS/WHO Workshop, Berlin, Germany, November 17-19, 2003.

Meetings Organized:

Co-organizer, Symposium on "Neurotoxicants and Adaptive Responses of the Nervous System,"American Society for Pharmacology and Experimental Therapeutics, New Orleans, Louisiana, April, l982.

Co-organizer, First International Symposium on Neurotoxicology of Chemicals, Chicago, IL, September 20-24, l982.

Organizer, Symposium on Neurotoxicity of Chlordecone, Chicago, IL, September 23-24, l982.

Scientific Program Chair and Co-organizer, Fourth International Conference on Neurotoxicology of Selected Chemicals, "Developmental Neurotoxicology in the Fetus and Child", Little Rock,

AR, September 9-13, 1985.

Coorganizer and Symposium Chair, "Structural and Functional Mechanisms of Toxicant-Induced Axonopathies". Society for Neuroscience, Washington, DC, November 9, 1986.

Coorganizer and Session Chair, "Cytotoxic agents as tools to study the structure and function of the hippocampus," The 20th Winter Conference on Brain Research, Vail, Colorado, January 24-31, 1987.

Coorganizer and Symposium Chair, "Neurotoxicology of Metals: From Man to Molecule", Society of Toxicology and Neurotoxicology Specialty Section, Washington, DC, February,

1987.

Scientific Program Co-chair, Fifth International Conference on Neurotoxicology, " Cognitive Dysfunction", Little Rock, AR, September 28 October 2, l987.

Co-organizer, Conference on "Screening for Neurotoxicity: Principles and Practices", Raleigh, NC, April 27-29, 1988.

Organizer and Chair, Continuing Education Course on Neurotoxicology, Society of Toxicology, Atlanta, GA, February 27 -March 3, 1989.

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Co-organizer, Seventh International Neurotoxicology Conference: Neurotoxicology and Risk Assessment, Little Rock, AR, September 18-21, 1989.

Co-organizer, 22nd Winter Conference on Brain Research, "Molecular and Cellular Mechanisms Underlying Neural Responses to Damage", Aspen, CO, January 28-February 3, 1990.

Chairman, Symposium on "Cellular and Molecular Mechanisms of Learning and Memory: Interactions with Neurotoxic Chemicals." Society of Toxicology, February 12-16, 1990.

Co-organizer, 8th International Neurotoxicology Conference: Role of Toxicants in Neurological Disorders: Experimental and Clinical Correlations, Little Rock, AR, October 1-4, 1990.

Chair, Panel on Research Needs, Workshop on Polychlorinated Biphenyls, Research Triangle Park, NC, September 14-15, 1992.

Chair, Symposium on Integrated Studies in Developmental Neurotoxicology, Tenth InternationalConference on Neurotoxicology, Little Rock, AR, September 27-October 1, 1992.

Co-Organizer, 15th International Neurotoxicology Conference: Developmental Neurotoxicity of Endocrine Disruptors, Hot Springs, AR, October 29-November 1, 1995.

Chairman, Workshop on “The Important of Dose and Route in the Interpretation of Neurotoxi-cological Risk”, Society of Toxicology, Seattle, Washington, March 4, 1998.

Co-Organizer, 16th International Neurotoxicology Conference: Pesticides and Susceptible Populations: Who is at Risk and When?, Little Rock, AR, September 13-16, 1998.

Co-Organizer, 17th International Neurotoxicology Conference: Children’s Health and the Environment: Mechanisms and Consequences of Developmental Neurotoxicology, LittleRock, AR, October 17-20, 1999.

Steering Committee, ORD Workshop on The Use of Mechanistic Data in Risk Assessment, Research Triangle Park, NC, June 10-11, 2003

Steering Committee, ORD Workshop on Computational Toxicology, Research Triangle Park, NC, September 29-October 1, 2003.

Steering Committee, ORD Workshop on Endocrine Disruptors, Research Triangle Park, NC, October 29-31, 2003.

Bibliography (Peer-Reviewed Papers) :

l. Tilson, H. A. and Cogan, D. C.: Effect of glucagon on learning an avoidance-escape response in the albino rat. Psychon. Sci. ll: 235-236, l968.

2. Tilson, H. A. and Sparber, S. B.: On the use of the push-pull cannula as a means of measuring biochemical changes during on-going behavior. Behav. Res. Meth. Instr. 2: l3l-l34, l970.

3. Tilson, H. A. and Sparber, S. B.: Differences in tolerance to mescaline produced by peripheral and direct central administration. Psychopharmacologia 19: 313-323, 1971.

4. Sparber, S. B. and Tilson, H. A.: Environmental influences upon drug-induced suppression of operant behavior. J. Pharmacol. Exp. Ther. l79: l-9, l97l.

5. Sparber, S. B. and Tilson, H. A.: Schedule-controlled and drug-induced release of norepinephrine- 7-H3 into the lateral ventricle of rats. Neuropharmacology ll: 453-464, l972.

6. Sparber S. B. and Tilson, H. A.: Tolerance and cross tolerance to mescaline and d-amphetamine administered intraventricularly or peripherally. Psychopharmacologia 23: 220-230, l972.

7. Tilson, H. A. and Sparber, S. B.: Studies on the concurrent behavioral and neurochemical effects of psychoactive drugs using the push-pull cannula. J. Pharmacol. Exp. Ther. l8l: 387-398, l972.

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8. Sparber, S. B. and Tilson, H. A.: The releasability of central norepinephrine and serotonin by peripherally administered d-amphetamine before and after tolerance. Life Sci. 11: l059-l067,

l972.

9. Tilson, H. A., Stolman, S., and Rech, R. H.: Attempts to transfer tolerance in rats treated chronically with morphine. Res. Comm. Chem. Path. Pharmacol. 4: 58l-586, l972.

l0. Tilson, H. A. and Rech, R. H.: Conditioned drug effects and absence of tolerance to d-amphet- amine-induced increases in motor activity. Pharmacol. Biochem. Behav. 1: l49-l53, l973.

ll. Tilson, H. A., Rech, R. H., and Stolman, S.: Hyperalgesia during withdrawal as a means of measuring the degree of dependence in morphine dependent rats. Psychopharmacologia 28: 287-300, l973.

l2. Tilson, H. A. and Sparber, S. B.: The effects of d- and l-amphetamine on fixed interval and fixed ratio behavior in the rat before and after tolerance. J. Pharmacol. Exp. Ther. l87: 372-379, l973.

l3. Tilson, H. A. and Sparber, S. B.: Similarities and differences between mescaline, lysergic acid diethylamide-25, and d-amphetamine on various components of fixed-interval responding in the rat. J. Pharmacol. Exp. Ther. l84: 376-384, l973.

14. Tilson, H. A. and Rech, R. H.: Prior drug experience and effects of amphetamine on schedule- controlled behavior. Pharmacol. Biochem. Behav. 1: 129-132, 1973.

15. Sparber, S. B., Tilson, H. A. and Peterson, D. W.: Environmental influences upon drug-induced suppression of operant behavior. Pharmacol. Biochem. Behav. 1: 133-136, 1973.

16. Tilson, H. A. and Rech, R. H.: The effects of p-chlorophenylalanine on morphine analgesia, tolerance and dependence in two strains of rats. Pschyopharmacologia 35: 45-60, 1974.

17. Baskin, S. I., Hinkamp, D. L., Marquis, W. J., and Tilson, H. A.: Effects of urine on psycho- motor activity in the rat. Neuropharmacology 13: 591-594, 1974.

18. Vrbanac, J. J., Tilson, H. A., Moore, K. E., and Rech, R. H.: Comparison of 2,5-dimethoxy-4- methylamphetamine (DOM) and d-amphetamine for in vivo efflux of catecholamines from rat brain. Pharmacol. Biochem. Behav. 3: 57-64, 1975.

19. Tilson, H. A., Rech, R. H. and Sparber, S. B.: Release of 14C-norepinephrine into the lateral cerebroventricle of rats by exposure to a conditioned aversive stimulus. Pharmacol. Biochem. Behav. 3: 385-389, 1975.

20. Gylys, J. A. and Tilson, H. A.: Pharmacological approaches to maintaining and improving waking functions. Res. Med. Chem. 10, 21-29, 1975.

21. Tilson, H. A, Baker, T. G. and Gylys, J. A.: A comparison of the discriminative stimulus properties of R-2,5-dimethoxy-4-methylamphetamine (R-DOM) and S-amphetamine in the rat. Psychopharmacologia 44: 225-228, 1975.

22. Tilson, H. A., Baker, T. G., Chamberlain, J. H., Marquis, W. M., and Rech, R. H.: Behavioral and neuropharmacological analysis of amphetamine and 2,5-dimethoxy-4-methylamphetamine

in the rat. Psychopharmacologia  44: 229-239, 1975.

23. Tilson, H. A., Maisel, A. S., Jourdan, M. G., and Rech, R. H.: Comparison, of the effects of d- amphetamine and lysergic acid diethylamide in two strains of rats having different behavioral . baselines. Behav. Biol. 17: 463-471, 1976.

24. Tilson, H. A., Chamberlain, J. H. and Gylys, J. A.: Behavioral comparisons of R-2-amino-1-(2,5-

dimethoxy-4-methylphenyl) butane (BL-3912-A) with R-DOM and S-amphetamine. Psychopharm- acology 54: 169-173, 1977.

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25 Stein, J. M., Wayner,M. J. and Tilson, H. A.: The effect of parachlorophenylalanine on the intake of ethanol and saccharin solutions. Pharmacol. Biochem. Behav. 6: 117-122, 1977.

26. Tilson, H. A., Chamberlain. J. H., Gylys, J. A., and Buyniski, J. P.: Behavioral suppressant effects of clonidine in strains of normotensive and hypertensive rats. Eur. J. Pharmacol. 43: 99-106, 1977.

27. Kantak, K. M., Wayner, M. J., Tilson, H. A., and Sved, A.: Turnover of 3H-5-hydroxytryptamine 3H-5-hydroxyindoleacetic acid and the 3H-5-methoxyindoles in non-deprived and 24 hr food- to deprived rats. Pharmacol. Biochem. Behav. 6: 22l-225, l977.

28.Tilson, H. A., Chamberlain, J. H., and Gylys, J. A.: Further studies on BL-39l2-A: Effects on avoidance behavior of rats with low baselines and on reaction thresholds to electric footshock. Pharmacol. Biochem. Behav. 6: 627-630, l977.

29. Cabe, P. A., Tilson, H. A., Mitchell, C. L., and Dennis, R.: A simple recording of grip strength device. Pharmacol. Biochem. Behav. 8: l0l-l02, l978.

30. Kantak, K. M. Wayner, M. J., Tilson, H. A., Stein, J.M., and Dwoskin, L. P.: Synthesis and turnover of 3H-5-hydroxytryptamine in the lateral cerebroventricle. Pharmacol. Biochem. Behav. 8: 153-161,

1978.

31.Tilson, H. A., Cabe, P. A. and Mitchell, C. L.: Behavioral and neurological toxicity of polybrom- inated biphenyls in rats and mice. Environ. Hlth Perspec. 23: 257-263, 1978.

32. Tilson, H. A. and Cabe, P. A.: Assessment of chemically-induced changes in the neuromuscular function of rats using a new strain gauge technique. Life Sci. 23: 1365-1370, 1978.

33. Tilson, H. A. and Cabe, P. A.: A strategy for the assessment of neurobehavioral consequences of environmental factors. Environ. Hlth. Perspec. 26: 287-299, 1978.

34. Cabe, P. A. and Tilson, H. A.: The hind limb extensor response: A method for assessing motor dysfunction in rats. Pharmacol. Biochem. Behav. 9: 133-136, 1978.

35. Kantak, K. M., Wayner, M. J., Stein, J. M., and Tilson, H. A.: Effect of imipramine on sertonin turnover in the lateral hypothalamus. Pharmacol. Biochem. Behav. 9: 693-696, 1978.

36. Tilson, H. A. and Cabe, P. A.: The effects of acrylamide given acutely or in repeated doses on fore- and hindlimb function of rats. Toxicol. Appl. Pharmacol. 47: 253-260, 1979.

37. Tilson, H. A., Cabe, P. A. and Spencer, P. S.: Acrylamide neurotoxicity in rats: Neurobehavioral and histopathological effects during exposure and after recovery of function. Neurotoxicology 1: 89- 104, 1979.

38. Tilson, H. A. and Cabe, P. A.: Studies on the neurobehavioral effects of polybrominated biphenyls in rats. Ann. N.Y. Acad. Sci. 320: 325-336, 1979.

39. Tilson, H. A., Cabe, P. A., Ellingwood, E. H., and Gonzalez, L. P.: Effects of carbon disulfide on motor function and responsiveness to d-amphetamine in rats. Neurobehav. Toxicol. 1: 57-63, 1979.

40. Tilson, H. A., Davis, J. G., McLachlan, J. A., and Lucier, G. W.: The effects of polychlorinated biphenyls given prenatally on the neurobehavioral development of mice. Environ. Res. l8: 466- 474, l979.

4l. Tilson, H. A., Mitchell, C. L., and Cabe, P. A.: Screening for neurobehavioral toxicity: The need for and examples of validation of testing procedures. Neurobehav. Toxicol. l(Suppl. l): l37-l48,

l979.

42. Tilson, H. A. and Lamartiniere, C. A.: Neonatal exposure to diethylstilbestrol affects the sexual differentiation of male rats. Neurobehav. Toxicol. l: l23-l28, l979.

43. Meyer, O. A., Tilson, H. A., Byrd, W. C., and Riley, M. T.: A method for the routine assessment of fore- and hindlimb grip strength of rats and mice. Neurobehav. Toxicol. l: 233-236, l979.

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44. Standridge, R. T., Howell, H. G., Tilson, H. A., Chamberlain, J. H., Holava, H. M., Gylys, J. A., Partyka, R. A., and Shulgin, A. T.: Phenylalkylamines with potential psychotherapeutic utility. 2. Nuclear substituted 2-amino-l-phenylbutanes. J. Med. Chem. 23: l54-l62, l980.

45. Cabe, P. A., Carmichael, N. G., and Tilson, H. A.: Effects of selenium, alone and in combination with silver or arsenic, in rats. Neurobehav. Toxicol. l: 275-278, l979.

46. Squibb, R. E., Carmichael, N. G., and Tilson, H. A.: Behavioral and neuromorphological effects of triethyl tin bromide in adult rats. Toxicol. Appl. Pharmacol. 55: l88-l97, l980.

47. Tilson, H. A., Squibb, R. E., Meyer, O., and Sparber, S. B.: Postnatal exposure to benzene alters the neurobehavioral functioning of rats when tested during adulthood. Neurobehav. Toxicol. 2:

l0l-l06, l980.

48. Burne, T. A. and Tilson, H. A.: Titration procedure with rats using a nose poke response and tail shock. Pharmacol. Biochem. Behav. l3: 653-656, l980.

49. Agrawal, A. K., Tilson, H. A., and Bondy, S. C.: 3,4,3'4'-Tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus. Toxicol. Lett. 7: 4l7-424, l98l.

50. Harry, G. J. and Tilson, H. A.: The effects of post partum exposure to triethyl tin on the neuro- behavioral functioning of rats. Neurotoxicology 2: 283-296, l98l.

5l. Agrawal, A. K., Seth, P. K., Squibb, R. E., Tilson, H. A., Uphouse, L. L., and Bondy, S. C.: Neurotransmitter receptor in brain regions of acrylamide-treated rats. I Effects of a single exposure to acrylamide. Pharmacol. Biochem. Behav. l4: 527-53l, l98l.

52. Bondy, S. C., Tilson, H. A., and Agrawal, A. K.: Neurotransmitter receptors in brain regions of acrylamide-treated rats. II. Effect of extended exposure to acrylamide. Pharmacol. Biochem. Behav. l4: 533-537, 1981.

53. Squibb, R. E. and Tilson, H. A.: Modified running wheel for continuous recording of locomotor and consummatory events. Physiol. Behav. 26: 735-739, l98l.

54. Tilson, H. A. and Burne, T. A.: Effects of triethyl tin on pain reactivity and neuromotor function of rats. J.Toxicol. Environ. Hlth.  8: 3l7-324, l98l.

55. Squibb, R. E., Tilson, H. A., Meyer, O. A., and Lamartiniere, C.: Neonatal exposure to monosodium glutamate alters the neurobehavioral performance of adult rats. Neurotoxicology 2:

47l-484, l98l.

56 Tilson, H. A.: The neurotoxicity of acrylamide: An Overview. Neurobehav. Toxicol. Teratol. 3: 445-461, 1981.

57 Harry, G. J. and Tilson, H. A.: Postpartum exposure to triethyl tin produces long-term alterations in responsiveness to apomorphine. Neurotoxicology 3: 64-7l, l982.

58. Tilson, H. A. and Squibb, R. E.: The effects of acrylamide on the behavioral suppression produced by psychoactive agents. Neurotoxicology 3: ll3-l20, l982.

59. Hong, J. S., Tilson, H. A., Agrawal, A. K., Karoum, F., and Bondy, S. C.: Postsynaptic location of acrylamide-induced modulation of striatal 3H-spiroperidol binding. Neurotoxicology 3: l08-ll2, l982.

60. Squibb, R. E. and Tilson, H. A.: Neurobehavioral changes in adult Fischer 344 rats exposed to dietary levels of chlordecone (KeponeR): 90-day chronic dosing study. Neurotoxicology 3: 59-66,

l982.

6l. Squibb, R. E. and Tilson, H. A.: Effects of gestational and perinatal exposure to chlordecone (KeponeR) on the neurobehavioral development of Fischer-344 rats. Neurotoxicology 3: l7-26, l982.

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62. Anderson, C. E., Tilson, H. A., and Mitchell, C. L.: Conditioned taste aversion following acutely administered acrylamide. Neurobehav. Toxicol. Teratol. 4: 497-499, l982.

63. Tilson, H. A., Squibb, R. E., and Burne, T. A.: Neurobehavioral effects following a single dose of chlordecone (KeponeR) administered neonatally to rats. Neurotoxicology 3: 45-52, l982.

64. Gerhart, J. M., Hong, J. S., Uphouse, L. L., and Tilson, H. A.: Chlordecone-induced tremor: Quantification and pharmacological analysis. Toxicol. Appl. Pharmacol. 66: 234-243, l982.

65. Mactutus, C. F., Unger, K. L., and Tilson, H. A.: Neonatal chlordecone exposure impairs early learning and memory in the rat on a multiple measure passive avoidance task. Neurotoxicology 3:

27-44, l982

66. Rosecrans, J. A., Hong, J. S., Squibb, R. E., Johnson, J. H., Wilson, W. E., and Tilson, H. A.: Effects of perinatal exposure to chlordecone (KeponeR) on neuroendocrine and neurochemical responsiveness of rats to environmental challenges. Neurotoxicology 3: l3l-l42, l982.

67. Tilson, H. A. and Mactutus, C.F.: Chlordecone neurotoxicity: A brief overview. Neurotoxicology 3: 1-8, 1982.

68 Pryor, G. T., Uyeno, E. T., Tilson, H. A., and Mitchell, C. L.: Assessment of chemicals using a battery of neurobehavioral tests: A comparative study. Neurobehav. Toxicol. Teratol. 5: 9l-ll7, l983.

69. Tilson, H. A., Mactutus, C. F., McLamb, R., and Burne, T. A.: Characterization of triethyl lead chloride neurotoxicity in adult rats. Neurobehav. Toxicol. Teratol. 4: 67l-68l, l982.

70. Hong, J. S., Tilson, H. A., and Yoshikawa, K.: Effects of lithium and haloperidol administration on the rat brain levels of substance P. J. Pharmacol. Exp. Ther. 224: 590-593, l983.

7l. Squibb, R. E., Tilson, H. A., and Mitchell, C. L.: Neurobehavioral assessment of 2,4-dichlorophen- oxyacetic acid (2,4-D) in rats. Neurobehav. Toxicol. Teratol. 5: 33l-335, l983.

72. Booze, R. M., Tilson H. A., Annau, Z., and Mactutus, C. F.: Neonatal triethyl lead neurotoxicity in rat pups: Initial behavioral observations and quantification. Neurobehav. Toxicol. Teratol. 5: 367- 375, l983.

73. Hong, J. S., Tilson, H. A., Hudson, P. M., Ali, S. F., Wilson, W. E., and Hunter, V. A.: Correlation of neurochemical and behavioral effects of triethyl lead chloride in rats. Toxicol. Appl. Pharmacol. 69: 47l- 479, l983.

74. Berthe, J., Remandet, B., Mazue, G., and Tilson, H. A.: Neurobehavioral effects of D-glaucine in rats. Neurobehav. Toxicol. Teratol. 5: 305-308, l983.

75.Mactutus, C. F. and Tilson, H. A.: Neonatal chlordecone impairs early learning and retention of active avoidance in the rat. Neurobehav. Toxicol. Teratol. 6: 75-83, l984.

76. Tilson, H. A. and Mitchell, C. L.: Neurotoxicants and adaptive responses of the nervous system: Introductory remarks. Fed. Proc. 42: 3l89-3l90, l983.

77. Uphouse, L. L., Tilson, H. A., and Mitchell, C. L.: Long-term effects of behavioral testing on serum hormones and brain weight. Life Sci. 33: l395-l400, l983.

78. Gerhart, J. M., Hong, J. S., and Tilson, H. A.: Studies on the possible sites of chlordecone-induced tremor in rats. Toxicol. Appl. Pharmacol. 70: 382-389, l983.

79. Mactutus, C. F., Unger, K. L., and Tilson, H. A.: Evaluation of neonatal chlordecone neurotoxicity during early development: Initial Characterization. Neurobehav. Toxicol. Teratol. 6: 67-73, l984.

80. Walsh, T. J. and Tilson, H. A.: Neurobehavioral toxicology of the organoleads. Neurotoxicol. 5: 67-86, l984.

8l. Hong, J. S., Tilson, H. A., Uphouse, L. L., Gerhart, J. M., Wilson, W. E., and Hunter, V. A.: Effects

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of chlordecone exposure on the brain neurotransmitters: Possible involvement of striatal serotonin system in chlordecone-elicited tremor. Toxicol. Appl. Pharmacol. 73: 336-344, l984.

82. Walsh, T. J., McLamb, R. M., and Tilson, H. A.: Organometal-induced anti-nociception: A time and dose-response comparison of triethyl and trimethyl lead and tin. Toxicol. Appl. Pharmacol. 73: 295-299, l984.

83. Tilson, H. A. and Mitchell, C. L.: Neurobehavioral techniques to assess the effects of chemicals on the nervous system. Ann. Rev. Pharmacol. Toxicol. 24: 425-450, l984.

84. Rosecrans, J. A., Johnson, J. H., Tilson, H. A., and Hong, J. S.: Hypothalamic-pituitary adrenal axis (HPAA) function in adult rats exposed to neurotoxic chemicals perinatally. Neurobehav. Toxicol. Teratol. 6: 28l-288, l984.

85. Walsh, T. J., Tilson, H. A., DeHaven, D. L., Mailman, R. B., Fisher, A., and Hanin, I.: AF64A, a cholinergic neurotoxin, selectively depletes acetylcholine in hippocampus and cortex, and produces long-term avoidance and radial-arm maze deficits in the rat. Brain Research 32l: 9l-l02, l984.

86. Chen, P. H., Tilson, H. A., Marbury, G. D., Karoum, F., and Hong, J. S.: Effect of chlordecone (Kepone) on the rat brain concentration of 3-methoxy-4-hydroxphenylglycol-evidence for a possible involvement of the norepinephrine system in chlordecone-induced tremor. Toxicol. Appl. Pharmacol.

77: l58-l64, l985.

87. Gerhart, J. M., Hong, J. S., and Tilson, H. A.: Studies on the mechanism of chlordecone-induced tremor in rats. Neurotoxicology 6: 2ll-230, l985.

88. Gildersleeve, R. P., Tilson, H. A. and Mitchell, C. L.: Injection of diethylstilbestrol (DES) on the first day of incubation affects morphology of sex glands and reproductive behavior of Japanese quail. Teratology 3l: l0l-ll0, l985.

89. Mactutus, C. F. and Tilson, H. A.: Evaluation of long-term consequences in behavioral and/or neural function following neonatal chlordecone exposure. Teratology 31: 177-186, 1985.

90. Rosecrans, J. A., Squibb, R. E., Johnson, J. H., Tilson, H. A., and Hong, J. S.: Effects of neonatal chlordecone exposure on pituitary-adrenal function in adult Fischer-344 rat. Neurobehav. Toxicol. Teratol. 7: 33-37, 1985.

91. Tilson, H. A., Hong, J. S., and Mactutus, C. F.: Effects of 5,5-diphenylhydantoin (Dilantin) on neurobehavioral toxicity of organochloride insecticides and permethrin. J. Pharmacol. Exp. Ther. 233: 285-289, 1985.

92. Herr, D. W., Hong, J. S., and Tilson, H. A.: DDT-induced tremor: Effects of pharmacological agents. Psychopharmacology, 86: 426-431, 1985.

93. Hudson, P. M., Tilson, H. A., Chen, P. H., and Hong, J. S.: Effects of p,p'-DDT on the rat brain concentrations of biogenic amine and amino acid neurotransmitters and their association with p,p'- DDT-induced tremor and hyperthermia. J. Neurochem. 45: 1349-1355, 1985.

94. Bondy, S. C., Walsh, T. J., Hong, J. S., Hall, D. L., and Tilson, H. A.: Effects of triethyl lead on hot plate responsiveness and biochemical changes in the hippocampus. Pharmacol. Biochem. Behav. 22: 1007-1011, 1985.

95. Walsh, T. W., Chrobak, J. J., Tilson, H. A., DeHaven, D. L., and Hanin, I.: AF64A produces long- term cognitive impairments following infusion into the lateral cerebral ventricles or the dorsal hip-

pocampus: Involvement of hippocampal cholinergic processes in learning and memory. Ann. N.Y. Acad. Science 444: 538-540, 1985.

96. Galvin, M. J., Tilson, H. A., Mitchell, C. L., Peterson, J. P. and McRee, D. I.: Influence of pre- and postnatal exposure of rats to 2.45 GHz (CW) microwave radiation on neurobehavioral functions. Bioelectromagnetics 7: 57-71, 1986.

97. Walsh, T. J., Schultz, D., Tilson, H. A. and DeHaven, D. L.: Acute exposure to triethyl lead enhances

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the behavioral effects of dopaminergic agonists: Involvement of brain dopamine in organolead neurotoxicity. Brain Research 363: 222-229, l986.

98. Tilson, H. A. and Wright, D. C.: Interpretation of behavioral teratology data. Neurobehav. Toxicol. Teratol. 7: 667-668, l985.

99. Adams, J., Buelke-Sam J., Kimmel, C. A., Nelson, C. J., Reiter, L. W., Sobotka, T. J., Tilson, H. A. and Nelson, B. K.: Collaborative behavioral teratology study: Protocol design and testing procedures. Neurobehav. Toxicol. Teratol. 7: 579-586, 1985.

l00. Walsh, T. J. and Tilson, H. A.: A comparison of the effects of R15, 1788 and chlordiazepoxide on hot-plate latencies locomotor activity and the acoustic startle response. Psychopharmacology 88: 514-519, 1986.

101. Herr, D. W., Hong, J. S., Chen, P., Tilson, H. A. and Harry, G. J.: Pharmacological modification of DDT-induced tremor and hyperthermia in rats: Distributional factors. Psychopharmacology 89:

278-283, l986.

102. Hudson, P. M., Tilson, H. A., Chen, P. and Hong, J. S.: Neurobehavioral effects of permethrin are associated with alterations in regional levels of biogenic amine metabolites and amino acid neuro- transmitters. Neurotoxicol. 7: 143-154, 1986.

103. Tilson, H. A., Emerich, D. and Bondy, S. C.: Inhibition of ornithine decarboxylase alters neurological responsiveness to a toxic agent. Brain Research 379: 147-150, 1986.

104. Walsh, T. J., McLamb, R. L. and Tilson, H. A.: Novelty of the test environment contributes to triethyl- lead-induced antinociception. Neurobehav. Toxicol. Teratol. 8: 311-315, 1986.

105. Tilson, H. A., McLamb, R. L. and Hong, J. S.: Behavioral effects of centrally administered and [D-ALA-D-Leu]-enkephalin (DADLE) in rats. Neuropeptides 8: 193-206, 1986.

106. Hong, J. S., Herr, D. W., Hudson, P. M., and Tilson, H. A.: Neurochemical effects of DDT in rat brain in vivo. Arch. Toxicol. Suppl. 9: 14-26, 1986.

107. Wilson, W. E., Hudson, P. M., Kanamatsu, T., Walsh, T. J., Tilson, H. A., Hong, J. S., Maronpot, R. R., and Thompson, M.: Trimethyltin-induced alterations in brain amino acids, amines and amine metabolites: Relationship to hyperammonemia. Neurotoxicol. 7: 63-74, 1986.

108. Walsh, T. J., McLamb, R. L., Bondy, S. C., Tilson, H. A., and Chang, L. S.:Triethyl and trimethyl lead: Effects on behavior, CNS morphology and concentrations of lead in blood and brain of rat. Neurotoxicol. 7: 21- 34, 1986.

109. Tilson, H. A., Hudson, P. M. and Hong, J. S.: 5,5-diphenylhydantoin antagonizes neurochemical and neurobehavioral effects of p,p'-DDT, but not chlordecone. J. Neurochem. 47: 1870-1878, 1986.

110. Walsh, T. J., Schultz, D. W., Tilson, H. A. and Schmechel, D. E.: Behavioral changes following colchicine-induced granule cell loss in the rat. Brain Research, 398: 23-36, 1986.

111. Herr, D. W., Gallus, J. A. and Tilson, H. A.: Pharmacological modification of tremor and enhanced startle by chlordecone and p,p-DDT. Psychopharmacology 91: 320-325, 1987.

112. Saitoh, K.. Shaw, S., Tilson, H. A.: Noradrenergic influence on the pre- pulse inhibition of acoustic

startle. Toxicol. Lett. 34: 209-216, 1986.

113. Saitoh, K., Shaw, S., Tilson, H. A. and Dyer, R.: Possible role of the brainstem in the mediation of prepulse inhibition in the rat. Neurosci. Lett. 75: 216-222, 1987.

114. Tilson, H. A., Shaw, S. and McLamb, R. L.: The effects of lindane on avoidance responding and seizure activity may have a GABAergic component. Toxicol. Appl. Pharmacol. 88: 57-65, 1987.

115. Gildersleeve, R. P., Tilson, H. A., Wiard, R. P. and Edens, F. W.: Direct administration of chlordecone into Japanese quail eggs has persistent effects on conditioned behavior of adults. Neurotoxicol. 8: 269-280, 1987.

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116. Sivam, S. P., Hudson, P. M., Tilson, H. A., and Hong, J. S.: GABA and dopamine interaction in the basal ganglia: Dopaminergic supersensitivity following chronic elevation of brain GABA levels. Brain Research 412: 29-35, 1987.

117. Tilson, H. A., Rogers, B. C., Grimes, L., Harry, G. J., Peterson, N. J., Hong, J. S., and Dyer, R. S.:

Time-dependent neurobiological effects of colchicine administered directly into the hippocampus of rats. Brain Research 408: 163-172, 1987.

118. Swartzwelder, S., Tilson, H. A., McLamb, R. L., and Wilson, W. E.:Baclofen disrupts passive avoidance retention in rats. Psychopharmacology 92: 398-401, 1987.

119. Tilson, H. A., Harry, J., Nanry, K., Rogers, B. C., Peterson, N. J., Jenson, K., and Dyer, R. S.: Experiential factors in the expression of hypermotility produced by intradentate colchicine: Lack of effect of GM1 gangliosides on colchicine-induced loss of granule cells and mossy fibers. J. Neuroscience Res. 17: 410-416, 1987.

120. Cook, L. L., Gordon, C. J., Tilson, H. A., and Edens, F. W.: Chlordecone-induced effects on thermoregulatory processes in the rat. Toxicol. Appl. Pharmacol. 90: 126-134, 1987.

121. Lapadula, D. M., Tilson, H. A., Campbell, G., and Abou-Donia, M.: Neurotoxic effects of combined treatment of 2,3-hexanedione and triethyl lead chloride. J. Toxicol. Env. Hlth. 21:

483-492, 1987.

122. Tilson, H. A.: Behavioral indices of neurotoxicology. What can be measured? Neurotoxicol. Teratol. 9: 427-443, 1987.

123. Tilson, H. A., McLamb, R. L., Shaw, S., Rogers, B. C., Pediaditakis, P., and Cook, L.: Radial arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agents. Brain Res. 438: 83-94, 1988.

124.Tilson, H. A. and Peterson, N. J.: Colchicine as an investigative tool in neurobiology. Toxicology 46: 159-173, 1987.

125. Tilson, H. A.: Symposium on neurotoxicology of heavy metals I. Fund. Appl. Pharmacol. 9: 599-607, 1987.

126. Tilson, H. A.: Practical considerations in establishing valid and sensitive neurobehavioral test methods. Zbl. Bakt. Hyg. B. 185: 10-15, 1987.

127. Herr, D. W. and Tilson, H. A.: Modulation of p,p'-DDT-induced tremor by catecholaminergic agents. Toxicol. Appl. Pharmacol. 91: 149-158, 1987.

128. Somkuti, S. G., Tilson, H. A., Campbell, G., and Abou-Donia, M.: Lack of delayed neurotoxic effect of tri-O-cresylphosphate treatment in male Fischer-344 rats: Biochemical, neurobehavioral and neuropathological studies. Fund. Appl. Toxicol. 10: 199-205, 1988.

129.Tilson, H. A., Harry, G. J., Nanry, K., Hudson, P. M., and Hong, J. S.: Ganglioside interactions with the dopaminergic system of rats. J. Neurosci. Res. 19: 88-93, 1988.

130. Grimes, L., McGinty, J., McLain, P., Mitchell, C., Tilson, H. A. and Hong, J. S.: Dentate granule cells are essential for kainic acid induced wet dog shakes but not seizures. J. Neurosci. 8: 256-264,

1988.

131. McLamb, R. L., Mundy, W. R. and Tilson, H. A.: Intradentate colchicine disrupts the acquisition and performance of a working memory task in the radial arm maze. Neurotoxicology 9: 521-528, 1988.

132. Mundy, W. R. and Tilson, H. A: Behavioral impairment in the rat after colchicine lesions of the hippocampus and nucleus basalis. Neurotoxicology 9: 511-520, 1988.

133. Mitchell, C. L., McRee, D. I., Peterson, N. J., and Tilson, H. A.: Some behavioral effects of short- term exposure of rats to 2.45 GHz microwave radiation. Bioelectromagnetics 9: 259-268, 1988.

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134. Sidel, E. S., Tilson, H. A., McLamb, R. L., Wilson, W. A., and Swartzwelder, H. S.: Potential interactions between GABAb and cholinergic systems: Baclofen augments scopolamine-induced performance deficits in the eight-arm maze. Psychopharmacology 96: 116-120, 1988.

135. Cook, L. L., Edens, F. W. and Tilson, H. A.: Possible brainstem involve ment in the modification of thermoregulatory processes by chlordecone in the rat. Neuropharmacology 27: 871-879, 1988.

136. Cook, L. L., Edens, F. W. and Tilson, H. A.: Pharmacological evaluation of central adrenergic involvement in chlordecone-induced hypothermia. Neuropharmacology 27: 881-887, 1988.

137. Tilson, H. A., Harry, G. J., McLamb, R. L., Peterson, N. J., Rogers, B. C., Pediaditakis, P., and Ali, S. F.: Role of dentate gyrus cells in retention of a radial-arm maze task and sensitivity of rats to cholinergic drugs. Behav. Neurosci. 102: 835-842, 1988

138. Zhang, W. Q., Tilson, H. A., Nanry, K. P., Hudson, P. M., Hong, J. S., and Stachowiak, M. K.: Increased dopamine release from striata of rats after unilateral nigrostriatal bundle damage. Brain Research 461: 335-342, 1988.

139. Tandon, P., McLamb, R. L., Novicki, D., Shuey, D. L., and Tilson, H. A.: Fetal hippocampal cell suspensions ameliorate behavioral effects on intra-dentate colchicine in the rat. Brain Research 473:

241-248, 1988.

140. McLamb, R. L., Mundy, W. R., and Tilson,H. A.: Intradentate colchicine impairs acquisition of a two-way active avoidance response in a Y-maze. Neurosci. Lett. 94: 338-342, 1988.

141. Tandon, P., Harry, G. J., and Tilson, H. A.: Colchicine-induced alterations in receptor-stimulated phosphoinositide hydrolysis in the rat hippocampus. Brain Research 477: 308-313, 1989.

142 Nanry, K. P., and Tilson, H. A.: The role of 5-HT1A receptors in the modulation of the acoustic startle reflex in rats. Psychopharmacology  97: 507-513, 1989.

143. Tilson, H. A.: Screening for neurotoxicity: Principles and Practices. J. Amer. Coll. Toxicol. 8: 13-17, 1989.

144. Zhang, W. Q., Tilson, H. A., Stachowiak, M. K. and Hong, J. S.: Repeated haloperiodol administration changes basal release of striatal dopamine and subsequent response to haloperidol challenge. Brain Research 484: 389-392, 1989.

145. Mitchell, C. L., McRee, D. I., Peterson, N. J., Tilson, H. A., Shandala, M. G., Rudnev, M. I., Varetskii, V. V. and Navakatikyan, M. I.: Results of a United States and Soviet Union Joint project on nervous system effects of microwave radiation. Env. Hlth. Persp. 81: 201-209, 1989.

146. Rogers, B., Mitchell, C. L., Barnes, M., and Tilson, H. A.: Functional deficits after sustained stimulation of the perforant pathway. Brain Research 493: 41-50, 1989.

147. Rogers, B. and Tilson, H. A.: MK-801 prevents cognitive and behavioral deficits produced by N-MDA receptor overstimulation in the rat hippocampus. Toxicol. Appl. Pharmacol. 99: 445-

453, 1989.

148. Tilson, H. A., Schwartz, R. D., Ali, S. F. and McLamb, R. L.: Colchicine administered into the area of the nucleus basalis decreases cortical nicotinic cholinergic receptors labelled by 3H- acetylcholine. Neuropharmacology 78: 855-861, 1989.

149. Nanry, K. P., Mundy, W. R., and Tilson, H. A.: Colchicine-induced alterations of reference memory in rats: Role of spatial versus nonspatial task components. Behav. Brain Res. 35: 45-93,

1989.

150.Tandon, P. and Tilson, H. A.: Characterization of receptor-coupled phosphoinositide hydrolysis in the rat hippocampus after intradentate colchicine. J. Neurochem. 53: 1117-1125, 1989.

151. Rogers, B. C., Mundy, W. R., Pediaditakis, P., and Tilson, H. A.: The neurobehavioral con- sequences of N–methyl-d-aspartate (N-MDA) administration in rats. Neurotoxicology 10: 671-

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684, 1989.

152. Herr, D. W., Mailman, R. B. and Tilson, H. A.: Blockade of only spinal a1-adrenoreceptors is insufficient to attenuate DDT-induced alterations in motor function. Toxicol. Appl. Pharmacol. 101: 11-26, 1989.

153. Tilson, H. A., Thai, L., Zhao, D., Sobotka, T. J., and Hong, J. S.: Oral administration of aspartame is not proconvulsant in rats. Neurotoxicology 10: 229-238, 1989.

154. Rogers, B. C. and Tilson, H. A.: Kainate-induced functional deficits are not blocked by MK-801. Neurosci. Lett. 109: 335-340, 1990.

155. McDaniel, K. L., Mundy, W. R. and Tilson, H. A.: Microinjection of dynorphin into the hippo-

campus impairs spatial learning in rats. Pharmacol. Biochem. Behav. 35: 429-435, 1990.

156. Rogers, B. C. and Tilson, H. A.: Stereospecificity of N-MDA-induced functional deficits. Neurotoxicol. 11: 13-22, 1990.

157. Grimes, L. M., Earnhardt, T. S., Mitchell, C. L., Tilson, H. A. and Hong, J. S.: Granule cells in the ventral, but not dorsal, dentate gyrus are essential for Kainic-acid-induced wet dog shakes. Brain Res. aspartame 514: 167-170, 1990.

158.Mundy, W. R., Barone, S. and Tilson, H. A.: Neurotoxic lesions of the nucleus basalis induced by colchicine: effects on spatial navigation in the water maze. Brain Research 512: 221-228, 1990.

159. Matthews, H.B., Dixon, D., Herr, D.W. and Tilson, H.A.: Subchronic toxicity studies indicate that tris(2-chloro-ethyl) phosphate administration results in lesions in the rat hippocampus. Toxicol. Indust. Hlth.6: 1-15, 1990.

160. Tilson, H.: Behavioral indicies of neurotoxicity. Toxicologic Pathology 18: 96-104, 1990.

161. Tilson, H. A., Jacobson, J. L. and Rogan, W. J.: Polychlorinated biphenyls and the developing nervous system: Cross-species comparisons. Neurotoxicol. Teratol. 12: 239-248, 1990.

162. Mundy, W.R. and Tilson, H.A.: Neurochemical recovery in the neocortex after colchincine lesions of the nucleus basalis magnocellularis in rats. Brain Res. Bull. 25: 207-209, 1990.

163. Tilson, H.A.: Neurotoxicology in the 1990s. Neurotoxicol. Teratol. 12: 293-300, 1990.

164. Mundy, W.R. and Tilson, H.A.: Neurotoxic effects of colchicine. Neurotoxicology, 11: 539-548, 1990.

165. Li, S.J., Jiang, H.K., Stachowiak, M.S., Hudson, P.M., Owyang, V., Nanry, K., Tilson, H.A. and Hong, J.S.: Influence of nigrostriatal dopaminergic tone on the biosynthesis of dynorphin and enkephalin in rat striatum. Molec Brain Research 8:219-225, 1990.

166. Zhang, W. Q., Rogers, B. C., Tandon, P., Hudson, P. M., Sobotka, T.J., Hong, J. S., Tilson, H. A.: Systemic administration of kainic acid increases GABA levels in perfusate from the hippocampus of rats in vivo. Neurotoxicology 11:593-600, 1990.

167. Zhang, W. Q., Tandon, P., Sobotka, T. J., Hong, J. S. and Tilson, H. A.: Alterations in acetylcholine- induced stimulation of inositol phospholipid hydroylysis with dorsal hippocampus of kindled rats. Neurosci. Lett. 118: 57-60, 1990.168. McLamb, R. L., Williams, L. R., Nanry, K., Wilson, W., and Tilson, H. A.: MK-801 impedes the

acquisition of a spatial memory task in rats. Pharmacol. Biochem. Behav. 37: 41-45, 1990.

169. Tilson, H.A., Veronesi, B., McLamb, R. and Matthews, H.B.: Acute exposure to tris(2-chloroethyl) phosphate produces hippocampal neuronal loss and impairs learning in rats. Toxicol. Appl. Pharmacol. 106: 254-269, 1990.

170. Tilson, H.A., Hong, J.S. and Sobotka, T.J.: High doses of aspartame have no effects on sensorimotor function or learning and memory in rats. Neurotoxicol. Teratol. 13: 27-35, 1990.

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171 Tandon, P., Barone, S., Drust, F.G. and Tilson, H. A.: Long-term behavioral and neurochemical effects of intradentate administration of colchicine in rats. Neurotoxicology 12: 67-78, 1991.

172. Zhang, W. Q., Hudson, A. M., Sobotka, T. J., Hong, J. S. and Tilson, H. A.: Extracellular concen- trations of amino acid transmitters in ventral hippocampus during and after the development of kindling. Brain Research 540: 315-318, 1991.

173.Tandon, P. and Tilson, H. A.: Age-dependent changes in receptor-stimulated phosphoinositide turnover in the rat hippocampus. Pharmacol. Biochem. Behav. 38: 861-867, 1991.

174. Barone, S., Nanry, K.P., Mundy, W.R., McGinty, J.F. and Tilson, H.A.: Spatial learning deficits are not solely due to cholinergic deficits following medial spetal lesions with colchicine. Psychobiology 19: 41-50, 1991.

175.Mundy, W. R., Tandon, P., Barone, S. and Tilson, H. A.: Long-term changes in phosphoinositide hydrolysis following colchicine lesions of the nucleus basalis magnocellularis. Brain Res. Bull.

26: 657-662, 1991.

176. Bonner, M. and Tilson, H.A.: Compensatory alterations in receptor-stimulated phosphoinositide hydrolysis in the hippocampus vary as a function of dose of colchicine. Toxicol. Lett. 58: 7-12, 1991.

177. Mundy, W., Tandon, P., Ali, S. and Tilson, H. A.: Age-related changes in receptor-mediated phosphoinositide hydroylsis in various regions of the brain. Life Sciences, 49: 97-102, 1991.

178. Barone, S., Tandon, P., McGinty, J.F. and Tilson, H.A.: The effects of NGF and fetal cell transplants on spatial learning after intradentate administration of colchicine. Exp. Neurol. 114: 1-13, 1991.

179. Barone, S., Bonner, M., Tandon, P. and Tilson, H.A.: The neurobiological effects of colchicine administration into the hippocampus. Modulation by NGF. Brain Res. Bull. 28:265-274, 1992.

180. Zhang, W. Q., Mundy, W., Thai, L., Hudson, P. M., Gallagher, M., Tilson, H. and Hong, J. S.: Decreased glutamate release correlates with elevated dynorphin content in the hippocampus of

aged rats with spatial learning deficits. Hippocampus 1:391-398. 1991.

181. Crofton, K. M., Howard, J. L., Moser, V. C., Gill , M. W., Reiter, L. W., Tilson, H. A. and MacPhail, R. C.: Interlaboratory comparison of motor activity experiments: Implications for neurotoxicological assessments. Neurobehav. Toxicol. Teratol. 13:599-609. 1991.

182. Tilson, H. A.: Comparison of screening approaches. Neurotoxicology 13:1-14,1992.

183. Tilson, H. A.: Study design considerations in developmental neurotoxicology. Neurotoxicol. Teratol. 14: 199-203, 1992.

184. Llorens, J., Crofton, K., Tilson, H., Ali, S.F., and Mundy, W.R. Characterization of disulfoton- induced behavioral and neurochemical effects following repeated exposure. Fund. Appl. Toxicol.

20:163-169, 1993.

185.Tandon, P., Pope, C., Padilla, S., Tilson, H.A. and Harry G.J.: Developmental changes in carbachol- stimulated inositolphosphate release in pigmented rat retina. Current Eye Research. 12: 439-449, 1993.

186.Tandon, P., Padilla, S., Pope, C.N., Barone, S. and Tilson, H.A.: Fenthion produces persistent decreases in muscarinic function in the adult rat retina. Toxicol. Appl. Pharmacol. 125:271-280, 1994.

187. Ward, T.R., Ferris, D.J., Tilson, H.A. and Mundy, W.R.: Correlation of the anticholinesterase activity of a series of organophosphates with their ability to compete with agonist binding to muscarinic receptors. Toxicol. Appl. Pharmacol. 122:300-307, 1993.

188.Mundy, W.R., Kodavanti, P., Dulchinos, V.F. and Tilson, H.A.: Aluminum alters calcium transport

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in plasma membrane and endoplasmic reticulum from rat brain . J. Biochem. Toxicol. 9:17-23, 1994.

189. Tandon, P., Barone, S., Bonner, M., Ali, S., and Tilson, H.A.: The role of the septohippocampal pathway in the mediation of colchicine-induced compensatory changes in the rat hippocampus. Neurotoxicology 14:41-50, 1993.

190. Kodavanti, P., Shin, D-S, Tilson, H.A. and Harry, G.J.: Comparative effects of two polychlorinated biphenyl congeners on calcium homeostasis in rat cerebellar granule cells. Toxicol. Appl. Pharmacol. 123:97-106, 1993.

191. Kodavanti, P., Mundy, W.R., Tilson, H.A. and Harry, G.J.: Effects of selected neuroactive chemicals on calcium transporting systems in rat cerebellum and on survival of cerebellar granule cells. Fund. Appl. Pharmacol. 21: 308-316, 1993.

192. Mundy, W.R., Ward, T.R., Dulchinos, V.F. and Tilson, H.A.: Effects of repeated organophosphate administration on carbachol-stimulated phosphoinositide hydrolysis in rat brain. Pharmacol. Biochem. Behav. 45:309-314, 1993.

193. Tilson, H.A.: Neurobehavioral methods used in neurotoxicological research. Toxicol. Lett. 68:231-240, 1993.

194. Tilson, H.A. and Reiter, L.W.: Environmental neurotoxicology: A young discipline with a long history. Hlth. Env. Dig. 7:4-5, 1993.

195. Tandon, P., Barone, S., Mundy, W.R. and Tilson, H.A.: Compensatory changes in the hippocampus following intradentate infusion of colchicine. Neurotoxicology 15: 513-524, 1994.

196. Shaughnessy, L.W., Barone, S., Mundy, W.R., Herr, D.W. and Tilson, H.A.: Comparison of intracranial infusions of colchicine and ibotenic acid as models of neurodegeneration in the basal forebrain. Brain Res. 637: 15-26, 1994.

197. Maier, W.E., Kodavanti, P.R.S., Harry, G.J. and Tilson, H.A. Sensitivity of adenosine triphosphatases in different brain regions to polychorinated biphenyl congeners. J. Appl. Toxicol. 14:225-229, 1994.

198. Shafer, T.J., Nostrandt, A.C., Tilson, H.A. and Mundy, W.R.: Mechanisms underlying AlCl3 inhibition of agonist-stimulated inositol phosphate accumulation. Biochem. Pharmacol. 47: 1417-1425, 1994.

199. Kodavanti, P.S., Shafer, T.J., Ward, T.R., Mundy, W.R., Freudenrich, T., Harry, G.J. and Tilson, H.A.: Differential effects of polychlorinated biphenyl congeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells. Brain Research 662: 75-82, 1994.

200. Kodavanti, P.S., Ward, T.R., McKinney, J.D. and Tilson, H.A.: Increased [3H]-phorbol ester binding in rat cerebellar granule cells by polychorinated biphenyl mixtures and congeners: qualitative structure activity relationships. Toxicol Appl. Pharmacol. 130: 140-148, 1995.

201. Goldey, E.S., Tilson, H.A. and Crofton, K.M.: Implications of the use of neonatal viability, body weight, and survivorship data for predicting developmental neurotoxicity: A survey of the literature. Neurotoxicol. Teratol. 17:313-332, 1995.

202. Tilson, H.A., MacPhail, R.C. and Crofton, K.M.: Defining neurotoxicity in a decision-making context. Neurotoxicology 16: 363-376, 1995.

203. Maier, W.E., Brown, H.W., Tilson, H.A., Luster, M.I. and Harry, G.J. Trimethyltin increases interleukin (IL)-1a, IL-6 and tumor necrosis factor a mRNA levels in rat hippocampus. J. Neuroimmunol. 59:65-75, 1995.

204. Tilson, H.A.: The concern for developmental neurotoxicology: Is it justified and what is being done about it? Environ. Hlth. Perspec. 103:147-151, 1995.

205. Kodavanti, P.R.S., Ward, T.R., McKinney, J.D. and Tilson, H.A.: Inhibition of microsomal and mitochondrial 45Ca2+ sequestration in rat cerebellum by polychlorinated biphenyl mixtures and congeners: Structure activity relationships. Arch. Toxicol. 70:150-157, 1996.

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206. Tilson, H.A., MacPhail, R.C. and Crofton, K.M.: Setting exposure standards: A decision process. Env. Hlth. Perspec. 104: 401-405, 1996.

207. Tilson, H.A.: Evolution and current status of neurotoxicity risk assessment. Drug Metabolism Reviews 28: 121-139, 1996.

208. Kodavanti, P.S., Ward, T.R., McKinney, J.D., Waller, C.D. and Tilson, H.A.: Increased [3H] phorbol ester binding in rat cerebellar granule cells and inhibition of 45Ca2+-sequestration in rat cerebellum by polychlorinated diphenyl ether congeners and analogs: Structure-activity relationships. Toxicol. Appl. Pharmacol. 138:251-261, 1996.

209. Hattis, D., Glowa, J., Tilson, H. And Ulbrich, B. Risk assessment for neurobehavioral toxicity:

SGOMSEC joint report. Environ. Hlth. Perspec. 104:217-226, 1996.210. Crofton, K.M., Padilla, S., Tilson, H.A., Anthony, D.C., Raymer, J.H. and MacPhail, R.C.: The

impact of dose rate on the neurotoxicity of acrylamide: The interaction of administered dose, target tissue concentrations, tissue damage and functional effects. Tox. Appl. Pharmacol. 139:163-176, 1996.

211. Crofton, K.M., MacPhail, R.C. and Tilson, H.A.: Letter to the Editor. Fund Appl. Toxicol. 32:126-127, 1996.

212. Kavlock, K.J. et al.: Research needs for the risk assessment of health and environmental effects of endocrine disruptors: A report of the US EPA-sponsored Workshop. Env. Hlth. Perspec. 104:715-740, 1996.

213. Shafer, T.J., Mundy, W.R., Tilson, H.A. and Kodavanti, P.R.S.: Disruption of inositol phosphate accumulation in cerebellar granule cells by polychlorinated biphenyls: A consequence of altered Ca2+ homeostasis. Toxicol. Appl. Pharmacol. 141:448-455, 1996.

214. Shaughnessy, L.W., Barone, S., Mundy, W.R. and Tilson, H.A.: Neurochemical and behavioral recovery after colchicine lesions of the nucleus basalis magnocellularis in rats. Restorative Neurol. Neurosci. 10:135-146, 1996.

215. Kodavanti, P. And Tilson, H. Letter to the Editor. Neurotoxicol. Teratol. 19:1-2, 1997.

216. Maier, W.E., Bartenbach, M.J., Brown, H.W., Tilson, H.A. and Harry, G.J.: Induction of tumor necrosis factor alpha in cultured glial cells by trimethyltin. Neurochem. Internat. 30: 385-392, 1997.

217. Tilson, H. and Kavlock, R.J.: The workshop on endocrine disruptor research needs: A report. Neurotoxicology 18:389-392, 1997.

218. Kodavanti, P. and Tilson, H.A.: Structure-activity relationship of potentially neurotoxic PCB congeners in the rat. Neurotoxicology 18:425-442, 1997.

219.Svendsgaard, D.J., Ward, T.R., Tilson, H.A. and Kodavanti, P.R.S. Empirical modeling of an in vitro activity of polychlorinated biphenyl congeners and mixtures. Environ. Hlth Perspec. 105:

1106-1115, 1997.

220.Tilson, H.A. and Kodavanti, P.R.S.: Neurochemical effects of polychlorinated biphenyls: An overview and research needs. Neurotoxicology 18:727-744, 1997.

221. Choksi, N.Y., Kodavanti, P.S., Tilson, H.A. and Booth, R.G.: Effects of polychlorinated biphenyls (PCBs) on brain tyrosine hydroxylase activity and dopamine synthesis in the rat. Fund Appl. Toxicol. 39: 76-80, 1997.

222. MacPhail, R.C., Tilson, H.A., Moser, V.C., Becking, G., Cuomo, V., Frantik, E., Kulig, B.M. and Winneke, G.: The IPCS collaborative study on neurobehavioral screening methods: Background and genesis. Neurotoxicology 18: 925-928, 1997.

223. Moser, V., Tilson, H., MacPhail, R., Becking, G.C., Cuomo, V., Frantik, E., Kulig, B. and Winneke, G.:

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The IPCS collaborative study of neuroabehavioral screening methods: II. Protocol design and testing procedures. Neurotoxicology 18: 929-938, 1997.

224. Moser, V.C., Becking, G.C., Cuomo, V., Frantik, E., Kulig, B., MacPhail, R.C., Tilson, H.A., Winneke, G., Brightwell, W.S., Cagiano, R., Gill, M.W., Haggerty, G.C., Hornychova, M., Lammers, J., Larsen, J., McDaniel, K.L., Nelson, B.K., and Ostergaard, G. : The IPCS collaborative study on neurobehavioral screening methods: III. Results of proficiency studies. Neurotoxicology 18: 939-946, 1997.

225. Tilson, H.A., MacPhail, R.C., Moser, V.C., Becking, G.C., Cuomo, V., Frantik, E., Kulig, B.M. and Winneke, G. The IPCS collaborative study on neurobehavioral screening methods: VII. Summary and conclusions. Neurotoxicology 18: 1065-1070, 1997.

226. Moser, V.C., Becking, G.C., Cuomo, V., Frantik, E., Kulig, B., MacPhail, R., Tilson, H., Winneke, G., Brightwell, W.S., DeSalvia, M., Gill, M.W., Haggerty, G.C., Hornychova, M., Lammers, J., Larsen, J.J., McDaniel, K.L., Nelson, B.K. and Ostergaard, G.: The IPCS collaborative study on neurobehavioral screening methods: IV. Control data. Neurotoxicology 18: 947-968, 1997.

227. Moser, V.C., Becking, G.C., Cuomo, V., Frantik, E., Kulig, B., MacPhail, R., Tilson, H., Winneke, G., Brightwell, W.S., DeSalvia, M., Gill, M.W., Haggerty, G.C., Hornychova, M., Lammers, J., Larsen, J.J., McDaniel, K.L., Nelson, B.K. and Ostergaard, G.: The IPCS collaborative study on neurobehavioral screening methods: V. Results of chemical testing. Neurotoxicology 18: 969-1056, 1997.

228. Nishida, N., Farmer, J.D., Kodavanti, P.R.S., Tilson, H.A. and MacPhail, R.C. Effects of acute and repeated exposures to Aroclor 1254 in adult rats: Motor activity and flavor-aversion conditioning. Fund. Appl. Toxicol. 40: 68-74, 1997.

229. Shaughnessy, L.W., Mundy, W.R., Tilson, H.A. and Barone, Jr., S. A time-course of changes in cholinergic and neurotrophic-related markers following infusion of colchicine into the basal forebrain. Brain Res. 781:62-77, 1998.

230. Harry, G.J., Billingsley, M., Bruinink, A., Campbell, I.L., Clasen, W., Dorman, D.C., Galli, C., Ray, D., Smith, R.A. and Tilson, H.A. In vitro techniques for the assessment of neurotoxicity. Environ. Hlth. Perspect. 106:131-158, 1998.

231. Barone, S., Haykal-Coates, N., Parran, D.K., and Tilson, H.A.: Gestational exposure to methylmercury alters the developmental pattern of trk-like immunoreactivity in the rat brain and results in cortical dysmorphology. Develop. Brain Res. 109:13-31, 1998.

232. Tilson, H.A.: Developmental neurotoxicology of endocrine disruptors and pesticides: Identification of information gaps and research needs. Environ. Hlth. Perspect. 106: 807-812, 1998.

233. Kodavanti, P.R.S., Derr-Yellin, E., Mundy, W.R., Shafer, T.J., Herr, D.W., Barone, Jr., S., Chosksi, N.Y., MacPhail, R.C., and Tilson, H.A. Repeated exposure of adult rats to Arochlor 1254 causes brain region specific changes in intracellular Ca2+ buffering and protein kinase C activity inthe absence of changes in tyrosine hydroxylase. Toxicol. Appl. Pharmacol. 153: 186-198, 1998.

234. Kodavanti, P.R.S., Ward, T.R., Derr-Yellin, E., Mundy, W.R., Casey, A.C., Bush, B., and Tilson, H.A. Congener-specific distribution of polychlorinated biphenyl in brain regions, blood, liver and fat of adult rats following repeated exposure to Aroclor 1254. Toxicol. Appl. Pharmacol. 153: 199-210, 1998.

235. Audesirk, G., Burbacher, T., Guilante, T., Laughlin, N.K., LoPachin, R., Suszki, W.J., and Tilson, H.A.: Understanding the NIH review process: A brief guide to writing grant proposals in neurotoxicology. Neurotoxicology 20: 91-98, 1999.

236. Tilson, H.A., Kodavanti, P.R.S., Mundy, W.R., and Bushnell, P.J.: Neurotoxicity of environmental chemicals and their mechanisms of action. Toxicol. Lett. 102-103: 631-635, 1998.

237. Kodavanti, P. and Tilson, H.A.: Neurochemical effects of environmental chemicals: In vitro and in vivo correlations on second messenger systems. Ann NY Acad Sci. 919: 97-105, 2000.

238. Tilson, H.A.: New horizons: Future directions in neurotoxicology. 108 (Suppl 3): 439-441, 2000.

239. Das, KP, Chao, S.L., White, L.D., Haines, W.T., Harry, G.J., Tilson, H.A., and Barone, S.: Differential patterns of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 mRNA and

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protein levels in developing regions of rat brain. Neuroscience 103: 739-761, 2001.

240. Kodavanti, P., Kannan, N., Yamashita, N., Derr-Yellin, E.C., Ward, T.R., Burgin, D.E., Tilson, H.A., Birnbaum, L.S.: Differential effects of two lots of Aroclor 1254: Congener-specific analysis and neuro- chemical end points. Environ Hlth Perspec 109: 1153-1161, 2001.

241. Harry, G.J., Tyler, K., Lefebvre d’Hellencourt, C., Tilson, H.A., Maier, W.E.: Morphological alterations and elevations in tumor necrosis factor-a, interleukin (IL)-1a, and IL-6 in mixed glia cultures following exposure to trimethyltin: Modulation by proinflammatory cytokine recombinant proteins and neutralizing antibodies. Toxicol. Appl. Pharmacol. 180: 205-218, 2002.

242. Kodavanti, P., Ward, TR, Derr-Yellin, EC, McKinney, JD, Tilson, HA: Increased [3H]phorbol ester binding in rat cerebellar granule cells and inhibition of 45 Ca2+ buffering in rat cerebellum by hydroxylated poly chlorinated biphenyls. Neurotoxicology 191: 1-11, 2002.

243. Kavlock, R, Ankley, GT, Collette, T, Francis, E., Hammerstrom, K, Fowle, J, Tilson, HA, Toth, G, Schmieder, P, Beith, GD, Weber, E, Wolf, C, and Young, D. Computational Toxicology; Framework, partnerships and program development. Reproductive Toxicology 19: 265-280, 2005.

244. Lein, P, Yang, D, Bachstetter, AD, Tilson, H, Harry, G, Mervis, R and Kodavanti, PS. Ontogenetic alterations in molecular and correlates of dendritic growth after developmental exposure to polychlor- inated biphenyls. Environmental Health Perspectives 115: 556-563, 2007.

Book Chapters, Conference Proceedings, Monographs:

l. Rech, R. H., Tilson, H. A., and Marquis, W. J.: Adaptive changes in behavior after repeated administration of various psychoactive drugs. In Mandell, A. J. (ed.): Neurobiological Mechanisms of Adaptation and Behavior. Raven Press, New York, l975, pp. 263-286.

2. Stein, J. M., Wayner, M. J., Cook, R. C., and Tilson, H. A.: The effect of para-chloroamphetamine on the intake of ethanol, saccharin, food, and water. In Seixis, F. (ed.): Currents in Alcoholism. Vol. III. Grune and Stratton, NY, l978, pp. l73-l90.

3. Tilson, H. A. and Mitchell, C. L.: Models for Neurotoxicity. In Hodgson, E., Bend, J. R., and Philpot,. R. M. (eds): Reviews in Biochemical Toxicology. Elsevier/North-Holland, New York, l980,pp. 265-294.

4. Tilson, H. A., Cabe, P. A., and Burne, T. A.: Behavioral procedures used in the assessment of neurotoxicity. In Spencer, P. S. and Schaumburg, H. H. (eds): Experimental and Clinical Neurotoxicology. The Williams and Wilkins Co., Baltimore, Maryland, l980, pp. 758-766.

5. Tilson, H. A. and Harry, G. J.: Behavioral principles for use in behavioral toxicology and pharmacology. In Mitchell, C. L. (ed.): Nervous System Toxicology. Raven Press, New York, l982, pp. l-27.

6. Mitchell, C. L., Tilson, H. A., and Cabe, P. A.: Screening for neurobehavioral toxicity: Factors to consider. In Mitchell, C. L. (ed.): Nervous System Toxicology. Raven Press, New York, l982, pp. 237-245.

7. Rosecrans, J. A., Hong, J. S., and Tilson, H. A.: Effects of conditioned analgesia (autoanalgesia) on pituitary-adrenal function and Brain neuropeptides in rats selected for differences in activity. In Costa, E. and Trabucchi, M. (eds.): Regulatory Peptides: From Molecular Biology to Function. Raven Press, New York, l982, pp. l5l-l56.

8. Mitchell, C. L. and Tilson, H. A.: Behavioral toxicology in risk assessment: Problems and research needs. CRC Reviews in Toxicology. CRC Press, Florida, l982.

9. Hong, J. S., Herr, D. W., Hudson, P. M., and Tilson, H. A.: Possible role of the sodium channel in the neuro toxicology of organochlorine insecticides in vivo in the rat. Proceedings of the 26th Congress ofthe European Society of Toxicology, June 16-19, Kuopio, Finland.

10.Tilson, H. A. and Wright, D. C.: Interpretation of behavioral teratology data. Proceedings of

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Workshop on Neurobehavioral Tests in Teratology, September 3-6, 1985.

11.Tilson, H. A.: Practical Considerations in Establishing Valid and Sensitive Neurobehavioral Test Methods.Proceedings of Conference on Neurobehavioral Methods in Safety Assessment of Chemicalsand Drugs, Dusseldorf, FGR, December 13-16, 1985.

12. Tilson, H. A.: Indices of behavioral neurotoxicity: What can be measured? Symposium paper on "Predicting Neurotoxicity and Behavioral Dysfunction from Preclinical Toxicologic Data", September 30, 1985, Bethesda, MD.

13. Lamartiniere, C. A., Sloop, C. A., Clark, J., Tilson, H. A. and Lucier, G. W.: Organizational effects of hormones and hormonally-active xenobiotics on postnatal development, In: 12th Conference on Environmental Toxicology. Dayton, Ohio, U.S. Air Force Publication: AFAMRL-TR-81-149,pp. 96-121, 1982.

14.Tilson, H. A., Cranmer, J. M. and Uphouse, L. (Eds): Chlordecone (Kepone) Neurotoxicity. Intox Press, 1982.

15.Tilson, H. A. and Cranmer, J. M. (Eds): Neurotoxicity in the Fetus and Child. Intox Press, 1986.

16.Grimes, L., Hong, J., McGinty, J., Mitchell, C., Obie, J., and Tilson, H. A.: Enkephalin contained in dendate granule cells is important for kainic acid-induced wet dog shakes. NIDA Research Monograph:Advances in Endogenous and Exogenous Opioid Peptides, 1987.

17.Walsh, T. J. and Tilson, H. A.: The use of pharmacological challenges in neurotoxicology. In: Behavioral Toxicology, Z. Annau (ed.), Johns Hopkins Press, Baltimore, MD, 1986, pp. 244-267.

18.Mactutus, C. F. and Tilson, H. A.: The neurobehavioral effects of prenatal exposure to insecticides. In: Handbook of Behavioral Teratology. Plenum Press, N.Y., 1986, pp. 335-390.

19.Tilson, H. A., Hong, J. S., Gerhart, J. M. and Walsh, T. J.: Animal models in neurotoxicology: The neurobehavioral effects of chlordecone (Kepone). In: Neurobehavioral Pharmacology, Volume 6, Lawrence Erlbaum Press, Hillsdale, NJ, 1987, pp. 249-273

20.Tilson, H. A. and Sparber, S. B. (Eds.): Neurotoxicants and Neurobiological Function - Effects of Organoheavy Metals. Wiley Press, NY, 1987.

21.Tilson, H. A., Zhao, D., Peterson, N. J., Nanry, K. and Hong, J. S.: Behavioral and neurological effects of aspartame. In: Dietary Phenylalanine and Brain Function. Birkhauser, Boston, 1988, pp 107-115.

22.Tilson, H. A.: Consequences of exposure to chlordecone on fetus and newborn. In: Toxicologic and Pharmacologic Principles in Pediatrics, S. Kacew and S. Lock (eds.), Hemisphere Publishing Co., New York, 1988, pp. 293-304.

23.Sparber, S. B., Cranmer, J. M. and Tilson, H. A. (Eds.): Cognitive Dysfunction in Children and Adults: Clinical and Basic Science Issues. Intox Press, 1988.

24.Tilson, H.A.: Animal neurobehavioral test battery in NTP assessment. In: Advances in Neurobehavioral Toxicology: Applications in Environmental and Occupational Health. B.L. Johnson (Ed.), Lewis Publishers, Chelsea, Michigan, 1990, pp. 403-418.

25.Tilson, H.A. and Mitchell, C. L. (Ed.): Target Organ Toxicity: Nervous System Toxicology, Raven Press, 1992.

26.Tilson, H. A. and Harry, G. J.: Neurobehavioral Toxicology. In Abou-Donia, M.B. (ed.): Textbook on Neurotoxicology. CRC Press, Boca Raton, FL, 1993.

27.Tilson, H.A.: Behavioral Toxicology: An overview. In: Handbook of Neurotoxicology I. Basic Principles and Current Concepts. L. Chang (ed.), M. Dekker, New York, in press, 1993.

28.Tilson, H.A. and Harry, G.J. Developmental neurotoxicology of polychlorinated biphenyls and related

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compounds. In: The Vulnerable Brain and Envionmental Risks, Vol. 3: Toxins in Air and Water, R.L. Isaacson and K.F. Jensen (Eds.), Plenum Press, New York, 1994..

29.Tilson, H. A.: Neurobehavioral methods used in neurotoxicology. Neurotoxicol. Teratol. NIDA Research Monograph. 136: 1-30, 1993.

30.Tilson, H.A. and MacPhail, R.C.: Interpretation of neurobehavioral data in toxicologic studies. In: Neurobehavioral Toxicology: Analysis and Interpretation, B. Weiss and J. O'Donoghue (Eds.), Raven Press, NY, 1994, pp. 345-356.

31 Tilson, H.A.: Behavioral toxicology: Introductory Overview. Handbook of Neurotoxicology, Volume I, Marcel Dekker, pp. 309-311, 1994.

32. Tilson, H.A.: Developmental neurotoxicity risk assessment. In: Developmental Neurotoxicology, Harry, G.J. (Ed.), CRC Press, pp. 157-169, 1994.

33.Tilson, H.A. and Mundy, W.R.: Bases of excitatory amino acid system-related neurotoxicity. In: Neurotoxicology: Approaches and Methods, L. Chang (Ed.), Academic Press, New York, pp. 359-370, 1995.

34. Tilson, H.A.: Risk assessment of neurotoxicity: An introductory overview. In: Neurotoxicology: Approaches and Methods, L. Chang and W. Slikker (Eds.), Academic Press, New York, pp. 767-770, 1995.

35. Tilson, H.A.: Developmental neurotoxicology risk assessment. In: Neurotoxicology: Approaches and Methods, L. Chang and W. Slikker (Eds.), Academic Press, New York, pp. 805-813, 1995.

36. MacPhail, R.C. and Tilson, H.A.: Behavioral screening tests: Past, present and future. In:Neurotoxicology: Approaches and Methods. L. Chang and W. Slikker (Eds.), Academic Press,New York, pp. 231-238, 1995.

37. Tilson, H.A.: Learning and memory. In: Comprehensive Toxicology, H. Lowndes and K. Reuhl, (Eds.), Elsevier, Oxford, England, 1996.

38.Tilson, H.A. (Senior Author): Principles of Neurotoxicity Risk Assessment. Federal Register 59:42360-42404, 1994.

39.Harry, G.J. and Tilson, H.A.: Neurodegeneration Methods and Protocols, Editors, Humana Press, Totowa, NJ, 1999.

40. Niesink, R.J.M., Jaspers, R.M.A., Kornet, L.M.W., van Ree, J.M., and Tilson, H.A.: Introduction to

Neurobehavioral Toxicology: Food and Environment, Editors, CRC Press, Boca Raton, FL, 1999.

41.Tilson, H.A. and Harry, G.J.: Neurotoxicology, Second Edition, Editors, Taylor and Francis, 1999.

42.Tilson, H.A. and Harry, G.J.: Principles of Neurotoxicity. In: Site-Specific Neurotoxicity, David Lester, William Slikker, Jan Johnannesen and Philip Lazarovici (Eds.). Harwood AcademicPublishers, Zurich, Switzerland, 1999.

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