45JSID Program 1211 · 2020. 12. 11. · 2nd Day, December 12, Saturday, 2020 Room A Room B Room...

1st Day, December 11, Friday, 2020

Room A Room B Room C On-Demand Service8:00

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Opening

International Psoriasis Mini Symposium

(A. Morita)

H. Bachelez, K. Kamiya

Luncheon Seminar 1(Y. Tada)

A. Otsuka, Y. Chinuki

Mitsubishi Tanabe Pharma Corporation /Teikoku Seiyaku Co., Ltd.

Sun Pharma RISING SUN AWARD 2020

Sun Pharma Japan Ltd.

Award Ceremony

Plenary Q&A Session I(Y. Aoyama, M. Sugaya, T. Honda)

Luncheon Seminar 2(T. Matsushita, R. Okuyama)

S. Shibata, M. Yasuda

AbbVie GK

Afternoon Seminar 1(H. Fujita, Y. Yamaguchi)

F. Yamazaki, H. Masuzaki

UCB Japan Co. Ltd.

Evening Seminar 1(M. Furue)

M. Bruin-Weller, S. Weidinger

Sanofi K.K.

Luncheon Seminar 3(S. Sato, M. Sugaya)

M. Jinnin, S. Morimura

NOV division, TOKIWA Pharmaceutical Co., Ltd.

Afternoon Seminar 2Janssen Pharmaceutical K.K./

TAIHO PHARMACEUTICAL CO., LTD.

Evening Seminar 2Novartis Pharma K.K.

Medical Division /Maruho Co., Ltd Medical Affairs Dept.

JDS Symposium(R. Abe)

R. Abe, J. A. McGrath, T. R. Matos, N. L. Jeon,

T. J. Hornyak, S. Shinkuma, H. Habernickel

9:50-10:00

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Dec. 11 (Fri.) 9:50-Dec. 13 (Sun.) 15:00


(A. Morita, K. Kabashima, T. Kawamura)

R. Watanabe, T. Honda, T. Matsushita

(A. Asahina)

T. Yamamoto

(A. Morita, K. Takahashi)

Y. Imai, G. Tsuji

0

amura)

ushita

Young JSID AwardPresenter: A. Morita

JSID’s Fellowship Shiseido Research GrantPresenter: R. Fujiwara

Diploma of Dermatological ScientistPresenter: A. Morita

JSID Honorary MembershipPresenter: A. Morita

Plenary and Concurrent Oral Session

Plenary Session I 【I -1～I -9】

Plenary Session II 【II -1～II -10】

Autoimmunity / Inflammation 【C01-01～C01-15】

Carcinogenesis /Growth Factors / Signal Transduction /Cancer Genetics

【C02-01～C02-04】Cell Adhesion /Matrix /Vascular Biology

【C03-01～C03-03】Human Clinical Research and Therapeutics

【C04-01～C04-10】Epidermal Structure and Function

【C05-01～C05-06】Epidemiology /Health Service Research

【C06-01】Genetic Disease /

Gene Regulation and Gene Therapy 【C07-01～C07-08】Tissue Regeneration /

Stem Cell and Wound Healing 【C08-01～C08-07】

Hair and Cutaneous Development 【C09-01～C09-04】

Immunology 1: Adaptive Immunity 【C10-01～C10-08】

Immunology 2: Innate Immunity and Microbiology 【C11-01～C11-07】

Photobiology 【C12-01～C12-03】

Pigmentation and Melanoma 【C13-01～C13-08】

Digital Poster Presentation

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Deliver a lecture live*. *Plenary Q&A sessions I and II will be held only for discussion. Please view the lecture data of Plenary Session on demand before.

Prerecorded lecture deliver on-time and after that there is Question and Answer session live.

Prerecorded lecture deliver on-time. There is no discussion live.

On-demand service, you can view this session during 45JSID meeting, from Dec. 11 (Fri.) 9:50 to Dec. 13 (Sun.) 15:00.

Chair: ( )

■ 取得可能単位数　　 2単位　　　1単位

■ 機構認定専門医制度の単位取得について単位は聴講記録（ログ）にて確認いたします。セッション開始15分以内～終了までの聴講記録が確認できた場合にのみ、会期終了後1ヶ月以内に単位付与（登録）いたします。

II

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2nd Day, December 12, Saturday, 2020


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The 21st Maruho Research Award

Presentations by award winners and award ceremony

Maruho Co., Ltd.

JDS Symposium(R. Abe)

R. Abe, J. A. McGrath, T. R. Matos, N. L. Jeon,

T. J. Hornyak, S. Shinkuma, H. Habernickel

Encore

Tanioku Kihei Memorial Lecture(M. Akiyama) A. S. Paller

JSID Award Lecture(A. Morita) H. Ujiie

Luncheon Seminar 4(M. Takeno)

Y. Kirino

Amgen K.K.

Plenary Q&A Session IIII(N. Kato, Y. Yamaguchi, Y. Shimomura)

Morning Seminar 1(R. Abe)

M. Sugaya, T. Miyagaki

MINOPHAGEN PHARMACEUTICAL CO., LTD.

Luncheon Seminar 5(K. Kabashima)

T. Honda, S. Tsuji

Nippon Boehringer Ingelheim Co., Ltd.

Afternoon Seminar 3(M. Murakami, A. Morita)

R. Watanabe, S. Morizane

Kyowa Kirin Co., Ltd.

Evening Seminar 3(H. Tanizaki, S. Motegi)

Y. Okubo, M. Kishimoto

UCB Japan Co. Ltd.

Morning Seminar 2(S. Aiba)

J. G. Smith, M. Jinnin, N. Pernodet

The Estée Lauder Companies Inc.

Luncheon Seminar 6(T. Nomura, K. Sugiura)

M. Kamata, H. Fujita

Eli Lilly Japan K.K./TORII PHARMACEUTICAL CO., LTD.

Afternoon Seminar 4(R. Okuyama, N. Katoh)

T. Honda, M. Kamata


Evening Seminar 4K. Yamasaki

AbbVie GK/Eisai Co., Ltd.

JSID-Asia-Oceania-Forum(T. Honda, H. Takahashi)

J. E. Common, L. Zhang, L. Wong, S. E. Lee, J. Chandra

9:10-11:10

11:20-11:50

11:55-12:25

12:25-12:30

12:40-13:40

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16:00-18:00

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8:00-9:00

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8:00-9:00

12:40-13:40

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18:10-19:10

Dec. 11 (Fri.) 9:50-Dec. 13 (Sun.) 15:00

(M. Amagai, S. Sato, K. Kabashima)

T. Kobayashi, S. Takashima, S. Takahashi, W. Matsumura



















JSID Kisaragi Award(A. Morita) Y. Ishida

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Chair: ( )





※再放送（Encore）は、単位付与の対象外です。

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3rd Day, December 13, Sunday, 2020


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JSID-Asia-Oceania-Forum (T. Honda, H. Takahashi)

J. E. Common, L. Zhang, L. Wong, S. E. Lee, J. Chandra

Encore

International Psoriasis Mini Symposium

(A. Morita)

H. Bachelez, K. Kamiya

Encore

Morning Seminar 3(H. Koga)

T. Shimokata

MSD K.K.

Luncheon Seminar 7(K. Yamanaka, H. Amano)

T. Watanabe, Y. Hashimoto

AbbVie GK

Morning Seminar 4(K. Yamanaka)

T. Mabuchi

TAIHO PHARMACEUTICAL CO., LTD./ Janssen Pharmaceutical K.K.

9:10-11:10

11:20-12:20

8:00-9:00

12:30-13:30

8:00-9:00 Dec. 11 (Fri.) 9:50-Dec. 13 (Sun.) 15:00



















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Chair: ( )

MEMO





※再放送（Encore）は、単位付与の対象外です。

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December 11, 2020, Room A

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Opening9:50-10:00

International Psoriasis Mini Symposium10:10-11:10 Chair: Akimichi Morita

IPS1 From the rare to the frequent, what lessons did we learn from monogenic variants of psoriatic disease?

○Hervé Bachelez

Department of Dermatology, AP-HP Saint-Louis Hospital, Laboratory of Genetics of Skin Diseases, INSERM U1163, Imagine Institutefor Human Genetic Diseases, University of Paris, Paris, France

IPS2 Results of epidemiological survey from 2013 to 2018 of psoriasis patients in Japanese Society for PsoriasisResearch

○Koji Kamiya

Department of Dermatology, Jichi Medical University, Shimotsuke, Japan

Luncheon Seminar 1"Therapeutic strategies for allergic skin disease"11:20-12:20 Chair: Yayoi Tada

LS1-1 New insights into the etiopathogenesis of atopic dermatitis

○Atsushi Otsuka

Kyoto University

LS1-2 Sensitization to environmental allergen plays a crucial role in several phenotypes of food allergy

○Yuko Chinuki

Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan

Co-sponsored by Mitsubishi Tanabe Pharma Corporation/Teikoku Seiyaku Co., Ltd.

Sun Pharma RISING SUN AWARD 202012:30-13:10 Chairs: Akimichi Morita, Kenji Kabashima, Tatsuyoshi Kawamura

SRA1 Resident memory T cells and skin disorders

○Rei Watanabe

Department of Integrative Medicine for Allergic and Immunological Diseases, Faculty of Medicine, Osaka University

SRA2 Lipid mediators in the regulation of cutaneous immune responses

○Tetsuya Honda

Department of Dermatology, Hamamatsu University School of Medicine

SRA3 The role of cytokine producing B cells in the pathogenesis of Systemic sclerosis

○Takashi Matsushita

Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University

Co-sponsored by Sun Pharma Japan Ltd.


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Award Ceremony14:00-14:30 Presenter: Akimichi Morita

Young JSID AwardSatoru Shinkuma, Department of Dermatology, Nara Medical University School of MedicineTakuya Takeichi, Department of Dermatology, Nagoya University Graduate School of MedicineAyumi Yoshizaki, Department of Dermatology, The University of Tokyo Graduate School of Medicine

JSID’s Fellowship Shiseido Research Grant Presenter: Rumiko Fujiwara

Observation of tight junction formation using cultured keratinocytes

○Hiroaki Iwata

Department of Dermatology, Faculty of Medicine and Graduate School of Medicine Hokkaido University

Dynamics in epigenetic environment in skin inflammatory diseases

○Sayaka Shibata

Department of Dermatology, Graduate School of Medicine, The University of Tokyo

Diploma of Dermatological Scientist Presenter: Akimichi Morita

Meijuan Jin, Department of Dermatology, Jichi Medical UniversityChanat Kumtornrut, Department of Dermatology, Tohoku University Graduate School of MedicineHainan Yue, Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine

JSID Honorary Membership Presenter: Akimichi Morita

JDS Symposium15:40-17:40 Chair: Riichiro Abe

JDS1 Introduction of Journal of Dermatological Science Seminar

○Riichiro Abe

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Japan

JDS2 Desmosomes, mutations and phenotypes: an update on the desmosomal genodermatoses

John Y. W. Lee,○John A. McGrath

St John’s Institute of Dermatology, King’s College London, U.K.

JDS3 Skin Resident T Cells: implications for immune homeostasis and disease

○Tiago R. Matos

Department of Dermatology, Amsterdam University Medical Center/University of Amsterdam, Netherlands

JDS4 Microfluidic Vascularized Skin Model

○Noo Li Jeon

School of Mechanical and Aerospace Engineering, Seoul National University, Korea

JDS5 Distinct Functional Properties of Murine Melanocyte Stem Cells in Regeneration

○Thomas J. Hornyak

Dermatology, University of Maryland School of Medicine, USA

JDS6 Advances in genome editing: application to skin diseases

○Satoru Shinkuma

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Japan

JDS7 COVID-19 and its Impact on Scholarly Publishing

○Helen Habernickel

Executive Publisher, Health & Medical Sciences, Elsevier, Berlin, Germany


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Plenary Q&A Session I19:00-20:00 Chairs: Yumi Aoyama, Makoto Sugaya, Tetsuya Honda

Only discussions will be held in this session. Please view the lecture on demand in advance and post yourquestion.

December 11, 2020, Room B

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Luncheon Seminar 2"What is rising in inflammatory skin diseases？"11:20-12:20 Chairs: Takashi Matsushita, Ryuhei Okuyama

LS2-1 Plasticity and regeneration power of the skin through crosstalk between epigenetic and transcriptional regulators

○Sayaka Shibata

Department of Dermatology, Graduate School of Medicine, The University of Tokyo

LS2-2 Overview: psoriasis, biologics, and malignancy

○Masahito Yasuda

Department of Dermatology, Gunma University Hospital

Co-sponsored by AbbVie GK

Afternoon Seminar 1"Approach to Psoriasis patients with Comorbidities"14:40-15:30 Chairs: Hideki Fujita, Yukie Yamaguchi

AS1-1 Should not underestimate the 3rd TNF inhibitor as a treatment option for psoriasis

○Fumikazu Yamazaki

Department of Dermatology, Kansai Medical University, Osaka, Japan

AS1-2 Obesity Disease, Metabolic Syndrome and Psoriasis: Molecular Interaction and Future Perspective

○Hiroaki Masuzaki

Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Graduate School of Medicine (Second Departmentof Medicine), University of the Ryukyus, Okinawa, Japan

Co-sponsored by UCB Japan Co. Ltd.

Evening Seminar 1"Updates of real-world evidence of dupilumab in the management of atopicdermatitis"17:50-18:50 Chair: Masutaka Furue

ES1-1 Real-world effectiveness and safety results of dupilumab from the Dutch BioDay registry

○Marjolein de Bruin-Weller

The Atopic Dermatitis Research Group, National Expertise Centre of Atopic Dermatitis, Dept. of Dermatology, University MedicalCenter Utrecht, The Netherlands

ES1-2 Advances in research drive the development of novel therapies for atopic dermatitis

○Stephan Weidinger

Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany

Co-sponsored by Sanofi K.K.

December 11, 2020, Room C

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Luncheon Seminar 3"Invitation to Dermatology by Experts"11:20-12:20 Chairs: Shinichi Sato, Makoto Sugaya

LS3-1 non-coding RNAs in scleroderma

○Masatoshi Jinnin

Department of Dermatology, Wakayama Medical University Graduate School of Medicine

LS3-2 Epithelial Cell Adhesion Molecule (EpCAM) regulates intestinal epithelial homeostasis and imiquimod-inducedpsoriasis-like skin inflammation

○Sohshi Morimura

Department of Dermatology, Faculty of Medicine, International University of Health and Welfare Narita Hospital, Chiba, Japan

Co-sponsored by NOV division, TOKIWA Pharmaceutical Co., Ltd.

Afternoon Seminar 214:40-15:30 Chair: Akihiko Asahina

AS2 Psoriatic arthritis: current topics of the pathogenesis and new therapies

○Toshiyuki Yamamoto

Department of Dermatology, Fukushima Medical University, Fukushima, Japan

Co-sponsored by Janssen Pharmaceutical K.K./TAIHO PHARMACEUTICAL CO., LTD.

Evening Seminar 2"Forefront of basic and clinical research for psoriatic disease"17:50-18:50 Chairs: Akimichi Morita, Kenzo Takahashi

ES2-1 The CCL20/IL-17 axis in psoriasis

○Yasutomo Imai

Department of Dermatology, Hyogo College of Medicine, Hyogo, Japan

ES2-2 Pathogenic implication of pruritus in psoriasis

○Gaku Tsuji1,2

1Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 2Research and Clinical Center for Yusho andDioxin, Kyushu University Hospital

Co-sponsored by Novartis Pharma K.K. Medical Division/Maruho Co., Ltd Medical Affairs Dept.


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JDS Symposium (Encore)9:10-11:10 Chair: Riichiro Abe

JDS1 Introduction of Journal of Dermatological Science Seminar

○Riichiro Abe

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Japan

JDS2 Desmosomes, mutations and phenotypes: an update on the desmosomal genodermatoses

John Y. W. Lee,○John A. McGrath

St John’s Institute of Dermatology, King’s College London, U.K.

JDS3 Skin Resident T Cells: implications for immune homeostasis and disease

○Tiago R. Matos

Department of Dermatology, Amsterdam University Medical Center/University of Amsterdam, Netherlands

JDS4 Microfluidic Vascularized Skin Model

○Noo Li Jeon

School of Mechanical and Aerospace Engineering, Seoul National University, Korea

JDS5 Distinct Functional Properties of Murine Melanocyte Stem Cells in Regeneration

○Thomas J. Hornyak

Dermatology, University of Maryland School of Medicine, USA

JDS6 Advances in genome editing: application to skin diseases

○Satoru Shinkuma

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Japan

JDS7 COVID-19 and its Impact on Scholarly Publishing

○Helen Habernickel

Executive Publisher, Health & Medical Sciences, Elsevier, Berlin, Germany

Tanioku Kihei Memorial Lecture11:20-11:50 Chair: Masashi Akiyama

TML Recent Progress in Pathogenesis-based Therapies: The Ichthyoses

○Amy S. Paller

Dermatology and Pediatrics, Skin Biology and Diseases Resource-based Center, Northwestern University Feinberg School ofMedicine, Chicago, IL, USA

JSID Award Lecture11:55-12:25 Chair and Presenter: Akimichi Morita

JAL Uncovering the mystery of autoimmunity in bullous pemphigoid

○Hideyuki Ujiie

Department of Dermatology, Hokkaido University Hospital

JSID Kisaragi Award12:25-12:30 Chair and Presenter: Akimichi Morita

JKA Understanding the skin through the lense of genomics

○Yoshihiro Ishida

Department of Dermatology, Kyoto University Graduate School of Medicine


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Luncheon Seminar 412:40-13:40 Chair: Mitsuhiro Takeno

LS4 Molecular Genetics of Behçet’s Disease and Real World Data of Apremilast

○Yohei Kirino

Department of Stem Cell and Immune, Yokohama City University, Yokohama, Japan

Co-sponsored by Amgen K.K.

The 21st Maruho Research Award Presentationsby award winners and award ceremony13:50-14:50 Chairs: Masayuki Amagai, Shinichi Sato, Kenji Kabashima

MRA1 Regulatory B1a Cells Suppress Melanoma Tumor Immunity via IL-10 Production and Inhibiting Th1 CytokineProduction by CD8+ T cells

○Tadahiro Kobayashi1, Kyosuke Oishi2, Ai Okamura1,3, Shintaro Maeda1, Akito Komuro1,3, Yasuhito Hamaguchi1, Manabu Fujimoto4,Kazuhiko Takehara1, Takashi Matsushita1

1Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan, 2Department ofDermatology, Toyama Red Cross Hospital, Toyama, Japan, 3Department of Plastic surgery, Kanazawa University Hospital, Kanazawa,Japan, 4Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

MRA2 Efficient gene reframing therapy for recessive dystrophic epidermolysis bullosa with CRISPR/Cas9

○Shota Takashima1, Satoru Shinkuma1,2,3, Yasuyuki Fujita1, Toshifumi Nomura1, Hideyuki Ujiie1, Ken Natsuga1, Hiroaki Iwata1,Hideki Nakamura1, Artem Vorobyev4, Riichiro Abe2, Hiroshi Shimizu1

1Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, 2Divisionof Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 3Department of Dermatology,Nara Medical University School of Medicine, Kashihara, Japan, 4Department of Dermatology, University of Lubeck, Lubeck, Germany

MRA3 Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronicitch development

○Sonoko Takahashi1, Azusa Ishida1, Akiharu Kubo3, Hiroshi Kawasaki3,4,5, Sotaro Ochiai1, Takashi Watanabe7, Manabu Nakayama6,Haruhiko Koseki5,7, Masayuki Amagai3,4, Takaharu Okada1,2

1Laboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan, 2Graduate School of Medical LifeScience, Yokohama City University, Kanagawa, Japan, 3Department of Dermatology, Keio University School of Medicine, Tokyo,Japan, 4Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan, 5Disease Biology Group,RIKEN Medical Sciences Innovation Hub Program, Kanagawa, Japan, 6Department of Technology Development, Kazusa DNAResearch Institute, Chiba, Japan, 7Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa,Japan

MRA4 Cultured epidermal autografts from clinically revertant skin as a potential wound treatment for recessivedystrophic epidermolysis bullosa

○Wakana Matsumura1, Yasuyuki Fujita1, Satoru Shinkuma1,2, Shotaro Suzuki1, Saki Yokoshiki3, Hideki Goto3,4, Hiroshi Hayashi3,Masukazu Inoie5, Shota Takashima1, Chihiro Nakayama1, Toshifumi Nomura1, Hideki Nakamura1, Riichiro Abe1,2, Norihiro Sato3,Hiroshi Shimizu1

1Department of Dermatology, Hokkaido University, Sapporo, 2Division of Dermatology, Niigata University, Niigata, 3Clinical Researchand Medical Innovation Center, Hokkaido University Hospital, Sapporo, 4Department of Hematology, Hokkaido University Faculty ofMedicine, Sapporo, 5Japan Tissue Engineering Co., Ltd., Gamagori

Co-sponsored by Maruho Co., Ltd.

JSID-Asia-Oceania-Forum"Skin barrier and immunity"16:00-18:00 Chairs: Tetsuya Honda, Hayato Takahashi

JAOF1 Skin microbiome signatures in atopic dermatitis

○John E. Common

Skin Research Institute of Singapore, A*STAR

JAOF2 Multiple functions of Antimicrobial peptides in the Coordinated, Layered innate Defense System of the Skin

○Ling-juan Zhang

School of Pharmaceutical Sciences, State Key Lab of Cellular Stress Biology, School of Pharmaceutical Science, Xiamen University,Xiamen, China


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JAOF3 The new progressive era on the pathogenesis and therapies of Chronic Pruritus

○Lai-San Wong

Department of Dermatology, Chang Gung Memorial Hospital-Kaohsiung Medical Center

JAOF4 Keratinocyte TRPV3 regulates skin barrier and drives itch and inflammation in response to heat

○Sang Eun Lee

Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea

JAOF5 Immune-modulation and immunotherapy in HPV-associated malignant disease

○Janin Chandra

The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia

Plenary Q&A Session II19:20-20:20 Chairs: Norito Kato, Yukie Yamaguchi, Yutaka Shimomura

Only discussions will be held in this session. Please view the lecture on demand in advance and post yourquestion.


- 27 -


Morning Seminar 1"Cutaneous T-Cell Lymphoma"8:00-9:00 Chair: Riichiro Abe

MS1-1 Management of primary cutaneous lymphomas in Japan

○Makoto Sugaya

The Department of Dermatology, International University of Health & Welfare, Chiba, Japan

MS1-2 The use of bexarotene in actual clinical practice

○Tomomitsu Miyagaki

The Department of Dermatology, St. Marianna University School of Medicine, Kanagawa, Japan

Co-sponsored by MINOPHAGEN PHARMACEUTICAL CO., LTD.

Luncheon Seminar 5"The Involvement of Cytokines in Psoriasis-Related Diseases"12:40-13:40 Chair: Kenji Kabashima

LS5-1 Regulation of neutrophil dynamics and function in psoriasis

○Tetsuya Honda

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan

LS5-2 Consideration of the mechanism of arthritis and osteitis in Pustulotic Arthro-Osteitis (PAO : Sonozaki Syndrome)

○Shigeyoshi Tsuji

Dept. of Rheumatology, NHO Osaka Minami Medical Center

Co-sponsored by Nippon Boehringer Ingelheim Co., Ltd.

Afternoon Seminar 3"The latest research for psoriasis"15:00-15:50 Chairs: Masamoto Murakami, Akimichi Morita

AS3-1 IL-17-producing T cells in the pathogenesis of psoriasis

○Rei Watanabe

Department of Integrative Medicine for Allergic and Immunological Diseases, Osaka University, Suita, Japan

AS3-2 Epidermal keratinocytes and cytokines in the pathogenesis of psoriasis

○Shin Morizane

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama,Japan

Co-sponsored by Kyowa Kirin Co., Ltd.

Evening Seminar 3"More Addressing to Treatment of Psoriatic Arthritis"18:10-19:10 Chairs: Hideaki Tanizaki, Sei-ichiro Motegi

ES3-1 Role of Dermatologists and Expectations for Certolizumab pegol in treatments for psoriatic arthritis

○Yukari Okubo

Department of Dermatology, Tokyo Medical University, Tokyo, Japan

ES3-2 Management of Psoriatic arthritis: Update

○Mitsumasa Kishimoto

Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo Japan

Co-sponsored by UCB Japan Co. Ltd.


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Morning Seminar 2"Circadian clocks and microRNAs: their importance against skin aging"8:00-9:00 Chair: Setsuya Aiba

MS2-1 Circadian function in the skin and beyond: local clocks see the light

○Jacob G. Smith

Laboratory of Paolo Sassone-Corsi, University of California Irvine

MS2-2 Molecular mechanisms of skin aging: involvement of exosomes and microRNAs

○Masatoshi Jinnin

Department of Dermatology, Wakayama Medical University Graduate School of Medicine

MS2-3 microRNAs, critical signaling molecules: miR-146a and its importance against skin cell aging

○Nadine Pernodet1,2, Klodjan Stafa1, Kelly Dong1, Dawn Layman1, Krystle Corallo1, Jacqueline Trivero1, Whitby Eagle1, Earl Goyarts1

1Research & Development, The Estee Lauder Companies, 2Estee Lauder Research Laboratories

Co-sponsored by The Estée Lauder Companies Inc.

Luncheon Seminar 6"Psoriasis Research Highlights 2020"12:40-13:40 Chairs: Toshifumi Nomura, Kazumitsu Sugiura

LS6-1 Pathogenesis of psoriasis and recent topics of psoriasis

○Masahiro Kamata

Department of Dermatology, Teikyo University School of Medicine

LS6-2 Improved quality of life of patients with generalized pustular psoriasis in Japan

○Hideki Fujita

Department of Dermatology, Nihon University, Tokyo, Japan

Co-sponsored by Eli Lilly Japan K.K./TORII PHARMACEUTICAL CO., LTD.

Afternoon Seminar 4"Psoriasis Update 2020: From bench to bedside"15:00-15:50 Chairs: Ryuhei Okuyama, Norito Katoh

AS4-1 IL-23 in the cytokine network in psoriasis

○Tetsuya Honda

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan

AS4-2 Evidence of tildrakizumab for the treatment of psoriasis

○Masahiro Kamata

Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan

Co-sponsored by Sun Pharma Japan Ltd.

Evening Seminar 418:10-19:10

ES4 Expanding application of biologics broaden molecular knowledge on inflammatory skin diseases

○Kenshi Yamasaki

Department of Dermatology, Tohoku University Graduate School of Medicine

Co-sponsored by AbbVie GK/Eisai Co., Ltd.


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JSID-Asia-Oceania-Forum (Encore)"Skin barrier and immunity"9:10-11:10 Chairs: Tetsuya Honda, Hayato Takahashi

JAOF1 Skin microbiome signatures in atopic dermatitis

○John E. Common

Skin Research Institute of Singapore, A*STAR

JAOF2 Multiple functions of Antimicrobial peptides in the Coordinated, Layered innate Defense System of the Skin

○Ling-juan Zhang

School of Pharmaceutical Sciences, State Key Lab of Cellular Stress Biology, School of Pharmaceutical Science, Xiamen University,Xiamen, China

JAOF3 The new progressive era on the pathogenesis and therapies of Chronic Pruritus

○Lai-San Wong

Department of Dermatology, Chang Gung Memorial Hospital-Kaohsiung Medical Center

JAOF4 Keratinocyte TRPV3 regulates skin barrier and drives itch and inflammation in response to heat

○Sang Eun Lee

Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea

JAOF5 Immune-modulation and immunotherapy in HPV-associated malignant disease

○Janin Chandra

The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia

International Psoriasis Mini Symposium (Encore)11:20-12:20 Chair: Akimichi Morita

IPS1 From the rare to the frequent, what lessons did we learn from monogenic variants of psoriatic disease?

○Hervé Bachelez

Department of Dermatology, AP-HP Saint-Louis Hospital, Laboratory of Genetics of Skin Diseases, INSERM U1163, Imagine Institutefor Human Genetic Diseases, University of Paris, Paris, France

IPS2 Results of epidemiological survey from 2013 to 2018 of psoriasis patients in Japanese Society for PsoriasisResearch

○Koji Kamiya

Department of Dermatology, Jichi Medical University, Shimotsuke, Japan


- 30 -


Morning Seminar 38:00-9:00 Chair: Hiroshi Koga

MS3 Caring for patients treated with immune checkpoint inhibitors～focusing the irAEs and COVID-19 era～○Tomoya Shimokata

Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Japan

Co-sponsored by MSD K.K.

Luncheon Seminar 7"What is rising in psoriasis？"12:30-13:30 Chairs: Keiichi Yamanaka, Hiroo Amano

LS7-1 The roles of high mobility group box-1 in psoriasis pathogenesis

○Tomoya Watanabe

Department of Dermatology, Yokohama City University

LS7-2 Future management of psoriasis using biologics and collaborative practice: application of a novel biomarker

○Yuki Hashimoto

Department of Dermatology, faculty of Medicine, Toho University

Co-sponsored by AbbVie GK


- 31 -


Morning Seminar 48:00-9:00 Chair: Keiichi Yamanaka

MS4 The role of IL-23 in the pathogenesis and treatment of psoriasis

○Tomotaka Mabuchi

Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan

Co-sponsored by TAIHO PHARMACEUTICAL CO., LTD./Janssen Pharmaceutical K.K.

December 11, 9:50 - December 13, 15:00, on-demand service

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Plenary Session I

I-1[P10-03]

Lymphotoxin β receptor signaling and CD11c+ dendritic cells form high endothelial venule-like vessels in murineatopic dermatitis model

○Shuto Kanameishi1, Sachiko Ono1, Tetsuya Honda2, Kenji Kabashima1

1Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Department of Dermatology, HamamatsuUniversity School of Medicine, Japan

I-2[P08-03]

Delayed wound healing in epithelial cell-specific Fli1 knockout mice due to impaired reepithelialization andextracellular matrix remodeling

○Jun Omatsu, Takehiro Takahashi, Takuya Miyagawa, Ryosuke Saigusa, Yuki Fukui, Satoshi Toyama, Kentaro Awaji,Ayumi Yoshizaki, Shinichi Sato, Yoshihide Asano

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

I-3[P13-01]

Distinct molecular signatures orchestrate tumor subpopulations in melanoma models mimicking tumormicroenvironment and drug tolerance

○Farzana Ahmed1, Abdullah A Emran1,2, Crystal A Tonnessen-Murray1, Brian Gabrielli3, Mitchell Stark1, Michelle Hill1,4,Helmut Schaider1, Loredana Spoerri1, Nikolas K Haass1

1The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia, 2The Centenary Institute,The University of Sydney, Newtown, NSW, Australia, 3Mater Research Institute, The University of Queensland, Brisbane, QLD,Australia, 4QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

I-4[P04-01]

Single-cell analysis of the psoriatic lesional skin identifies the new subpopulation of IL-1B and IL23A producingdendritic cells in human

○Satoshi Nakamizo1,2, Charles-Antoine Dutertre2, Xiao Meng Zhang2, Josephine Lum2, Baptiste Janela2, Kahbing Jasmine Tan2,Reiko Sato1, Valerie Julia3, Feriel Hacini-Rachinel3, Kenji Kabashima1,2, Florent Ginhoux2

1Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Singapore Immunology Network, Agencyfor Science, Technology and Research, Singapore, 3Nestle Skin Health R&D/GALDERMA, La Tour-de-Peilz, Switzerland

I-5[P11-01]

The axis of drug-specific CD8+ T cells-neutrophils trigger Stevens-Johnson syndrome and toxic epidermalnecrolysis

○Manao Kinoshita1, Youichi Ogawa1, Natsumi Hama2, Inkin Ujiie3, Akito Hasegawa2, Saeko Nakajima4, Takashi Nomura4,Shinji Shimada1, Yasuyuki Fujita3, Hayato Takahashi5, Yoshiko Mizukawa6, Keisuke Nagao7, Riichiro Abe2, Tatsuyoshi Kawamura1

1Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan, 2Division of Dermatology, NiigataUniversity Graduate School of Medical and Dental Sciences, Niigata, Japan, 3Department of Dermatology, Hokkaido UniversityGraduate School of Medicine, Sapporo, Japan, 4Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto,Japan, 5Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 6Department of Dermatology, KyorinUniversity School of Medicine, Tokyo, Japan, 7Cutaneous Leukocyte Biology Section, Dermatology Branch, National Institute ofArthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD, USA

I-6[P07-02]

Elucidating the genotype-phenotype correlation in recessive dystrophic epidermolysis bullosa using a rapidgenome editing system in mice

○Takashi Shimbo1,2, Satoshi Takaki2,3, Sho Yamazaki2,3, Katsuto Tamai2

1StemRIM Institute of Regeneration-Inducing Medicine, Osaka University, 2Department of Stem Cell Therapy Science, OsakaUniversity, 3StemRIM Co., Ltd.

I-7[P02-01]

Glucose-6-Phosphate Dehydrogenase Correlates with the Tumor Immune Activity Including PD-L1 Expression inMerkel Cell Carcinoma

○Motoki Nakamura1, Maki Yoshimitsu1, Tetsuya Magara1, Yuka Nojiri1, Hiroshi Kato1, Kotaro Nagase2, Akimichi Morita1

1Departments of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya,Japan, 2Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan

I-8[P09-01]

WNT, SHH, and EDA signal agonists potentiate human iPS cell-derived dermal papilla substitutes in in vitro hairfollicle regeneration assay

○Masahiro Fukuyama1, Aki Tsukashima1, Momoko Kimishima1, Yoshimi Yamazaki1, Hideyuki Okano2, Manabu Ohyama1

1The Department of Dermatology, Kyorin University Faculty of Medicine, Tokyo, Japan, 2Department of Physiology, Keio UniversitySchool of Medicine, Tokyo, Japan

I-9[P12-01]

Identification and Quantification of Senescent Cells In UV-induced Skin Pathologies

○Audrey Wang1, Satoshi Nakamizo1,2,3, Yoshihiro Ishida2, Genevieve Klassen4, Priscilla Chong4, John Lim5, Graham Wright5,Kenji Kabashima2,3,4, Oliver Dreesen1

1Skin Research Institute Singapore, A*STAR, 2Kyoto University Graduate School of Medicine, Japan, 3Singapore Immunology Network(SIgN), 4School of Biological Sciences, Nanyang Technological University, 5A*STAR Microscopy Platform


- 33 -

Plenary Session II

II-1[P10-01]

FcγRIIB-dependent blockade of class-switch is crucial tolerogenic process to prevent pemphigus onset inpathogenic Dsg3 specific BCR KI mice

○Hisashi Nomura1, Naoko Wada1, Hayato Takahashi1, Shohei Egami1, Jun Yamagami1, Takashi Watanabe2, Osamu Ohara2,Shigeo Koyasu2, Masayuki Amagai1,2

1Department of Dermatology, Keio University, School of Medicine, Tokyo, Japan, 2RIKEN Center for Integrative Medical Sciences

II-2[P03-01]

Interleukin 6 signalling in endovascular progenitors is a driver of melanoma vascularisation and metastasis

○James Dight, Ghazaleh Hashemi, Laura Sormani, Ho Yi Wong, Jatin Patel, Kiarash Khosrotehrani

UQ Diamantina Institute, UQ, Brisbane, Australia

II-3[P01-01]

Antifibrotic effect of a novel compound LG283 in bleomycin-induced systemic sclerosis model

○Akira Utsunomiya1, Takenao Chino1, Noritaka Oyama1, Shin-ichiro Niwa2, Masami Otsuka3, Hironobu Ihn4, Minoru Hasegawa1

1Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan, 2Link GenomicsCo., Ltd., Tokyo, Japan, 3Department of Bioorganic Medical Chemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto,Japan, 4Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

II-4[P01-02]

PD-L1 expressed on Langerhans cell negatively regulates imiquimod-induced psoriasis-like dermatitis

○Ryota Tanaka1, Yuki Ichimura1, Noriko Kubota1, Akimasa Saito1, Seiya Mizuno2, Satoshi Takahashi2, Manabu Fujimoto3,Naoko Okiyama1

1Department of Dermatology, Faculty of Medicine, University of Tsukuba, Japan, 2Laboratory Animal Resource Center, Faculty ofMedicine, University of Tsukuba, Japan, 3Department of Dermatology, Graduate School of Medicine, Osaka University, Japan

II-5[P05-01]

Characterizing normal human eccrine sweat gland components at single-cell resolution

○Duerna Tie, Saeko Nakajima, Hiroyuki Irie, Masashi Iwata, Kenji Kabashima

Department of Dermatology, University of Kyoto, Kyoto, Japan

II-6[P01-03]

Mitochondrial transfer of mesenchymal stem cells effectively protects melanocytes from oxidative stress-inducedmitochondrial dysfunction

○Zhe Jian, Jiaxi Chen, Qi Wang

The Department of Dermatology, Xijing Hospital, Firth Military Medical University, Xi’an, China

II-7[P01-04]

IL-27 plays an important role in anti-desmoglein 3 antibody production in pemphigus vulgaris mouse model

○Aki Kamata1,2, Hayato Takahashi2, Hiroki Yoshida3, Jun Yamagami2, Masayuki Amagai2

1The Department of Dermatology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan, 2Department of Dermatology, KeioUniversity School of Medicine, Tokyo, Japan, 3Division of Molecular and Cellular Immunoscience, Department of BiomolecularSciences, Saga Medical School, Saga, Japan

II-8[P07-01]

Identification of aberrantly high cytoplasmic Ca2+ in granular keratinocytes preceding hyperkeratosis in KIDsyndrome by intravital imaging

○Teruasa Murata, Tetsuya Honda, Hiromi Doi, Teruki Dainichi, Kenji Kabashima

Department of dermatology, Kyoto University, Kyoto, Japan

II-9[P08-01]

Mitochondrial failure in T cells accelerates skin ageing

○Elisa Carrasco1,2,3, Gonzalo Soto-Heredero1,2,3, Eva M Blanco2,3, Maria Mittelbrunn1,2,3

1Universidad Autónoma de Madrid (UAM), Madrid, Spain, 2Centro de Biología Molecular Severo Ochoa (CBMSO, CSIC-UAM),Madrid, Spain, 3Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain

II-10[P08-02]

Transcriptome Atlas of Human nail unit defined by single cell RNAseq

○Hyun Je Kim1, Jun-Ho Shim3, Ji-Hye Park1,4, Woong-Yang Park3,4, Jong Sup Shim2,4, Dong-Youn Lee1,4

1The Department of Dermatology, Samsung Medical Center, Seoul, Korea, 2Department of Orthopedic Surgery, 3Samsung GenomicInstitute, 4Sungkyunkwan University School of Medicine

Concurrent Oral Session 1(Autoimmunity/Inflammation)

C01-01[P01-05]

Generation of type XVII collagen-reactive T cell clones

○Norihiro Yoshimoto, Ken Muramatsu, Takamasa Ito, Zheng Miao, Ken Natsuga, Hiroaki Iwata, Wataru Nishie, Hiroshi Shimizu,Hideyuki Ujiie

Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

C01-02[P01-06]

Spinal cord ERK2 is essential for central sensitization of itch in chronic skin inflammation

○Shinsuke Matsuo1, Takashi Hashimoto1, Aiko Furuya1, Sayako Itakura2, Shogo Endo3, Yasushi Satoh4, Takahiro Satoh1

1The Department of Dermatology, National Defense Medical College, Saitama, Japan, 2The Department of Anesthesiology, NationalDefense Medical College, Saitama, Japan, 3Tokyo Metropolitan Geriatric Hosp. and Inst. of Gerontology, Tokyo, Japan, 4TheDepartment of Biochemistry, National Defense Medical College, Saitama, Japan


- 34 -

C01-03[P01-07]

Inflammatory monocyte-derived dendritic cells mediate autoimmunity in murine lupus

○Fumi Miyagawa, Hideo Asada

Department of Dermatology, Nara Medical University, Nara, Japan

C01-04[P01-08]

Endomorphin preferentially induces mechanical alloknesis under the enzymatic control of DPPIV

○Eriko Komiya1, Ryo Hatano2, Takumi Itoh2, Kotaro Honda1, Yayoi Kamata1,3, Sumika Toyama1, Catharina Sagita Moniaga1,Haruna Otsuka2, Kei Ohnuma2, Mitsutoshi Tominaga1,3, Chikao Morimoto2, Kenji Takamori1,3,4

1Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender Specific Medicine, Graduate School of Medicine,Juntendo University, Chiba, Japan, 2Department of Therapy Development and Innovation for Immune Disorders and Cancers,Graduate School of Medicine, Juntendo University, Tokyo, Japan, 3Anti-Aging Skin Research Laboratory, Juntendo University GraduateSchool of Medicine, Chiba, Japan, 4Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan

C01-05[P01-09]

Calreticulin, an endoplasmic reticulum stress sensor, modulates human melanocytes apoptosis: possibleimplication in vitiligo pathogenesis?

○Pu Song, Weigang Zhang, Gang Wang, Tianwen Gao, Chunying Li, Ling Liu

Deaprtment of Dermatology, The Fourth Military Medical University, Xi’an, China

C01-06[P01-10]

Detection of bullous pemphigoid and mucous membrane pemphigoid autoantibodies using native BP180/integrinα6β4 complexes from keratinocytes○Shoko Mai1, Yosuke Mai1, Kentaro Izumi1, Norito Ishii2, Daisuke Sawamura3, Franziska Schauer4, Dimitra Kiritsi4, Wataru Nishie1

1Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Department of Dermatology,Kurume University School of Medicine, Fukuoka, Japan, 3Department of Dermatology, Hirosaki University Graduate School ofMedicine, Hirosaki, Japan, 4Department of Dermatology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg,Germany

C01-07[P01-11]

Effect of hBD-3 on Th2 cytokine-mediated modulation of autophagy in human keratinocytes

○Ge Peng1,2, Risa Ikutama1,2, Yoshie Umehara1, Juan Valentin Trujillo1, Hainan Yue1,2, Le Thanh Hai Nguyen1,2, Miho Takahashi1,2,Shun Kageyama3, Masaaki Komatsu3, Ko Okumura1, Hideoki Ogawa1, Shigaku Ikeda1,2, François Niyonsaba1,4

1Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology andAllergology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Physiology, Juntendo University Graduate School ofMedicine, Tokyo, Japan, 4Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan

C01-08[P01-12]

The possible linkage of granzyme B-producing resident memory T cells with the disease prognosis of alopeciaareata

○Hanako Koguchi-Yoshioka1,2, Rei Watanabe1,2, Yutaka Matsumura1,2, Naoko Okiyama2, Yasuhiro Fujisawa2, Manabu Fujimoto1,2

1The Department of Dermatology, Osaka University, Osaka, Japan, 2The Department of Dermatology, University of Tsukuba, Ibaraki,Japan

C01-09[P01-13]

The pathogenic role of classical monocyte-derived cells in psoriatic inflammation

○Joohee Lee1, Lihua Che1, Sung Hee Kim2, Je Yeon Park2, Soo Min Kim3, Burkhard Becher4, Doyoung Kim2, Tae-Gyun Kim1,2,Min-Geol Lee2

1Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul, South Korea, 2Department ofDermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea, 3Department of Dermatology, NationalHealth Insurance Service Ilsan Hospital, Goyang, South Korea, 4Institute of Experimental Immunology, University of ZurichSwitzerland

C01-10[P01-14]

Estradiol regulates imiquimod-induced psoriasiform dermatitis in mice by suppressing the infiltration ofneutrophils and monocytes

○Akimasa Adachi1, Tetsuya Honda1, Pierre Chambon2, Koichi Ikuta3, Kenji Kabashima1,4

1The Department of Dermatology, Kyoto University, Kyoto, Japan, 2Institut de Genetique et de Biologie Moleculaire et Cellulaire,CNRS/INSERM/ULP, College de France, Paris, France, 3Laboratory of Immune Regulation, Department of Virus Research, Institute forFrontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, 4Singapore Immunology Network (SIgN) and Skin ResearchInstitute of Singapore (SRIS), Technology and Research (A*STAR), Biopolis, Singapore

C01-11[P01-15]

PD1+ CD8+ resident memory T cells (TRM) abundantly infiltrating in the epidermis possibly represent apathogenic TRM subset in psoriasis

○Pawit Phadungsaksawasdi, Toshiharu Fujiyama, Kazuo Kurihara, Taisuke Ito, Tetsuya Honda, Yoshiki Tokura

Department of Dermatology, Hamamatsu university school of medicine, Shizuoka, Japan

C01-12[P01-18]

The role of TSLPR in the pathogenesis of chronic graft-versus-host disease

○Kazuya Goto, Mai Ishigaki, Akihiko Kitoh, Kenji Kabashima

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan

C01-13[P01-19]

Loss of nuclear-localized AIM2 attenuates autoimmunity by impairing Tfh cell differentiation

○Haijing Wu

Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China

C01-14[P01-20]

CD147/Basigin regulates Th17 cell differentiation and contributes to the pathogenesis of psoriasis

○Aoi Okubo1, Youhei Uchida1, Yuko Higashi1, Akihiro Ryuge2, Kenji Kadomatsu2, Takuro Kanekura1

1Department of Dermatology, Kagoshima University, Kagoshima, Japan, 2Department of Biochemistry, Nagoya University, Aichi, Japan


- 35 -

C01-15[P01-22]

Suppression of Neuropeptide by Botulinum Toxin Improves Imiquimod-induced Psoriasis-like Dermatitis via theRegulation of Neuroimmune System

○Syahla N. Amalia, Akihiko Uchiyama, Hritu Baral, Yuta Inoue, Sahori Yamazaki, Chisako Fujiwara, Akiko Sekiguchi,Yoko Yokoyama, Sachiko Ogino, Ryoko Torii, Mari Hosoi, Osamu Ishikawa, Sei-ichiro Motegi

Department of Dermatology, Gunma University, Maebashi

Concurrent Oral Session 2(Carcinogenesis/Growth Factors/Signal Transduction/Cancer Genetics)

C02-01[P02-02]

Targeting the JAK/STAT3 pathway with Ruxolitinib in a novel mouse model of RDEB-cSCC

○Joanna Jackow1,2, Avian Rami1, Ryota Hayashi1, Corey Hansen1, Zongyou Guo1, Dom DeLorenzo1, Alberto Pappalardo1,Arianna L. Kim1, Rolando Perez-Lorenzo1, David M. Owens1, Angela M. Christiano1

1Department of Dermatology, Columbia University, New York, USA, 2St John’s Institute of Dermatology, King’s College London (Guy’scampus), London, UK

C02-02[P02-03]

Extramammary Paget’s disease patient-derived xenografts harboring ERBB2 S310F mutation show sensitivity totargeted therapy and chemotherapy

○Takuya Maeda1, Shinya Kitamura1, Hiroshi Nishihara2, Teruki Yanagi1

1Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan,2Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan

C02-03[P02-04]

Multi-sample Exome Sequencing of Porocarcinoma Shows High Intratumoral Heterogeneity and Early Branchingfrom Preceding Poroma

○Hiroyuki Irie, Yoshihiro Ishida, Atsushi Otsuka, Kenji Kabashima


C02-04[P02-05]

Genomic analysis of extramammary Paget disease identifies disease subtypes that converge in PIK3/Akt pathway

○Yoshihiro Ishida, Hiroyuki Irie, Atsushi Otsuka, Kenji Kabashima

Department of Dermatology, Kyoto University

Concurrent Oral Session 3(Cell Adhesion/Matrix/Vascular Biology)

C03-01[P03-02]

The Effect of Conditional Sox9 Knockout in the Endothelium on Melanoma Tumour Vascularisation andMetastasis

○Ghazaleh Hashemi, James Dight, Laura Sormani, Kiarash Khosrotehrani

The University of Queensland Diamantina Institute, Translational Research Institute, QLD, Australia

C03-02[P03-03]

A calpain inhibitor ALLN ameliorates bleomycin-induced skin fibrosis via antagonizing TGF-β/Smad signalingpathway

○Hiroshi Kasamatsu1, Akira Utsunomiya1, Natsuko Utsunomiya1, Takumi Hasegawa1, Takenao Chino1, Noritaka Oyama1,Masami Yamada2, Minoru Hasegawa1

1Department of Dermatology, University of Fukui, Fukui, Japan, 2Department of Cell Biology and Biochemistry, University of Fukui,Fukui, Japan

C03-03[P03-04]

Hypoxia causes dysregulation of BMP10/GATA6 axis in pulmonary artery hypertension

○Tetsuo Toyama1, Hinako Saito1, Sohshi Morimura1, Maria Trojanowska2, Makoto Sugaya1

1Department of Dermatology, International University of Health and Welfare, Narita, Japan, 2Arthritis Center, Boston University Schoolof Medicine, Boston, MA, USA

Concurrent Oral Session 4(Human Clinical Research and Therapeutics)

C04-01[P04-02]

Biomonitoring analysis is beneficial for full-thickness skin grafting

○Takao Oda1, Hiroshi Kato1, Motoki Nakamura1, Maki Yoshimitsu2, Azusa Magara3, Akimichi Morita1

1Department of Geriatric and Environmental Dermatology, Nagoya City University, Aichi, Japan, 2Okazaki city hospital, Aichi, Japan,3Konan Kosei Hospital, Aichi, Japan

C04-02[P04-03]

Botulinum toxin B injection for digital ulcers and Raynaud’s phenomenon in systemic sclerosis: Double-Blind,Randomized Controlled Trial

○Sei-ichiro Motegi1, Akiko Sekiguchi1, Miho Oue2, Hisako Sumiyoshi2, Tetsuya Nakamura2, Osamu Ishikawa1

1Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan, 2Clinical Investigation and ResearchUnit, Gunma University Graduate School of Medicine, Maebashi, Japan


- 36 -

C04-03[P04-04]

Skin atrophy caused by topical glucocorticoids is less common in patients with atopic dermatitis than in thosewith psoriasis

○Chung Hyeok Lee1, Sung Jay Choe1, Dong Hye Kim1, Eun Jung Kim1, Minseob Eom2, Seung-Phil Hong1, Eung Ho Choi1

1Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea, 2Department of Pathology,Yonsei University Wonju College of Medicine, Wonju, Republic of Korea

C04-04[P04-05]

The effect of topical minoxidil on autosomal recessive woolly hair/hypotrichosis caused by LIPHmutations

○Tomoki Taki1, Kana Tanahashi1,2, Takuya Takeichi1, Takenori Yoshikawa1, Yuya Murase1, Kazumitsu Sugiura2, Masashi Akiyama1

1The Department of Dermatology, Nagoya University Graduate School of Medicine, Aichi, Japan, 2Department of Dermatology, FujitaHealth University School of Medicine, Aichi, Japan

C04-05[P04-06]

Macrophages are the major cellular sources of IL-31 in atopic dermatitis: a novel network of itch comprisingTSLP, periostin, and basophils

○Takashi Hashimoto1,2, Yuki Yamazaki1, Hiroo Yokozeki2, Takahiro Satoh1

1Department of Dermatology, National Defense Medical College, Tokorozawa, Japan, 2Department of Dermatology, Graduate Schoolof Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

C04-06[P04-07]

Dupilumab Safety and Efficacy in Adult Patients With Moderate-to-Severe Atopic Dermatitis: An Analysis of upto 100 Weeks (LIBERTY AD OLE)

○JooYoung Roh1, ChunWook Park2, KyuHan Kim3, Joohyung Lee4, Xian Sun5, Ana B. Rossi6, Brad Shumel5

1Department of Dermatology, Gachon University College of Medicine, Gil Medical Center, Incheon, South Korea, 2Department ofDermatology, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, 3Department of Dermatology, Seoul NationalUniversity College of Medicine, Seoul, South Korea, 4Sanofi Genzyme, Seoul, South Korea, 5Regeneron Pharmaceuticals, Inc.,Tarrytown, NY, USA, 6Sanofi Genzyme, Cambridge, MA, USA

C04-07[P04-08]

Assessment of psoriasis skin lesion using AI

○Takashi Okamoto1, Masataka Kawai2, Shinji Shimada1, Tatsuyoshi Kawamura1

1Department of Dermatology, University of Yamanashi, Yamanashi, Japan, 2Department of Human pathology, University ofYamanashi, Yamanashi, Japan

C04-08[P04-09]

Ultraviolet A1 light emitting diodes for dyshidrotic palmoplantar eczema

○Kyoko Ikumi1, Tomohiko Kio1,2, Kan Torii1, Hideyuki Masuda1,2, Akimichi Morita1

1Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya,Japan, 2R&D Group, Biomedical Division, USHIO INC, Tokyo, Japan

C04-09[P04-10]

The oral microbial composition and diversity affected the clinical course of palmoplantar pustulosis patients afterdental infection control

○Michiyoshi Kouno1, Yurie Akiyama2, Masaki Minabe2, Jyunichiro Inada2, Takeshi Nomura2, Kazuyuki Ishihara3, Shinichi Takahashi1

1The Department of Dermatology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan, 2The Department of Oral Medicine,Oral and Maxillofacial Surgery, Tokyo Dental College, 3The Department of Microbiology, Tokyo Dental College

C04-10[P04-11]

Dupilumab Decreases Blood Biomarkers in Patients With Erythrodermic Atopic Dermatitis - A Pooled SubgroupAnalysis

○Emma Guttman-Yassky1, Jonathan I. Silverberg2, Alan D. Irvine3,4, Kenji Kabashima5, Moon Bum Kim6, Zhen Chen7, Hiroyuki Fujita8,Kazuhiko Arima8, Sivan Harel7, Yufang Lu7, Ana B. Rossi9, Arsalan Shabbir7

1Icahn School of Medicine at Mount Sinai Medical Center, New York, NY, 2George Washington University School of Medicine,Washington, DC, USA, 3Trinity College Dublin, Dublin, Ireland, 4National Children’s Research Centre, Our Lady’s Children’s HospitalCrumlin, Dublin, Ireland, 5Kyoto University Graduate School of Medicine, Kyoto, Japan, 6Pusan National University Hospital, Busan,South Korea, 7Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA, 8Sanofi K.K., Tokyo, Japan, 9Sanofi Genzyme, Cambridge, MA,USA

Concurrent Oral Session 5(Epidermal Structure and Function)

C05-01[P05-02]

Aberrant sebaceous lipid metabolism in the early stage of spontaneous dermatitis in Tmem79-deficient mice

○Ari Morimoto1,2, Yoshihiro Ito1,2, Takashi Sasaki3, Aiko Shiohama1, Hiroshi Kawasaki1,4, Ai Hirabayashi2, Mayuko Sato5,Kiminori Toyooka5, Eiryo Kawakami6,7, Tatsuro Naganuma8,9, Makoto Arita8,9, Haruhiko Koseki4,10, Takeshi Matsui2, Masayuki Amagai1,2

1Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Laboratory for Skin Homeostasis, RIKEN Center forIntegrative Medical Sciences, Yokohama, Japan, 3Center for Supercentenarian Medical Research, Keio University School of Medicine,Tokyo, Japan, 4Immunology Data Integration Unit, RIKEN Medical Sciences Innovation Hub Program, Yokohama, Japan, 5MassSpectrometry and Microscopy Unit, RIKEN Center for Sustainable Resource Science, Yokohama, Japan, 6RIKEN Medical SciencesInnovation Hub Program, Yokohama, Japan, 7Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba,Japan, 8Division of Physiological Chemistry and Metabolism, Faculty of Pharmacy, Keio University, Tokyo, Japan, 9Laboratory forMetabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 10Laboratory for Developmental Genetics, RIKENCenter for Integrative Medical Sciences, Yokohama, Japan


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C05-02[P05-03]

Kinetic analysis of regulatory T cells in skin barrier disruption

○Sumika Toyama1, Catharina Sagita Moniaga1, Mitsutoshi Tominaga1,2, Hideoki Ogawa1, Kenji Takamori1,2,3

1Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate Schoolof Medicine, Chiba, Japan, 2Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, 3Department ofDermatology, Juntendo University Urayasu Hospital

C05-03[P05-04]

Trichohyalin-like 1 protein plays a crucial role in the proliferation of normal human keratinocytes and squamouscell carcinoma cells

○Teruhiko Makino1, Megumi Mizawa1, Yoko Yoshihisa1, Seiji Yamamoto2, Yoshiaki Tabuchi3, Masashi Miyai4, Tadamichi Shimizu1

1Department of Dermatology, University of Toyama, Toyama, Japan, 2Department of Pathology, University of Toyama, Toyama, Japan,3Division of Molecular Genetics Research, Life Science Center, University of Toyama, Toyama, Japan, 4Shiseido Global InnovationCenter, Yokohama, Japan

C05-04[P05-05]

Sphingosine 1-phosphate receptor 2 (S1PR2) deficiency promotes S. aureus invasion

○Satomi Igawa1,2, Phoebe Pham2, Zhenping Wang2, Ayaka Ohzono2, Teuaki Nakatsuji2, Akemi Ishida-Yamamoto1, Anna Di Nardo2

1The Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan, 2The Department of Dermatology, School ofMedicine, University of California, San Diego, La Jolla, USA

C05-05[P05-06]

Ceramide reduction in stratum corneum in autosomal recessive congenital ichthyosis caused by a NIPAL4mutation

○Yuya Murase1, Takuya Takeichi1, Akane Kawamoto2, Kana Tanahashi1, Yusuke Okuno3, Hiroyuki Takama4, Eri Shimizu5,Junko Ishikawa2, Tomoo Ogi6, Masashi Akiyama1

1Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Biological Science ResearchLaboratories, Kao Corporation, Haga, Japan, 3Center for Advanced Medicine and Clinical Research, Nagoya University Hospital,Nagoya, Japan, 4Department of Dermatology, Aichi Medical University, Nagakute, Japan, 5Analytical Science Research Laboratories,Kao Corporation, Haga, Tochigi, Japan, 6Department of Genetics, Research Institute of Environmental Medicine, Nagoya University,Nagoya, Japan

C05-06[P05-08]

The effect of antimicrobial peptide derived from insulin-like growth factor-binding protein 5 on skin barrierregulation

○Hai LT. Nguyen1,2, Juan Valentin Trujillo2, Ge Peng1,2, Hainan Yue1,2, Risa Ikutama1,2, Miho Takahashi1,2, Yoshie Umehara2,Hideoki Ogawa2, Shigaku Ikeda1,2, François Niyonsaba2,3

1Department of Dermatology and Allergology, Juntendo University Graduate School of Medecine, Tokyo, Japan, 2Atopy (Allergy)Research Center, Juntendo University, Tokyo, Japan, 3Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan

Concurrent Oral Session 6(Epidemiology/Health Service Research)

C06-01[P06-01]

Withdrawn

Concurrent Oral Session 7(Genetic Disease/Gene Regulation and Gene Therapy)

C07-01[P07-03]

Association of IL-12B polymorphism with secondary failure of Infliximab therapy to psoriasis

○Kan Torii, Akimichi Morita

Department of Geriatric and Environmental Dermatology, Nagoya City University, Aichi, Japan

C07-02[P07-04]

Generation of junctional epidermal model mice with revertant mosaicism

○Hong Ha Nguyen1, Satoru Shinkuma1, Shota Takashima2, Masashi Mori3, Masahito Ikawa3, Hiroshi Shimizu2, Riichiro Abe1

1Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 2Department ofDermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 3Department of Experimental Genome Research,Genome Information Research Center, Osaka University, Osaka, Japan

C07-03[P07-05]

Nanopore sequencing reveals filaggrin gene structure and mutation patterns associated with gene evolution andichthyosis vulgaris phenotypes

Colin Wong1, Vipin Narang2, Simon Denil1, Duan Kaibo2, Yik Weng Yew3, Bernett Lee2,○John E. Common1

1Skin Research Institute of Singapore, A*STAR, Singapore, 2Singapore Immunology Network, A*STAR, Singapore, 3National SkinCentre, Singapore


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C07-04[P07-06]

Intravenous injection of multilineage-differentiating stress-enduring (Muse) cells as a therapeutic approach forepidermolysis bullosa mice

○Yasuyuki Fujita1,2, Miho Komatsu1, San Eun Lee1,3, Yoshihiro Kushida4, Chihiro Nakayama-Nishimura1, Wakana Matsumura1,Shota Takashima1, Satoru Shinkuma1,5, Toshifumi Nomura1, Naoya Masutomi6, Makoto Kawamura6, Mari Dezawa4, Hiroshi Shimizu1

1Department of Dermatology, Hokkaido University Graduate School of Medicine and Faculty of Medicine, Sapporo, Japan,2Department of Dermatology, Sapporo City General Hospital, Sapporo, Japan, 3Department of Dermatology, Gangnam SeveranceHospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea, 4Department of Stem CellBiology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan, 5Department of Dermatology, Nara MedicalUniversity School of Medicine, Kashihara, Japan, 6Life Science Institute Inc., Tokyo, Japan

C07-05[P07-07]

A genetic correlation study identified eight diseases and traits associated with psoriasis

○Yukinori Okada, Kotaro Ogawa

Department of Statistical Genetics, Osaka University Graduate School of Medicine

C07-06[P07-08]

Aberrant keratin assembly causes impaired mitochondrial movement and function: Implications forepidermolysis bullosa simplex pathogenesis

○Osamu Ansai1, Ryota Hayashi1, Satoru Shinkuma1,2, Asuka Suto3, Hiroshi Shimizu3, Riichiro Abe1

1Division of Dermatology, Niigata University School of Medical and Dental Science, 2Department of Dermatology, Nara MedicalUniversity School of Medicine, 3Department of Dermatology, Hokkaido University Graduate School of Medicine

C07-07[P07-09]

Delineating the chain of events that trigger premature cell ageing in Hutchinson-Gilford Progeria Syndrome

○Oliver Dreesen1, Peh Fern Ong1, Alexandre Chojnowski2, Mattheus Xing Rong Foo1

1Skin Research Institute of Singapore, 2Institute of Medical Biology, Singapore

C07-08[P07-10]

Phenotypic suppression of acral peeling syndrome in a patient with autosomal recessive congenital ichthyosis

○Janan Mohamad1,2, Arti Nanda3, Mor Pavlovsky1, Alon Peled1,2, Natalia Malchin1, Kiril Malovitski1,2, Rashida Pramanik4,Daphna Weissglas-Volkov5, Noam Shomron5, John A. McGrath4, Ofer Sarig1, Eli Sprecher1,2

1Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 2Department of Human Molecular Genetics andBiochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel, 3As’ad Al-Hamad Dermatology Center, Kuwait, 4StJohn’s Institute of Dermatology, King’s College London, London, UK, 5Department of Cell and Developmental Biology, Sackler Facultyof Medicine, Tel-Aviv University, Tel Aviv, Israel

Concurrent Oral Session 8(Tissue Regeneration/Stem Cell and Wound Healing)

C08-01[P08-04]

Abrogation of Sox9 expression in the endothelium blocks aberrant vascular EndMT and fibrosis

○Jilai Zhap1, Jatin Patel1, Sam Kahler1, Hamish Hamilton1, Isabella Hogan1, James Dight1, Ho Yi Wong1, SeenLing Sim1,Mervyn Yoder2, Kiarash Khosrotehrani1

1Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia, 2Indiana University School of Medicine, Indianapolis,Indiana, United States of America

C08-02[P08-05]

Effect of human β-defensin-3 on wound healing○Miho Takahashi1,2, Yoshie Umehara1, Hainan Yue1,2, Juan Valentin Trujillo1, Ge Peng1,2, Le Thanh Hai Nguyen1,2, Risa Ikutama1,2,Ko Okumura1, Hideoki Ogawa1, Shigaku Ikeda1,2, François Niyonsaba1,3

1Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology andAllergology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Faculty of International Liberal Arts, JuntendoUniversity, Tokyo, Japan

C08-03[P08-06]

Ninjurin-1 contributes to skin wound healing by promoting pericyte-endothelial cell interaction

○Risa Matsuo, Mari Kishibe, Shin Iinuma, Mizue Fujii, Satomi Igawa, Masaru Homma, Akemi Ishida-Yamamoto

The Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan

C08-04[P08-07]

Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healingvia MAPK pathways

○Hainan Yue1,2, Yoshie Umehara2, Juan Valentin Trujillo2, Ge Peng1,2, Hai LT. Nguyen1,2, Miho Takahashi1,2, Risa Ikutama1,2,Ko Okumura2, Shigaku Ikeda1,2, Hideoki Ogawa2, François Niyonsaba2,3

1The Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Atopy (Allergy)Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Faculty of International Liberal Arts, JuntendoUniversity Graduate School of Medicine, Tokyo, Japan

C08-05[P08-08]

The importance of Sirtuins in skin and new findings about Sirt2 and its link to mechanobiology

○Jacqueline Trivero1, Kelly Dong1, Earl Goyarts1, Edward Pelle1, Donald Collins1, Krystle Corallo1, Nadine Pernodet1,2

1Research & Development, The Estee Lauder Companies, Melville, New York, USA, 2Estee Lauder Research Laboratories, Melville,New York, USA


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C08-06[P08-09]

Specific Visualization of Skin Graft Neoangiogenesis in a Flt1-tdsRed BAC Transgenic Mouse Model

○Mohamed Abdelhakim1, Teruyuki Dohi1, Mizuho Yamato1, Hiroya Takada1, Masatsugo Ema2, Shigetomo Fukuhara3, Rei Ogawa1

1Department of Plastic, Reconstructive, and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan, 2Department of Stem Cells &Human Disease Models, Shiga University of Medical Science, Tokyo, Japan, 3Department of Molecular Pathophysiology, Institute ofAdvanced Medicine, Nippon Medical School, Tokyo, Japan

C08-07[P08-10]

IL-36 receptor antagonist (IL36Ra) deficiency disturbs wound healing in cutaneous ischemia-reperfusion injury

○Yoshihito Tanaka1, Yohei Iwata1, Yurie Hasegawa1, Hidehiko Fukushima1, Kenta Saito1, Soichiro Watanabe1, Masashi Akiyama2,Kazumitsu Sugiura1

1Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan, 2Department of Dermatology, NagoyaUniversity Graduate School of Medicine, Aichi, Japan

Concurrent Oral Session 9(Hair and Cutaneous Development)

C09-01[P09-02]

Hair follicle stem cell progeny repair subepidermal blisters at the expense of skin development

○Yu Fujimura1, Mika Watanabe1,2, Kota Ohno3, Yasuaki Kobayashi3, Hideki Nakamura1, Andrea Lauria2,4, Valentina Proserpio2,4,Hideyuki Ujiie1, Hiroaki Iwata1, Wataru Nishie1, Masaharu Nagayama3,5, Salvatore Oliviero2,4, Giacomo Donati2, Hiroshi Shimizu1,Ken Natsuga1

1Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Department of Life Sciences andSystems Biology, Molecular Biotechnology Centre, University of Turin, Turin, Italy, 3Research Institute for Electronic Science,Hokkaido University, Sapporo, Japan, 4Italian Institute for Genomic Medicine, Candiolo (TO), Italy, 5Japan Science and TechnologyAgency, CREST, Kawaguchi, Japan

C09-02[P09-03]

Multicolor three-dimensional reconstruction of whole murine sweat glands using optical clearing and two-photon excitation microscopy

○Tadatsune Iida, Daiki Fukae, Hiroo Yokozeki

Department of dermatology, Tokyo Medical and Dental University, Tokyo, Japan

C09-03[P09-04]

An underlying mechanism of hair loss in acrodermatitis enteropathica

○Riko Asakawa, Shinji Shimada, Tatsuyoshi Kawamura

Department of Dermatology, University of Yamanashi, Yamanashi, Japan

C09-04[P09-05]

Introduction of hTERT and hBMI1 genes extends the life span of human dermal papilla cells with hair inductiveactivity

○Mayumi Ikeda1,2, Shigeharu Yabe2, Masahiro Kiso2, Naoko Ishiguro3, Tetsuya Tsuchida1, Koichiro Nakamura1, Yuichiro Tsunemi1,Hitoshi Okochi2

1Department of Dermatology, Saitama Medical University, 2Department of Regenerative Medicine, Research Institute, National Centerfor Global Health and Medicine, 3Department of Dermatology, Tokyo Women Medical University

Concurrent Oral Session 10(Immunology 1: Adaptive Immunity)

C10-01[P10-04]

CD4+ resident memory T cells colocalize with conventional DC subset 2 in lymphocyte clusters in a murinedelayed-type hypersensitivity model

○Ryota Asahina, Gyohei Egawa, Kenji Kabashima

The Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

C10-02[P10-05]

Suppression of IL-23-mediated psoriasis-like inflammation by regulatory B cells

○Kie Mizumaki, Miyu Kano, Takashi Matsushita

The Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, KanazawaUniversity, Kanazawa, Japan

C10-03[P10-06]

Cell model of Stevens-Johnson syndrome and toxic epidermal necrolysis

○Akito Hasegawa, Tomoki Nishiguchi, Riichiro Abe

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

C10-04[P10-07]

AIM2 regulates anti-tumor immunity and serves as a viable therapeutic target for melanoma

○Keitaro Fukuda1, Rebecca L. Riding2, Xueli Fan2, Sean M. McCauley3, Jeremy Luban3, Takeru Funakoshi1, Tomonori Yaguchi4,Yutaka Kawakami4, Anastasia Khvorova5, Katherine A. Fitzgerald6, John E. Harris2

1Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Department of Dermatology, University ofMassachusetts Medical School, Worcester, MA, USA, 3Department of Biochemistry and Molecular Pharmacology, University ofMassachusetts Medical School, Worcester, MA, USA, 4Division of Cellular Signaling, Institute for Advanced Medical Research, KeioUniversity School of Medicine, Tokyo, Japan, 5Department of Molecular Medicine, University of Massachusetts Medical School,Worcester, MA, USA, 6Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester,MA, USA


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C10-05[P10-08]

Tumor necrosis factor-alpha plays pivotal role in cytotoxic T lymphocyte-induced dermatitis

○Toshiya Miyake, Gyohei Egawa, Kenji Kabashima

Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

C10-06[P10-09]

FABP5 as a possible biomarker in atopic march: FABP5-induced Th17 polarization, both in mouse model andhuman samples

Jungsoo Lee1,2,3, Bomi Kim1, Howard Chu1,○Kelun Zhang1,4, Hyeran Kim1, Ji Hye Kim1,4, Seo Hyeong Kim1,4, Youdong Pan5,Ji Yeon Noh1, ZhengWang Sun1, Jung-Won Park6,7, Thomas S Kupper5, Chang Ook Park1,4,5,7, Kwang Hoon Lee1,6,7

1Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea,2Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea, 3Research Institute for Convergence ofBiomedical Science and Technology, Yangsan, Korea, 4Brain Korea 21 Project for Medical Science, Yonsei University College ofMedicine, Seoul, Korea, 5Department of Dermatology & Harvard Skin Disease Research Center, Brigham and Women’s Hospital,Boston, Harvard Medical School, Boston, Massachusetts, USA, 6Division of Allergy and Immunology, Department of InternalMedicine, Yonsei University College of Medicine, Seoul, Korea, 7Institute of Allergy, Yonsei University College of Medicine, Seoul,Korea

C10-07[P10-10]

Character and function of human epidermal resident regulatory CD4+ T cells

○Takuya Sato, Youichi Ogawa, Shinji Shimada, Tatsuyoshi Kawamura


C10-08[P10-12]

Attenuation of percutaneous sensitization by oral tolerance induction is independent of Treg-mediatedimmunosuppression in the skin

○Arisa Akagi1, Akihiko Kitoh1, Sho Hanakawa1, Kenji Kabashima1,2

1Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Singapore Immunology Network and SkinResearch Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore

Concurrent Oral Session 11(Immunology 2: Innate Immunity and Microbiology)

C11-01[P11-02]

Single-Cell RNA Sequencing Reveals Novel Cutaneous Group 2 Innate Lymphoid Cell Subtypes, Circulating ILC2,and Skin-Resident ILC2

○Minori Kusakabe1, Yasutomo Imai1, Makoto Nagai1, Koubun Yasuda2, Etsushi Kuroda2, Michio Tomura3, Kiyofumi Yamanishi1

1Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan, 2Department of Immunology, Hyogo College ofMedicine, Nishinomiya, Japan, 3Laboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University, Osaka, Japan

C11-02[P11-03]

Skin bacteria in serum exosome related to dysbiosis of skin microbiome in atopic dermatitis

○Toru Kawai1, Ryota Hayashi1, Akito Hasegawa1, Akihiko Yuki1, Osamu Ansai1, Koichi Tomii1, Jun Adachi2,3, Takeshi Tomonaga2,3,Riichiro Abe1

1Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, 2Laboratory of Proteome Research,National Institute of Biomedical Innovation, Health and Nutrition, 3Laboratory of Proteomics for Drug Discovery, Center for DrugDesign Research, National Institute of Biomedical Innovation

C11-03[P11-04]

CRH receptor mediated signalling is a therapeutic target for stress-related diseases by controlling excessive mastcells biology

○Mika Yamanaka-Takaichi, Koji Sugawara, Daisuke Tsuruta

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan

C11-04[P11-05]

The dysregulation of DNA methylation enzymes and synchronized gene expression of retrotransposon and type Iinterferon in dermatomyositis

○Yuko Kuriyama, Akira Shimizu, Saki Kanai, Sei-ichiro Motegi, Osamu Ishikawa

The Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan

C11-05[P11-06]

Female hormones enhance HIV-1 acquisition in female Langerhans cells, but not in male Langerhans cells

○Youichi Ogawa, Shinji Shimada, Tatsuyoshi Kawamura


C11-06[P11-07]

Essential role of the CCL2-CCR2 pathway in the pathogenesis of chronic irritant contact dermatitis

○Rintaro Shibuya1, Akihiko Kitoh1, Sho Hanakawa1, Yoshihiro Ishida1, Kenji Kabashima1,2

1Department of Dermatology, Kyoto University Graduate School of Medicine, 2Singapore Immunology Network and Skin ResearchInstitute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore

C11-07[P11-08]

Differential lipid recognition by mouse vs human CD300f, inhibiting IgE-mediated anaphylaxis, depends on asingle amino acid substitution

○Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Akie Maehara, Moe Matsuzawa, Taiki Ando, Takuma Ide, Yoko Okamoto,Saaya Fukase, Mayuki Kojima, Anna Kamei, Meiko Kimura, Hexing Wang, Ko Okumura, Jiro Kitaura

Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan


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Concurrent Oral Session 12(Photobiology)

C12-01[P12-02]

Skin regulatory T cells possessing a healing function are expanded by ultraviolet-B exposure

○Sayuri Yamazaki1, Hiroaki Shime1, Mizuyu Odanaka1, Makoto Tsuiji2, Takuma Matoba1,3, Masaki Imai1, Yoshiaki Yasumizu4,Ryuta Uraki1, Kiyoshi Minohara1,3, Maiko Watanabe1, Anthony John Bonito5, Hidehiro Fukuyama6, Naganari Ohkura4,7,Shimon Sakaguchi4, Akimichi Morita8

1Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, 2Department ofMicrobiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan, 3Department of Oto-rhino-laryngology and Head-and-neck-surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, 4Departmentof Experimental Immunology, World Premier International Research Center Initiative, Immunology Frontier Research Center, OsakaUniversity, Osaka, Japan, 5Immunoassay Research & Development, Laboratory Diagnostics, Siemens Healthineers, NY, USA,6Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan,7Immunopharmaceutical Development Unit, Center of Medical Innovation Research, Graduate School of Medicine, Osaka University,Osaka, Japan, 8Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of MedicalSciences, Nagoya, Japan

C12-02[P12-04]

Nicotinamide Modulates Photoaging in Human Primary Keratinocytes

○Christina YR Tan1, Chye L Tan1, Toby Chin1, Holly A Rovito2, Malgorzata E Morenc1, Ling S Quek1, John E Oblong2,Sophie Bellanger1

1Skin Stemness, Differentiation and Aging, Skin Research Institute of Singapore, A*STAR, Singapore, 2Beauty Technology Division, TheProcter & Gamble Company, Cincinnati, OH, USA

C12-03[P12-05]

The study of threshold of acute reactions on human skin with shorter wavelength UVC

○Nozomi Yamano1, Makoto Kunisada1, Aiko Nishiaki-Sawada2, Hiroyuki Ohashi2, Tatsushi Igarashi2, Chikako Nishigori1

1Division of Dermatology, Department of Internal Related, Graduate School of Medicine, Kobe University, Kobe, Japan, 2Ushio Inc.,Chiyoda-ku, Tokyo, Japan

Concurrent Oral Session 13(Pigmentation and Melanoma)

C13-01[P13-02]

Biomechanically regulated cellular processes of melanoma cell invasion and survival in confined environments

○Robert J Ju, Yash Chhabra, Samantha S Stehbens, Nikolas K Haass

The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia

C13-02[P13-03]

Increase in melanoma-antigen specific intracellular PD-1+ T cells in advanced melanoma patients

○Ryo Takahashi1, Yohei Sato2, Momoko Kimishima2, Manabu Ohyama1,2

1Flow Cytometry Core Facility, Kyorin University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology, KyorinUniversity Faculty of Medicine, Tokyo, Japan

C13-03[P13-05]

Usefulness of monitoring circulating tumor cells as a therapeutic biomarker in melanoma with BRAF mutation

○Yukiko Kiniwa1, Kenta Nakamura1, Asuka Mikoshiba1, Atsuko Ashida1, Yasuyuki Akiyama2, Atsushi Morimoto2, Ryuhei Okuyama1

1Department of Dermatology, Shinshu University School of Medicine, 2Life Science Research Laboratory, Tosoh Corporation

C13-04[P13-06]

microRNA expression and functional analysis in melanoma cells in vitro and in vivo

○Tatiana Ruksha, Elena Nikolaeva, Mariya Aksenenko, Nadezhda Palkina, Danil Zemtsov, Irina Dubovtseva

The Department of Pathophysiology, Krasnoyarsk State Medical University

C13-05[P13-08]

Establishment of co-culture of human induced pluripotent stem (iPS) cell-derived melanocyte and keratinocytesin vitro

○Tamihiro Kawakami, Toshiro Komatsu, Kae Yokoyama, Takaharu Ikeda, Kazuo Takahashi, Yupeng Dong

The Division of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan

C13-06[P13-09]

Functional melanoma cell heterogeneity is regulated by MITF-dependent cell-matrix interactions

○Loredana Spoerri1, Crystal A Tonnessen-Murray1, Gency Gunasingh1, David S Hill2,3, Kimberley A Beaumont2,3, Russell J Jurek4,Helmut Schaider1, Wolfgang Weninger2,3, Brian Gabrielli5, Nikolas K Haass1,2,3

1The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia, 2The Centenary Institute,The University of Sydney, Newtown, NSW, Australia, 3Discipline of Dermatology, Sydney Medical School, The University of Sydney,Camperdown, NSW, Australia, 4CSIRO Astronomy & Space Sciences, Australia Telescope National Facility, Epping, NSW, Australia,5Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia

C13-07[P13-10]

CD8 T cells multifunctionality and PD-L1 expression as a biomarker of anti-PD-1 antibodies in advancedmelanoma

○Keiko Manabe1, Osamu Yamasaki1, Yuki Nakagawa1, Tomoko Miyake1, Heiichiro Udono2, Shin Morizane1

1Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama,Japan, 2Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama, Japan


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C13-08[P13-11]

Effect of particulate matter on melanogenesis

○Eun Jung Lee1, Yuri Ahn1, Ji Young Kim1, Jimyung Seo2, Shinwon Hwang1, Sang Ho Oh1

1Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine,Seoul, Korea, 2Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Engineering (KAIST),Daejeon, Korea

December 11, 9:50 - December 13, 15:00, Digital Poster

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Poster Presentation2019 JSID’s Fellowship Shiseido Research Grant

SE-1 The analysis of Schwann cells in cutaneous immunity

○Atsushi Otsuka

Kyoto University

SE-2 Discovering and identifying novel genetic pathomechanisms for autoinflammatory keratinization diseases

○Takuya Takeichi

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Category 1 (P01): Autoimmunity/Inflammation

P01-01[II-3]

Antifibrotic effect of a novel compound LG283 in bleomycin-induced systemic sclerosis model

○Akira Utsunomiya1, Takenao Chino1, Noritaka Oyama1, Shin-ichiro Niwa2, Masami Otsuka3, Hironobu Ihn4, Minoru Hasegawa1

1Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan, 2Link GenomicsCo., Ltd., Tokyo, Japan, 3Department of Bioorganic Medical Chemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto,Japan, 4Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

P01-02[II-4]

PD-L1 expressed on Langerhans cell negatively regulates imiquimod-induced psoriasis-like dermatitis

○Ryota Tanaka1, Yuki Ichimura1, Noriko Kubota1, Akimasa Saito1, Seiya Mizuno2, Satoshi Takahashi2, Manabu Fujimoto3,Naoko Okiyama1

1Department of Dermatology, Faculty of Medicine, University of Tsukuba, Japan, 2Laboratory Animal Resource Center, Faculty ofMedicine, University of Tsukuba, Japan, 3Department of Dermatology, Graduate School of Medicine, Osaka University, Japan

P01-03[II-6]

Mitochondrial transfer of mesenchymal stem cells effectively protects melanocytes from oxidative stress-inducedmitochondrial dysfunction

○Zhe Jian, Jiaxi Chen, Qi Wang

The Department of Dermatology, Xijing Hospital, Firth Military Medical University, Xi’an, China

P01-04[II-7]

IL-27 plays an important role in anti-desmoglein 3 antibody production in pemphigus vulgaris mouse model

○Aki Kamata1,2, Hayato Takahashi2, Hiroki Yoshida3, Jun Yamagami2, Masayuki Amagai2

1The Department of Dermatology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan, 2Department of Dermatology, KeioUniversity School of Medicine, Tokyo, Japan, 3Division of Molecular and Cellular Immunoscience, Department of BiomolecularSciences, Saga Medical School, Saga, Japan

P01-05[C01-01]

Generation of type XVII collagen-reactive T cell clones

○Norihiro Yoshimoto, Ken Muramatsu, Takamasa Ito, Zheng Miao, Ken Natsuga, Hiroaki Iwata, Wataru Nishie, Hiroshi Shimizu,Hideyuki Ujiie

Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

P01-06[C01-02]

Spinal cord ERK2 is essential for central sensitization of itch in chronic skin inflammation

○Shinsuke Matsuo1, Takashi Hashimoto1, Aiko Furuya1, Sayako Itakura2, Shogo Endo3, Yasushi Satoh4, Takahiro Satoh1

1The Department of Dermatology, National Defense Medical College, Saitama, Japan, 2The Department of Anesthesiology, NationalDefense Medical College, Saitama, Japan, 3Tokyo Metropolitan Geriatric Hosp. and Inst. of Gerontology, Tokyo, Japan, 4TheDepartment of Biochemistry, National Defense Medical College, Saitama, Japan

P01-07[C01-03]

Inflammatory monocyte-derived dendritic cells mediate autoimmunity in murine lupus

○Fumi Miyagawa, Hideo Asada

Department of Dermatology, Nara Medical University, Nara, Japan

P01-08[C01-04]

Endomorphin preferentially induces mechanical alloknesis under the enzymatic control of DPPIV

○Eriko Komiya1, Ryo Hatano2, Takumi Itoh2, Kotaro Honda1, Yayoi Kamata1,3, Sumika Toyama1, Catharina Sagita Moniaga1,Haruna Otsuka2, Kei Ohnuma2, Mitsutoshi Tominaga1,3, Chikao Morimoto2, Kenji Takamori1,3,4

1Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender Specific Medicine, Graduate School of Medicine,Juntendo University, Chiba, Japan, 2Department of Therapy Development and Innovation for Immune Disorders and Cancers,Graduate School of Medicine, Juntendo University, Tokyo, Japan, 3Anti-Aging Skin Research Laboratory, Juntendo University GraduateSchool of Medicine, Chiba, Japan, 4Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan

P01-09[C01-05]

Calreticulin, an endoplasmic reticulum stress sensor, modulates human melanocytes apoptosis: possibleimplication in vitiligo pathogenesis?

○Pu Song, Weigang Zhang, Gang Wang, Tianwen Gao, Chunying Li, Ling Liu

Deaprtment of Dermatology, The Fourth Military Medical University, Xi’an, China


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P01-10[C01-06]

Detection of bullous pemphigoid and mucous membrane pemphigoid autoantibodies using native BP180/integrinα6β4 complexes from keratinocytes○Shoko Mai1, Yosuke Mai1, Kentaro Izumi1, Norito Ishii2, Daisuke Sawamura3, Franziska Schauer4, Dimitra Kiritsi4, Wataru Nishie1

1Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Department of Dermatology,Kurume University School of Medicine, Fukuoka, Japan, 3Department of Dermatology, Hirosaki University Graduate School ofMedicine, Hirosaki, Japan, 4Department of Dermatology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg,Germany

P01-11[C01-07]

Effect of hBD-3 on Th2 cytokine-mediated modulation of autophagy in human keratinocytes

○Ge Peng1,2, Risa Ikutama1,2, Yoshie Umehara1, Juan Valentin Trujillo1, Hainan Yue1,2, Le Thanh Hai Nguyen1,2, Miho Takahashi1,2,Shun Kageyama3, Masaaki Komatsu3, Ko Okumura1, Hideoki Ogawa1, Shigaku Ikeda1,2, François Niyonsaba1,4

1Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology andAllergology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Physiology, Juntendo University Graduate School ofMedicine, Tokyo, Japan, 4Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan

P01-12[C01-08]

The possible linkage of granzyme B-producing resident memory T cells with the disease prognosis of alopeciaareata

○Hanako Koguchi-Yoshioka1,2, Rei Watanabe1,2, Yutaka Matsumura1,2, Naoko Okiyama2, Yasuhiro Fujisawa2, Manabu Fujimoto1,2

1The Department of Dermatology, Osaka University, Osaka, Japan, 2The Department of Dermatology, University of Tsukuba, Ibaraki,Japan

P01-13[C01-09]

The pathogenic role of classical monocyte-derived cells in psoriatic inflammation

○Joohee Lee1, Lihua Che1, Sung Hee Kim2, Je Yeon Park2, Soo Min Kim3, Burkhard Becher4, Doyoung Kim2, Tae-Gyun Kim1,2,Min-Geol Lee2

1Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul, South Korea, 2Department ofDermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea, 3Department of Dermatology, NationalHealth Insurance Service Ilsan Hospital, Goyang, South Korea, 4Institute of Experimental Immunology, University of ZurichSwitzerland

P01-14[C01-10]

Estradiol regulates imiquimod-induced psoriasiform dermatitis in mice by suppressing the infiltration ofneutrophils and monocytes

○Akimasa Adachi1, Tetsuya Honda1, Pierre Chambon2, Koichi Ikuta3, Kenji Kabashima1,4

1The Department of Dermatology, Kyoto University, Kyoto, Japan, 2Institut de Genetique et de Biologie Moleculaire et Cellulaire,CNRS/INSERM/ULP, College de France, Paris, France, 3Laboratory of Immune Regulation, Department of Virus Research, Institute forFrontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, 4Singapore Immunology Network (SIgN) and Skin ResearchInstitute of Singapore (SRIS), Technology and Research (A*STAR), Biopolis, Singapore

P01-15[C01-11]

PD1+ CD8+ resident memory T cells (TRM) abundantly infiltrating in the epidermis possibly represent apathogenic TRM subset in psoriasis

○Pawit Phadungsaksawasdi, Toshiharu Fujiyama, Kazuo Kurihara, Taisuke Ito, Tetsuya Honda, Yoshiki Tokura

Department of Dermatology, Hamamatsu university school of medicine, Shizuoka, Japan

P01-16 Influence of inflammatory factors on epidermal stem cells/progenitor cells due to age-related lymphaticdysfunction

○Yoshie Higuchi, Shunsuke Iriyama

The Global Innovation Center, Shiseido co., ltd., Yokohama, Japan

P01-17 The crosstalk between systemic sclerosis- and systemic lupus erythematosus-related disease processes in a mousemodel of overlap syndrome

○Satoshi Toyama, Shunsuke Miura, Ryosuke Saigusa, Takashi Yamashita, Kouki Nakamura, Megumi Hirabayashi, Takuya Miyagawa,Yuki Fukui, Jun Omatsu, Kentaro Awaji, Ayumi Yoshizaki, Shinichi Sato, Yoshihide Asano

The Department of Dermatology, University of Tokyo, Tokyo, Japan

P01-18[C01-12]

The role of TSLPR in the pathogenesis of chronic graft-versus-host disease

○Kazuya Goto, Mai Ishigaki, Akihiko Kitoh, Kenji Kabashima


P01-19[C01-13]

Loss of nuclear-localized AIM2 attenuates autoimmunity by impairing Tfh cell differentiation

○Haijing Wu

Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China

P01-20[C01-14]

CD147/Basigin regulates Th17 cell differentiation and contributes to the pathogenesis of psoriasis

○Aoi Okubo1, Youhei Uchida1, Yuko Higashi1, Akihiro Ryuge2, Kenji Kadomatsu2, Takuro Kanekura1

1Department of Dermatology, Kagoshima University, Kagoshima, Japan, 2Department of Biochemistry, Nagoya University, Aichi, Japan


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P01-21 A dietary oxysterol, 7-ketocholesterol, exacerbates imiquimod-induced psoriasis-like dermatitis in steatohepatitismice

○Ayami Saga1, Masahiro Koseki1, Kotaro Kanno1, Jiuyang Chang1, Masumi Asaji1, Takeshi Okada1, Hiroyasu Inui1,Yinghong Yinghong1, Tohru Ohama1, Makoto Nishida2, Shizuya Yamashita3, Yasushi Sakata1

1Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan, 2Health Care Division,Health and Counseling Center, Osaka University, Osaka, Japan, 3Rinku General Medical Center, Osaka, Japan

P01-22[C01-15]

Suppression of Neuropeptide by Botulinum Toxin Improves Imiquimod-induced Psoriasis-like Dermatitis via theRegulation of Neuroimmune System

○Syahla N. Amalia, Akihiko Uchiyama, Hritu Baral, Yuta Inoue, Sahori Yamazaki, Chisako Fujiwara, Akiko Sekiguchi,Yoko Yokoyama, Sachiko Ogino, Ryoko Torii, Mari Hosoi, Osamu Ishikawa, Sei-ichiro Motegi

Department of Dermatology, Gunma University, Maebashi

P01-23 Effect of LL-37 on autophagy in human keratinocytes

○Risa Ikutama1,2, Ge Peng1,2, Yoshie Umehara1, Juan Valentin Trujillo1, Hainan Yue1,2, Le Thanh Hai Nguyen1,2, Miho Takahashi1,2,Ko Okumura1, Hideoki Ogawa1, Shigaku Ikeda1,2, François Niyonsaba1,3


P01-24 Beta-hydroxybutyrate reduces psoriasiform dermatitis

○Toshihiko Mochizuki, Mayumi Tamaki, Sora Takeuchi, Tomomitsu Miyagaki, Takafumi Kadono

The Department of Dermatology, St. Marianna University of Medicine, Kawasaki, Japan

P01-25 Mouse models of sweating disturbance associated with dry skin induced by cutaneous inoculation of herpessimplex virus

○Yumiko Asanuma1, Hironobu Ishimaru1, Tetsuko Sato1, Takenobu Yamamoto2, Yumi Aoyama1

1The Department of Dermatology, Kawasaki Medical School, Okayama, Japan, 2The Department of Dermatology, Kawasaki MedicalSchool, General Medical Center

P01-26 Increase of CD26-positive T cells and fibroblasts in bullous pemphigoid and dipeptidyl peptidase-4 inhibitor-related bullous pemphigoid

○Miao Zheng1, Ryo Hatano2, Norihiro Yoshimoto1, Ken Muramatsu1, Takamasa Ito1, Chikao Morimoto2, Hideyuki Ujiie1

1Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan,2Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, JuntendoUniversity, Tokyo, Japan

P01-27 Nuclear IL-33 is involved in IL-31-mediated filaggrin downregulation by acting as a transcription cofactor ofSTAT3 in keratinocytes

○Xiuju Dai, Ryo Utsunomiya, Ken Shiraishi, Hideki Mori, Jun Muto, Masamoto Murakami, Koji Sayama

Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan

P01-28 Development of non-steroidal topical therapy for inflammatory skin disorders focusing on AP-1, NF-κB and JAK○Minori Sasakura, Hitoshi Urakami, Kenta Ikeda, Shin Morizane

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama,Japan

P01-29 Calcitriol improves the symptoms of atopic dermatitis mice

○Yoshie Umehara1, Juan Valentin Trujillo Paez1, Ge Peng1, Mitsutoshi Tominaga2, Hainan Yue1, Le Thanh Hai Nguyen1,Risa Ikutama1,3, Miho Takahashi1,3, Kenji Takamori2,4, Ko Okumura1, Hideoki Ogawa5, François Niyonsaba1,5

1Atopy (Allergy) Research Center, Juntendo University School of Medicine, Tokyo, Japan, 2Juntendo Itch Research Center (JIRC),Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan,3Department of Dermatology and Allergology, Juntendo University School of Medicine, Tokyo, Japan, 4Department of Dermatology,Juntendo University Urayasu Hospital, Chiba, Japan, 5Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan

P01-30 Expression of serum and skin gamma-chain levels in patients with Stevens-Johnson syndrome and toxic epidermalnecrolysis

○Yuko Watanabe, Yukie Yamaguchi, Noriko Komitsu, Tomoya Watanabe, Michiko Aihara

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine

P01-31 Exploration of cytoprotectant on sorafenib-induced hand-foot syndrome

○Yayoi Kamata1,2, Mitsutoshi Tominaga1,2, Rui Kato1,3, Yasushi Suga2,3, Hideoki Ogawa1, Kenji Takamori1,2,3

1Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate Schoolof Medicine, Chiba, Japan, 2Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, Chiba, Japan,3Department of Dermatology, Juntendo Urayasu Hospital, Chiba, Japan

P01-32 Food-induced anaphylaxis caused by epicutaneous sensitization is prevented with prior oral exposure to antigen

○Tsukasa Ugajin1, Yukari Mori1, Kohei Okada1, Naoshi Umemoto1, Ken Igawa1,2, Hiroo Yokozeki1

1The Department of Dermatology, Tokyo Medical and Dental University, Tokyo, Japan, 2The Department of Dermatology, DokkyoMedical University


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P01-33 Olfactory receptor mRNA expression in skin surface lipids as potential biomarkers for sensitive skin

○Yuya Uehara1,2, Takayoshi Inoue1, Noriyasu Ota1, Shigaku Ikeda2, Takatoshi Murase1

1Biological Science Laboratories, Kao Corporation, Tokyo, Japan, 2Department of Dermatology and Allergology, Juntendo UniversityGraduate School of Medicine, Tokyo, Japan

P01-34 Serum IP-10 as an immunological marker to predict poor control after omalizumab treatment in spontaneouschronic urticaria

○Nobuko Sagawa1, Naoko Inomata1, Saki Takahashi1, Rie Fukuzawa1, Masako Tanaka1, Aiko Takano1, Yukitoshi Takahashi2,Michiko Aihara1

1Department of Dermatology, Yokohama City University School of Medicine, Yokohama, Japan, 2Department of Pediatrics, NationalEpilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan

P01-35 Evaluation of anti-desmocollin antibodies and eosinophil infiltration for pemphigus

○Norito Ishii1, Hiroshi Koga1, Kwesi Teye2, Takekuni Nakama1

1Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan, 2Kurume University Institute of Cutaneous CellBiology, Fukuoka, Japan

P01-36 A possible murine model eosinophilic fasciitis and examination of eosinophil infiltration in the facia

○Takashi Ito, Toshiyuki Yamamoto

Fukushima Medical University School of Medicine, Department of Dermatology

P01-37 Increased IL-36γ in keratinocytes may induce epithelial-mesenchymal transition in patients with systemicsclerosis

○Asami Akita-Enoki, Yukie Yamaguchi, Yukihiko Watanabe, Yasushi Ototake, Noriko Komitsu-Ikeda, Michiko Aihara

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan

P01-38 Effects of decanoic acid on imiquimod-induced psoriasis-like dermatitis in mice

○Kinuko Irie, Shohei Igari, Toshiyuki Yamamoto


P01-39 Anti-inflammatory Activity of traditionally used, bioactive Mushrooms in Skin

○Rocky Graziose1, Donald Collins1, Tieraona Low Dog4, Andrew Weil5, Steven Schnittger1, Wei Ii Le2, Susan Green2,Nadine Pernodet1,3

1The Estee Lauder Companies, 2SUNY DownState, Medical School, 3Stony Brook University, Materials Science and Engineering, Stony,4Chief Medical Officer, Healthy Lifestyle Brands, 5Director, Andrew Weil University of Arizona Center for Integrative Medicine

Category 2 (P02): Carcinogenesis/Growth Factors/Signal Transduction/CancerGenetics

P02-01[I-7]

Glucose-6-Phosphate Dehydrogenase Correlates with the Tumor Immune Activity Including PD-L1 Expression inMerkel Cell Carcinoma

○Motoki Nakamura1, Maki Yoshimitsu1, Tetsuya Magara1, Yuka Nojiri1, Hiroshi Kato1, Kotaro Nagase2, Akimichi Morita1

1Departments of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya,Japan, 2Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan

P02-02[C02-01]

Targeting the JAK/STAT3 pathway with Ruxolitinib in a novel mouse model of RDEB-cSCC

○Joanna Jackow1,2, Avian Rami1, Ryota Hayashi1, Corey Hansen1, Zongyou Guo1, Dom DeLorenzo1, Alberto Pappalardo1,Arianna L. Kim1, Rolando Perez-Lorenzo1, David M. Owens1, Angela M. Christiano1

1Department of Dermatology, Columbia University, New York, USA, 2St John’s Institute of Dermatology, King’s College London (Guy’scampus), London, UK

P02-03[C02-02]

Extramammary Paget’s disease patient-derived xenografts harboring ERBB2 S310F mutation show sensitivity totargeted therapy and chemotherapy

○Takuya Maeda1, Shinya Kitamura1, Hiroshi Nishihara2, Teruki Yanagi1

1Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan,2Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan

P02-04[C02-03]

Multi-sample Exome Sequencing of Porocarcinoma Shows High Intratumoral Heterogeneity and Early Branchingfrom Preceding Poroma

○Hiroyuki Irie, Yoshihiro Ishida, Atsushi Otsuka, Kenji Kabashima


P02-05[C02-04]

Genomic analysis of extramammary Paget disease identifies disease subtypes that converge in PIK3/Akt pathway

○Yoshihiro Ishida, Hiroyuki Irie, Atsushi Otsuka, Kenji Kabashima

Department of Dermatology, Kyoto University


- 47 -

P02-06 Age-dependent mechanotransduction responses of keratinocytes by uniaxial cyclic stretches

○Daigo Inoue, Satoshi Horiba, Kazuki Takagaki

Shiseido Global Innovation Center

P02-07 Targeting field canerisation in epidermal cancers

○Ho Yi Wong1, Edwige Roy1, Stuti Kapadia1, Valentine Murigneux2, Sharene Chong1,3, Kiarash Khosrotehrani1,3

1University of Queensland, 2QFAB Bioinformatics, 3Princess Alexandra Hospital

P02-08 Novel ex vivo disease model for extramammary Paget’s disease using the cancer tissue-originated spheroidmethod

○Takahiro Arita1, Jumpei Kondo2, Yuka Kaneko1, Miho Tsutsumi1, Mai Kanemaru1, Mari Matsui1, Yukiyasu Arakawa1, Norito Katoh1,Masahiro Inoue2, Jun Asai1

1Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan,2Department of Clinical Bio-resource Research and Development, Graduate School of Medicine Kyoto University, Kyoto, Japan

P02-09 Characterization of keratin expression during cutaneous squamous cell carcinoma progression

○Hiroshi Mitsui, Takahiro Sunaga, Yoshinori Muto, Tatsuyoshi Kawamura


P02-10 Activation-induced cytidine deaminase is expressed in squamous cell carcinoma arising from lichen sclerosus etatrophicus

○Hiroyuki Ito, Yohei Iwata, Hidehiko Fukushima, Kenta Saito, Soichiro Watanabe, Yoshihito Tanaka, Masaru Arima,Kazumitsu Sugiura

The Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan

P02-11 Regulation and function of YAP in development and tumorigenesis of melanoma

○Jimyung Seo, Kee Yang Chung, Mi Ryung Roh

Department of Dermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

Category 3 (P03): Cell Adhesion/Matrix/Vascular Biology

P03-01[II-2]

Interleukin 6 signalling in endovascular progenitors is a driver of melanoma vascularisation and metastasis

○James Dight, Ghazaleh Hashemi, Laura Sormani, Ho Yi Wong, Jatin Patel, Kiarash Khosrotehrani

UQ Diamantina Institute, UQ, Brisbane, Australia

P03-02[C03-01]

The Effect of Conditional Sox9 Knockout in the Endothelium on Melanoma Tumour Vascularisation andMetastasis

○Ghazaleh Hashemi, James Dight, Laura Sormani, Kiarash Khosrotehrani

The University of Queensland Diamantina Institute, Translational Research Institute, QLD, Australia

P03-03[C03-02]

A calpain inhibitor ALLN ameliorates bleomycin-induced skin fibrosis via antagonizing TGF-β/Smad signalingpathway

○Hiroshi Kasamatsu1, Akira Utsunomiya1, Natsuko Utsunomiya1, Takumi Hasegawa1, Takenao Chino1, Noritaka Oyama1,Masami Yamada2, Minoru Hasegawa1

1Department of Dermatology, University of Fukui, Fukui, Japan, 2Department of Cell Biology and Biochemistry, University of Fukui,Fukui, Japan

P03-04[C03-03]

Hypoxia causes dysregulation of BMP10/GATA6 axis in pulmonary artery hypertension

○Tetsuo Toyama1, Hinako Saito1, Sohshi Morimura1, Maria Trojanowska2, Makoto Sugaya1

1Department of Dermatology, International University of Health and Welfare, Narita, Japan, 2Arthritis Center, Boston University Schoolof Medicine, Boston, MA, USA

P03-05 Mesenchymal stem cell-derived exosomes suppress skin fibrosis in murine model of systemic sclerosis

○Hritu Baral, Akiko Sekiguchi, Yuta Inoue, Syahla N. Amalia, Akihiko Uchiyama, Sahori Yamazaki, Chisako Fujiwara,Sachiko Ogino, Yoko Yokoyama, Ryoko Torii, Mari Hosoi, Osamu Ishikawa, Sei-ichiro Motegi

The Department of Dermatology, Gunma University, Maebashi, Japan

P03-06 Regulation of dermal oxytalan fibers by epidermal-dermal interactions targeting EMILIN-1

○Soichiro Shiga, Shinya Kondo, Shino Nishizawa, Takeshi Tohgasaki, Tetsuhito Sakurai

FANCL Research Institute, FANCL Corporation, Yokohama, Japan

P03-07 Preferential Presence of Elements of Tertiary Lymphoid Organ in Pseudolymphomas But not in MycosisFungoides

○Fatimah Budair1, Takashi Nomura2, Masahiro Hirata3, Toshiaki Kogame2, Kenji Kabashima2

1Dermatology, Imam Abdulrahman Bin Faisal University, Saudi Arabia, 2Dermatology Department, Kyoto University, Kyoto, Japan,3Pathology Department, Kyoto University, Kyoto, Japan


- 48 -

P03-08 Glycation: impact on skin cells’ functions and ECM mechanical properties

○Dawn Layman1, Miriam Rafailovich2, Nadine Pernodet1,3

1Research & Development, The Estee Lauder Companies, Melville, New York, USA, 2Materials Science and Engineering, Stony BrookUniversity, Stony Brook, New York, 3Estee Lauder Research Laboratories

P03-09 Surface wettabilities on different hyaluronic acid distribution in vitro

○Nobuyuki Tanaka1, Asako Sato1, Nobuko Fujita1, Yoshihide Haruzono2, Hiromitsu Nasu2, Yo Tanaka1

1Center for Biosystems and Dynamics Research, RIKEN, Osaka, Japan, 2Kitagawa Corporation

Category 4 (P04): Human Clinical Research and Therapeutics

P04-01[I-4]

Single-cell analysis of the psoriatic lesional skin identifies the new subpopulation of IL-1B and IL23A producingdendritic cells in human

○Satoshi Nakamizo1,2, Charles-Antoine Dutertre2, Xiao Meng Zhang2, Josephine Lum2, Baptiste Janela2, Kahbing Jasmine Tan2,Reiko Sato1, Valerie Julia3, Feriel Hacini-Rachinel3, Kenji Kabashima1,2, Florent Ginhoux2

1Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Singapore Immunology Network, Agencyfor Science, Technology and Research, Singapore, 3Nestle Skin Health R&D/GALDERMA, La Tour-de-Peilz, Switzerland

P04-02[C04-01]

Biomonitoring analysis is beneficial for full-thickness skin grafting

○Takao Oda1, Hiroshi Kato1, Motoki Nakamura1, Maki Yoshimitsu2, Azusa Magara3, Akimichi Morita1

1Department of Geriatric and Environmental Dermatology, Nagoya City University, Aichi, Japan, 2Okazaki city hospital, Aichi, Japan,3Konan Kosei Hospital, Aichi, Japan

P04-03[C04-02]

Botulinum toxin B injection for digital ulcers and Raynaud’s phenomenon in systemic sclerosis: Double-Blind,Randomized Controlled Trial

○Sei-ichiro Motegi1, Akiko Sekiguchi1, Miho Oue2, Hisako Sumiyoshi2, Tetsuya Nakamura2, Osamu Ishikawa1

1Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan, 2Clinical Investigation and ResearchUnit, Gunma University Graduate School of Medicine, Maebashi, Japan

P04-04[C04-03]

Skin atrophy caused by topical glucocorticoids is less common in patients with atopic dermatitis than in thosewith psoriasis

○Chung Hyeok Lee1, Sung Jay Choe1, Dong Hye Kim1, Eun Jung Kim1, Minseob Eom2, Seung-Phil Hong1, Eung Ho Choi1

1Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea, 2Department of Pathology,Yonsei University Wonju College of Medicine, Wonju, Republic of Korea

P04-05[C04-04]

The effect of topical minoxidil on autosomal recessive woolly hair/hypotrichosis caused by LIPHmutations

○Tomoki Taki1, Kana Tanahashi1,2, Takuya Takeichi1, Takenori Yoshikawa1, Yuya Murase1, Kazumitsu Sugiura2, Masashi Akiyama1

1The Department of Dermatology, Nagoya University Graduate School of Medicine, Aichi, Japan, 2Department of Dermatology, FujitaHealth University School of Medicine, Aichi, Japan

P04-06[C04-05]

Macrophages are the major cellular sources of IL-31 in atopic dermatitis: a novel network of itch comprisingTSLP, periostin, and basophils

○Takashi Hashimoto1,2, Yuki Yamazaki1, Hiroo Yokozeki2, Takahiro Satoh1

1Department of Dermatology, National Defense Medical College, Tokorozawa, Japan, 2Department of Dermatology, Graduate Schoolof Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

P04-07[C04-06]

Dupilumab Safety and Efficacy in Adult Patients With Moderate-to-Severe Atopic Dermatitis: An Analysis of upto 100 Weeks (LIBERTY AD OLE)

○JooYoung Roh1, ChunWook Park2, KyuHan Kim3, Joohyung Lee4, Xian Sun5, Ana B. Rossi6, Brad Shumel5

1Department of Dermatology, Gachon University College of Medicine, Gil Medical Center, Incheon, South Korea, 2Department ofDermatology, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, 3Department of Dermatology, Seoul NationalUniversity College of Medicine, Seoul, South Korea, 4Sanofi Genzyme, Seoul, South Korea, 5Regeneron Pharmaceuticals, Inc.,Tarrytown, NY, USA, 6Sanofi Genzyme, Cambridge, MA, USA

P04-08[C04-07]

Assessment of psoriasis skin lesion using AI

○Takashi Okamoto1, Masataka Kawai2, Shinji Shimada1, Tatsuyoshi Kawamura1

1Department of Dermatology, University of Yamanashi, Yamanashi, Japan, 2Department of Human pathology, University ofYamanashi, Yamanashi, Japan

P04-09[C04-08]

Ultraviolet A1 light emitting diodes for dyshidrotic palmoplantar eczema

○Kyoko Ikumi1, Tomohiko Kio1,2, Kan Torii1, Hideyuki Masuda1,2, Akimichi Morita1

1Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya,Japan, 2R&D Group, Biomedical Division, USHIO INC, Tokyo, Japan

P04-10[C04-09]

The oral microbial composition and diversity affected the clinical course of palmoplantar pustulosis patients afterdental infection control

○Michiyoshi Kouno1, Yurie Akiyama2, Masaki Minabe2, Jyunichiro Inada2, Takeshi Nomura2, Kazuyuki Ishihara3, Shinichi Takahashi1

1The Department of Dermatology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan, 2The Department of Oral Medicine,Oral and Maxillofacial Surgery, Tokyo Dental College, 3The Department of Microbiology, Tokyo Dental College


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P04-11[C04-10]

Dupilumab Decreases Blood Biomarkers in Patients With Erythrodermic Atopic Dermatitis - A Pooled SubgroupAnalysis

○Emma Guttman-Yassky1, Jonathan I. Silverberg2, Alan D. Irvine3,4, Kenji Kabashima5, Moon Bum Kim6, Zhen Chen7, Hiroyuki Fujita8,Kazuhiko Arima8, Sivan Harel7, Yufang Lu7, Ana B. Rossi9, Arsalan Shabbir7

1Icahn School of Medicine at Mount Sinai Medical Center, New York, NY, 2George Washington University School of Medicine,Washington, DC, USA, 3Trinity College Dublin, Dublin, Ireland, 4National Children’s Research Centre, Our Lady’s Children’s HospitalCrumlin, Dublin, Ireland, 5Kyoto University Graduate School of Medicine, Kyoto, Japan, 6Pusan National University Hospital, Busan,South Korea, 7Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA, 8Sanofi K.K., Tokyo, Japan, 9Sanofi Genzyme, Cambridge, MA,USA

P04-12 Serum interleukin-10 level increases in patients with severe signs or symptoms of herpes zoster and predicts theduration of neuralgia

○Atsuko Fukuyasu1, Masahiro Kamata1, Carren Sy Hau1, Mayumi Nagata1, Saki Fukaya1, Kotaro Hayashi1, Takamitsu Tanaka1,Takeko Ishikawa1, Takamitsu Ohnishi1, Yayoi Tada1, Naoko Kanda1,2

1The Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan, 2Department of Dermatology, Nippon MedicalSchool, Chiba Hokusoh Hospital

P04-13 Long-Term Dupilumab Treatment up to 100 Weeks Reduces Serum Biomarkers in Patients With Moderate-to-Severe Atopic Dermatitis

○Lisa A. Beck1, Diamant Thaci2, Robert Bissonnette3, Mette Deleuran4, Sivan Harel5, Zhen Chen5, Kazuhiko Arima6, Hiroyuki Fujita6,Brad Shumel5, Ana B. Rossi7

1University of Rochester Medical Center, Rochester, NY, USA, 2Institute and Comprehensive Center for Inflammation Medicine,University of Luebeck, Luebeck, Germany, 3Innovaderm Research, Montreal, QC, Canada, 4Aarhus University Hospital, Aarhus,Denmark, 5Regeneron Pharmaceuticals, Inc., Tarrytown, 6Sanofi K.K., Tokyo, Japan, 7Sanofi Genzyme, Cambridge, MA, USA

P04-14 Long-term efficacy and safety of intravenous injection of mesenchymal stem cells in five adults with moderate tosevere atopic dermatitis

○Hyun-Tae Shin1, Si Hyub Lee1, Hee Seong Yoon1, Ji Hye Heo1, Seon Bok Lee1, Ji Won Byun1, Jeonghyun Shin1, Yun-Kyoung Cho3,Eunkyung Chung3, Myung-Shin Jeon2, Sun U. Song2,3, Gwang Seong Choi1

1Department of Dermatology, Inha University School of Medicine, Incheon, Republic of Korea, 2Department of Integrated BiomedicalSciences, Inha University School of Medicine, Incheon, Republic of Korea, 3SCM Lifesciences Co. Ltd., Incheon, Republic of Korea

P04-15 Neutrophil-to-lymphocyte ratio as a useful biomarker can predict outcomes in dipeptidyl peptidase-4 inhibitorassociated bullous pemphigoid

○Seiko Sugiyama1,2, Takenobu Yamamoto1,2, Yumi Aoyama2

1The Department of Dermatology, Kawasaki Medical School General Medical Center, 2The Department of Dermatology, KawasakiMedical School

P04-16 Skin mycobiome in patients with psoriasis under treatment with biologics

○Yuta Koike1, Sayaka Kuwatsuka1, Katsutaro Nishimoto2, Daisuke Motooka3, Hiroyuki Murota1

1Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Department ofDermatology, Nagasaki Ekisaikai Hospital, Nagasaki, Japan, 3Department of Infection Metagenomics, Genome Information ResearchCenter, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

P04-17 Persistent HHV-6 infection has an increased risk of more severe complications in patients with DIHS

○Yuki Nishimura1, Fumi Miyagawa1, Hideaki Watanabe2, Masahiro Kira3, Saeko Nakajima4, Yuko Higashi5, Hideo Asada1

1Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan, 2Department of Dermatology, ShowaUniversity School of Medicine, Tokyo, Japan, 3Department of Dermatology, Ikeda City Hospital, Ikeda, Japan, 4Department ofDermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 5Department of Dermatology, Kagoshima University,Kagoshima, Japan

P04-18 Skin Microbiome and its Correlation to Skin Aging

○Steven Schnittger, Shannon Sanacora, Tom Mammone, Jaimie Jerome, Michael Sullivan, Brian Asciutto, Rocky Graziose,Kurt Schilling

The Estee Lauder Companies

P04-19 Inhibitory effects of peptidomimetics on neurotransmission

○Tom Mammone, Jaime Emmetsberger

The Estee Lauder Companies, Melville, New York

P04-20 The association between the severity of hydroa vacciniforme and Monokine induced by gamma interferon

○Tomoko Miyake1, Yoji Hirai1, Takenobu Yamamoto2, Keiji Iwatsuki1,3, Shin Morizane1

1Departments of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama,Japan, 2Departments of Dermatology, Kawasaki Medical School, Okayama, Japan, 3Departments of Dermatology, Fujita HealthUniversity, Aichi, Japan

P04-21 Cross-reactive antibody response between royal jelly and typical allergens in atopic dermatitis patients

○Taketoshi Hata1,2, Tomoko Takahashi1, Kenji Ichihara2, Mariko Seishima1

1Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan, 2Nagaragawa Research Center, API Co., Ltd.,Gifu, Japan


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P04-22 Artificial Intelligence (AI) in Dermatology: an Application in Sub-Saharan Africa

○Christophe Hsu1, Ludovic Amruthalingam1, Philippe Gottfrois1, Herizo Andriambololoniaina5, Shuang Zhao2, Rune Philemon4,Valerie Amann1, Yi Xiao2, Michelle Rodrigues6, Fahafantsoa Rapelanoro Rabenja5, Peter Schmid-Grendelmeier3, Weihong Huang2,7,Daudi Mavura4, Xiang Chen2, Alexander Navarini1

1The Department of Dermatology - University of Basel, Switzerland, 2Xiangya Hospital - Department of Dermatology, Changsha,China, 3University Hospital Zurich; Dept of Dermatology, Zurich, Switzerland, 4Regional Dermatology Training Centre; Dermatology,Moshi, Tanzania, 5University of Antananarivo, Madagascar, 6Department of Dermatology, Royal Childrens Hospital, Melbourne,Australia, 7Mobile Health -Ministry of Education - China Mobile Joint Laboratory, Changsha, China

P04-23 Treatment of benign lichenoid keratosis in face: Single Center Experience in Korea

Kwang Joong Kim,○Ji Ha Yoon

The Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea

P04-24 Lactobacillus Extract and its Effect on the Growth of Cutibacterium acnes

○Shannon Sanacora, Steven Schnittger, Jaimie Jerome, Michael Sullivan, Brian Asciutto, Kurt Schilling, Tom Mammone

The Estee Lauder Companies

P04-25 Prognosis of patients with pustulotic arthro-osteitis during past 10 years in our department

○Tomoko Hiraiwa, Toshiyuki Yamamoto


Category 5 (P05): Epidermal Structure and Function

P05-01[II-5]

Characterizing normal human eccrine sweat gland components at single-cell resolution

○Duerna Tie, Saeko Nakajima, Hiroyuki Irie, Masashi Iwata, Kenji Kabashima

Department of Dermatology, University of Kyoto, Kyoto, Japan

P05-02[C05-01]

Aberrant sebaceous lipid metabolism in the early stage of spontaneous dermatitis in Tmem79-deficient mice

○Ari Morimoto1,2, Yoshihiro Ito1,2, Takashi Sasaki3, Aiko Shiohama1, Hiroshi Kawasaki1,4, Ai Hirabayashi2, Mayuko Sato5,Kiminori Toyooka5, Eiryo Kawakami6,7, Tatsuro Naganuma8,9, Makoto Arita8,9, Haruhiko Koseki4,10, Takeshi Matsui2, Masayuki Amagai1,2

1Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Laboratory for Skin Homeostasis, RIKEN Center forIntegrative Medical Sciences, Yokohama, Japan, 3Center for Supercentenarian Medical Research, Keio University School of Medicine,Tokyo, Japan, 4Immunology Data Integration Unit, RIKEN Medical Sciences Innovation Hub Program, Yokohama, Japan, 5MassSpectrometry and Microscopy Unit, RIKEN Center for Sustainable Resource Science, Yokohama, Japan, 6RIKEN Medical SciencesInnovation Hub Program, Yokohama, Japan, 7Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba,Japan, 8Division of Physiological Chemistry and Metabolism, Faculty of Pharmacy, Keio University, Tokyo, Japan, 9Laboratory forMetabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 10Laboratory for Developmental Genetics, RIKENCenter for Integrative Medical Sciences, Yokohama, Japan

P05-03[C05-02]

Kinetic analysis of regulatory T cells in skin barrier disruption

○Sumika Toyama1, Catharina Sagita Moniaga1, Mitsutoshi Tominaga1,2, Hideoki Ogawa1, Kenji Takamori1,2,3

1Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate Schoolof Medicine, Chiba, Japan, 2Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, 3Department ofDermatology, Juntendo University Urayasu Hospital

P05-04[C05-03]

Trichohyalin-like 1 protein plays a crucial role in the proliferation of normal human keratinocytes and squamouscell carcinoma cells

○Teruhiko Makino1, Megumi Mizawa1, Yoko Yoshihisa1, Seiji Yamamoto2, Yoshiaki Tabuchi3, Masashi Miyai4, Tadamichi Shimizu1

1Department of Dermatology, University of Toyama, Toyama, Japan, 2Department of Pathology, University of Toyama, Toyama, Japan,3Division of Molecular Genetics Research, Life Science Center, University of Toyama, Toyama, Japan, 4Shiseido Global InnovationCenter, Yokohama, Japan

P05-05[C05-04]

Sphingosine 1-phosphate receptor 2 (S1PR2) deficiency promotes S. aureus invasion

○Satomi Igawa1,2, Phoebe Pham2, Zhenping Wang2, Ayaka Ohzono2, Teuaki Nakatsuji2, Akemi Ishida-Yamamoto1, Anna Di Nardo2

1The Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan, 2The Department of Dermatology, School ofMedicine, University of California, San Diego, La Jolla, USA

P05-06[C05-05]

Ceramide reduction in stratum corneum in autosomal recessive congenital ichthyosis caused by a NIPAL4mutation

○Yuya Murase1, Takuya Takeichi1, Akane Kawamoto2, Kana Tanahashi1, Yusuke Okuno3, Hiroyuki Takama4, Eri Shimizu5,Junko Ishikawa2, Tomoo Ogi6, Masashi Akiyama1

1Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Biological Science ResearchLaboratories, Kao Corporation, Haga, Japan, 3Center for Advanced Medicine and Clinical Research, Nagoya University Hospital,Nagoya, Japan, 4Department of Dermatology, Aichi Medical University, Nagakute, Japan, 5Analytical Science Research Laboratories,Kao Corporation, Haga, Tochigi, Japan, 6Department of Genetics, Research Institute of Environmental Medicine, Nagoya University,Nagoya, Japan


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P05-07 Single nucleotide polymorphisms of the aldo-keto reductase 1C3 gene in psoriasis

○Yuka Nojiri1, Motoki Nakamura1, Aya Nakada1, Emi Nishida1, Kyoko Ikumi1, Kan Torii1, Thomas Haarmann-Stemmann2

1The Department of Dermatology, Nagoya City University, Aichi, Japan, 2IUF- Leibniz Research Institute for Environmental Medicine,Düsseldorf, Germany

P05-08[C05-06]

The effect of antimicrobial peptide derived from insulin-like growth factor-binding protein 5 on skin barrierregulation

○Hai LT. Nguyen1,2, Juan Valentin Trujillo2, Ge Peng1,2, Hainan Yue1,2, Risa Ikutama1,2, Miho Takahashi1,2, Yoshie Umehara2,Hideoki Ogawa2, Shigaku Ikeda1,2, François Niyonsaba2,3

1Department of Dermatology and Allergology, Juntendo University Graduate School of Medecine, Tokyo, Japan, 2Atopy (Allergy)Research Center, Juntendo University, Tokyo, Japan, 3Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan

P05-09 The role of keratinocyte proline-rich protein in skin immunity and barrier function

○Ai Matsuno1, Hayakazu Sumida1, Yoshifumi Ikeyama2, Ayumi Yoshizaki1, Hirofumi Nakanishi2, Shumpei Ishikawa3, Shinichi Sato1

1Department of Dermatology, Graduate School of Medicine, The University of Tokyo, 2Rohto Pharmaceutical Co., Ltd, 3Department ofPreventive Medicine, Graduate School of Medicine, The University of Tokyo

P05-10 Caffeine enhances epidermal hydration by increasing the transepithelial electric potential and electro-osmosis

○Jaime Emmetsberger1, Vasile Ionita-Manzatu2, Thomas Mammone2

1Tom Ford Research, Melville, New York, 2The Estee Lauder Companies, Melville, New York

P05-11 Regulation of skin tight junction barrier function by calcitriol in diabetic milieu

○Juan Valentin Trujillo1, Hai LT. Nguyen1,2, Yoshie Umehara1, Hainan Yue1,2, Risa Ikutama1,2, Miho Takahashi1,2, Ge Peng1,2,Hideoki Ogawa1, Shigaku Ikeda1,2, François Niyonsaba1,3

1Atopy (Allergy) Research Center, Juntendo University, Tokyo, Japan, 2Department of dermatology and Allergology, JuntendoUniversity Graduate School of Medicine, Tokyo, Japan, 3Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan

P05-12 A Lipid Mixture with Ceramide NP with Fatty Acids of Diverse Chain Lengths Restores the Skin Barrier Impairedby Topical Corticosteroid

○Sung Ha Lim1, Eun Jung Kim1, Chung Hyuk Lee1, Gi Hyun Park2, Kang Min Yoo2, Sung Ju Nam2, Kyong-Oh Shin3, Kyungho Park3,Eung Ho Choi1

1Department of Dermatology, Yonsei Unviersity Wonju College of Medicine, Wonju, Republic of Korea, 2CMS LAB, Seoul, Republic ofKorea, 3Department of Food Science and Nutrition, Convergence Program of Material Science for Medicine and Pharmaceutics,Hallym University, Chuncheon, Republic of Korea

P05-13 Polyoxyethylene/polyoxypropylene dimethyl ether copolymer improves lipid ordering in the stratum corneum ofan epidermal-equivalent model

○Yuki Umino1, Sari Ipponjima2, Mitsuhiro Denda1

1Shiseido Global Innovation Center, Yokohama, Japan, 2Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan

P05-14 The correlation between ceramide profile and the effectiveness of ceramide care on remission of skin symptomsof atopic dermatitis patients

Yuriko Sho1, Takashi Sakai1, Takaoki Sato1, Moe Sonezaki1, Hidetoshi Taima2, Hiroyuki Taguchi2,○Yutaka Takagi2, Kazuhiro Kaizu2,Takahiro Nishizaka2, Yutaka Hatano1

1The Department of Dermatology, Oita University, Oita, Japan, 2Kao Corporation, Research & Development

Category 6 (P06): Epidemiology/Health Service Research

P06-01[C06-01]

Withdrawn

P06-02 Patient Characteristics in Generalized Pustular Psoriasis (GPP) Versus Psoriasis Vulgaris: A Medical Data Vision(MDV) Claims-Based Study

○Akimichi Morita1, Kumiko Saito2, Reiko Shimizu2, Amanda Golembesky3, Ran Gao4, Nirali Kotowsky4

1Nagoya City University, Nagoya, Japan, 2Nippon Boehringer Ingelheim Co., Ltd., Tokyo, Japan, 3Boehringer Ingelheim InternationalGmbH, Ingelheim, Germany, 4Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA

P06-03 Longitudinal association between polypharmacy and development of pruritus: nationwide, cohort study in aJapanese population

○Toshiaki Kogame1, Tsukasa Kamitani2,4,5, Shunichi Fukuhara2,3, Kenji Kabashima1, Yosuke Yamamoto1,4,5

1Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Section of Clinical Epidemiology,Department of community medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 3Center for Innovative Researchfor Communities and Clinical Excellence, Fukushima Medical University, Fukushima City, Fukushima, Japan, 4Department ofHealthcare Epidemiology, School of Public Health in the Graduate School of Medicine Kyoto University Graduate School ofMedicine, 5Institute for Health Outcomes and Process Evaluation Research (iHope International), Kyoto, Japan


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Category 7 (P07): Genetic Disease/Gene Regulation and Gene Therapy

P07-01[II-8]

Identification of aberrantly high cytoplasmic Ca2+ in granular keratinocytes preceding hyperkeratosis in KIDsyndrome by intravital imaging

○Teruasa Murata, Tetsuya Honda, Hiromi Doi, Teruki Dainichi, Kenji Kabashima

Department of dermatology, Kyoto University, Kyoto, Japan

P07-02[I-6]

Elucidating the genotype-phenotype correlation in recessive dystrophic epidermolysis bullosa using a rapidgenome editing system in mice

○Takashi Shimbo1,2, Satoshi Takaki2,3, Sho Yamazaki2,3, Katsuto Tamai2

1StemRIM Institute of Regeneration-Inducing Medicine, Osaka University, 2Department of Stem Cell Therapy Science, OsakaUniversity, 3StemRIM Co., Ltd.

P07-03[C07-01]

Association of IL-12B polymorphism with secondary failure of Infliximab therapy to psoriasis

○Kan Torii, Akimichi Morita

Department of Geriatric and Environmental Dermatology, Nagoya City University, Aichi, Japan

P07-04[C07-02]

Generation of junctional epidermal model mice with revertant mosaicism

○Hong Ha Nguyen1, Satoru Shinkuma1, Shota Takashima2, Masashi Mori3, Masahito Ikawa3, Hiroshi Shimizu2, Riichiro Abe1

1Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 2Department ofDermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 3Department of Experimental Genome Research,Genome Information Research Center, Osaka University, Osaka, Japan

P07-05[C07-03]

Nanopore sequencing reveals filaggrin gene structure and mutation patterns associated with gene evolution andichthyosis vulgaris phenotypes

Colin Wong1, Vipin Narang2, Simon Denil1, Duan Kaibo2, Yik Weng Yew3, Bernett Lee2,○John E. Common1

1Skin Research Institute of Singapore, A*STAR, Singapore, 2Singapore Immunology Network, A*STAR, Singapore, 3National SkinCentre, Singapore

P07-06[C07-04]

Intravenous injection of multilineage-differentiating stress-enduring (Muse) cells as a therapeutic approach forepidermolysis bullosa mice

○Yasuyuki Fujita1,2, Miho Komatsu1, San Eun Lee1,3, Yoshihiro Kushida4, Chihiro Nakayama-Nishimura1, Wakana Matsumura1,Shota Takashima1, Satoru Shinkuma1,5, Toshifumi Nomura1, Naoya Masutomi6, Makoto Kawamura6, Mari Dezawa4, Hiroshi Shimizu1

1Department of Dermatology, Hokkaido University Graduate School of Medicine and Faculty of Medicine, Sapporo, Japan,2Department of Dermatology, Sapporo City General Hospital, Sapporo, Japan, 3Department of Dermatology, Gangnam SeveranceHospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea, 4Department of Stem CellBiology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan, 5Department of Dermatology, Nara MedicalUniversity School of Medicine, Kashihara, Japan, 6Life Science Institute Inc., Tokyo, Japan

P07-07[C07-05]

A genetic correlation study identified eight diseases and traits associated with psoriasis

○Yukinori Okada, Kotaro Ogawa

Department of Statistical Genetics, Osaka University Graduate School of Medicine

P07-08[C07-06]

Aberrant keratin assembly causes impaired mitochondrial movement and function: Implications forepidermolysis bullosa simplex pathogenesis

○Osamu Ansai1, Ryota Hayashi1, Satoru Shinkuma1,2, Asuka Suto3, Hiroshi Shimizu3, Riichiro Abe1

1Division of Dermatology, Niigata University School of Medical and Dental Science, 2Department of Dermatology, Nara MedicalUniversity School of Medicine, 3Department of Dermatology, Hokkaido University Graduate School of Medicine

P07-09[C07-07]

Delineating the chain of events that trigger premature cell ageing in Hutchinson-Gilford Progeria Syndrome

○Oliver Dreesen1, Peh Fern Ong1, Alexandre Chojnowski2, Mattheus Xing Rong Foo1

1Skin Research Institute of Singapore, 2Institute of Medical Biology, Singapore

P07-10[C07-08]

Phenotypic suppression of acral peeling syndrome in a patient with autosomal recessive congenital ichthyosis

○Janan Mohamad1,2, Arti Nanda3, Mor Pavlovsky1, Alon Peled1,2, Natalia Malchin1, Kiril Malovitski1,2, Rashida Pramanik4,Daphna Weissglas-Volkov5, Noam Shomron5, John A. McGrath4, Ofer Sarig1, Eli Sprecher1,2

1Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 2Department of Human Molecular Genetics andBiochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel, 3As’ad Al-Hamad Dermatology Center, Kuwait, 4StJohn’s Institute of Dermatology, King’s College London, London, UK, 5Department of Cell and Developmental Biology, Sackler Facultyof Medicine, Tel-Aviv University, Tel Aviv, Israel

P07-11 Laser capture microdissection reveals the cause of Phakomatosis pigmentovascularis is GNAQ mutation at thevascular endothelial cell

○Yoshihito Minami1,2, Atsushi Osada2, Katsuhiko Tsukamoto2, Atsushi Nemoto3, Tamao Shinohara3, Toshio Oyama4, Yosuke Hirotsu5,Kenji Amemiya5, Masao Omata5, Tatsuyoshi Kawamura1

1Department of Dermatology, University of Yamanashi, Yamanashi, Japan, 2Department of Dermatology, Yamanashi PrefecturalCentral Hospital, Yamanashi, Japan, 3Neonatology Unit, Yamanashi Prefectural Central Hospital, Yamanashi, Japan, 4Department ofPathology, Yamanashi Prefectural Central Hospital, Yamanashi, Japan, 5Genome Analysis Center, Yamanashi Prefectural CentralHospital, Yamanashi, Japan


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P07-12 Impact of a novel keratin 14 mutation in epidermolysis bullosa simple pathogenesis

○Mari Kishibe1, Risa Matsuo1, Akiharu Kubo2, Akemi Ishida-Yamamoto1

1Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan, 2Department of Dermatology, Keio University Schoolof Medicine, Tokyo, Japan

P07-13 Characterization of four missense mutations in the EDAR gene responsible for autosomal recessive hypohidroticectodermal dysplasia

○Shuichiro Yasuno1, Osamu Ansai2, Tomoko Okita1, Nobuyuki Asano1, Ryota Hayashi2, Riichiro Abe2, Yutaka Shimomura1

1The Department of Dermatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan, 2The Division ofDermatology, Niigata University Graduate School of Medicine and Dental Sciences, Niigata, Japan

P07-14 Seasonal fluctuation observed in Papillon-Lefèvre syndrome; functional analysis and its implications for clinicalphenotype

○Akari Sakai1, Satoru Shinkuma2, Ryota Hayashi1, Mahoko Oginezawa1, Mami Nakajima1, Tatsuya Katsumi1, Toru Kawai1,Tokiko Deguchi1, Riichiro Abe1

1Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 2Department ofDermatology, Nara Medical University School of Medicine

P07-15 Genotype/phenotype correlations in harlequin ichthyosis with ABCA12 mutations revisited

○Takenori Yoshikawa1, Takuya Takeichi1, Hiromasa Wakita2, Masahiro Hayakawa2, Tomoo Ogi3, Masashi Akiyama1

1The Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Department of Pediatrics,Nagoya University Graduate School of Medicine, Nagoya, Japan, 3Department of Genetics, Research Institute of EnvironmentalMedicine, Nagoya University, Nagoya, Japan

P07-16 Acute generalized exanthematous pustulosis triggered by acetaminophen in an IL36RN variant alleleheterozygote

○Chiaki Murase1, Takuya Takeichi1, Kazumitsu Sugiura2, Masashi Akiyama1

1The Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Department of Dermatology,Fujita Health University School of Medicine, Toyoake, Japan

P07-17 MEDNIK-like syndrome due to compound heterozygous mutations in AP1B1

○Yasutoshi Ito1, Takuya Takeichi1, Shohei Igari2, Tatsuhiko Mori2, So Takeuchi1, Yoshinao Muro1, Tomoo Ogi3, Toshiyuki Yamamoto2,Masashi Akiyama1

1Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Department of Dermatology,Fukushima Medical University, Fukushima, Japan, 3Department of Genetics, Research Institute of Environmental Medicine, NagoyaUniversity, Nagoya, Japan

P07-18 Whole-exome sequencing facilitates causative mutation detection in diffuse palmoplantar keratoderma

○So Takeuchi1, Takuya Takeichi1, Yasutoshi Ito1, Tomoo Ogi2, Masashi Akiyama1

1The Department of Dermatology, Nagoya University Graduate School of Medicine, Aichi, Japan, 2The Department of Genetics,Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan

P07-19 Dysfunction of SERCA2 suppresses skin carcinogenesis

○Emi Sato1, Yuka Fujita2, Narumi Yano2, Shinichi Imafuku1

1Department of Dermatology, Fukuoka University Faculty of Medicine, 2Department of Pharmaceutics, Fukuoka University Faculty ofPharmaceutical Sciences

P07-20 Chronic mucocutaneous candidiasis due to STAT1 gene mutation

○Kyoko Fukai, Daisuke Utsumi, Sayaka Yamaguchi, Kenzo Takahashi

The Department of Dermatology, University of Ryukyus, Okinawa, Japan

Category 8 (P08): Tissue Regeneration/Stem Cell and Wound Healing

P08-01[II-9]

Mitochondrial failure in T cells accelerates skin ageing

○Elisa Carrasco1,2,3, Gonzalo Soto-Heredero1,2,3, Eva M Blanco2,3, Maria Mittelbrunn1,2,3

1Universidad Autónoma de Madrid (UAM), Madrid, Spain, 2Centro de Biología Molecular Severo Ochoa (CBMSO, CSIC-UAM),Madrid, Spain, 3Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain

P08-02[II-10]

Transcriptome Atlas of Human nail unit defined by single cell RNAseq

○Hyun Je Kim1, Jun-Ho Shim3, Ji-Hye Park1,4, Woong-Yang Park3,4, Jong Sup Shim2,4, Dong-Youn Lee1,4

1The Department of Dermatology, Samsung Medical Center, Seoul, Korea, 2Department of Orthopedic Surgery, 3Samsung GenomicInstitute, 4Sungkyunkwan University School of Medicine

P08-03[I-2]

Delayed wound healing in epithelial cell-specific Fli1 knockout mice due to impaired reepithelialization andextracellular matrix remodeling

○Jun Omatsu, Takehiro Takahashi, Takuya Miyagawa, Ryosuke Saigusa, Yuki Fukui, Satoshi Toyama, Kentaro Awaji,Ayumi Yoshizaki, Shinichi Sato, Yoshihide Asano

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan


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P08-04[C08-01]

Abrogation of Sox9 expression in the endothelium blocks aberrant vascular EndMT and fibrosis

○Jilai Zhap1, Jatin Patel1, Sam Kahler1, Hamish Hamilton1, Isabella Hogan1, James Dight1, Ho Yi Wong1, SeenLing Sim1,Mervyn Yoder2, Kiarash Khosrotehrani1

1Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia, 2Indiana University School of Medicine, Indianapolis,Indiana, United States of America

P08-05[C08-02]

Effect of human β-defensin-3 on wound healing○Miho Takahashi1,2, Yoshie Umehara1, Hainan Yue1,2, Juan Valentin Trujillo1, Ge Peng1,2, Le Thanh Hai Nguyen1,2, Risa Ikutama1,2,Ko Okumura1, Hideoki Ogawa1, Shigaku Ikeda1,2, François Niyonsaba1,3


P08-06[C08-03]

Ninjurin-1 contributes to skin wound healing by promoting pericyte-endothelial cell interaction

○Risa Matsuo, Mari Kishibe, Shin Iinuma, Mizue Fujii, Satomi Igawa, Masaru Homma, Akemi Ishida-Yamamoto

The Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan

P08-07[C08-04]

Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healingvia MAPK pathways

○Hainan Yue1,2, Yoshie Umehara2, Juan Valentin Trujillo2, Ge Peng1,2, Hai LT. Nguyen1,2, Miho Takahashi1,2, Risa Ikutama1,2,Ko Okumura2, Shigaku Ikeda1,2, Hideoki Ogawa2, François Niyonsaba2,3

1The Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Atopy (Allergy)Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Faculty of International Liberal Arts, JuntendoUniversity Graduate School of Medicine, Tokyo, Japan

P08-08[C08-05]

The importance of Sirtuins in skin and new findings about Sirt2 and its link to mechanobiology

○Jacqueline Trivero1, Kelly Dong1, Earl Goyarts1, Edward Pelle1, Donald Collins1, Krystle Corallo1, Nadine Pernodet1,2

1Research & Development, The Estee Lauder Companies, Melville, New York, USA, 2Estee Lauder Research Laboratories, Melville,New York, USA

P08-09[C08-06]

Specific Visualization of Skin Graft Neoangiogenesis in a Flt1-tdsRed BAC Transgenic Mouse Model

○Mohamed Abdelhakim1, Teruyuki Dohi1, Mizuho Yamato1, Hiroya Takada1, Masatsugo Ema2, Shigetomo Fukuhara3, Rei Ogawa1

1Department of Plastic, Reconstructive, and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan, 2Department of Stem Cells &Human Disease Models, Shiga University of Medical Science, Tokyo, Japan, 3Department of Molecular Pathophysiology, Institute ofAdvanced Medicine, Nippon Medical School, Tokyo, Japan

P08-10[C08-07]

IL-36 receptor antagonist (IL36Ra) deficiency disturbs wound healing in cutaneous ischemia-reperfusion injury

○Yoshihito Tanaka1, Yohei Iwata1, Yurie Hasegawa1, Hidehiko Fukushima1, Kenta Saito1, Soichiro Watanabe1, Masashi Akiyama2,Kazumitsu Sugiura1

1Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan, 2Department of Dermatology, NagoyaUniversity Graduate School of Medicine, Aichi, Japan

P08-11 Peroxiredoxin 4 uniquely prevents age-related delayed wound healing in mice

○Reimon Yamaguchi1,2, Xin Guo2, Jianbo Zheng2, Akihiro Shioya2, Jia Han2, Jing Zhang2, Hiroto Ono1, Hidetaka Uramoto3,Takashi Mochizuki1, Sohsuke Yamada2

1The Department of Dermatology, Kanazawa Medical University, Ishikawa, Japan, 2The Department of Pathology and LaboratoryMedicine, Kanazawa Medical University, 3The Department of Thoracic Surgery, Kanazawa Medical University

P08-12 IL-33 knockout protects skin from ulcer formation in ischemia-reperfusion-induced decubitus mouse model

○Meijuan Jin, Mayumi Komine, Mamitaro Ohtsuki

The Department of Dermatology, Jichi Medical University, Tochigi, Japan

P08-13 Hair-follicle associated pluripotent (HAP) stem cells from rat differentiate to beating cardiac tissue sheets

○Nanako Takaoka1, Michiko Yamane1, Koya Obara2, Kyoumi Shirai2, Yuko Hamada2, Nobuko Arakawa2, Ryoichi Aki2,Robert M Hoffman3,4, Yasuyuki Amoh2

1Department of Dermatology, Kitasato University Graduate School of Medical Sciences, Kanagawa, Japan, 2Department ofDermatology, Kitasato University School of Medicine, Kanagawa, Japan, 3AntiCancer, Incorporated, San Diego, United States ofAmerica, 4Department of Surgery, University of California, San Diego, United States of America

P08-14 Facilitation of wound healing by keratinocyte-like cells trans-differentiated from human adipose-derived stemcells in mice

○Jonghun Kim1, Toshio Hasegawa1, Akino Wada1, Yuichiro Maeda1, Shigaku Ikeda1,2

1Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Atopy ResearchCenter, Juntendo University Graduate School of Medicine, Tokyo, Japan

P08-15 Identification of melanocyte progenitor cells in human subcutaneous adipose tissue: potential to differentiateinto mature melanocytes

○Yuri Ikeda1, Akino Wada1, Toshio Hasegawa1, Shigaku Ikeda1,2

1The Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, 2Atopy (Allergy) ResearchCenter, Juntendo University Graduate School of Medicine


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P08-16 Adiponectin-Based Peptide (ADP355) Inhibits Transforming Growth Factor-beta 1-Induced Fibrosis in Keloids

Claudia C. Darmawan1, Sara E. Montenegro1, Gwanghyun Jo1, Novi Kusumaningrum2, Si-Hyung Lee1, Jin-Ho Chung1,○Je-Ho Mun1

1Department of Dermatology, Seoul National University College of Medicine, 2Department of Dermatology and Venereology,Diponegoro University

P08-17 Plasma metabolomic and lipidomic profiling in keloid-prone individuals: a case-control study

○Alexandros Onoufriadis1, Chao-Kai Hsu2,3, Ming-Jer Tang3,4, John A. McGrath1

1St John’s Institute of Dermatology, School of Basic and Medical Biosciences, King’s College London, London, United Kingdom,2Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University,Tainan, Taiwan, 3International Research Center of Wound Repair and Regeneration (iWRR), National Cheng Kung University, Tainan,Taiwan, 4Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

P08-18 miR-146a and its importance against skin cell aging

○Nadine Pernodet1,2, Klodjan Stafa1, Kelly Dong1, Dawn Layman1, Krystle Corallo1, Jacqueline Trivero1, Whitby Eagle1, Earl Goyarts1

1Research & Development, The Estee Lauder Companies, Melville, New York, 2Estee Lauder Research Laboratories, Melville, NewYork

P08-19 A challenge to prolong survival in primary keratinocyte culture

○Takeshi Yanagishita, Noriko Kato, Hiroyuki Takama, Yuichiro Ohshima, Daisuke Watanabe

Department of Dermatology, Aichi Medical University School of Medicine

Category 9 (P09): Hair and Cutaneous Development

P09-01[I-8]

WNT, SHH, and EDA signal agonists potentiate human iPS cell-derived dermal papilla substitutes in in vitro hairfollicle regeneration assay

○Masahiro Fukuyama1, Aki Tsukashima1, Momoko Kimishima1, Yoshimi Yamazaki1, Hideyuki Okano2, Manabu Ohyama1

1The Department of Dermatology, Kyorin University Faculty of Medicine, Tokyo, Japan, 2Department of Physiology, Keio UniversitySchool of Medicine, Tokyo, Japan

P09-02[C09-01]

Hair follicle stem cell progeny repair subepidermal blisters at the expense of skin development

○Yu Fujimura1, Mika Watanabe1,2, Kota Ohno3, Yasuaki Kobayashi3, Hideki Nakamura1, Andrea Lauria2,4, Valentina Proserpio2,4,Hideyuki Ujiie1, Hiroaki Iwata1, Wataru Nishie1, Masaharu Nagayama3,5, Salvatore Oliviero2,4, Giacomo Donati2, Hiroshi Shimizu1,Ken Natsuga1

1Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Department of Life Sciences andSystems Biology, Molecular Biotechnology Centre, University of Turin, Turin, Italy, 3Research Institute for Electronic Science,Hokkaido University, Sapporo, Japan, 4Italian Institute for Genomic Medicine, Candiolo (TO), Italy, 5Japan Science and TechnologyAgency, CREST, Kawaguchi, Japan

P09-03[C09-02]

Multicolor three-dimensional reconstruction of whole murine sweat glands using optical clearing and two-photon excitation microscopy

○Tadatsune Iida, Daiki Fukae, Hiroo Yokozeki

Department of dermatology, Tokyo Medical and Dental University, Tokyo, Japan

P09-04[C09-03]

An underlying mechanism of hair loss in acrodermatitis enteropathica

○Riko Asakawa, Shinji Shimada, Tatsuyoshi Kawamura


P09-05[C09-04]

Introduction of hTERT and hBMI1 genes extends the life span of human dermal papilla cells with hair inductiveactivity

○Mayumi Ikeda1,2, Shigeharu Yabe2, Masahiro Kiso2, Naoko Ishiguro3, Tetsuya Tsuchida1, Koichiro Nakamura1, Yuichiro Tsunemi1,Hitoshi Okochi2

1Department of Dermatology, Saitama Medical University, 2Department of Regenerative Medicine, Research Institute, National Centerfor Global Health and Medicine, 3Department of Dermatology, Tokyo Women Medical University

P09-06 Squaric acid dibutylester promotes hair regeneration via induction of M2 macrophages

○Koichi Tomii1,2, Arata Takeuchi2, Daichi Kobayashi2, Tomoya Katakai2, Riichiro Abe1

1Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 2Department ofImmunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

P09-07 Induction of alopecia areata in C3H/HeJ mice using cryopreserved lymphocytes

○Kei Hashimoto, Mika Fujikawa, Kota Sekiguchi, Shoichi Matsuda, Yusuke Kumagai, Narumi Koretou, Sachi Mori,Tatsumi Matsumoto

Kyoto R&D Center, Maruho Co., Ltd.

P09-08 Ahed is a novel component of spliceosome and is required for cell proliferation of epidermal keratinocytes

○Mikiro Takaishi1, Tatsushi Ishimoto1, Masahiro Tokunaga2, Chikara Kokubu3, Junji Takeda4, Shigetoshi Sano1

1Dept. Dermatol., Kochi Med. School, Kochi Univ., 2Dept. Hematol., Suita Municipal Hosp., 3Child Healthcare and Genetic ScienceLab, Grad. School Med., Osaka Univ., 4Research Inst. Microb. Diseases, Osaka Univ.


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P09-09 The comparison of the hair morphology and the gene expression profiles of two kinds of mice models foralopecia areata (AA) and human AA

○Satoshi Koyama1, Nagisa Yoshihara1, QiaoFeng Zao1, Atsushi Takagi1, Etsuko Komiyama1, Tomotaka Mabuchi2, Akira Oka3,Shigaku Ikeda1

1Department of Dermatology and Allergology, and Atopy (Allergy) Research Center, Juntendo University Graduate School ofMedicine, 2Department of Dermatology, Tokai University School of Medicine, 3The Institute of Medical Sciences, Tokai University

P09-10 Mutation analysis for 36 patients with syndromic forms of congenital hair loss disorders among the Japanesepopulation

○Ryota Hayashi1, Yutaka Shimomura2, Satoru Shinkuma3, Atsushi Fujimoto1, Hiroki Fujikawa1, Riichiro Abe1

1Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 2Department ofDermatology, Yamaguchi University Graduate School of Medicine, Ube, Japan, 3Department of Dermatology, Nara MedicalUniversity School of Medicine, Nara, Japan

Category 10 (P10): Immunology 1: Adaptive Immunity

P10-01[II-1]

FcγRIIB-dependent blockade of class-switch is crucial tolerogenic process to prevent pemphigus onset inpathogenic Dsg3 specific BCR KI mice

○Hisashi Nomura1, Naoko Wada1, Hayato Takahashi1, Shohei Egami1, Jun Yamagami1, Takashi Watanabe2, Osamu Ohara2,Shigeo Koyasu2, Masayuki Amagai1,2

1Department of Dermatology, Keio University, School of Medicine, Tokyo, Japan, 2RIKEN Center for Integrative Medical Sciences

P10-02 Transcription factor EHF contributes to differentiation of Langerhans cells and development of allergic contactdermatitis

○Nobuhiro Nakano1, Jiro Kitaura1, Ko Okumura1, Hideoki Ogawa1,2, Shigaku Ikeda1,2

1Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology andAllergology, Juntendo University Graduate School of Medicine, Tokyo, Japan

P10-03[I-1]

Lymphotoxin β receptor signaling and CD11c+ dendritic cells form high endothelial venule-like vessels in murineatopic dermatitis model

○Shuto Kanameishi1, Sachiko Ono1, Tetsuya Honda2, Kenji Kabashima1

1Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Department of Dermatology, HamamatsuUniversity School of Medicine, Japan

P10-04[C10-01]

CD4+ resident memory T cells colocalize with conventional DC subset 2 in lymphocyte clusters in a murinedelayed-type hypersensitivity model

○Ryota Asahina, Gyohei Egawa, Kenji Kabashima

The Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

P10-05[C10-02]

Suppression of IL-23-mediated psoriasis-like inflammation by regulatory B cells

○Kie Mizumaki, Miyu Kano, Takashi Matsushita

The Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, KanazawaUniversity, Kanazawa, Japan

P10-06[C10-03]

Cell model of Stevens-Johnson syndrome and toxic epidermal necrolysis

○Akito Hasegawa, Tomoki Nishiguchi, Riichiro Abe

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

P10-07[C10-04]

AIM2 regulates anti-tumor immunity and serves as a viable therapeutic target for melanoma

○Keitaro Fukuda1, Rebecca L. Riding2, Xueli Fan2, Sean M. McCauley3, Jeremy Luban3, Takeru Funakoshi1, Tomonori Yaguchi4,Yutaka Kawakami4, Anastasia Khvorova5, Katherine A. Fitzgerald6, John E. Harris2

1Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Department of Dermatology, University ofMassachusetts Medical School, Worcester, MA, USA, 3Department of Biochemistry and Molecular Pharmacology, University ofMassachusetts Medical School, Worcester, MA, USA, 4Division of Cellular Signaling, Institute for Advanced Medical Research, KeioUniversity School of Medicine, Tokyo, Japan, 5Department of Molecular Medicine, University of Massachusetts Medical School,Worcester, MA, USA, 6Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester,MA, USA

P10-08[C10-05]

Tumor necrosis factor-alpha plays pivotal role in cytotoxic T lymphocyte-induced dermatitis

○Toshiya Miyake, Gyohei Egawa, Kenji Kabashima

Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan


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P10-09[C10-06]

FABP5 as a possible biomarker in atopic march: FABP5-induced Th17 polarization, both in mouse model andhuman samples

Jungsoo Lee1,2,3, Bomi Kim1, Howard Chu1,○Kelun Zhang1,4, Hyeran Kim1, Ji Hye Kim1,4, Seo Hyeong Kim1,4, Youdong Pan5,Ji Yeon Noh1, ZhengWang Sun1, Jung-Won Park6,7, Thomas S Kupper5, Chang Ook Park1,4,5,7, Kwang Hoon Lee1,6,7

1Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea,2Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea, 3Research Institute for Convergence ofBiomedical Science and Technology, Yangsan, Korea, 4Brain Korea 21 Project for Medical Science, Yonsei University College ofMedicine, Seoul, Korea, 5Department of Dermatology & Harvard Skin Disease Research Center, Brigham and Women’s Hospital,Boston, Harvard Medical School, Boston, Massachusetts, USA, 6Division of Allergy and Immunology, Department of InternalMedicine, Yonsei University College of Medicine, Seoul, Korea, 7Institute of Allergy, Yonsei University College of Medicine, Seoul,Korea

P10-10[C10-07]

Character and function of human epidermal resident regulatory CD4+ T cells

○Takuya Sato, Youichi Ogawa, Shinji Shimada, Tatsuyoshi Kawamura


P10-11 PD-1 regulates passive anaphylaxis: possible role of the mast cell intracellular inhibitory signaling

○Tatsuya Ogawa1, Yosuke Ishitsuka1, Manabu Fujimoto2

1Department of Dermatology, University of Tsukuba, Japan, 2Department of Dermatology, Osaka University, Japan

P10-12[C10-08]

Attenuation of percutaneous sensitization by oral tolerance induction is independent of Treg-mediatedimmunosuppression in the skin

○Arisa Akagi1, Akihiko Kitoh1, Sho Hanakawa1, Kenji Kabashima1,2

1Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Singapore Immunology Network and SkinResearch Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore

P10-13 CD103 negative memory T cells may play important roles in making regulatory T cell-enriched environments inskin cancer

○Yoshiyuki Nakamura1, Rei Watanabe2, Zhu Zhenjie1, Manabu Fujimoto2, Yasuhiro Fujisawa1

1The Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, 2The Department ofDermatology, Graduate School of Medicine, Osaka University, Japan

P10-14 Different reactivity of CD4 and CD8 T cells to interleukin-23 in non-lesional psoriatic skin

○Yutaka Matsumura1,2, Rei Watanabe1,2, Sa Vo1, Hanako Koguchi-Yoshioka1,2, Junichi Furuta1, Yasuhiro Fujisawa1, Manabu Fujimoto1,2

1Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan, 2Department of Dermatology, Course ofIntegrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan

P10-15 Photodynamic therapy with immune-adjuvant nanoparticles for effective tumor immunotherapy

○Qianru Li1,2, Qianqian Liu3, Liyun Dong1,2, Jintao Zhu3, Juan Tao1,2

1Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST),Wuhan, China, 2Hubei Engineering Research Center for Skin Repair and Theranostics, Wuhan, China, 3Key Laboratory of MaterialChemistry for Energy Conversion and Storage, Ministry of Education (HUST), School of Chemistry and Chemical Engineering, HUST,Wuhan, China

P10-16 Characterization of human epidermal resident memory CD8+ T cells: Relevance for the involvement ofpathogenesis of vitiligo

○Yoshinori Muto, Youichi Ogawa, Takuya Sato, Shinji Shimada, Tatsuyoshi Kawamura


P10-17 High-throughput RNA sequencing reveals major alterations of inflammatory molecules involved in pathogenesisof psoriasis

○Pinyadapat Vacharanukrauh1, Mayumi Komine2, Jitlada Meephansan1, Saranyoo Ponnikorn1

1The Department of Dermatology, Internation College of Medicine, Thammasat University, 2Department of Dermatology, andDepartment of Biochemistry, Jichi Medical University

P10-18 Epicutaneous vaccination with protease allergen prevents airway inflammation induced by protease allergeninhalation in mice

○Shinya Kunimine1,2, Toshiro Takai1, Seiji Kamijo1, Natsuko Maruyama1, Toru Kimitsu1,2, Yurie Masutani1,2, Tomoko Yoshimura1,2,Saya Shimizu1, Punyada Suchiva1,2, Ko Okumura1, Hideoki Ogawa2, Shigaku Ikeda1,2

1Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2Department of Dermatology and Allergology,Juntendo University Graduate School of Medicine

P10-19 Epicutaneous vaccination with ovalbumin prevents airway IL-33-dependent antigen-specific Th2 differentiationin mice

○Toru Kimitsu1, Toshiro Takai1, Shinya Kunimine1,2, Seiji Kamijo1, Natsuko Maruyama1, Yurie Masutani1,2, Tomoko Yoshimura1,2,Punyada Suchiva1,2, Saya Shimizu1, Ko Okumura1, Hideoki Ogawa2, Shigaku Ikeda1,2



- 58 -

P10-20 Epicutaneous sensitization to protease allergen via detergent-treated skin promotes IgE production and skininflammation

○Tomoko Yoshimura1,2, Toshiro Takai1, Takasuke Ogawa2, Natsuko Maruyama1, Haruto Yamanashi2, Seiji Kamijo1, Yurie Masutani1,2,Toru Kimitsu1,2, Ko Okumura1, Hideoki Ogawa2, Shigaku Ikeda1,2


P10-21 Inhibition of both COX-1 and -2 promotes epicutaneous sensitization to protease allergen and subsequent airwayinflammation in mice

○Yurie Masutani1,2, Punyada Suchiva1,2, Toshiro Takai1, Seiji Kamijo1, Natsuko Maruyama1, Toru Kimitsu1,2, Tomoko Yoshimura1,2,Shinya Kunimine1,2, Saya Shimizu1, Takehiko Yokomizo3, Yukihiko Sugimoto4, Ko Okumura1, Shigaku Ikeda1,2, Hideoki Ogawa2

1Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2Department of Dermatology and Allergology,Juntendo University Graduate School of Medicine, 3Department of Biochemistry, Juntendo University Graduate School of Medicine,4Department of Pharmaceutical Biochemistry, Kumamoto University Graduate School of Medicine

Category 11 (P11): Immunology 2: Innate Immunity and Microbiology

P11-01[I-5]

The axis of drug-specific CD8+ T cells-neutrophils trigger Stevens-Johnson syndrome and toxic epidermalnecrolysis

○Manao Kinoshita1, Youichi Ogawa1, Natsumi Hama2, Inkin Ujiie3, Akito Hasegawa2, Saeko Nakajima4, Takashi Nomura4,Shinji Shimada1, Yasuyuki Fujita3, Hayato Takahashi5, Yoshiko Mizukawa6, Keisuke Nagao7, Riichiro Abe2, Tatsuyoshi Kawamura1

1Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan, 2Division of Dermatology, NiigataUniversity Graduate School of Medical and Dental Sciences, Niigata, Japan, 3Department of Dermatology, Hokkaido UniversityGraduate School of Medicine, Sapporo, Japan, 4Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto,Japan, 5Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 6Department of Dermatology, KyorinUniversity School of Medicine, Tokyo, Japan, 7Cutaneous Leukocyte Biology Section, Dermatology Branch, National Institute ofArthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD, USA

P11-02[C11-01]

Single-Cell RNA Sequencing Reveals Novel Cutaneous Group 2 Innate Lymphoid Cell Subtypes, Circulating ILC2,and Skin-Resident ILC2

○Minori Kusakabe1, Yasutomo Imai1, Makoto Nagai1, Koubun Yasuda2, Etsushi Kuroda2, Michio Tomura3, Kiyofumi Yamanishi1

1Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan, 2Department of Immunology, Hyogo College ofMedicine, Nishinomiya, Japan, 3Laboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University, Osaka, Japan

P11-03[C11-02]

Skin bacteria in serum exosome related to dysbiosis of skin microbiome in atopic dermatitis

○Toru Kawai1, Ryota Hayashi1, Akito Hasegawa1, Akihiko Yuki1, Osamu Ansai1, Koichi Tomii1, Jun Adachi2,3, Takeshi Tomonaga2,3,Riichiro Abe1

1Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, 2Laboratory of Proteome Research,National Institute of Biomedical Innovation, Health and Nutrition, 3Laboratory of Proteomics for Drug Discovery, Center for DrugDesign Research, National Institute of Biomedical Innovation

P11-04[C11-03]

CRH receptor mediated signalling is a therapeutic target for stress-related diseases by controlling excessive mastcells biology

○Mika Yamanaka-Takaichi, Koji Sugawara, Daisuke Tsuruta

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan

P11-05[C11-04]

The dysregulation of DNA methylation enzymes and synchronized gene expression of retrotransposon and type Iinterferon in dermatomyositis

○Yuko Kuriyama, Akira Shimizu, Saki Kanai, Sei-ichiro Motegi, Osamu Ishikawa

The Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan

P11-06[C11-05]

Female hormones enhance HIV-1 acquisition in female Langerhans cells, but not in male Langerhans cells

○Youichi Ogawa, Shinji Shimada, Tatsuyoshi Kawamura


P11-07[C11-06]

Essential role of the CCL2-CCR2 pathway in the pathogenesis of chronic irritant contact dermatitis

○Rintaro Shibuya1, Akihiko Kitoh1, Sho Hanakawa1, Yoshihiro Ishida1, Kenji Kabashima1,2

1Department of Dermatology, Kyoto University Graduate School of Medicine, 2Singapore Immunology Network and Skin ResearchInstitute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore

P11-08[C11-07]

Differential lipid recognition by mouse vs human CD300f, inhibiting IgE-mediated anaphylaxis, depends on asingle amino acid substitution

○Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Akie Maehara, Moe Matsuzawa, Taiki Ando, Takuma Ide, Yoko Okamoto,Saaya Fukase, Mayuki Kojima, Anna Kamei, Meiko Kimura, Hexing Wang, Ko Okumura, Jiro Kitaura

Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan


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P11-09 Acquired dysfunction of Agr quorum sensing in MRSA induces antibiotic persistence and resistance during long-time survival in NICU

○Yuriko Yamazaki1, Yuumi Nakamura2, Akiko Takaya3, Hiroki Takahashi4, Toshibumi Taniguchi5, Hidetoshi Igari5, Yoshiteru Osone6,Naoki Shimojo6, Hiroyuki Matsue1

1Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan, 2Cutaneous Immunology, ImmunologyFrontier Research Center, Osaka University, 3Laboratory of Microbiology and Immunology, Graduate School of PharmaceuticalSciences, Chiba University, 4Medical Mycology Research Center, 5Department of Infectious Diseases, Chiba University hospital,6Department of Pediatrics, Chiba university Graduate School of medicine

P11-10 Skin colonized Staphylococcus aureus increases the susceptibility to inflammation via activation of neutrophils

○Masashi Iwata, Saeko Nakajima, Duerna Tie, Kenji Kabashima


P11-11 The lipoprotein receptor LRP1 is required for AMP-IBP5-induced migration and proliferation of keratinocytesand fibroblasts

○François Niyonsaba1,2, Panjit Chieosilapatham3, Hainan Yue1,4, Yoshie Umehara1, Juan Valentin Trujillo Paez1, Ge Peng1,4,Le Thanh Hai Nguyen1,4, Miho Takahashi1,4, Risa Ikutama1,4, Ko Okumura1, Shigaku Ikeda1,4, Hideoki Ogawa1

1Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Faculty of International LiberalArts, Juntendo University, Tokyo, Japan, 3Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai,Thailand, 4Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan

P11-12 Dupilumab’s Effects on Circulating Group 2 Innate Lymphoid Cell and T Helper Type 2 Cell Populations inPatients with Atopic Dermatitis

○Yasutomo Imai, Minori Kusakabe, Makoto Nagai, Yukako Inoue, Masaru Natsuaki, Kiyofumi Yamanishi

Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan

P11-13 Topical application of toll-like receptor 3 inhibitors ameliorates chronic allergic skin inflammation in mice

○Risa Tamagawa-Mineoka1, Mayumi Ueta2, Yukiyasu Arakawa1, Risa Yasuike1, Yasushi Okuno3, Ichiro Hijikuro4, Shigeru Kinoshita2,Norito Katoh1

1Department of Dermatology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 2Department of Frontier Medical Science andTechnology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 3Department of Biomedical Data Intelligence,Kyoto University, Kyoto, Japan, 4Farnex Inc., Yokohama, Japan

P11-14 Oral administration of S. aureus and S. danieliae exacerbates skin inflammation of imiquimod-inducedpsoriasis-like dermatitis

○Karin Okada, Yoshiaki Matsushima, Kento Mizutani, Keiichi Yamanaka

Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

P11-15 Reduced induction of human β-defensins is involved in the pathological mechanism of cutaneous adverse effectscaused by EGFR inhibitors

○Rie Ommori1, Yuki Nakamura1, Fumi Miyagawa1, Chinatsu Shobatake1, Kohei Ogawa1, Fumikazu Koyama2, Masayuki Sho2,Ichiro Ota3, Tadashi Kitahara3, Shigeto Hontsu4, Sigeo Muro4, Hideo Asada1

1Department of Dermatology, Nara Medical University, Nara, Japan, 2Department of Surgery, Nara Medical University, Nara, Japan,3Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Nara, Japan, 4Second Department of InternalMedicine (Department of Respiratory Medicine), Nara Medical University, Nara, Japan

P11-16 Phosphatidylinositol-specific phospholipase C enhances penetration of Staphylococcus aureus across theepidermis

○Yoshikazu Nakamura1, Kaori Kanemaru1, Madoka Shoji2, Kengo Totoki2, Karen Nakamura2, Hidemasa Nakaminami2,Norihisa Noguchi2, Kiyoko Fukami2

1The Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Chiba, Japan,2Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

P11-17 Alteration of the fecal and salivary microbiome in patients with Behçet’s disease compared with recurrentaphthous ulcer

○Jin Cheol Kim1, Mi Jin Park1, Sun Park2, Eun-So Lee1

1The Department of Dermatology, School of Medicine, Ajou University, Suwon, Korea, 2The Department of Microbiology andImmunology, School of Medicine, Ajou University, Suwon, Korea

P11-18 Skin Microbiota composition is determined by host genetics: a genome wide association study

○Jack A Galbraith, Julien Legrand, Nicholas Muller, Katie Togher, Nicholas Matigian, Betoul Baz, Grant Morahan, Graeme Walker,Mark Morrison, Kiarash Khosrotehrani

The University of Queensland

P11-19 Regulation of Innate Immune in Response to S.aureus by Protein Geranylgeranylation and Expression of PGGT1Bin PBMC of Psoriasis

○Zhimin Hao1, Donghai Wang2, Heng Gu1

1Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 2Duke University


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Category 12 (P12): Photobiology

P12-01[I-9]

Identification and Quantification of Senescent Cells In UV-induced Skin Pathologies

○Audrey Wang1, Satoshi Nakamizo1,2,3, Yoshihiro Ishida2, Genevieve Klassen4, Priscilla Chong4, John Lim5, Graham Wright5,Kenji Kabashima2,3,4, Oliver Dreesen1

1Skin Research Institute Singapore, A*STAR, 2Kyoto University Graduate School of Medicine, Japan, 3Singapore Immunology Network(SIgN), 4School of Biological Sciences, Nanyang Technological University, 5A*STAR Microscopy Platform

P12-02[C12-01]

Skin regulatory T cells possessing a healing function are expanded by ultraviolet-B exposure

○Sayuri Yamazaki1, Hiroaki Shime1, Mizuyu Odanaka1, Makoto Tsuiji2, Takuma Matoba1,3, Masaki Imai1, Yoshiaki Yasumizu4,Ryuta Uraki1, Kiyoshi Minohara1,3, Maiko Watanabe1, Anthony John Bonito5, Hidehiro Fukuyama6, Naganari Ohkura4,7,Shimon Sakaguchi4, Akimichi Morita8

1Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, 2Department ofMicrobiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan, 3Department of Oto-rhino-laryngology and Head-and-neck-surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, 4Departmentof Experimental Immunology, World Premier International Research Center Initiative, Immunology Frontier Research Center, OsakaUniversity, Osaka, Japan, 5Immunoassay Research & Development, Laboratory Diagnostics, Siemens Healthineers, NY, USA,6Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan,7Immunopharmaceutical Development Unit, Center of Medical Innovation Research, Graduate School of Medicine, Osaka University,Osaka, Japan, 8Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of MedicalSciences, Nagoya, Japan

P12-03 Photo-aging Associated Change in M1/M2 Balance of Macrophage Modulates the Senescence of DermalFibroblasts

○Satoshi Horiba, Junichi Hosoi

Shiseido Global Innovation Center, Yokohama, Japan

P12-04[C12-02]

Nicotinamide Modulates Photoaging in Human Primary Keratinocytes

○Christina YR Tan1, Chye L Tan1, Toby Chin1, Holly A Rovito2, Malgorzata E Morenc1, Ling S Quek1, John E Oblong2,Sophie Bellanger1

1Skin Stemness, Differentiation and Aging, Skin Research Institute of Singapore, A*STAR, Singapore, 2Beauty Technology Division, TheProcter & Gamble Company, Cincinnati, OH, USA

P12-05[C12-03]

The study of threshold of acute reactions on human skin with shorter wavelength UVC

○Nozomi Yamano1, Makoto Kunisada1, Aiko Nishiaki-Sawada2, Hiroyuki Ohashi2, Tatsushi Igarashi2, Chikako Nishigori1

1Division of Dermatology, Department of Internal Related, Graduate School of Medicine, Kobe University, Kobe, Japan, 2Ushio Inc.,Chiyoda-ku, Tokyo, Japan

P12-06 A reanalysis of public omics datasets identifies possible epigenetically regulated genes in photoaging

○Taiki Tsutsui, Takako Shibata

Shiseido Global Innovation Center

P12-07 Effect of elastic UV-transparent pad for targeted phototherapy

○Hideyuki Masuda1,2, Akimichi Morita1

1Department of Geriatric and Environmental Dermatology, Nagoya City University, Graduate School of Medical Sciences, Nagoya,Japan, 2USHIO INC. Tokyo, Japan

P12-08 Usefulness of UVA lamp for follow up of oral antifungal treatment of onychomycosis

○Tomotaka Sato, Tomohiro Suzuki, Kazuhiro Aoyama

Department of dermatology, Teikyo University, Chiba Medical Center

Category 13 (P13): Pigmentation and Melanoma

P13-01[I-3]

Distinct molecular signatures orchestrate tumor subpopulations in melanoma models mimicking tumormicroenvironment and drug tolerance

○Farzana Ahmed1, Abdullah A Emran1,2, Crystal A Tonnessen-Murray1, Brian Gabrielli3, Mitchell Stark1, Michelle Hill1,4,Helmut Schaider1, Loredana Spoerri1, Nikolas K Haass1

1The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia, 2The Centenary Institute,The University of Sydney, Newtown, NSW, Australia, 3Mater Research Institute, The University of Queensland, Brisbane, QLD,Australia, 4QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

P13-02[C13-01]

Biomechanically regulated cellular processes of melanoma cell invasion and survival in confined environments

○Robert J Ju, Yash Chhabra, Samantha S Stehbens, Nikolas K Haass

The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia

P13-03[C13-02]

Increase in melanoma-antigen specific intracellular PD-1+ T cells in advanced melanoma patients

○Ryo Takahashi1, Yohei Sato2, Momoko Kimishima2, Manabu Ohyama1,2

1Flow Cytometry Core Facility, Kyorin University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology, KyorinUniversity Faculty of Medicine, Tokyo, Japan


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P13-04 Targeting DNAJB1 synergistically enhances hyperthermia induced melanoma cell death

○Hexiao Wang, Lan Zhang, Yang Yang, Xinghua Gao, Hongduo Chen

Department of Dermatology, The First Hospital of China Medical University, Shenyang, P.R.China

P13-05[C13-03]

Usefulness of monitoring circulating tumor cells as a therapeutic biomarker in melanoma with BRAF mutation

○Yukiko Kiniwa1, Kenta Nakamura1, Asuka Mikoshiba1, Atsuko Ashida1, Yasuyuki Akiyama2, Atsushi Morimoto2, Ryuhei Okuyama1

1Department of Dermatology, Shinshu University School of Medicine, 2Life Science Research Laboratory, Tosoh Corporation

P13-06[C13-04]

microRNA expression and functional analysis in melanoma cells in vitro and in vivo

○Tatiana Ruksha, Elena Nikolaeva, Mariya Aksenenko, Nadezhda Palkina, Danil Zemtsov, Irina Dubovtseva

The Department of Pathophysiology, Krasnoyarsk State Medical University

P13-07 Five novel mutations of SASH1 in Japanese families with lentiginous phenotypes

○Yuta Araki1, Ken Okamura1, Yutaka Hozumi1, Kazuhiko Matsumoto2, Ken Natsuga3, Junko Nishimoto4, Yoko Funasaka5,Yaei Togawa6, Tamio Suzuki1

1The Department of Dermatology, Yamagata University Faculty of Medicine, Yamagata, Japan, 2The Department of Dermatology,Shinshu University School of Medicine, Matsumoto, Japan, 3The Department of Dermatology, Hokkaido University Graduate Schoolof Medicine, Sapporo, Japan, 4The Department of Dermatology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan, 5TheDepartment of Dermatology, Nippon Medical School, Tokyo, Japan, 6The Department of Dermatology, Graduate School of Medicine,Chiba University, Chiba, Japan

P13-08[C13-05]

Establishment of co-culture of human induced pluripotent stem (iPS) cell-derived melanocyte and keratinocytesin vitro

○Tamihiro Kawakami, Toshiro Komatsu, Kae Yokoyama, Takaharu Ikeda, Kazuo Takahashi, Yupeng Dong

The Division of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan

P13-09[C13-06]

Functional melanoma cell heterogeneity is regulated by MITF-dependent cell-matrix interactions

○Loredana Spoerri1, Crystal A Tonnessen-Murray1, Gency Gunasingh1, David S Hill2,3, Kimberley A Beaumont2,3, Russell J Jurek4,Helmut Schaider1, Wolfgang Weninger2,3, Brian Gabrielli5, Nikolas K Haass1,2,3

1The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia, 2The Centenary Institute,The University of Sydney, Newtown, NSW, Australia, 3Discipline of Dermatology, Sydney Medical School, The University of Sydney,Camperdown, NSW, Australia, 4CSIRO Astronomy & Space Sciences, Australia Telescope National Facility, Epping, NSW, Australia,5Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia

P13-10[C13-07]

CD8 T cells multifunctionality and PD-L1 expression as a biomarker of anti-PD-1 antibodies in advancedmelanoma

○Keiko Manabe1, Osamu Yamasaki1, Yuki Nakagawa1, Tomoko Miyake1, Heiichiro Udono2, Shin Morizane1

1Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama,Japan, 2Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama, Japan

P13-11[C13-08]

Effect of particulate matter on melanogenesis

○Eun Jung Lee1, Yuri Ahn1, Ji Young Kim1, Jimyung Seo2, Shinwon Hwang1, Sang Ho Oh1

1Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine,Seoul, Korea, 2Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Engineering (KAIST),Daejeon, Korea

P13-12 Expression of BATF2 in malignant melanoma as a novel invasive marker

○Hisashi Kanemaru, Hidemi Tagawa, Toshihiro Kimura, Haruka Kuriyama, Soichiro Sawamura, Ikko Kajihara, Azusa Miyashita,Jun Aoi, Satoshi Fukushima, Hironobu Ihn

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

P13-13 Withdrawn

P13-14 Dermoscopic diagnostic performance of Japanese dermatologists for skin tumor differs by patient origin: A deepneural network closes the gap

○Akane Minagawa1, Hiroshi Koga1, Tasuku Sano1, Kazuhisa Matsunaga2, Yoshihiro Teshima2, Akira Hamada2, Yoshiharu Houjou2,Ryuhei Okuyama1

1The Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan, 2Casio Computer Co., Ltd., Tokyo, Japan

P13-15 Re-evaluation of analogues of a potent tyrosinase inhibitor

○Jaimie Jerome, Thomas Mammone

The Estee Lauder Companies, Melville, New York

P13-16 Ectopic proliferation of keratinocytes with abnormal expressions of trace mineral-trafficking molecules in thepathology of solar lentigo

○Mikiko Odawara1, Minori Mezaki1, Tomohisa Yoshimura2, Tohru Nagahama1, Akiko Takaoka1, Fumino Oda3, Hidehisa Saeki3,Yoko Funasaka3

1R&D Laboratories, Self-Medication, Taisho Pharmaceutical Co., LTD., Saitama, Japan, 2Self-Medication Business Planning, TaishoPharmaceutical Co., LTD., Saitama, Japan, 3Department of Dermatology, Nippon Medical School, Tokyo, Japan


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P13-17 Cellular senescence in non-segmental vitiligo

○Jin Wook Lee1,2, Tae Hyung Kim3, Tae Jun Park1,4,5, Hee Young Kang1,3

1Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon, Republic of Korea, 2Department ofDermatology, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea, 3Department of Dermatology, AjouUniversity School of Medicine, Suwon, Republic of Korea, 4Department of Biochemistry and Molecular Biology, Ajou UniversitySchool of Medicine, Suwon, Republic of Korea, 5Institute on Ageing, Ajou University Medical Center, Suwon, Republic of Korea

P13-18 Establishment of a risk assessment system for chemical leukoderma

○Akira Tazaki, Lisa Kondo-Ida, Chiaki Tsuchiya, Lanyue Zhang, Delgama A.S.M. Nishadhi, Hidemi Hayashi

Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan

P13-19 Possible mechanism underlying hypopigmentation in psoriatic lesion

○Kimiko Nakajima, Yukiko Aoyama, Shigetoshi Sano

The Department of Dermatology, Kochi Medical School, Kochi University, Kochi, Japan

P13-20 A systems biology approach for skin brightening, including autophagy as a critical mechanism to controlpigmentation

○Kelly Dong1, Dawn Layman1, Nadine Pernodet1,2

1The Estee Lauder Companies, Melville, New York, USA, 2Estee Lauder Research Laboratories, Melville, New York, USA

45JSID Program 1211 · 2020. 12. 11. · 2nd Day, December 12, Saturday, 2020 Room A Room B Room...

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