Lecture 1 Introduction to CHEM 346 September 3rd 2013

346 Organic Chemistry Laboratory Fall 2013

“The Undivided Mind” Imaginary Foundation, 2010

READY FOR RESEARCH

Blackwell et al, J. Chem. Educ. 2006, 83, 1835-1843

UNDERGRADUATE CHEM 344

What is CHEM 346?

-  chemical information resources

Part 1 - Learning

-  intermediate/advanced lab techniques

-  scientific writing

-  ethics in scientific research

-  new organic chemistry

New organic chemistry & techniques

-  3 “scripted” lab projects

1.  Total synthesis of a sulfa-antibiotic - protecting groups - EAS - antibacterial testing

NH2SO

OH2N

Sulfanilamide

What is CHEM 346?

Gerhard Domagk

What is CHEM 346?

New organic chemistry & techniques

-  3 “scripted” lab projects

2. Visible light photocatalysis - ligand synthesis/coordination chemistry - photocatalysis of a Diels-Alder reaction - screening reaction conditions - collating & discussing experimental data

Ru

N

N

NN

N

N

NN

NN

NN

[Ru(bpz)3]2+

2+

R1

R2 R3R2

R1

R4R3

R4+

Diels-Alder

[Ru(bpz)3]2+

Prof. Tehshik Yoon UW-Madison

What is CHEM 346?

New organic chemistry & techniques

-  3 “scripted” lab projects

3. Jacobsen epoxidation - ligand synthesis/coordination chemistry - asymmetric epoxidation of an alkene - mechanistic details

R1

R2

R1

R2O

Jacobsen catalyst

NaOCl

N N

O OMn

Jacobsen catalyst

Cl

Prof. Eric Jacobsen Harvard University

What is CHEM 346?

Chemical information resources

-  2 sessions with chemistry librarian

Scientific writing

Ethics in scientific research

-  overview and case studies

- peer review of first draft comments graded final draft

-  3 lab reports written in Organic Letters template

What is CHEM 346?

-  chemical information resources

Part 1 - Learning

-  intermediate/advanced lab techniques

-  scientific writing

-  ethics in scientific research

-  new organic chemistry

Part II - Applying

-  research project/lab placement

-  poster presentation

This week

-  processing/work-up of NMR data (Kaz)

Today

-  training on NMR instrument (Dr. Fry)

-  lab drawer check-in B341

Thursday

-  begin sulfanilamide lab project

-  read lab manual, know what you are doing