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Tackling infectious diseases

French-based international research

networksFrançois Dabis

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Infectious diseases: 2/3 of all deaths in children <5 years

Black RE – Lancet 2010

18%

15%

31%

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The French-based international infectious

diseases research networks

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4 networks of excellenceactive in most of the developing world

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Respiratory Infections Encephalitis

HIV/AIDSHepatitisZoonosisDengueMalaria

Research toolsMicroorganism

cultureBiobank/Databank

SurveillanceCohorts

Entomology

Priority areasPublic health reference labs

ResearchTraining

Asia-Pacific Region

9 Institutes

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The HIV/AIDS pandemic significant challenges

Pressing need to increase research efforts

in prevention and care 34 million of people living with HIV worldwide in 2010

2.6 million new HIV infections in 2010 only (7 000 / day)

1.4 million have started antiretroviral treatment in 2010

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Low 4-year mortality on antiretroviral treatment is achievable in developing countries (Lancet 2006)

sub-Saharan Africa (ART-LINC)18 cohorts4,810 pts

Europe & North America (ART-CC)

Months after start of ART

0 12 24 36 48

Cum

ulat

ive

mor

talit

y (%

)

0

5

10

15

Risk of death (%)

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Lowering the risk of mother-to-child transmission of HIV in pregnant women

Côte d’Ivoire ANRS experience(Lancet 1999, AIDS 2005, PLoS Medicine 2007)

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From animal modelto phase I/II

(safety, pk, viral resistance) in

Cambodia, Côte d’Ivoire and

South Africa

Prevention of Mother-to-Child Transmission of HIV

Antimicrob Agents Chemother 2009, 2011 a, b, c, dAIDS 2009, 2010Clin Pharmacol Ther 2009

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Antiretrovirals for the prevention of mother-to-child

transmission of HIVfrom phase I/II

toWHO guidelines

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Toward elimination of pediatric HIV

infection by 2015

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Perspectives

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(1) Public/private investments from basic to translational research:

MultidisciplinaryUsing existing networksClassic and emerging pathogens

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Perspectives

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(2) Public/private partnerships

should include phase IV and pharmaco-epidemiology

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Perspectives

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(3) A viable market

Deauville, May 26-27, 2011 (VI / 60)G8 encourages drug companies to work with

Medicines Patent Pool and welcomes the development of AMC

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