3. perinatal infections; pediatric pathology

Pediatric PathologyPediatric Pathology

Dr. Krishna Tadepalli, MD, www.mletips.com

1

3. Perinatal Infections3. Perinatal Infections


2

Perinatal Infections• Infections of fetus (after 20wks.) and neonate• Trans- cervical = Ascending• Mostly bacterial and few viral• Route of microbial entry – cervico -vaginal• Mode of infection ;- fetal inhalation of infected amniotic fluid or during passage

through birth canal• Risk factors ;- preterm baby, PPROM, • Pathologically ;- inflammation of membranes and cord• Clinically ;- MC are Pneumonia, sepsis, meningitis• Transplacental (hematologic)• Mostly parasitic and viral and few bacterial• Route of microbial entry; – Transplacental via villi• When?;- anytime during gestation or during labor (HBV, HIV)• Risk factors ;- preterm baby, PPROM, • pathologically -;- inflammation of membranes and cord• Clinically ;- Erythema infectiosum or 5th disease (Parvo B19) without any damage,

TORCH group – fever, encephalitis, chorioretinits, pneumonitis, Myocarditis, hemolytic anemia

• Complications;- MR, Blindness (cataracts), Congenital Heart anomalies, bone defects


3

Parvovirus B 19Parvovirus B 19


4

Perinatal Infections• Sepsis• Can be• Early onset = within 7 days of postnatal life; present with pneumonia and sepsis;

MCC – Group B strep. (MCC of bacterial meningitis); • Late onset = > 7days; Listeria and Candida


5


6

3. perinatal infections; pediatric pathology

Health & Medicine

Transcript of 3. perinatal infections; pediatric pathology