271 GHS-Cyano-4-hydroxycinnamic acid - HCCA- - USA- · PDF fileacc. to ISO/DIS 11014 ......

MSDS208241Material Safety Data SheetsStarter Kit for MALDI-TOF

Country: United States

ContentsMSDS 201344 Alpha-Cyano-4-hydroxycinnamic acidMSDS 201345 Sinapinic acidMSDS 201346 2,5-Dihydroxybenzoic acidMSDS 206195 Peptide Calibration StandardMSDS 206355 Protein Calibration Standard IMSDS 207234 MSDS 207234 Protein Standard IIMSDS 217498 Tryptic digest of Bovine Serum Albumin

MALDI-TOF

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Material Safety Data Sheetacc. to ISO/DIS 11014

Printing date 09/13/2011 Reviewed on 05/18/2011

DR

1 Identification of the substance/mixture and of the company/undertaking

· Product identifier

· Trade name: αααα-Cyano-4-hydroxycinnamic acid (HCCA)

· CAS Number:28166-41-8

· EC number:248-879-1

· Application of the substance / the preparation Laboratory chemicals

· Details of the supplier of the safety data sheet· Manufacturer/Supplier:

Bruker Daltonik GmbHFahrenheitstrasse 4D-28359 Bremen / GermanyTel.: +49(421) 2205-0Fax : +49(421) 2205-100E-mail: [email protected]

· Information department:Bruker Daltonik GmbHTel.: +49 (421) 2205-240

· Emergency telephone number:Emergency Phone : +61 3 9474 7000 ; 1800 278537 ; +49 421 2205 0Tel.: +49 (361)730730Gemeinsames Giftinformationszentrum (GGIZ) (Posion Information Center)

2 Composition/information on ingredients

· Chemical characterization: Substances· CAS No. Description:

28166-41-8 2-cyano-3-(4-hydroxyphenyl)acrylic acid· Identification number(s):· EC number: 248-879-1

3 Hazards identification

· Classification of the substance or mixture

GHS07

H315 Causes skin irritation.

H319 Causes serious eye irritation.

H335 May cause respiratory irritation.

· Classification according to Directive 67/548/EEC or Directive 1999/45/EC

Xi; Irritant

R36/37/38: Irritating to eyes, respiratory system and skin.· Information concerning particular hazards for human and environment:

The product has to be labelled due to the calculation procedure of the "General Classification guideline forpreparations of the EU" in the latest valid version.

· Label elements· GHS label elements

The substance is classified and labelled according to the Globally Harmonized System (GHS).(Contd. on page 2)

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Trade name: αααα-Cyano-4-hydroxycinnamic acid (HCCA)

(Contd. of page 1)

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· Hazard pictograms

GHS07

· Signal word Warning· Hazard statements

Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

· Precautionary statementsAvoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy todo. Continue rinsing.Specific treatment (see on this label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

· Classification system· NFPA ratings (scale 0-4)

20

0

Health = 2Fire = 0Reactivity = 0

4 First aid measures

· General information Immediately remove any clothing soiled by the product.· After inhalation

Supply fresh air.Seek medical treatment in case of complaints.

· After skin contactIf skin irritation continues, consult a doctor.Immediately wash with water and soap and rinse thoroughly.

· After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor.· After swallowing

Rinse the mouth with water immediatelyImmediately call a doctor.

· Information for doctor No particular measures are known - treat according to symptoms.

5 Firefighting measures

· Suitable extinguishing agentsCO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.

· For safety reasons unsuitable extinguishing agents Water with full jet.· Special hazards arising from the substance or mixture

Formation of toxic gases is possible during heating or in case of fire.Nitrogen oxides (NOx)Hydrogen cyanide (HCN)Carbon dioxide (CO2)Carbon monoxide (CO)

· Protective equipment: Wear self-contained respiatory protective device.(Contd. on page 3)

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(Contd. of page 2)

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· Additional informationDispose of fire debris and contaminated fire fighting water in accordance with official regulations.

6 Accidental release measures

· Personal precautions, protective equipment and emergency proceduresEnsure adequate ventilationAvoid formation of dust.Wear protective clothing.Avoid contact with eyes and skin.

· Environmental precautions: Do not allow product to reach sewage system or any water course.· Methods and material for containment and cleaning up:

Pick up mechanically.Avoid causing dust.Ensure adequate ventilation.

· Reference to other sectionsClean the accident area carefully.See Section 8 for information on personal protection equipment.

7 Handling and storage

· Handling· Precautions for safe handling

Keep receptacles tightly sealed.Prevent formation of dust.Provide suction extractors if dust is formed.Avoid contact with the eyes and skin.

· Information about protection against explosions and fires: No special measures required.· Storage· Requirements to be met by storerooms and receptacles:

Store only in unopened original receptacles.Protect from dampness and humidity.

· Information about storage in one common storage facility: Store away from foodstuffs.· Further information about storage conditions:

Store in cool, dry conditions in well sealed receptacles.Store receptacle in a well ventilated area.Protect from exposure to the light.Avoid contact with air / oxygen.

· Storage class 11· Specific end use(s) No further relevant information available.

8 Exposure controls/personal protection

· Additional information about design of technical systems: No further data; see item 7.· Components with limit values that require monitoring at the workplace: Not required.· Additional information: The lists that were valid during the creation were used as basis.· Personal protective equipment· General protective and hygienic measures

Keep away from foodstuffs, beverages and feed.Wash hands before breaks and at the end of work.Avoid contact with the eyes and skin.Immediately remove all soiled and contaminated clothing

· Breathing equipment:In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposureuse respiratory protective device that is independent of circulating air.

(Contd. on page 4)

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(Contd. of page 3)

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· Recommended filter device for short term use:

Filter P1

· Protection of hands:

Only use chemical-protective gloves with CE-labelling of category III.

The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/the chemical mixture.Selection of the glove material on consideration of the penetration times, rates of diffusion and thedegradationPreventive skin protection by use of skin-protecting agents is recommended.

· Material of glovesThe selection of the suitable gloves does not only depend on the material, but also on further marks of qualityand varies from manufacturer to manufacturer.

· Penetration time of glove materialThe exact break trough time has to be found out by the manufacturer of the protective gloves and has to beobserved.

· Not suitable are gloves made of the following materials:Leather glovesStrong gloves

· Eye protection:

Tightly sealed goggles.

· Body protection: Protective work clothing.

9 Physical and chemical properties

· General Information· Appearance:

Form: Powder

Color: Light yellow· Odor: Characteristic

· Change in conditionMelting point/Melting range: 245-250°C (473-482 °F)

Boiling point/Boiling range: undetermined

· Flash point: Not applicable

· Flammability (solid, gaseous) Product is not flammable.

· Danger of explosion: Product does not present an explosion hazard.

· Density: Not determined

· Solids content: 100.0 %· Other information No further relevant information available.

10 Stability and reactivity

· Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.(Contd. on page 5)

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(Contd. of page 4)

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· Incompatible materials:strong acidsAcid anhydrides

· Hazardous decomposition products:in the event of fire:Carbon monoxide and carbon dioxideNitrogen oxides (NOx)Hydrogen cyanide (prussic acid)

11 Toxicological information

· Acute toxicity:· Primary irritant effect:· on the skin: Irritant to skin and mucous membranes.· on the eye: Irritating effect.· Sensitization: No sensitizing effects known.· Additional toxicological information:

Possibly harmful by inhalation, harmful if swallowed and harmful in contact with skin.Warning, substance not yet fully tested

12 Ecological information

· Acquatic toxicity: No further relevant information available.· Persistence and degradability No further relevant information available.· Behavior in environmental systems:· Bioaccumulative potential No further relevant information available.· Ecotoxical effects: Not determined· Additional ecological information:· General notes:

Water danger class 3 (German Regulation) (Self-assessment): extremely hazardous for water.Do not allow product to reach ground water, water course or sewage system, even in small quantities.Danger to drinking water if even extremely small quantities leak into the ground.

13 Disposal considerations

· Waste treatment methods· Recommendation Must be specially treated adhering to official regulations.

· Uncleaned packagings:· Recommendation: Disposal must be made according to official regulations.

14 Transport information

· UN-Number· DOT, ADR, ADN, IMDG, IATA Void

· UN proper shipping name· DOT, ADR, ADN, IMDG, IATA Void

· Transport hazard class(es)

· DOT, ADR, ADN, IMDG, IATA· Class Void

· Packing group· DOT, ADR, IMDG, IATA Void

(Contd. on page 6)

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(Contd. of page 5)

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· Special precautions for user Not applicable.

· Transport in bulk according to Annex II ofMARPOL73/78 and the IBC Code Not applicable.

· Transport/Additional information: Not dangerous according to the above specifications.

· UN "Model Regulation": -

15 Regulatory information

· Cancerogenity categories

· EPA (Environmental Protection Agency)

Substance is not listed.

· IARC (International Agency for Research on Cancer)


· NTP (National Toxicology Program)


· TLV (Threshold Limit Value established by ACGIH)


· MAK (German Maximum Workplace Concentration)


· NIOSH-Ca (National Institute for Occupational Safety and Health)


· OSHA-Ca (Occupational Safety & Health Administration)


· GHS label elementsThe substance is classified and labelled according to the Globally Harmonized System (GHS).


GHS07




· National regulations

· Water hazard class: Water danger class 3 (Self-assessment): extremely hazardous for water.(Contd. on page 7)

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(Contd. of page 6)

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· Sara

· Section 355 (Exremely hazardous substances):


· Section 313 (Specific toxic chemical listings):


· TSCA (Toxic Substances Control Act):

Substance is not listed

· Chemicals known to cause cancer:


16 Other information

This information is based on our present knowledge. However, this shall not constitute a guarantee for anyspecific product features and shall not establish a legally valid contractual relationship.Changes made since last issue dated 20.12.2010 at the following points: *

· Department issuing MSDS:IGG-AD Ingenieurbüro für Gefahrstoff- und GefahrgutberatungBismarckstraße 10D-68623 LampertheimFax: 0049-(0)6206-58422 http://www.igg-ad.de [email protected]

· Contact:Dr. U. Prinz ([email protected])Dipl.-Chem. H. Hinse ([email protected])

· Abbreviations and acronyms:ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)RID: Règlement international concernant le transport des marchandises dangereuses par chemin de fer (Regulations Concerning theInternational Transport of Dangerous Goods by Rail)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationICAO: International Civil Aviation OrganizationACGIH: American Conference of Governmental Industrial HygienistsEINECS: European Inventory of Existing Commercial Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)NFPA: National Fire Protection Association (USA)MAL-Code: Måleteknisk Arbejdshygiejnisk Luftbehov (Regulation for the labeling concerning inhalation hazards, Denmark)

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* 1 Identification of the substance/mixture and of the company/undertaking


· Trade name: Sinapinic acid (SA)

· CAS Number:530-59-6

· EC number:208-487-3

· Application of the substance / the preparation Laboratory chemicals





* 2 Composition/information on ingredients


530-59-6 3,5-Dimethoxy-4-hydroxy-cinnamic acid· Identification number(s):· EC number: 208-487-3· Additonal information: Synonyme: Sinapic acid

* 3 Hazards identification


GHS07





Xi; Irritant

R36/37/38: Irritating to eyes, respiratory system and skin.


The substance is classified and labelled according to the Globally Harmonized System (GHS).· Hazard pictograms

GHS07

· Signal word Warning(Contd. on page 2)

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Trade name: Sinapinic acid (SA)

(Contd. of page 1)

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· Hazard statementsCauses skin irritation.Causes serious eye irritation.May cause respiratory irritation.



10

0


* 4 First aid measures



· After skin contact Immediately wash with water and soap and rinse thoroughly.· After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor.· After swallowing






Formation of toxic gases is possible during heating or in case of fire.· Protective equipment: Wear self-contained respiatory protective device.· Additional information

Dispose of fire debris and contaminated fire fighting water in accordance with official regulations.


· Personal precautions, protective equipment and emergency proceduresEnsure adequate ventilationWear protective clothing.Avoid contact with eyes and skin.Avoid formation of dust.


Pick up mechanically.Dispose contaminated material as waste according to item 13.Ensure adequate ventilation.

(Contd. on page 3)

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(Contd. of page 2)

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* 7 Handling and storage


Thorough dedusting.Keep receptacles tightly sealed.Ensure good ventilation/exhaustion at the workplace.Keep eye irrigation utensils (bottle) ready for use at place of work.The usual precautionary measures for handling chemicals must be observed.


Keep container securely closed, store at 2 - 8 °CStore only in the original receptacle.Protect from dampness and humidity.Provide floor trough without outlet.

· Information about storage in one common storage facility: Store away from foodstuffs.· Further information about storage conditions: Keep receptacle tightly sealed.· Specific end use(s) No further relevant information available.

* 8 Exposure controls/personal protection


Keep away from foodstuffs, beverages and feed.Wash hands before breaks and at the end of work.Avoid contact with the eyes and skin.Immediately remove all soiled and contaminated clothing



Filter P1




(Contd. on page 4)

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(Contd. of page 3)

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· For the permanent contact of a maximum of 15 minutes gloves made of the following materials aresuitable:PVC or PE gloves

· As protection from splashes gloves made of the following materials are suitable: PVC or PE gloves· Not suitable are gloves made of the following materials:

Strong glovesLeather gloves

· Eye protection:





Form: Powder

Color: Light yellow· Odor: Not determined

. · Odour threshold: Not determined.

· pH-value: Not determined.

· Change in conditionMelting point/Melting range: 202°C (396 °F)






· Solubility in / Miscibility withWater: Not determined.

Solids content: 100 %· Other information No further relevant information available.


· Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.· Incompatible materials:

strong oxidizing agentsstrong bases

· Hazardous decomposition products: Carbon monoxide and carbon dioxide USA

(Contd. on page 5)

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(Contd. of page 4)

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* 11 Toxicological information

· Acute toxicity:· Primary irritant effect:· on the skin: Irritant to skin and mucous membranes.· on the eye: Irritating effect.· Sensitization: No sensitizing effects known.· Subacute to chronic toxicity:

no carcinogenic effect admitsno mutagenic effect admits

· Additional toxicological information:Warning, substance not yet fully testedPossibly harmful by inhalation, harmful if swallowed and harmful in contact with skin.

* 12 Ecological information















(Contd. on page 6)

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(Contd. of page 5)

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GHS07





· Water hazard class: Water danger class 3 (Self-assessment): extremely hazardous for water.· Sara





(Contd. on page 7)

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(Contd. of page 6)

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Substance is not listed



* 16 Other information




· Abbreviations and acronyms:ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)RID: Règlement international concernant le transport des marchandises dangereuses par chemin de fer (Regulations Concerning theInternational Transport of Dangerous Goods by Rail)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationICAO: International Civil Aviation OrganizationACGIH: American Conference of Governmental Industrial HygienistsEINECS: European Inventory of Existing Commercial Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)NFPA: National Fire Protection Association (USA)MAL-Code: Måleteknisk Arbejdshygiejnisk Luftbehov (Regulation for the labeling concerning inhalation hazards, Denmark)

· * Data compared to the previous version altered. USA

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DR

* 1 Identification of the substance/mixture and of the company/undertaking


· Trade name: 2,5-Dihydroxybenzoic acid

· Article number: 201346· CAS Number:

490-79-9· EC number:

207-718-5· Application of the substance / the preparation Laboratory chemicals





* 2 Composition/information on ingredients


490-79-9 gentisic acid· Identification number(s):· EC number: 207-718-5



GHS07

H302 Harmful if swallowed.





Xn; Harmful

R22: Harmful if swallowed.

Xi; Irritant

R36/37/38: Irritating to eyes, respiratory system and skin.


The substance is classified and labelled according to the Globally Harmonized System (GHS).(Contd. on page 2)

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Trade name: 2,5-Dihydroxybenzoic acid

(Contd. of page 1)

DR


GHS07

· Signal word Warning

· Hazard-determining components of labelling:2,5-Dihydroxybenzoic acid

· Hazard statementsHarmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.



20

0





· After skin contactImmediately wash with water and soap and rinse thoroughly.Seek medical advice.

· After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor.· After swallowing





Formation of toxic gases is possible during heating or in case of fire.· Protective equipment: Wear self-contained respiatory protective device.· Additional information

Dispose of fire debris and contaminated fire fighting water in accordance with official regulations. USA

(Contd. on page 3)

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(Contd. of page 2)

DR

* 6 Accidental release measures

· Personal precautions, protective equipment and emergency proceduresEnsure adequate ventilationAvoid formation of dust.Wear protective equipment. Keep unprotected persons away.Avoid contact with eyes and skin.


Pick up mechanically.Avoid causing dust.Ensure adequate ventilation.




Keep receptacles tightly sealed.Prevent formation of dust.Prevent formation of aerosols.Provide suction extractors if dust is formed.Avoid contact with the eyes and skin.Keep eye irrigation utensils (bottle) ready for use at place of work.The usual precautionary measures for handling chemicals must be observed.


Store only in the original receptacle.Protect from dampness and humidity.

· Information about storage in one common storage facility: Store away from foodstuffs.· Further information about storage conditions:

Store in cool, dry conditions in well sealed receptacles.Store receptacle in a well ventilated area.

· Specific end use(s) No further relevant information available.



Keep away from foodstuffs, beverages and feed.Wash hands before breaks and at the end of work.Avoid contact with the eyes and skin.Immediately remove all soiled and contaminated clothingStore protective clothing separately.


(Contd. on page 4)

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(Contd. of page 3)

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Filter P1

· Protection of hands:Protective gloves.





· For the permanent contact of a maximum of 15 minutes gloves made of the following materials aresuitable:PVC or PE gloves

· As protection from splashes gloves made of the following materials are suitable: PVC or PE gloves· Eye protection:



* 9 Physical and chemical properties


Form: Crystalline

Color: Light yellow· Odor: Characteristic

· Change in conditionMelting point/Melting range: 204 - 208°C (399 - 406 °F) (lit.)






· Solids content: 100.0 %· Other information No further relevant information available.

USA

(Contd. on page 5)

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(Contd. of page 4)

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* 10 Stability and reactivity


strong oxidizing agentsstrong basesAcid chloridesAcid anhydrides

· Hazardous decomposition products:in the event of fire:Carbon monoxide and carbon dioxide

* 11 Toxicological information

· Acute toxicity:

· LD/LC50 values that are relevant for classification:

490-79-9 2,5-Dihydroxybenzoic acid

Oral LD50 4500 mg/kg (Mouse)

800 mg/kg (rat)

· Primary irritant effect:· on the skin: Irritant to skin and mucous membranes.· on the eye: Irritating effect.· Sensitization: No sensitizing effects known.· Subacute to chronic toxicity:

Germ cell mutagenicity:Genotoxicity in vitro - Human - lymphocyteDNA inhibitionCarcinogenic toxicityno carcinogenic effect admitsReproductive toxicity:animal studies indicate reproductive toxic effect

· Additional toxicological information:Harmful if swallowed.Possibly harmful by inhalation and harmful if absorbed through the skin.Warning, substance not yet fully tested



Water danger class 3 (German Regulation) (Self-assessment): extremely hazardous for water.Do not allow product to reach ground water, water course or sewage system, even in small quantities.



(Contd. on page 6)

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(Contd. of page 5)

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* 15 Regulatory information


















GHS07

(Contd. on page 7)

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(Contd. of page 6)

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· Signal word Warning

· Hazard-determining components of labelling:2,5-Dihydroxybenzoic acid

· Hazard statementsHarmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.









Substance is listed.







· Abbreviations and acronyms:ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)RID: Règlement international concernant le transport des marchandises dangereuses par chemin de fer (Regulations Concerning theInternational Transport of Dangerous Goods by Rail)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationICAO: International Civil Aviation OrganizationACGIH: American Conference of Governmental Industrial HygienistsEINECS: European Inventory of Existing Commercial Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)NFPA: National Fire Protection Association (USA)MAL-Code: Måleteknisk Arbejdshygiejnisk Luftbehov (Regulation for the labeling concerning inhalation hazards, Denmark)LC50: Lethal concentration, 50 percentLD50: Lethal dose, 50 percent


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DR



· Trade name: Peptide Calibration Standard

· Article number: 206195· Application of the substance / the preparation Laboratory chemicals






· Chemical characterization: Mixtures· Description: Peptide mixture, lyophilized

· Dangerous components: Void


· Classification of the substance or mixtureThe product is not classified according to the Globally Harmonized System (GHS).

· Classification according to Directive 67/548/EEC or Directive 1999/45/EC not applicable· Information concerning particular hazards for human and environment:

The product does not have to be labelled due to the calculation procedure of the "General Classificationguideline for preparations of the EU" in the latest valid version.

· Label elements

· Labelling according to EU guidelines:Observe the general safety regulations when handling chemicalsThe product is not subject to classification according to the calculation methods of the "GeneralClassification Guideline for Preparations of the EU" as issued in the latest valid version.The product is not subject to identification regulations under EU Directives and the Ordinance on HazardousMaterials (GefStoffV).

· Special labelling of certain preparations:Warning - contains substances not yet fully testedWarning - contains substance not yet fully tested


00

0



· General information Immediately remove any clothing soiled by the product.(Contd. on page 2)

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Trade name: Peptide Calibration Standard

(Contd. of page 1)

DR

· After inhalationTake affected persons into fresh air and keep quiet.Seek medical treatment in case of complaints.


Rinse the mouth with water immediatelySeek immediate medical advice.




During heating or in case of fire poisonous gases are produced.· Protective equipment: Wear self-contained respiatory protective device.· Additional information Cool endangered receptacles with water spray.


· Personal precautions, protective equipment and emergency proceduresWear protective equipment. Keep unprotected persons away.Ensure adequate ventilationAvoid formation of dust.Use respiratory protective device against the effects of fumes/dust/aerosol.Avoid contact with eyes and skin.

· Environmental precautions:Do not allow product to reach sewage system or any water course.Do not allow to penetrate the ground/soil.

· Methods and material for containment and cleaning up:Pick up mechanically.Dispose of the collected material according to regulations.Ensure adequate ventilation.

· Reference to other sectionsClean the accident area carefully.See Section 13 for disposal information.See Section 8 for information on personal protection equipment.



Ensure good ventilation/exhaustion at the workplace.Prevent formation of dust.Avoid contact with the eyes and skin.Avoid spillingKeep eye irrigation utensils (bottle) ready for use at place of work.

· Information about protection against explosions and fires: No special measures required.· Storage· Requirements to be met by storerooms and receptacles: Store only in the original receptacle.· Information about storage in one common storage facility: Store away from foodstuffs.· Further information about storage conditions:

Keep receptacle tightly sealed.Store in a cool place.

· Recommended storage temperature: < 0°C(Contd. on page 3)

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(Contd. of page 2)

DR



· Additional information about design of technical systems: No further data; see item 7.· Components with limit values that require monitoring at the workplace:

The product does not contain any relevant quantities of materials with critical values that have to bemonitored at the workplace.

· Additional information: The lists that were valid during the creation were used as basis.· Personal protective equipment· General protective and hygienic measures

Keep away from foodstuffs, beverages and feed.Wash hands before breaks and at the end of work.Avoid contact with the eyes and skin.Do not inhale dust / smoke / mist.Immediately remove all soiled and contaminated clothing

· Breathing equipment: If dust is produced.· Recommended filter device for short term use:

Filter P1



The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/the chemical mixture.Selection of the glove material on consideration of the penetration times, rates of diffusion and thedegradation

· Material of glovesThe selection of the suitable gloves does not only depend on the material, but also on further marks of qualityand varies from manufacturer to manufacturer. As the product is a preparation of several substances, theresistance of the glove material can not be calculated in advance and has therefore to be checked prior to theapplication.



· Eye protection:


· Body protection: Protective work clothing. USA

(Contd. on page 4)

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(Contd. of page 3)

DR



Form: Solid.lyophilized

Color: - · Odor: -

· Change in conditionMelting point/Melting range: undetermined



· Auto igniting: Product is not selfigniting.



· Solubility in / Miscibility withWater: mixable

· Other information No further relevant information available.



strong acidsstrong bases

· Hazardous decomposition products: none, if stored and handled correctly.


· Acute toxicity:· Primary irritant effect:· on the skin: irritative effect possible· on the eye: irritative effect possible· Sensitization: Prolonged or repeated exposure may cause allergic reactions· Additional toxicological information:

Possibly harmful by inhalation, harmful if swallowed and harmful in contact with skin.The product is not subject to classification according to the calculation method of the General EUClassification Guidelines for Preparations as issued in the latest version:




USA

(Contd. on page 5)

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(Contd. of page 4)

DR


· Waste treatment methods· Recommendation For disposal,local regulations issued by the authorities must be observed.















None of the ingredients is listed.













· Markings according to EU guidelines:Observe the general safety regulations when handling chemicalsThe product is not subject to classification according to the calculation methods of the "GeneralClassification Guideline for Preparations of the EU" as issued in the latest valid version.

(Contd. on page 6)

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(Contd. of page 5)

DR

The product is not subject to identification regulations under EU Directives and the Ordinance on HazardousMaterials (GefStoffV).

· Special labeling of certain preparations:Warning - contains substance not yet fully tested















· Abbreviations and acronyms:ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)RID: Règlement international concernant le transport des marchandises dangereuses par chemin de fer (Regulations Concerning theInternational Transport of Dangerous Goods by Rail)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationICAO: International Civil Aviation OrganizationACGIH: American Conference of Governmental Industrial HygienistsNFPA: National Fire Protection Association (USA)MAL-Code: Måleteknisk Arbejdshygiejnisk Luftbehov (Regulation for the labeling concerning inhalation hazards, Denmark)


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DR



· Trade name: Protein Calibration Standard I







· Chemical characterization: Mixtures· Description: Protein mixture, lyophilized

· Dangerous components: Void





· Label elements



00

0




Take affected persons into fresh air and keep quiet.Seek medical treatment in case of complaints.

(Contd. on page 2)

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Trade name: Protein Calibration Standard I

(Contd. of page 1)

DR















· Information about protection against explosions and fires: No special measures required.· Storage· Requirements to be met by storerooms and receptacles: Store only in the original receptacle.· Information about storage in one common storage facility:

Store away from foodstuffs.Store away from oxidizing agents.

· Further information about storage conditions:Keep receptacle tightly sealed.Store in a cool place.

· Recommended storage temperature: < 0°C(Contd. on page 3)

USA

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(Contd. of page 2)

DR








Filter P1







· Eye protection:



(Contd. on page 4)

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(Contd. of page 3)

DR



Form: Solid.lyophilized

Color: Red-brown· Odor: -











strong oxidizing agentsstrong acidsstrong bases



· Acute toxicity:· Primary irritant effect:· on the skin: irritative effect possible· on the eye: irritative effect possible· Sensitization: Prolonged or repeated exposure may cause allergic reactions· Additional toxicological information:

Possibly harmful by inhalation, harmful if swallowed and harmful in contact with skin.The product is not subject to classification according to the calculation method of the General EUClassification Guidelines for Preparations as issued in the latest version:




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Danger to drinking water if even extremely small quantities leak into the ground.




* 14 Transport information


























· Markings according to EU guidelines:Observe the general safety regulations when handling chemicals

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The product is not subject to classification according to the calculation methods of the "GeneralClassification Guideline for Preparations of the EU" as issued in the latest valid version.The product is not subject to identification regulations under EU Directives and the Ordinance on HazardousMaterials (GefStoffV).








9007-43-6 Cytochrome c









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· Trade name: Protein Standard II







· Chemical characterization: Mixtures· Description: Protein mixture, lyophilized

· Dangerous components:

CAS: 9002-08-8EINECS: 232-651-3

Trypsinogen Xn R42; Xi R36/37/38

H334; H315; H319; H335

2.5-10%

· Additional information For the wording of the listed risk phrases refer to section 16.



GHS08 Health hazard

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.


Xn; Harmful

R42: May cause sensitization by inhalation.· Information concerning particular hazards for human and environment:

The product has to be labelled due to the calculation procedure of the "General Classification guideline forpreparations of the EU" in the latest valid version.

· Label elements

· Labelling according to EU guidelines:Observe the general safety regulations when handling chemicalsThe product has been classified and marked in accordance with EU Directives / Ordinance on HazardousMaterials

· Code letter and hazard designation of product:

Xn Harmful

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Trade name: Protein Standard II

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· Hazard-determining components of labelling:Trypsinogen

· Risk phrases:42 May cause sensitization by inhalation.

· Safety phrases:36 Wear suitable protective clothing.45 In case of accident or if you feel unwell, seek medical advice immediately.60 This material and its container must be disposed of as hazardous waste.

· Special labelling of certain preparations: Warning - contains substances not yet fully tested· Classification system· NFPA ratings (scale 0-4)

00

0




Take affected persons into fresh air and keep quiet.Seek medical treatment in case of complaints.











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· Recommended storage temperature: < 0°C· Specific end use(s) No further relevant information available.







Filter P1



The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/the chemical mixture.

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Selection of the glove material on consideration of the penetration times, rates of diffusion and thedegradation




· Eye protection:

Safety glasses




Form: Solid.

Color: - · Odor: -










· Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.· Incompatible materials: strong oxidizing agents· Hazardous decomposition products: none, if stored and handled correctly.


· Acute toxicity:· Primary irritant effect:· on the skin: irritative effect possible· on the eye: irritative effect possible· Sensitization: Sensitization possible through inhalation.

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· Additional toxicological information:Harmful if swallowed.Possibly harmful by inhalation and harmful if absorbed through the skin.The product shows the following dangers according to the calculation method of the General EUClassification Guidelines for Preparations as issued in the latest version:Harmful







* 14 Transport information














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· Markings according to EU guidelines:Observe the general safety regulations when handling chemicalsThe product has been classified and marked in accordance with EU Directives / Ordinance on HazardousMaterials

· Code letter and hazard designation of product:

Xn Harmful

· Hazard-determining components of labelling:Trypsinogen

· Risk phrases:42 May cause sensitization by inhalation.

· Safety phrases:36 Wear suitable protective clothing.45 In case of accident or if you feel unwell, seek medical advice immediately.60 This material and its container must be disposed of as hazardous waste.








9048-46-8 Albumins, blood serum



16 Other information


· Relevant phrasesH315 Causes skin irritation.

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H319 Causes serious eye irritation.H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.H335 May cause respiratory irritation.

R36/37/38 Irritating to eyes, respiratory system and skin.R42 May cause sensitization by inhalation.





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· Trade name: Tryptic digest of Bovine Serum Albumin







· Chemical characterization: Mixtures· Description: Peptide mixture, lyophilized

· Dangerous components: Void· Additional information For the wording of the listed risk phrases refer to section 16.





· Label elements


· Special labelling of certain preparations:Warning - contains substance not yet fully testedContains Trypsin. May produce an allergic reaction.


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0


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Trade name: Tryptic digest of Bovine Serum Albumin

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· General information Immediately remove any clothing soiled by the product.· After inhalation Supply fresh air; consult doctor in case of complaints.· After skin contact Immediately wash with water and soap and rinse thoroughly.· After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor.· After swallowing







* 6 Accidental release measures

· Personal precautions, protective equipment and emergency proceduresEnsure adequate ventilationAvoid formation of dust.Avoid contact with eyes and skin.


Pick up mechanically.Dispose of the collected material according to regulations.Ensure adequate ventilation.




Ensure good ventilation/exhaustion at the workplace.Prevent formation of dust.Avoid contact with the eyes and skin.




· Recommended storage temperature: < 0°C· Storage class 11

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Filter P1







· Eye protection:



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* 9 Physical and chemical properties


Form: Solid.

Color: Not determined-

· Odor: Not determined-









* 10 Stability and reactivity


strong oxidizing agentsstrong acidsstrong bases



· Acute toxicity:· Primary irritant effect:· on the skin: irritative effect possible· on the eye: irritative effect possible· Sensitization: No sensitizing effects known.· Additional toxicological information:

Possibly harmful by inhalation, harmful if swallowed and harmful in contact with skin.The product is not subject to classification according to the calculation method of the General EUClassification Guidelines for Preparations as issued in the latest version:When used and handled according to specifications, the product does not have any harmful effects accordingto our experience and the information provided to us.

* 12 Ecological information



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Danger to drinking water if even extremely small quantities leak into the ground.






























· Markings according to EU guidelines:Observe the general safety regulations when handling chemicals

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(Contd. of page 5)

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The product is not subject to classification according to the calculation methods of the "GeneralClassification Guideline for Preparations of the EU" as issued in the latest valid version.The product is not subject to identification regulations under EU Directives and the Ordinance on HazardousMaterials (GefStoffV).

· Special labeling of certain preparations:Warning - contains substance not yet fully testedContains Trypsin. May produce an allergic reaction.








9048-46-8 Albumins, blood serum

9002-07-7 Trypsin









271 GHS-Cyano-4-hydroxycinnamic acid - HCCA- - USA- · PDF fileacc. to ISO/DIS 11014 ......

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Transcript of 271 GHS-Cyano-4-hydroxycinnamic acid - HCCA- - USA- · PDF fileacc. to ISO/DIS 11014 ......