24115385 Pathophysiology of Diabetes Mellitus Type 2
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Transcript of 24115385 Pathophysiology of Diabetes Mellitus Type 2
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Precipitating factors:1. frequent or chronic infections2. eating too much sweets
3. development of glucoseintolerance during drugtherapy
4. delivery of over 9 lbs infants5. diet6. sedentary lifestyle
Predisposing factors:1. family history of !2. obesity
3. "ge above 4#
$%haustion of beta cells
"bsorption of glucose by the cell
&ell starvation
egradation of proteins 'rea(down of fat
)nsulin production*decrease secretion of
insulin
+timulation of hunger mechanism via hypothalamus
,unger
)nsulin resistance
Ideal Pathophysiology of Diabetes Mellitus Type II
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-'+ 14# mg*d
/0/,")"
,/$&$!)"
-'+to 1# mg*d
idney filtration mechanism impaired
&0+)"
"cidity of urine
rethral flora
7)
8erve emyeliniation
/aresthesias :numbness
)mpaired painsensation
&irculatingblood volume
elayed woundhealing
angrene
/0)" :"'!)8)"
&apillary basementmembrane thic(ening
,ypovolemia
,/07$8+)08 :7"&,&")"
iffuse glomerularsclerosis
enal failure;aginitis
8$/,0/"7,
8$0/"7,
808
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8umber of solute relative to water
+odium ions lost
7issue dehydration
/otassium ion retention
&ardiac arrythmias
- : $ imbalance
/0)/+)"
&apillary basementmembrane thic(ening
"bnormal retinal vascularpermeability
+carring
7hic(ening of bloodvessel walls
0cclusion of plaque
'lood flow bloc(ed
'lood pressure
!usculos(eletal effects
)mpaired glucose absorption inthe muscle tissue
=oint contractures
)ncrease viscosity ofblood
blindness
'lurring of vision
'lindness+tro(e
-"7)$
!yocardialinfarction
!yocardialischemia
iminishedperipheral
pulse
,eart -ailure
$"7,
$7)80/"7,
,/$7$8+)08
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'rea(down of fat -atty acids :glycerol
-at content of theblood
,yperlipidemia
-ormation of fattydeposits on the
walls of the bloodvessels
(etone bodies inthe general circulation
hydro%ybutyricacid
acetoacetic
"cetone breath
>eight oss
epressed centralnervous system
'ody attempts to preventfurther decrease in p,
? &ellular /otassium"bdominal pain8ausea and vomiting
"therosclerosis
!etabolic acidosis&onvulsions
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/oor appetite &ardiac arrhythmias
,eadache
ussmaul@s respirations
&oma
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!obiliation *degradation of proteins
"mino acid in thegeneral circulation
ecreased urinarynitrogen
,yperaminoacidemia
-urther sodium ion loss /otassium ion retention
&ardiac arrhythmiasehydration
$"7,
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hunger
