223.20 Principles of Cell Signaling2015
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Transcript of 223.20 Principles of Cell Signaling2015
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223.20 Principles of Cell Signaling
Cell Signaling-Receptors
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Cell Signaling-Receptors: Intracellular
Cell Signaling
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Cell Signaling
Cell Signaling-four general kinds
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Cell Signaling - Contact dependent
Autocrine Signaling
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Cell Signaling - Cell Surface Receptors: Ion-channel linked
Rapid signal Multipass transmembrane channel
protein changes potential
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Cell Signaling - Cell Surface Receptors: G-protein linked
Indirect signal 7-pass transmembrane protein
with conformational change
Cell Signaling - Cell Surface Receptors: Enzyme linked
Ligand binding activates receptors’ catalytic domains
single-pass transmembrane proteins
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223.20 Principles of Cell Signaling
Signal Transduction Cascade
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Signal Transduction Cascade
Cell Signaling-Phosphorylation
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Cell Signaling-Phosphorylation
Two main types of GTP-binding proteins 1. Large trimeric GTP-
binding proteins (G-proteins) relay messages from G-protein-coupled receptors (next lecture)
2. Monomeric GTP binding proteins that are GTPases (shown here)
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Cell Signaling
Cell Signaling
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Cell Signaling