2017 Program Cover - UC Davis HealthJames Bodfish, Ph.D. Vanderbilt University Susan L. Hepburn,...

On Research and Theory in Intellectual and Developmental Disabilities

Annual

March 8-10, 2017

Outcome Measures, Biomarkers, and Treatment Possibilities

Hotel Contessa on the Riverwalk

San Antonio, Texas

We extend our gratitude to the following sponsors for their financial contributions and generous support of the

2017 Gatlinburg Conference:

American Psychological Association-Division 33

Center on Human Development and Disability, University of Washington

Eunice Kennedy Shriver Center, University of Massachusetts Medical School

Life Span Institute, University of Kansas

MIND Institute, University of California, Davis

National Fragile X Foundation

University of California, Los Angeles

University of North Carolina at Chapel Hill

Vanderbilt Kennedy Center, Vanderbilt University

Waisman Center, University of Wisconsin-Madison

CONFERENCE SUPPORT

This conference is supported by grant number R13HD084155 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Neurological Disorders and Stroke,

and the National Institute on Aging.

Acknowledgments

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E X E C U T I V E C O M M I T T E E

Leonard Abbeduto, Ph.D., Conference Chair

University of California, Davis

Vittorio Gallo, Ph.D. Children’s National Health System

Laura Lee McIntyre, Ph.D. University of Oregon

Shannon S.C. Bert, Ph.D. University of Oklahoma

Matthew Goodwin, Ph.D. Northeastern University

Chris Oliver, BSc, MPhil, Ph.D., CPsychol

University of Birmingham

Lauren Bishop-Fitzpatrick, Ph.D. University of Wisconsin-Madison

Tarik F. Haydar, Ph.D. Boston University

Jane Roberts, Ph.D. University of South Carolina

James Bodfish, Ph.D. Vanderbilt University

Susan L. Hepburn, Ph.D. University of Colorado at Denver

Richard Serna, Ph.D. University of Massachusetts-Lowell

Brian Boyd, Ph.D. University of North Carolina at

Chapel Hill

Shafali S. Jeste, M.D. University of California, Los Angeles

Leann E. Smith, Ph.D. University of Wisconsin-Madison

Lauren Bullard, B.A. University of California, Davis

Marygrace Yale Kaiser, Ph.D. Eureka College

Frank J. Symons, Ph.D. University of Minnesota

Marie Moore Channell, Ph.D. University of Illinois at

Urbana-Champaign

Connie Kasari, Ph.D., Conference Co-Chair

University of California, Los Angeles

Julie Lounds Taylor, Ph.D. Vanderbilt Kennedy Center

Anna Esbensen, Ph.D. Cincinnati Children’s Hospital

Sandra M. Magaña, Ph.D. University of Illinois at Chicago

Angela John Thurman, Ph.D. University of California, Davis

Deborah Fidler, Ph.D. Colorado State University

Jennifer Zarcone, Ph.D., BCBA Kennedy Krieger Institute

T H E M E C O M M I T T E E

Leonard Abbeduto, Ph.D.

University of California, Davis

James Bodfish, Ph.D. Vanderbilt University

Brian Boyd, Ph.D. University of North Carolina at

Chapel Hill

C O N F E R E N C E M A N A G E M E N T

Rebecca L. Shilts, Conference Manager University of California Davis, MIND Institute

Mobile Phone: 916-753-8659

Brenda L. Shelton, Conference Co-Manager University of California Davis, MIND Institute

Mobile Phone: 916-296-4346

Visit our website to view symposium and poster abstracts in their entirety at:

mindinstitute/gatlinburg/program-schedule.html

50TH Annual

Gatlinburg Conference The Gatlinburg Conference continues its tradition as one of the premier conferences in the United States

for behavioral scientists conducting research in intellectual and related developmental disabilities.

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Invited Speakers

Jacqueline N. Crawley, Ph.D. University of California, Davis

Michela Fagiolini, Ph.D. Boston Children’s Hospital

Mouse Models of Autism to Test Hypotheses about Causes and to Discover Therapeutics Wednesday, March 8th • 8:15–9:30 a.m. • Contessa Ballroom Autism is a neurodevelopmental disorder diagnosed by two classes of behavioral criteria: (a) social interaction and communication deficits, and (b) repetitive behaviors with restricted interests. Over 100 risk genes for autism spectrum disorder have been identified over the past decade. Mice with targeted mutations in many of these risk genes are increasingly available to test hypotheses about genetic causes of autism. Our laboratory designed mouse behavioral paradigms with conceptual analogies to the diagnostic and associated symptoms of autism. Reciprocal social interactions are assayed longitudinally across developmental stages with simple automated measures of sociability, and with in-depth scoring of reciprocal social interactions. Communication in mice is inferred from the emission, detection, and responses to olfactory and auditory social cues. Repetitive behaviors are assayed for spontaneous motor stereotypies, repetitive self-grooming, digging, marble burying and perseveration. Mouse behavioral assays relevant to associated symptoms of autism, including anxiety, hyperactivity, cognitive impairments, and reactions to sensory stimuli, provide further insights into genetic substrates of additional phenotypes. Forward and reverse genetic models will be presented, including BTBR T+ Itpr3tf/J, an inbred strain that displays abnormalities on multiple autism-relevant behavioral tasks, Shank3, a knockout mouse with a mutation in a central risk gene for autism and Phelan-McDermid syndrome, Engrailed2, a knockout mouse with a haplotype variant associated with autism, and 16p11.2 deletion, a human Syndrome associated with autism and intellectual disabilities. Mouse models further offer preclinical translational tools to discover pharmacological targets and to evaluate treatment efficacy. We employ lines of mice with the most robust autism-relevant traits for the discovery of effective therapeutic targets. Proof-of-principle results will be presented on hypothesis-driven pharmacological interventions that reversed components of autism-relevant behavioral phenotypes in mouse models.

Circuit Analysis and Novel Therapies in Neurodevelopmental Disorders Wednesday, March 8th • 4:45–6:00 p.m. • Contessa Ballroom Our research has identified for the first time a visual phenotype in mouse models of Rett syndrome and demonstrated its rescue by environmental and genetic manipulation (Durand et al, Neuron 2012). These results have paved the way to the identification of a specific role for Mecp2 in the experience-dependent refinement of cortical circuits by regulating the excitation of pivotal inhibitory neurons (Mierau et al., Biological Psychiatry 2015). The identification of a particular receptor pathway within a specific cortical circuit offers an accessible membrane target for drug intervention strategies that do not rely on the re-expression of Mecp2 itself. Dr. Fagiolini’s laboratory has recently completed a pre-clinical trial of a low dose of ketamine, a FDA-approved NMDA antagonist, in a murine model of RTT (Patrizi et al., Biological Psychiatry 2016). Daily exposure to ketamine reverses deficits in cortical neuronal activity and connectivity in conjunction with significant improvements in general health and survival. Since human studies have also identified abnormalities in NMDA receptor subunits early on in RTT, it is possible that drugs modulating NMDA receptors may be able to prevent or delay the developmental regression that occurs in girls with RTT. The results found in the animal models strongly suggests that visual processing in RTT patients may also be altered and can be used as a robust biomarker of both cortical status and its response to therapy. To this end, Dr. Fagiolini has begun a fruitful collaboration with the Rett Clinic at BCH and the laboratory of Cognitive Neuroscience to assess the cortical function of the visual system in young girls with RTT using visual evoked potentials (VEP) as previously done in Mecp2 mutant mice. Remarkably, they found significant differences between typically developing children and RTT patients (Le Blanc et al., Annals of Neurology 2015) supporting the introduction of standardized VEP analysis in clinical and research settings to probe the neurobiological mechanism underlying functional impairment and to longitudinally monitor progression of the disorder and response to treatment.

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Invited Speakers

James McCracken, M.D. David Geffen School of Medicine at UCLA

Jeremy Veenstra-VanderWeele, M.D. Columbia University

TUESDAY

MARCH 7, 2017

4:00 p.m. – Pre-Conference Check-in / Registration Contessa Ballroom Foyer

4:30–6:30 p.m. Pre-Conference Training Seminar on Statistics and Methodology Contessa Ballroom B Presenter: Keith Widaman, Ph.D. University of California, Riverside

Innovations Big and Small in ASD Clinical Trials Thursday, March 9th • 8:00–9:15 a.m. • Contessa Ballroom As treatment development in ASD continues to evolve, there is a need for clinical trial methodology and design to also adapt to a number of challenges. These challenges range from large to small, but each issue represents obstacles to further advances in ASD therapeutics. They include dealing with the heterogeneity of ASD, identifying more objective and replicable treatment endpoints, ethical questions, and accelerating the pace of intervention studies. This talk will present a variety of conceptual and methodologic pitfalls that future ASD trials will face, and offer recommendations, possible solutions, and topics for discussion.

Precision Medicine versus Symptomatic Treatment in Developmental Disorders Friday, March 10th • 11:30–12:45 p.m. • Contessa Ballroom Two main approaches are being pursued to identify new medication treatments that may benefit children with developmental disorders. The genomic revolution has generated a lot of excitement around what has been termed “precision medicine.” This approach focuses on developing treatments that target the known genetic mutations or variants that are causing, or at least contributing substantial risk, for a disorder. Exciting work in cellular and animal models has generated reasonable ideas of treatments to study in human populations with genetic disorders including fragile X syndrome, Rett syndrome, Down syndrome, and Tuberous sclerosis. In contrast, we have a long history of treatments that target specific symptoms in developmental disorders. These symptomatic treatments typically do not address the full spectrum of an individual’s difficulties, but they can be very effective for targeted problems, such as hyperactivity or irritability. Emerging work mapping the neurochemicals and brain circuits responsible for key mental functions, from social engagement to learning, points to potential novel treatments that reflect an understanding of the brain without a precise understanding of the genetic (or other) cause of an individual’s disorder. I will first lay out these two different approaches, using the example of fragile X syndrome for precision medicine and oxytocin for symptomatic treatment. I will then argue that both pathways have merit but that expectations and study designs need to be shaped to reflect their disparate challenges. Finally, I will suggest opportunities for these approaches to meet in the middle, with knowledge emerging from each pathway informing research in the other.

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WEDNESDAY

MARCH 8, 2017

7:30 a.m. – Check-in / Registration Contessa Ballroom Foyer 8:00–8:15 a.m.

OPENING REMARKS Contessa Ballroom

Leonard Abbeduto, Ph.D., Conference Chair University of California Davis, MIND Institute Connie Kasari, Ph.D., Conference Co-Chair University of California, Los Angeles 8:15–9:30 a.m.

PLENARY SESSION 1 Contessa Ballroom Mouse Models of Autism to Test Hypotheses about Causes and to Discover Therapeutics

Presenter: Jaqueline N. Crawley, Ph.D. University of California, Davis 9:30–10:00 a.m. — BREAK 10:00–11:30 a.m.

SYMPOSIUM 1 Contessa Ballroom A Outcomes for Young Children with Intellectual and Developmental Disabilities: A Discussion of Behavioral Phenotypes, Differential Responses and Outcome Measures Chair: Jena McDaniel Vanderbilt University

Discussant: Steven Warren University of Kansas

Contributions to Goal Directed Outcomes in Toddlers with Down Syndrome Elizabeth Will, Deborah Fidler, Lisa Daunhauer

Resistance to Structure Moderates the Effect of Treatment Intensity in Young Children with Intellectual Disabilities Jena McDaniel, Paul Yoder, Steven Warren, Marc Fey

Beyond Rates of Communication Nancy Brady, Kandace Fleming, Rebecca Swinburne Romine, Alison Holbrook, Connie Kasari

10:00–11:30 a.m.

SYMPOSIUM 2 Contessa Ballroom B Convergent Findings with Different Methodologies when Assessing Sleep in Children with Intellectual and Developmental Disabilities Chair: Anna J. Esbensen Cincinnati Children’s Hospital Medical Center

Discussant: Deborah Fidler Colorado State University

Memory Consolidation across Polysomnography-assessed Naps in Preschoolers with Down Syndrome Goffredina Spanò, Rebecca Gómez, Bianca Demara, Stephen Cohen, Jamie Edgin

Sleep in Children with Autism Spectrum Disorder: Exploring Bidirectional Relations with Daytime Challenging Behaviors Emily A. Abel, A. J. Schwichtenberg, Sharon L. Christ, Matthew T. Brodhead

Sleep Problems in Children with Down Syndrome: The Impact of Raters on Outcomes Anna J. Esbensen, Emily K. Hoffman

10:00–11:30 a.m.

SYMPOSIUM 3 Magnolia The FMR1 Premutation: Biomarkers and Discriminating Phenotypes Chair: Jessica Klusek Department of Communication Sciences and Disorders, University of South Carolina

Discussant: Kim Cornish Monash Institute for Cognitive and Clinical Neurosciences, Monash University, Melbourne

Autonomic Dysfunction is Associated with Pragmatic Language Impairments in Women with the FMR1 Premutation and the Broad Autism Phenotype Jessica Klusek, Jane E. Roberts

Automated Screening for Fragile X Premutation Carriers Based on Linguistic and Cognitive Computational Phenotypes Arezoo Movaghar, Jan Greenberg, Marsha Mailick, Audra Sterling, Krishanu Saha

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WEDNESDAY

MARCH 8, 2017

Identifying Modifying Genes to Explain the Variation in Severity of FMR1 Premutation-Associated Disorders Emily G. Allen, Krista Charen, Lisa Shubeck, Christina Trevino, David Cutler, Michael Zwick, Michael Epstein, Peng Jin, Stephen T. Warren, Stephanie L. Sherman

11:30–1:00 p.m. — LUNCH

1:00–2:30 p.m.

SYMPOSIUM 4 Contessa Ballroom A Co-parenting Relationships among Parents of Children with Autism Spectrum Disorder Chair: Robert Hock Texas Christian University

Discussant: Sandra Magaña University of Illinois at Chicago

The Co-parenting Relationship and Well-Being of Parents of Children with Autism Spectrum Disorder Megan M. Pruitt, Lisa Timmons, Naomi V. Ekas

Mother and Father Parental Attributions for Positive Behaviors in Children with Autism Spectrum Disorder Paige M. Bussanich, Sigan L. Hartley, Daniel Bolt

Feasibility and Acceptability of an Intervention to Strengthen Co-parent Relationships among Parents of Children with Autism Spectrum Disorder Robert Hock, Nina Nelson, Katherine Wallace

1:00–2:30 p.m.

SYMPOSIUM 5 Contessa Ballroom B Electrophysiological Biomarkers of Risk Prediction and Outcome in Neurodevelopmental Disorders: Methodological Considerations and Insights Gained from Studies in ASD, ID, and ADHD Chair: Shafali Jeste University of California, Los Angeles

EEG Data Collection Strategies for Children with ASD: The Role of State in Data Quality and Spectral Power Charlotte DiStefano, Shafali Jeste

Spontaneous EEG Oscillations Relate to Cognitive Function in Autism Spectrum Disorder Abby Dickinson, Shafali Jeste

EEG Biomarkers of Attention and Learning Associated with Rare Genetic Variants Caitlin M. Hudac, Raphael A. Bernier

Refining EEG Biomarkers in ADHD for Diagnosis and Treatment Response Monitoring Sandra Loo

1:00–2:30 p.m.

SYMPOSIUM 6 Magnolia Social Motivation: Innovative Social Skills Treatments and Meaningful Outcome Measures for Individuals with ASD Chair: Grace Gengoux Stanford University

Neural Correlates of Reward Anticipation and Processing in Children with and without Autism Spectrum Disorder Katherine Stavropoulos, Leslie Carver

Measuring Social Motivation in Children with Autism Spectrum Disorder Jennifer Phillips, Salena Schapp, Elizabeth Solomon, Emma Salzman, Lauren Allerhand, Christine Blasey, Tom Frazier, Antonio Hardan

Social Motivation Intervention for Children with Autism Spectrum Disorder: Improving Peer Initiations Grace W. Gengoux, Jessica Hopkins, Rachel Schuck, Maria Estefania Milan, Antonio Y. Hardan

Using Parent Assistance and Virtual Coaching to Improve Social Skills in Teens with Autism: The UCLA PEERS® Program Elizabeth A. Laugeson, Mi N. Park, Yasamine Bolourian, Jessie Sanchez, Jessica Hopkins

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WEDNESDAY

MARCH 8, 2017

2:45–4:15 p.m.

SYMPOSIUM 7 Contessa Ballroom A Development and Validation of Novel Outcome Measures for Children with Developmental Disabilities Chair: Brian A. Boyd University of North Carolina at Chapel Hill

Discussant: James W. Bodfish Vanderbilt University

Measuring the Functional Impact of Behavioral Inflexibility for Children with ASD Brian A. Boyd, James W. Bodfish, Luc Lecavalier, Clare Harrop, Allison Whitten, Jill Pritchett

Toward Outcome Measurement of Anxiety in Youth with ASD Luc Lecavalier, Robert T. Schultz, Michael Aman, Karen Bearss, Judith Miller, Christopher Taylor, John Herrington, Michael Edwards, Lawrence Scahill

Measuring Changes in Social Communication in Children and Adults with ASD Catherine Lord, Rebecca Grzadzinski

Expressive Language Sampling as an Outcome Measure for Clinical Trials Leonard Abbeduto, Angela John Thurman, Andrea McDuffie, Elizabeth Berry-Kravis, Audra Sterling, Jamie Edgin, Stephanie Sherman

2:45–4:15 p.m.

SYMPOSIUM 8 Contessa Ballroom B Qualitative Approaches to Understanding Family Experiences Chair: Gael I. Orsmond Boston University

Discussant: Julie Lounds Taylor Vanderbilt University

“Sometimes I Wish I Could Cut Into Half”: A Case Analysis of Social Roles and Behaviors of an Adolescent Sibling and Her Brother with ASD Jasin Wong, Gael I. Orsmond, Ellen S. Cohn

Understanding the Perspectives of Individuals with Intellectual and Developmental D4isabilities (IDD) and their Siblings Regarding Independent Living, Employment, and Self-Determination Meghan M. Burke, Chung eun Lee, Sarah Hall, Zachary Rossetti

Concerns of Family Caregivers of Individuals with Autism Spectrum Disorder across the Lifespan Carolyn M. Shivers, Gloria K. Lee

2:45–4:15 p.m.

SYMPOSIUM 9 Magnolia Innovations in Parent-training Interventions for Parents of Children with Intellectual and Developmental Disabilities Chair: Kate Guastaferro The Pennsylvania State University

Discussant: Ann Kaiser Vanderbilt University

The Efficacy of the Incredible Years Parent Training to Reduce Problem Behavior in Children with DD Laura Lee McIntyre, Davis S. DeGarmo

Mechanisms for Change: Using Peers to Deliver Parent Education for Latina Mothers of Children with Autism Spectrum Disorder (ASD) Sandy Magaña, Wendy Machalicek, Kristina Lopez

Tele-Behavioral Consultation for Families of Young Males with FXS Who Engage in Challenging Behavior Wendy Machalicek, Andrea McDuffie

4:15–4:45 p.m. — BREAK

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WEDNESDAY

MARCH 8, 2017

4:45–6:00 p.m.

PLENARY SESSION 2 Contessa Ballroom Circuit Analysis and Novel Therapies in Neurodevelopmental Disorders

Presenter: Michela Fagiolini, Ph.D. Boston Children's Hospital

6:00–7:30 p.m.

POSTER RECEPTION 1 (Posters 1-38) Laurel & Cedar Rooms *This is a mandatory session for all travel award recipients.

Poster #

Name Title

1 Kelli A. Sanderson Vanderbilt University

Who Helps? Characteristics and Correlates of Informal Supporters to Adults with Intellectual and Development Disabilities

2 Ana Mendoza UCLA PEERS Clinic

The Relationship between Social Anxiety and Perceived Intelligence and Happiness among Adolescents with Autism Spectrum Disorder

3 Meghan M. Burke University of Illinois at Urbana-Champaign

Identifying the Correlates and Barriers of Future Planning Among Parents of Adults with Intellectual and Developmental Disabilities

4 Emily K. Hoffman Cincinnati Children's Hospital

Medical Center

Measurement of Sleep in School-Age Children with Down Syndrome

5 Neilson Chan Loma Linda University

The Effect of Mindful Parenting on Behavior Problems and Social Skills among Children with Developmental Delays: The Mediating Role of Parenting Behaviors

6 Marah Sutherland University of Oregon

Predictors of Parent Involvement and Parent-teacher Relationships in Families of Children with Autism Spectrum Disorder

7 Katrina Ferrara Georgetown University

Visuospatial Skills in Adults after Perinatal Stroke

8 Tara Benninger The Ohio State University

Exploratory Factor Analysis of Two Measures of Behavior in Children with Autism Spectrum Disorder

9 Chung eun Lee University of Illinois at Urbana-Champaign

Correlates of Current Caregiving and other Roles for Siblings of Adults with Intellectual and Development Disabilities (IDD)

10 Breanne J. Byiers University of Minnesota

A Preliminary Evaluation of the Reliability of Skin Temperature Measurement in Rett Syndrome

11 Hilary Adams Children's Hospital of New Orleans

Selections and Influential Factors of Interventions for Autism Spectrum Disorder: Caregiver Survey Results

12 Yuan Zhang UCLA PEERS Clinic

Self-esteem as a Mediator of Social Skills Improvement and Social Anxiety for Adolescents with Autism Spectrum Disorder (ASD) following the UCLA PEERS® Program

13 Anne Hoffmann Rush University Medical Center

A Pilot Study of Video Self-Modeling in Fragile X Syndrome

14 Carly Moser University of South Carolina

The Role of Autonomic Function in Predicting Parenting Stress and Social Support in Mothers with the FMR1 Premutation

15 Noud Frielink Tilburg University

The Relationship between Autonomy Support and Well-Being in Adults with Intellectual Disability

16 Richard Rector Birmingham-Southern College

Maternal Characteristics Associated with Language Outcomes of Children Born at Less than 32 Weeks Gestational Age

17 Lisa A. Daunhauer Colorado State University

Longitudinal Achievement and Predictors of Academic Outcomes in Elementary School for Students with Down Syndrome

18 Leona Kelly University of California, Davis

Characterization of Dysfluencies in Speech Flow in Males with Fragile X Syndrome

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WEDNESDAY

MARCH 8, 2017

6:00–7:30 p.m.

POSTER RECEPTION 1 (Posters 1-38) Laurel & Cedar Rooms

*This is a mandatory session for all travel award recipients.

Poster #

Name Title

19 Emily Schworer Colorado State University

Parent Behavior and Executive Function in Children with Down Syndrome

20 Lindsey W. Williams University of North Carolina,

TEACCH Autism Program

Perceived Barriers to Autism Spectrum Disorder Services

21 Stephanie S. Benson University of Minnesota

Comparing Endorsements of Self-Injurious Behavior across Two Questionnaires for Parents of Individuals with Rett Syndrome and MECP2 Duplication

22 Angela M. Becerra University of Louisville

Early Gestural and Lexical Abilities as Predictors of Cognitive and Vocabulary Abilities at 4 Years of Age in Children with Williams Syndrome

23 Melissa Trites Drake University

Trends in Psychotropic Medication Use following Outpatient Behavioral Assessments

24 Alyssa Merbler University of Minnesota

Using Actigraphy to Characterize Sleep in Rett Syndrome

25 Emily Lorang University of Wisconsin-Madison

The Impact of ASD on Gesture and Spoken Language Integration in DS and FXS

26 Brianne Gerlach-McDonald Colorado State University

Executive Function and Adaptive Behavior in Young Adults with Down Syndrome

27 Audrey Thurm National Institute of Mental Health

Phenotypic Characteristics of Phelan-McDermid Syndrome from the Phelan-McDermid Syndrome International Registry

28 Abbie Popa University of California, Davis

Children with 22q11.2 Deletion Syndrome Show Lower Spatial and Temporal Acuity than Typically Developing Children in Continuously Varying Tasks

29 Karina M. González University of California, Davis

Language Performance in Preschoolers with Fragile X Syndrome or Nonsyndromic Autism Spectrum Disorder

30 Lauren Bishop-Fitzpatrick University of Wisconsin-Madison

Participation in Recreational Activities Buffers the Impact of Perceived Stress on Quality of Life in Adults with Autism Spectrum Disorder

31 Olivia D. Conover University of Hawaii

Parents’ Behaviors Facilitate Competent Social Behavior in Children with Intellectual Disability

32 Scott Huberty University of California, Los Angeles

Longitudinal Analysis of EEG Power and Cognition in 15q11.2-Q13.1 Duplications (Dup15q Syndrome)

33 Ya-Chih Chang California State University,

Los Angeles

Mediation of Treatment Effect in a Teacher-Implemented Social Communication Intervention for Preschool Children with Autism: Teachers’ Strategy Adoption

34 Samantha Goldman Assumption College

Using School-Home Communication to Decrease Off-Task Behavior for Students with Autism Spectrum Disorders

35 Heather V. Fielding University of Kansas

Early Vocal Predictors of Later Language Ability in Children with Fragile X Syndrome

36 Myles C. Maxey Utah State University

Disabilities within Families

37 Yue Yu Indiana University-Purdue

University Indianapolis

The Outcomes of Caregivers of Individuals with Autism Spectrum Disorder in the Transition Period

38 Clare Harrop University of North Carolina at

Chapel Hill

Using Focus Groups to Guide Measure Development for Behavioral Inflexibility in Developmental Disabilities

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THURSDAY

MARCH 9, 2017


PLENARY SESSION 3 Contessa Ballroom Innovations Big and Small in ASD Clinical Trials

Presenter: James McCracken, M.D. University of California, Los Angeles

9:15–9:45 a.m. — BREAK

9:45–11:15 a.m.

SYMPOSIUM 10 Contessa Ballroom A Anxiety in Autism and Fragile X Syndrome Chair: Jane E. Roberts University of South Carolina

Discussant: Susan Hepburn Colorado State University

Early Risk Markers of Anxiety in Infant Siblings of Children with Autism Spectrum Disorder Abigail L. Hogan, Shannon L. O’Connor, Nicolas Poupore, Bridgette Tonnsen, Jane Roberts

Anxiety Disorders in Preschool Children with Fragile X Syndrome Kelly E. Caravella, Jane E. Roberts

Characterizing Anxiety through Eye Tracking: Attentional Bias toward Threat in Fragile X Syndrome Bridgette L. Tonnsen, Abigail L. Hogan, Jordan A. Ezell, Kelly E. Caravella, Jane E. Roberts

Differential Effects of Anxiety and Autism on Social Scene Scanning in Males with Fragile X Syndrome Hayley Crawford, Joanna Moss, Chris Oliver, Deborah Riby

9:45–11:15 a.m.

SYMPOSIUM 11 Contessa Ballroom B Biomarkers of Aging and Alzheimer Disease in Down Syndrome Chair: Benjamin L. Handen University of Pittsburgh School of Medicine

Discussant: Sigan Hartley University of Wisconsin-Madison

Declines in Cognitive Functioning related to Increasing Amyloid-β over 3-years in Adults with Down Syndrome Iulia Mihaila, Sigan Hartley, Benjamin Handen, Regina Hardison, Darlynne Devenny, Patrick Lao, William Klunk, Brad Christian

Identifying Mild Cognitive Impairment in Adults with Down Syndrome: Change in Performance over Time Wayne Silverman, Sharon J. Krinsky-McHale, Warren B. Zigman, Edmund C. Jenkins, Nicole Schupf

Identifying Mild Cognitive Impairment in Adults with Down Syndrome: Assessment at a Single Point in Time Sharon J. Krinsky-McHale, Nicole Schupf, Warren B. Zigman, Joseph H. Lee, Wayne Silverman

9:45–11:15 a.m.

SYMPOSIUM 12 Magnolia Capturing Change in Behaviour over Time in Individuals with Genetic Syndromes Associated with Intellectual Disability Chair: Chris Oliver University of Birmingham

Discussant: Jennifer Zarcone Kennedy Kreiger Institute

Sleep Disorders, Painful Health Conditions and Challenging Behaviour in Children with Smith-Magenis Syndrome (SMS) and Angelman Syndrome (AS): A Temporal Analysis Caroline Richards, Jayne Trickett, Mary Heald, Chris Oliver

The Temporal Associations of Difficult Behaviours in Tuberous Sclerosis Complex Stacey Bissell, Lucy Wilde, Chris Oliver

The Lifespan Trajectory of Mood, Interest and Pleasure in Cornelia de Lange Syndrome Laura Groves, Jo Moss, Lisa Nelson, Chris Stinton, Chris Oliver

A Ten Year Longitudinal Study of Behaviour in Smith-Magenis Syndrome Lucy Wilde, Suzanne Whittall, Hannah Callaghan, Jenny Sloneem, Chris Oliver, Alice Welham

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THURSDAY

MARCH 9, 2017

11:30–1:00 p.m. — LUNCH

1:00–2:30 p.m.

SYMPOSIUM 13 Contessa Ballroom A Utilizing Cognitive Neuroscience to Predict and Enhance Treatment Outcomes for Children and Adolescents with Autism Chair: Jennifer Frey The George Washington University Chair: Kevin Pelphrey Children’s National Health System

Discussant: Kevin Pelphrey Children’s National Health System

Neural Predictors and Neural Pathway of Response to Pivotal Response Treatment in Young Children with Autism Pamela Ventola, Daniel Yang, Kevin Pelphrey

Mu Suppression During Biological Motion Perception as a Stratification Biomarker for ASD Clinical Trials Michael Crowley, Jia Wu, Courtney Paisley, Sebiha Abdullahi, Linda Mayes, Kevin Pelphrey, Pamela Ventola

Neural Mechanisms of CBT for Anxiety in Children with Autism Spectrum Disorder Denis G. Sukhodolsky, Kevin Pelphrey, Emilie Bertschinger, Theresa Gladstone, Shivani Kaushal, Brent Vander Wyk

Quantitative Behavioral Analysis with Automation for Music-Based Robotic Therapy for Children with Autism Spectrum Disorder Chung-Hyuk Park, Rachael Bevill, Myounghoon Jeon, Ayanna Howard

1:00–2:30 p.m.

SYMPOSIUM 14 Contessa Ballroom B Improving Measurement of Behavioral Constructs in Neurodevelopmental Disorders: Graduate Student Research Symposium Chair: Kathryn Unruh Vanderbilt Brain Institute, Vanderbilt University

Discussant: Sigan Hartley University of Wisconsin-Madison

Prevalence and Correlates of Anxiety Disorders in Adolescent and Adult Males with Fragile X Syndrome and Autism Spectrum Disorder Jordan Ezell, Sara Matherly, Leonard Abbeduto, Jane E. Roberts

Cortisol Profiles Differentiate Young Adult Males with Autism Spectrum Disorder from Fragile X Syndrome Sara Matherly, Jessica Klusek, Angela John Thurman, Andrea McDuffie, Jane E. Roberts, Leonard Abbeduto

Comparison of Methods for Assessing Spoken Language in Young Children with FXS or ASD Lauren Bullard, Robyn Tempero Feigles, Stephanie Summers, Andrea McDuffie, Angela John Thurman, Leonard Abbeduto

Inferential Language Use by School-Aged Boys with Fragile X Syndrome: Effects of a Parent-Implemented Spoken Language Intervention Sarah Nelson, Amy Banasik, Robyn Tempero Feigles, Andrea McDuffie, Leonard Abbeduto

Developing an Eye-Tracking Biomarker to Measure Social Motivation in Minimally Verbal Children with ASD Kathryn Unruh, Emily Morrow, Jim Bodfish

1:00–2:30 p.m.

SYMPOSIUM 15 Magnolia Exploring Positive Adaptation in Mothers of Children with Autism Spectrum Disorder and Intellectual Disability Chair: Naomi V. Ekas Texas Christian University

Discussant: Robert Hock University of South Carolina

The Construct of Maternal Positivity in Mothers of Children with Intellectual Disability Mikeda Jess, Vasiliki Totsika, Richard. P. Hastings

Optimism and Coping Strategies among Latina Mothers of Children with Autism Spectrum Disorder Kristina Lopez, Sandra Magaña

Predicting Positive Adaptation in Mothers of Children with Autism Spectrum Disorder: The Role of Religion and Spirituality Naomi V. Ekas

11

THURSDAY

MARCH 9, 2017

2:45–4:15 p.m.

SYMPOSIUM 16 Contessa Ballroom A Couple Relationships in Parents of Children with Autism Spectrum Disorder: Insight into Risk, Variability, and Partner Coping using Multilevel Modeling Chair: Sigan Hartley University of Wisconsin-Madison

Discussant: Leann Smith University of Wisconsin-Madison

Couple Conflict in Parents of Children with Versus Without Autism: Self-Reported and Observed Findings Emily J. Hickey, Sigan L. Hartley, Lauren M. Papp, Iulia Mihaila, Paige M. Bussanich, Greta L. Goetz

Parental Relationship Satisfaction in Families of Children with Autism: A Multilevel Analysis

Emma Langley, Vasiliki Totsika, Richard Hastings

The Actor and Partner Effects of Coping Strategies on Family Cohesion for Parents of Children with Autism Spectrum Disorder Lisa Timmons, Megan Pruitt, Naomi V. Ekas

2:45–4:15 p.m.

SYMPOSIUM 17 Contessa Ballroom B Using Technology Advances in Interventions for Children with Intellectual and Developmental Disabilities Chair: MaryAnn Romski Georgia State University Chair: Rose A. Sevcik Georgia State University

Discussant: Nancy Brady University of Kansas

Telehealth in Children with Prader-Willi Syndrome: Understanding the Unique Benefits and Challenges of Remote Intervention Anastasia Dimitropoulos, Olena Zyga, Ellen Doernberg, Sandra Russ

Maternal Response to Coaching in the Context of a Language Intervention Delivered Via Telehealth Amy Banasik, Sarah Nelson, Lauren Bullard, Andrea McDuffie, Leonard Abbeduto

Mobile Health Technology to Optimize Communication Outcomes for South African Children with Neuro-Developmental Disorders MaryAnn Romski, Juan Bornman, Rose A. Sevcik, Vuledzani Madima, Marika King

Coaching Insights from the Personalized Service and Care Platform Samuel Sennott

2:45–4:15 p.m.

SYMPOSIUM 18 Magnolia Psychophysiological Biomarkers: Expanding Assessment Options in IDD Research Chair: Alexandra P. Key Vanderbilt University Medical Center

Discussant: Alexandra P. Key Vanderbilt University Medical Center

Biomarker Development in ASD: Electrophysiological Response during Auditory Gap Detection is Associated with Symptom Severity Jennifer H. Foss-Feig , Katherine K.M. Stavropoulos, Emily Isenstein, James C. McPartland, Mark T. Wallace, Wendy L. Stone, Alexandra P. Key

Skin Conductance and Respiratory Sinus Arrhythmia: Autonomic Markers of Emotion in Childhood Stuttering Robin Jones, Hatun Zengin-Bolatkale, Edward G. Conture, Tedra Walden

Cortical Markers of Emotion Reactivity and Regulation in Childhood Stuttering Hatun Zengin-Bolatkale, Edward G. Conture, Alexandra P. Key, Tedra Walden, Robin Jones

Eye Tracking and ERP Measures as Objective Markers of Hyperphagia in Prader-Willi Syndrome Alexandra P. Key, Dorita Jones, Elizabeth Roof, Hailee Hunt-Hawkins, Elisabeth Dykens

4:30–5:45 p.m.

NIH Training Session Contessa Ballroom Updates on Outcome Measures, Biomarkers, and Clinical Trials Presenters: Alice Kau, Ph.D., Tracy King, M.D., M.P.H., Melissa Parisi, M.D., Ph.D.

12

THURSDAY

MARCH 9, 2017

6:00–7:30 p.m.



Poster #

Name Title

39 Maya Matheis Louisiana State University

Premature Birth, Birth Weight, and Positive Screening for Autism Spectrum Disorder

40 Kim van den Bogaard Tilburg University

Challenging Behavior in People with Mild to Borderline Intellectual Disability and Co-Occurring Psychopathology

41 Gregor Nathanael Schwarz University of Wisconsin-Milwaukee

Relations between BRIEF Parent Ratings and DCCS Lab-Based Performance for Youth with Williams Syndrome

42 Rhideeta Jalal University of California, Los Angeles

Positive Self-Esteem as a Predictor of Treatment Outcome in Adolescents with ASD following the UCLA PEERS® Intervention

43 Hannah Morgan University of California, Davis

Children with Chromosome 22q11.2 Deletion Syndrome Show Common Visuospatial Impairments in Two Analogous Line Bisection Tasks

44 Trent Robinson The University of Alabama

Developmental Trajectory Analysis of Verbal and Every Day Long Term Memory: A Comparison of Persons with Intellectual Disability with and Without Down Syndrome

45 Alexis Brewe University of South Carolina

Joint Attention Gaze and Gesture Use in Infants at High-Risk for Autism

46 Eva Kurtz-Nelson University of Oregon

Predicting Externalizing Problem Behavior from Adaptive Behavior and Parental Intrusion for Young Children with Developmental Delays

47 Meredith Dennis Loma Linda University

The Influence of Parenting Stress on Child Behavior and Development in Children with Developmental Delay: The Role of the Parenting Process

48 Kristin Lee University of Wisconsin-Milwaukee

Problem Behaviors in Young Children with Williams Syndrome: Parent and Teacher Perspectives

49 Tracy Jane Raulston University of Oregon

The Role of Mindful Parenting on Caregiver Stress and Depression in Parents of Children with Autism Spectrum Disorder

50 Alexander Tu Vanderbilt University

The Impact of Singing on Multisensory Integration in Children with Autism Spectrum Disorder: A Pilot Study

51 Philip Lai University of Wisconsin-Madison

Communication between Mothers and Children with Autism Spectrum Disorder during a Free-Play Interaction

52 Elizabeth J. Halstead University of Brighton

Maternal Depression and Family Life Events as Risk Factors for Behavioural and Emotional Problems in Children with Intellectual and Developmental Disabilities and the Function of Child Resilience as a Compensatory Factor in this Relationship

53 Adele F. Dimian University of Minnesota

The Impact of Delay in Early Intensive Behavioral Intervention on Educational Outcomes for Children with Autism

54 César Hoyos Alvarez University of California, Davis

Validation of the Expressive Communication Indicator as an Outcome Measure in Young Children with Neurodevelopmental Disorders

55 Megan M. Griffin University of New Mexico

In Their Own Words: Bullying Experiences of People with Developmental Disabilities

56 Anna Wallisch University of Kansas Medical Center

Occupational Performance Coaching Via Telehealth: A 12-Week Intervention for Families of Children with Autism Spectrum Disorders

57 Kathryn D. Slaboch Vanderbilt University

Developing an Observational Measure of the Flexible Use of Pre-linguistic Vocalizations in Preverbal Children with Autism

58 Claire O. Burns Louisiana State University

A Comparison of Developmental Functioning in Infants and Toddlers with Genetic Disorders

59 Chantel C. Barney Gillette Children's Specialty

Healthcare

The Psychometric Properties of the Brief Pain Inventory for Individuals with Cerebral Palsy

13

THURSDAY

MARCH 9, 2017

6:00–7:30 p.m.



Poster #

Name Title

60 Alyssa Wilkinson Drake University

Longitudinal Analysis of Stereotypy: What Changes, What Remains the Same

61 Laura Friedman University of Wisconsin-Madison

Conversational Language in Adults with ASD

62 Christopher Daniell Vanderbilt University

Rates of Autism Spectrum Disorder in Adults with Prader-Willi Syndrome

63 Kathleen Angkustsiri University of California, Davis

What Might Explain Social Impairments in Children with Chromosome 22q11.2 Deletion Syndrome?

64 Carla A. Wall University of South Carolina

Developmental Trajectories of Sex Differences in Negative Affect in Infants with FXS

65 C. Holley Pitts University of Louisville

Cognitive Profile of Children with Williams Syndrome as Measured by the Differential Ability Scales-II School-Aged Battery

66 Judith S. Miller University of Pennsylvania

Creatine Transporter Deficiency and Potential Outcome Variables for the Severely Impaired

67 Sydney Lerner Texas Christian University

Maternal and Child Characteristics as Predictors of Interactions with the Religious Community

68 Erica Lydey Michigan State University

Collateral Effects of Object Labeling of Children with Autism

69 Lizbeth H. Finestack University of Minnesota

A Comparison of Language Measures to Evaluate Treatment Outcomes for School-age Boys with Fragile X Syndrome

70 Marisa H. Fisher Michigan State University

Social Skills Deficits in Adults with Williams Syndrome

71

Joanna Greer Northumbria University

An EEG Investigation of the Alpha and Beta Frequency Bands during Resting States in Adults with Williams Syndrome

72

Anne C. Wheeler RTI International

Feasibility of Use of Portable, Wireless EEG Measurement in Individuals with Fragile X Syndrome

73

No Poster

74

Blair Lloyd Vanderbilt University

Generalizability of Direct Observation Measures of Classroom Problem Behavior and Behavior-Environment Contingencies

75

Laura J. Hahn University of Illinois at Urbana-Champaign

Early Risk of Autism Spectrum Disorders in Infants with Down Syndrome

76

Kim Decelle University of South Carolina

Factors Predicting Help Seeking Propensity in Autism Spectrum Disorder

14

FRIDAY

MARCH 10, 2017


POSTER BREAKFAST (Posters 77-110) Laurel & Cedar Rooms


Poster #

Name Title

77 Greta Goetz University of Wisconsin-Waisman

Parenting Styles and Associations with Child Behavior Problems in Parents of Children with and Without ASD

78 Andrea Barton-Hulsey University of Wisconsin-Waisman

Social Communication and Expressive Language in Children with Idiopathic ASD and Comorbid ASD and Fragile X Syndrome

79 Marinie P. Joseph University of Louisville

Predictive Validity of the MacArthur-Bates Communicative Development Inventory: Words & Sentences at Age 30 Months for Language and Intellectual Abilities at Age 48 Months: Children with Williams Syndrome

80 Lindamarie Olson University of South Carolina

Exploring Help-Seeking and Stigma Related to Autism Spectrum Disorder among Parents in India

81 Courtney Durdle University of California, Davis

Bigger is better! Spatiotemporal Hypergranularity Theory Explored: Quantifying the Resolution of Spatial and Temporal Attention in Children with Chromosome 22q11.2 Deletion Syndrome

82 Stephanie Summers University of California, Davis

Maternal Language Input to Children with FXS and Idiopathic ASD

83 Juliana Eovino University of Louisville

Concurrent Validity of the MacArthur-Bates Communicative Development Inventory for 48-month-olds with Williams Syndrome: Relations to Naturalistic Language Sampling and Standardized Language and Intellectual Ability Assessments

84 Jessica Scherr Nationwide Children's Hospital

Examining the Relationship of Autism Spectrum Disorder and Cultural Factors on Caregiver Stress and Behavioral Feeding Intervention Outcomes

85 Leann E. Smith University of Wisconsin-Madison

Working Together: Family Education and Support Intervention for Young Adults with ASD

86 Jacob I. Feldman Vanderbilt University

Associations between Sensory Integration and Sensory Responsiveness in Children with and Without Autism Spectrum Disorder

87 Kandace Fleming University of Kansas

The Dynamic Dyad: Relationships between Maternal Responsivity and Communication and Adaptive Functioning Outcomes in Children with FXS

88 Moshe Maiman Drexel University

Differential Effects of Sex and Intellectual Ability Level on 'Cool' and 'Hot' Executive Function Impairments in Youth With Down Syndrome

89 Olena Zyga Case Western Reserve University

Promoting Parent-Child Engagement and Social Interaction in Preschoolers with Prader-Willi Syndrome: The Feasibility of a Telehealth Parent-Training Program

90 Zachary Himmelberger The University of Alabama

Predicting Attitudes towards People with ID

91 Melissa Raspa RTI International

Sensory Difficulties in Individuals with Fragile X Syndrome

92 Kylee Miller RTI International

Health Care Decision Making in Context: Who and How

93 Anne Wheeler RTI International

Integrating Technologies for Measuring Change in Behavior in Individuals with Intellectual and Developmental Disabilities

94 Karla Audserau University of Wisconsin-Madison

Parent Strategies to Support Mealtime Participation for Children with Autism Spectrum Disorders

15

FRIDAY

MARCH 10, 2017

8:00–9:30 a.m.

POSTER BREAKFAST (Posters 77-110) Laurel & Cedar Rooms


Poster #

Name Title

95 Emily Abel Purdue University

Characterizing Sleep Problems in Infants and Toddlers with Neurogenetic Syndromes: A Cross-Group Comparison

96 Douglas A. Roberts, Jr. Georgia State University

Barriers and Facilitators to Exercise for Adolescents and Adults with Intellectual and Developmental Disabilities

97 Lani Shellhouse University of Alabama

Auditory vs. Visual Sustained Attention to Response Task Performance Trajectories in Down Syndrome

98 Shannon L. O'Connor University of South Carolina

ADHD Symptomatology in Preschoolers with Fragile X or Autism

99 Maria Paula Mello Vanderbilt University

Characteristics of Students Who Do and Do Not Receive Transition Services

100 Meg Stone Nationwide Children's Hospital

Investigating the Relationship of Autism Severity and Symptomology on Parenting Stress and Behavioral Feeding Treatment Outcomes

101 Jane Waite University of Birmingham

Associations between Executive Functioning and Temper Outbursts: Evidence from Lowe Syndrome

102 Carrie Ballantyne University of the West of Scotland

Expressive Drawing Ability, Emotion Recognition and Theory of Mind in Children with ASD and FXS

103 Ruth Brown Virginia Commonwealth

University

Depressive Symptoms and DNA Methylation in People with Mosaicism for Down Syndrome

104 Mary Godfrey Drexel University

Comparing Social, Communicative, and Repetitive Behaviors in Children with Down Syndrome and Idiopathic Autism Spectrum Disorder Matched on Verbal Mental Ability Level

105 Emma Cooper University of California, Davis

Autism Symptoms in Adolescents and Young Adult Males with Fragile X Syndrome: Predictors of ADOS Severity Scores

106 Eric Butter Nationwide Children's Hospital

Improving Access to Developmental Monitoring Over Time in a Neurodevelopmental Assessment Clinic

107 Rowena Ng University of Minnesota,

Twin Cities

The Association between Social and Language Phenotypes in Specific Language Impairment versus High Functioning Autism

108 Jamie Edgin University of Arizona

A Novel Computerized Assessment for Examining Memory in Children with Intellectual Disability

109

Kristen Medeiros University of Missouri

The Relationship between Physical, Socioemotional, Intellectual, and Behavioral Deficits and Family Impact across Diagnostic Groups

110

Lisa Rague Purdue University

Measuring Early Social Communication Skills in Neurogenetic Syndromes using the CSBS-ITC

16

FRIDAY

MARCH 10, 2017

9:30–11:00 a.m.

SYMPOSIUM 19 Contessa Ballroom A Measuring Small but Meaningful Change Chair: Connie Kasari University of California, Los Angeles

Discussant: Nancy Brady University of Kansas

Does Joint Engagement Mediate Intervention Outcomes of Joint Attention in Young Children with ASD in Preschool Classrooms? Wendy Shih, Ya-Chih Chang, Stephanie Shire, Connie Kasari

The Power of Play: How Even Small Changes in Play Diversity Lead to Expressive Language Gains Amanda Gulsrud, Justin Williams, Wendy Shih, Connie Kasari

Advancing Spoken Comments in School Age Children with Autism who are Minimally Verbal: Benchmarks for Caregiver Implementation Stephanie Shire, Wendy Shih, Connie Kasari

9:30–11:00 a.m.

SYMPOSIUM 20 Contessa Ballroom B Spoken Language Abilities in Down Syndrome Chair: Marie Moore Channell University of Illinois at Urbana-Champaign

Discussant: MaryAnn Romski Georgia State University

Verb Production in Down Syndrome, Intellectual Disability, and Typical Development Marie Moore Channell, Susan J. Loveall, Frances A. Conners, Leonard Abbeduto

Density and Diversity of Verb Use by Individuals with Down Syndrome during Narrative Storytelling Susan J. Loveall, Marie Moore Channell, Frances A. Conners, Leonard Abbeduto

Inference Generation in Narrative Retells by Youth with Down Syndrome Shealyn Ashby, Marie Moore Channell, Leonard Abbeduto

Modeling the Relationships among Sustained Attention, Short-Term Memory, and Language in Down Syndrome Gayle G. Faught, Frances A. Conners, Lani Shellhouse

9:30–11:00 a.m.

SYMPOSIUM 21 Magnolia From Behavior to Biomarkers: Challenges and Advances in Outcome Measures for IDD Chair: Audrey Thurm National Institute of Mental Health Chair: Cristan Farmer National Institute of Mental Health

Discussant: Elizabeth Berry-Kravis Rush University Medical Center

Outcome Measure Selection for Samples with ASD and Intellectual Impairment: A Vineland-II Vignette Cristan Farmer, Jesse Troy, Audrey Thurm

The Meaning of SRS-2 Scores is Relative: The Importance of Measurement Invariance in Outcome Measure Selection Vanessa Hus Bal, Alexandra Havdahl, Somer Bishop, Audrey Thurm, Cristan Farmer

Smith-Lemli-Opitz Syndrome (SLOS) Biomarker—Behavior Relationships over Time and Development Audrey Thurm, Elaine Tierney, Cristan Farmer, Simona Bianconi, Christopher Wassif, Forbes Porter

11:00–11:30 a.m. — BREAK

11:30–12:45 p.m.

PLENARY SESSION 4 Contessa Ballroom Precision Medicine Versus Symptomatic Treatment in Developmental Disorders

Presenter: Jeremy M. Veenstra-VanderWeele, M.D. Columbia University 12:45 p.m.

CLOSING REMARKS Contessa Ballroom Leonard Abbeduto, Ph.D., Conference Chair Connie Kasari, Ph.D., Conference Co-Chair

17

Award Recipients

Congratulations to the 2017 Gatlinburg Conference Travel Award Recipients!

Amer ican Psycho log i ca l Assoc ia t ion -Div i s ion 33 Graduate S tudent Trave l Award

Jessica Scherr

Nationwide Children's Hospital

David Zeaman Graduate Award

Marinie Joseph

University of Louisville

Emily Lorang University of Wisconsin-Madison

Iulia Mihaila University of Wisconsin-Madison

Kathryn Unruh

Vanderbilt Brain Institute, Vanderbilt University

Disser ta t ion Award

Gayle Faught

University of Alabama

John G. Borkowsk i D ivers i ty Trave l Award

Tara Benninger

The Ohio State University

Maria Mello Vanderbilt University

Lara ine Mas te rs Gl idden Undergraduate Award

Alyssa Wilkinson

Drake University

Nat iona l Frag i l e X Foundat ion Award Heather Fielding

University of Kansas

Theodore T jossem Pos tdoc tora l Award

Charlotte DiStefano University of California,

Los Angeles

Abigail Hogan University of South Carolina

Caitlin Hudac University of Washington

Stephanie Shire University of California,

Los Angeles

18

50TH Anniversary

GATLINBURG CONFERENCE History

The Gatlinburg Conference on Research and Theory in Intellectual and Developmental Disabilities began in 1967 as a forum to advance interdisciplinary research and training. The initial conference brought together faculty and students from the University of Alabama, Vanderbilt University, and the University of Illinois. The faculty leaders for the first conference were Norman Ellis, Carl Haywood, and Samuel Kirk. The Conference was held for its first two decades in Gatlinburg, Tennessee owing to the natural beauty of the Smokey Mountains and its relative accessibility to the three participating universities. NICHD funding for the Conference began in 1975. The initial conference featured 25 presentations. Today’s Gatlinburg Conference comprises over 100 poster presentations and nearly two dozen symposia. The number of universities represented at any annual meeting is typically over 50 and the number of attendees is near 300. Although the conference has grown (and we have opted for more urban destinations rather than the mountains), we have stayed true to the original mission of the Conference: sharing cutting-edge science; training the next generation of scientists and leaders; promoting interdisciplinarity; and most importantly, working to improve the lives of people with intellectual and developmental disabilities and their families. It is also important to acknowledge that the responsibility for organizing the Conference shifts to a different university every five years in keeping with the notion that the conference is important to the field and not just a single program or small groups of scientists. UC Davis and UCLA are proud to provide oversight for the Conference during this 50th year anniversary.

_____________________________________________________________

Special Acknowledgment TO OUR EXHIBITORS

Brookes Publishing Co.

Lumos Pharma, Inc.

Taylor & Francis Group

University of Arizona

19

Notes

20

Notes

21

SAVE THE DATE

51st Gatlinburg Conference Theme: “Biological and Cultural Perspectives

on the Family: Implications for IDD”

April 11-13th, 2018

Hyatt Regency Mission Bay Spa and Marina

1441 Quivira Road | San Diego, California

For more information contact:

Rebecca L. Shilts, Conference Manager University of California Davis, MIND Institute

[email protected] • 916-703-0263

Brenda L. Shelton, Conference Co-Manager University of California Davis, MIND Institute

[email protected] • 916-703-0343

306 W. Market Street, San Antonio, TX 78205

Phone: 210.229.9222 • 866.435.0900

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Program at a Glance

Tuesday — March 7, 2017 4:00 p.m. Pre-Conference Check-in / Registration

Contessa Ballroom Foyer

4:30–6:30 p.m. Pre-Conference Training Seminar on Statistics and Methodology Presenter: Keith Widaman, Ph.D.

Contessa Ballroom B

Wednesday — March 8, 2017 7:30 a.m. Conference Check-in / Registration

Contessa Ballroom Foyer

8:00–8:15 a.m.

Opening Remarks – Leonard Abbeduto, Ph.D., Conference Chair & Connie Kasari, Ph.D., Conference Co-Chair

Contessa Ballroom

8:15–9:30 a.m. Plenary Session 1 Mouse Models of Autism to Test Hypotheses about Causes and to Discover Therapeutics Presenter: Jaqueline N. Crawley, Ph.D.

Contessa Ballroom

9:30–10:00 a.m.

BREAK Retama / Mesquite (Refreshments)

10:00–11:30 a.m. SYMPOSIUM 1 Contessa Ballroom A

Outcomes for Young Children with Intellectual and Developmental Disabilities: A Discussion of Behavioral Phenotypes, Differential Responses and Outcome Measures Chair: Jena McDaniel

SYMPOSIUM 2 Contessa Ballroom B

Convergent Findings with Different Methodologies when Assessing Sleep in Children with Intellectual and Developmental Disabilities Chair: Anna Esbensen

SYMPOSIUM 3 Magnolia

The FMR1 Premutation: Biomarkers and Discriminating Phenotypes Chair: Jessica Klusek

11:30–1:00 p.m.

LUNCH

1:00–2:30 p.m. SYMPOSIUM 4 Contessa Ballroom A

Co-parenting Relationships among Parents of Children with Autism Spectrum Disorder Chair: Robert Hock


Electrophysiological Biomarkers of Risk Prediction and Outcome in Neurodevelopmental Disorders: Methodological Considerations and Insights Gained from Studies in ASD, ID, and ADHD Chair: Shafali Jeste


Social Motivation: Innovative Social Skills Treatments and Meaningful Outcome Measures for Individuals with ASD Chair: Grace Gengoux


Development and Validation of Novel Outcome Measures for Children with Developmental Disabilities Chair: Brian Boyd


Qualitative Approaches to Understanding Family Experiences Chair: Gael Orsmond


Innovations in Parent-training Interventions for Parents of Children with Intellectual and Developmental Disabilities Chair: Kate Guastaferro

4:15–4:45 p.m.

BREAK

Retama / Mesquite (Refreshments)

4:45–6:00 p.m. Plenary Session 2 Circuit Analysis and Novel Therapies in Neurodevelopmental Disorders Presenter: Michela Fagiolini, Ph.D.

Contessa Ballroom

6:00–7:30 p.m. Poster Reception 1 (Posters 1-38) *Mandatory session for all travel award recipients

Laurel & Cedar Rooms

Thursday — March 9, 2017

7:30 a.m. Conference Check-in / Registration Contessa Ballroom Foyer

8:00–9:15 a.m. Plenary Session 3 Innovations Big and Small in ASD Clinical Trials Presenter: James McCracken, M.D.

Contessa Ballroom

Program at a Glance

Thursday — March 9, 2017

9:15–9:45 a.m.

BREAK



Anxiety in Autism and Fragile X Syndrome Chair: Jane Roberts


Biomarkers of Aging and Alzheimer Disease in Down Syndrome Chair: Benjamin Handen


Capturing Change in Behaviour Over Time in Individuals with Genetic Syndromes Associated with Intellectual Disability Chair: Chris Oliver

11:30–1:00 p.m.

LUNCH


Utilizing Cognitive Neuroscience to Predict and Enhance Treatment Outcomes for Children and Adolescents with Autism Chair: Jennifer Frey


Improving Measurement of Behavioral Constructs in Neurodevelopmental Disorders: Graduate Student Research Symposium Chair: Kathryn Unruh


Exploring Positive Adaptation in Mothers of Children with Autism Spectrum Disorder and Intellectual Disability Chair: Naomi Ekas


Couple Relationships in Parents of Children with Autism Spectrum Disorder: Insight into Risk, Variability, and Partner Coping using Multilevel Modeling Chair: Sigan Hartley


Using Technology Advances in Interventions for Children with Intellectual and Developmental Disabilities Chair: MaryAnn Romski


Psychophysiological Biomarkers: Expanding Assessment Options in IDD Research Chair: Alexandra Key

4:30–5:45 p.m. NIH Training Session Updates on Outcome Measures, Biomarkers, and Clinical Trials Presenters: Alice Kau, Ph.D., Tracy King, M.D., M.P.H., Melissa Parisi, M.D., Ph.D.

Contessa Ballroom

6:00–7:30 p.m. Poster Reception 2 (Posters 39-76) *Mandatory session for all travel award recipients


Fr iday — March 10, 2017

7:30 a.m. Conference Check-in / Registration Contessa Ballroom Foyer

8:00–9:30 a.m. Poster Breakfast (Posters 77-110) *Mandatory session for all travel award recipients



Measuring Small but Meaningful Change Chair: Connie Kasari


Spoken Language Abilities in Down Syndrome Chair: Marie Moore Channell


From Behavior to Biomarkers: Challenges and Advances in Outcome Measures for IDD Chair: Audrey Thurm

11:00– 11:30 a.m. BREAK


11:30–12:45 p.m. Plenary Session 4 Precision Medicine Versus Symptomatic Treatment in Developmental Disorders Presenter: Jeremy M. Veenstra-VanderWeele, M.D.

Contessa Ballroom

12:45 p.m. Closing Remarks Leonard Abbeduto, Ph.D., Conference Chair Connie Kasari, Ph.D., Conference Co-Chair

Contessa Ballroom

2017 Program Cover - UC Davis HealthJames Bodfish, Ph.D. Vanderbilt University Susan L. Hepburn,...

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Transcript of 2017 Program Cover - UC Davis HealthJames Bodfish, Ph.D. Vanderbilt University Susan L. Hepburn,...