2016 ) - Alexandria Faculty of Medicine · 1.4. Perform the main procedures required in hematology....

واالعتمادهيئة القومية لضمان جودة التعليم ال

University: Alexandria

Faculty : Medicine

Program Specifications

(Academic year: 2015\2016 )


A. Basic Information:

1. Program title: : Master Degree in Hematology

2. Department offering the program; Internal medicine ( Clinical Hematology Unit)

3. Program Coordinator: Prof. Dr. Nahla A. Hamed.

4. External evaluator(s): Prof Dr Sameh Shamaa

5. Type of the program: Single

6. Date of most recent program specifications approval: October 2015. B. Professional Information:

1- Program Aims: This program is designed to provide candidates with the basic knowledge and

skills that allow them to:

1.1. Diagnose and manage successfully common diseases of blood and bone marrow.

1.2. Identify hematological manifestations of medical diseases and solid tumors.

1.3. Deal with emergency situation in hematology.

1.4. Perform the main procedures required in hematology.

1.5. Acquire the skills needed in carrying out research.

2- Acdemic reference standards (ARS)& ILOs:

Academic reference standards of Master Degree in Hematology designed and approved by

Department of Internal Medicine (Hematology Unit) Faculty of Medicine. Alexandria

University. Based on:

Generic Academic Reference Standards (ARS): Postgraduate Medical Education, Egypt

(2009). Published by National Authority for Quality Assurance and Accreditation of

Education (NAQAAE) National

[http://naqaae.org/main/php/book/index.php]

Adapted from;

Specialty Training Curriculum for Hematology by Joint Royal Colleges of Physicians

Training Board (www.jrcptb.org.uk)

Domain Academic Reference

Standards (ARS)

ILOs

A. Knowledge and

understanding

Graduate of this program

must:

• Demonstrate the basic

knowledge of established

and evolving data about

types, diagnosis,

management of anaemia,

coagulation abnormalities.

a1 Describe the indications and

technique of performing bone

marrow aspirate and trephine

biopsy.

a2 – Identify the underlying causes

of anemia.

a3 –Describe steps and regulation of

hematopoiesis.

a4 Discuss presentation,

complications, diagnosis and

management of different types of


• Understand the

classification, course and

management of

haematological

malignancies

• Demonstrate basic

knowledge concerning

dealing with special

situation such as

pregnancy, solid tumors

amd systemic diseaseas

anemia

a5 –Outline the molecular basis of

abnormal hemoglobins and

thalassemia syndromes and

explain the laboratory methods

used in their screening and

diagnosis.

a6 –Describe pathology, diagnosis

and management of inherited and

acquired bone marrow failure.

a7 –Describe presentation, diagnosis,

classification and management of

acute and chronic leukemias in

adults.

a8 –Describe the classification,

natural history, molecular

biology, presentation, staging and

therapeutic modalities of

hematological malignancies.

a9 –Outline the most recent

histological classification of

lymphomas approved by the

WHO.

a10 –Describe normal hemostasis

and fibrinolysis.

a11–Outline the natural history,

presentation and complications of

congenital coagulation and

platelet disorders, the diagnostic

methods used in their assessment

and their management

a12 –Describe the

pharmaceuticals and blood

products available for the

management of excessive

bleeding, their indications and

side-effects.

a13 –Describe the etiology,

natural history and classification

of pancytopenia

a14 –Explain the use of blood

product support, the principles of

clinical blood transfusion and

define the complications of long

term transfusion.

a15 –Describe the


• Demonstrate basic data

in therapy especially

chemotherapy and bone

marrow transplantation

pathophysiology and

classification of

myeloproliferative disorders, the

required diagnostic methods and

the therapeutic options.

a16 –Outline the impact of

systemic disease on the blood and

bone marrow.

a17 –Identify the role of the

hematologist in management of

haemostatic problems in

pregnancy

a18 –Identify hematological

manifestations of solid tumors

a19 –Outline indications and

complications of bone marrow

transplantation

a20 –Define the principles of

chemotherapy regimens: mode of

action, side effects and

interactions of agents used in the

management of hematological

malignancies.

B. Intellectual

skills • Interpret and correlate

clinical data to make

diagnostic and therapeutic

decisions based on best

evidence

• Interact with patients in

a respected and

sympathetic manner.

• Cooperate

appropriately with

b1 Perform collection of entry and

follow up data.

b2 Conduct history and examination

competently.

b3 Interpret laboratory testing results

and advise on the initial

management of common

hematological disorders.

b4 Apply knowledge of lymphoma

classification to the patient

management.

b5 Correlate the examination,

differential diagnosis and

investigations to establish the

diagnosis and appropriate

treatment planning.

b6 Explain planned treatment clearly

to the patient

b7 Contribute to work of

multidisciplinary team for

managing complication through


members of medical staff.

an appropriate writing of letter of

referral

b8 Apply evidence based medicine

from updated reference.

C. Professional

skills • provide patient care in

a compassionate,

appropriate, and effective

manner for the treatment

of health problems and the

promotion of health

• Apply specific

maneuvers required by

haematologist

• Perform laboratory

tests and interpret reports.

c1 –Analyze and interpret blood

films and bone marrow smears

c2 –Interpret presenting features

and conduct history and

examination competently

c3 –Select and evaluate appropriate

laboratory investigations to

establish diagnosis.

c4 –Interpret and apply laboratory

results to patient management.

c5 –Formulate an appropriate

management plan and offer full

explanation to patients.

c6 –Prescribe combination

chemotherapy regimens

appropriately.

c7 –Practice appropriate use of

antibiotic regimens for

treatment and prophylaxis in the

immunosuppressed patient.

c8 –Manage complications of

blood transfusion appropriately

c9 –Interpret and evaluate

monitoring of anticoagulation

and advises appropriately

c10 –Assess suitability for stem

cell transplantation

c11 -Diagnose & provide initial

management of hematological

emergencies.

c12 –Practice appropriate use of

Central lines.

c13 –Perform lumbar puncture

competently and obtains CSF

sample for analysis

c14 Administer intrathecal

chemotherapy under guide

c15 –Perform and interpret blood

film, marrow aspirate and

trephine biopsy under


supervision.

D. General and

transferrable

skills

Graduate should:

• Perfect communication

skills with patients.

• Co-operate with

colleagues and seniors.

• Integrate information

from different sources.

d1- Offer full explanation of the

side effects of chemotherapy to

patients.

d2-Communicate effectively with

blood donors

d3- Manage effectively the use of

transplantation and its limitations to

patient and family.

d4-Communicate effectively with

colleagues in other specialties for

proper diagnosis and treatment of the

patients.

d5-Perform leadership

responsibilities in his work

d6- Refer the patient to seniors

whenever indicated.

d7- Write appropriate reports.

d8-Recognize the value of

continuous self lifelong learning

d9-Upgrade his scientific

information utilizing all available

printed and electronic sources.

E. Attitudes and

ethical

behavior

• Appreciate ethical,

religious and law

regulations during his

practice.

e1 Treat patients with respect.

e2 Demonstrate ethical

communication of informed

consent after full discussion with

the patient and relative.

e3 –Consult to obtain appropriate

action.

e4 - Communicate effectively with

terminal patients and their

relatives.

e5 –Recognize the importance of

supportive care for successive

patient outcome.

e6 – Consult with other relevant

specialist appropriately.

e7 –Recognize the importance of

good communication in

hematology practice.

e8 –Contribute in multidisciplinary

team working.

e9 Demonstrate ability to conduct


sympathetically bad news

including terminal progress.

Program courses ILOs Matrix

ILOs

Course title

A

1

A

2

A

3

A

4

A

5

A

6

A

7

A

8

A

9

A

1

0

A

1

1

A

1

2

A

1

3

A

1

4

A

1

5

A

1

6

A

1

7

A

1

8

A

1

9

A

2

0 Medical Biochemistry x

Medical Physiology x x x x x

Pharmacology x x x x

Microbiology and

Immunology X x

General Pathology x x

Clinical Pathology x x X x x

Internal Medicine for

hematology l x


hematology ll x

Hemopoiesis x

Iron metabolism. And

anemia, x x x x x

Acute leukemias X x

Chronic leukemias x

Stem cell disorders x

Lymphomas I x

, myeloma I x

Hemostasis x

Blood transfusion x X

Hematological

manifestations of

medical diseases

x x x

integrated hematology I


ILOs

Course title

d1 d2 d3 d4 d5 d6 d7 d8 d9 e1 e2 e3 e4 e5 e6 e7 e8 e9

Medical Biochemistry

Medical Physiology x

Pharmacology x

Microbiology and

Immunology

General Pathology x x

Clinical Pathology


hematology l x


hematology ll x

Hemopoiesis

Iron metabolism. And anemia, x

Acute leukemias x x x x x x

Chronic leukemias x

Stem cell disorders x x

Lymphomas, x x

myeloma x x

Hemostasis x x

Blood transfusion x

Hematological manifestations

of medical diseases


ILOs

Course title

B

1

B

2

B

3

B

4

B

5

B

6

B

7

B

8

C

1

C

2

C

3

C

4

C

5

C

6

C

7

C

8

C

9

C

1

0

C

1

1

C

1

2

C

1

3

C13

C

1

4

C

1

5

Medical Biochemistry

Medical Physiology x

Pharmacology x x

Microbiology and Immunology

General Pathology x x x

Clinical Pathology x x x x

Internal Medicine for hematology l x x x

Internal Medicine for hematology ll x x x

Hemopoiesis

Iron metabolism. And anemia, x x x x x

Acute leukemias x x x x x x x x x x x x x x x

Chronic leukemias x x x x x x x x

Stem cell disorders x x x x x x

Lymphomas, x x x x x x

Myeloma x x x x x x

Hemostasis x x x x x x x

Blood transfusion x

Hematological manifestations of medical

diseases



3- Curriculum Structure:

-Program duration: This program is fulfilled in not less than 2 years with a maximum of 5 years (4

semesters & thesis).

-Program structure:

1. Total hours: 40 Credit hours.

2. basics of Research: 3 credit Hours

3. Obligatory subjects: 29 Credit Hours. 4. Thesis :8 Credit Hours. 5. 2 Elective Subjects: one Credit Hour Each.

-Program Content:

A. Obligatory Courses: Code

Course

Credit Hours Contact hours

Lectures Practical Others

1 05500801 Basic of research 3

2 051608151 Medical Biochemistry for

Haematology

1 14

3 052008151 MedicalPhysiology for Haematology 1 14

4 050608151 Clinical Pharmacology for

Haematology

1 14

5 051808151 MedicalMicrobiology for

Haematology

1 14

6 052808151 Pathology for Haematology 1 14

7 Internal Medicine for Haematology I 2 14 14

8 051508151-1 Internal Medicine for Haematology

II

4 28 14 14

9 050508151 Clinical and chemical Pathology for

Haematology I

2 14 14

10 05151801 Haemopoiesis I 1 14

11 05151802 Iron Metabolism, Iron Deficiency

and Disorders of Haem Synthesis,

Megaloblastic Anaemia, Haemolytic

Anaemias, Aplastic Anaemia

3 28 14

12 05151803 Acute Leukaemias I 1 7 7

13 05151804 Chronic Leukaemias I 1 7 7

14 05151805 Stem Cell Disorders I 1 7 7

15 05151806 Lymphomas I 1 7 7

16 05151807 Myeloma I 1 7 7

17 05151808 Haemostasis I 1 7 7

18 05151809 Blood Transfusion I 1 14

19 05151810 Hematological Manifestations of

Medical Diseases

2 28

20 05151811 Integrated hematology I

Prerequisite 151801-810

3 42


B. Elective Courses:

Course

Code

Course Title No of Hours/Week Contact hours

Lectures Practical Others

05070739 Biostatistics and

Computer

1

05210702 General Psychiatry 1

053108151 Imaging for

haematology

1

05160832 Molecular Biology 1

- Others According

to the Field of the

Thesis

1

4- Program Admission Requirements:

According to the regulations of the credit hour bylaws of the Faculty of Medicine

Alexandria University (annex).

5- Regulations for Progression and Program Completion:

According to the regulations of the credit hour bylaws of the Faculty of Medicine

Alexandria University (annex).

6- Methods of student assessment:

Methods Intended Learning outcomes to be

assessed

1. Written Exam a1-a20,c6,c7

2. Practical Exam b1-8, c1-15, e1-9

3. Assignments d1-9

4.Thesis b1,2-c2,3-d4,5,8,9-e2,3,7,8

7- Methods of program evaluation:

Evaluator Tool Sample

1. Students enrolled in the program Questionnaires.

2. Alumni --------

3. Stakeholders (Employers) Focus group

4. External Evaluator (s) yes

5. Others:

Program Director: Prof. Dr. Hassan Nafea

Program Coordinator: Prof Dr. Nahla A Hamed


COURSE DESCRIPTION

1 Code Credit hours (2)

Course Prerequisites

051608151 Medical Biochemistry -

This course is given in 1 credit hour lectures including: introduction to carbohydrate structure,

digestion and absorption of carbohydrates, glycolysis, fates of pyruvate, hexose monophosphate

shunt, glycogen metabolism, uronic acid pathway, metabolism of galactose and fructose, regulation

of carbohydrate metabolism, introduction for lipid structures, digestion and absorption of lipids,

oxidation of fatty acids, ketone body metabolism, cholesterol metabolism, fatty acid synthesis,

metabolism of acyl glycerols, phospholipids and glycolipid synthesis, regulation of lipid metabolism,

introduction for protein structure, digestion and absorption of proteins, removal of amino acid

ammonia and catabolism of amino acids.



052008151 Physiology

In this course the student is studying essential information on the functions of different body organs

and their abnormalities.



050608151 Pharmacology for

Haematology

General Pharmacology; Drug sources and formulations, routes of drug administration,

pharmacodynamic concepts, ligands, agonists, antagonist, reverse agonists, dose-responses, affinity,

efficacy, potency, .. etc. Kinetic of drug/channel/receptor/enzyme interaction, molecular concepts, on

channels: G proteins coupled receptors: PKs: receptor TK, Ras-MAP Kinase/JAK-STAT pathways,

on non-receptor TK, serine, threonine kinases, on cytosolic & nuclear receptors, on cell cycle

machinery, on apoptotic machinery, Pharmacokinetic concepts, absorption, 1st pass metabolism,

protein binding, distribution kinetics (AUC, zero order, 1st order kinetics), metablosim and

biotransformation, elimination, cmax, t1/2, steady state, peak/trough ration, factors modifying drug

response, tolerance, idiosyncrasy, dependence, adverse drug reactions, drug interactions.

Drug Toxicology; Drug safely, drug hazards, narrow therapeutic index, drug monitoring, mechanisms

of drug toxicity, toxic drug categories, drugs and organ toxicity, rational treatment of drug toxicity,

antidotes.

Autonomic Pharmacology; Adrenoceptor agonists, adrenoceptor antagonist, adrenolytis,

cholinomimetics, cholinolytics, NANC.

Paracrine Autocrine and Immunopharmacology of; Monoamines, Purines, NO, Peptides,

Eicosanoides, Cytokine, Chemokines, adhesion molecules, immunoglobulin and other

immunotherapeutic trends.



051808151 General Microbiology


This course includes 15 theoretical Credit hours (1) (2 credit hours).

The Credit hours (1) cover the following topics: Bacterial growth; focal metabolites and their

interconversions; cell structure and endospores; protein synthesis; synthesis of cell wall

peptidoglycan and lipopolysaccharides; enzyme synthesis and regulation; oncogenes and tumor

suppressor genes; gene therapy and apoptosis.



05280833 General Pathology for Other

Departments

Cell injury, acute and chronic inflammation, tissue repair, hemodynamic disorders, disorders of the

immune system, neoplasia, genetic diseases, environmental diseases, general pathology of infectious

diseases, granulomatous diseases.



051507151 Internal Medicine for

haematology

-

Chest diseases -renal diseases - heptobiliary diseases - endocrinology diseases - CNS diseases -

Diabetes and metabolic diseases - Muscloskeletal diseases - CVS diseases - GIT diseases.



050508151 Laboratory Clinical

Pathology

-

Include all clinical pathological test involved in hematology.



05151801 Hematology Principles -

Haempoiesis -The red cell -Basic aspects of anaemia - Iron metabolism and hypochromic anaemias -

Aplastic anaemia and bone marrow failure -Haemolytic anaemias - Polycythaemias - Quantitative

disorders of leucocytes - Acute lymphoblastic leukaemia - Acute myeloid leukaemia -Chronic

lymphocytic leukaemia - Chronic granulocytic leukaemia -Myeloproliferative Diseases - Multiple

Myeloma - Malignant lymphomas -Haemostasis and abnormal bleeding.

Clinical examinations.

Course Specifications


Faculty: Medicine

Department: Internal Medicine

Course InformationCourse Code: 05151809 Course Name: Hematological Manifestations of

Medical DiseasesProgram in which the Course is Given Master Degree in Hematology

Number of Credit Hours 1 Theoretical Clinical/Practical

Course Aimsto provide candidates with the basic data and skills that allow them to diagnose Hematological

Manifestations of Medical Diseases

Intended Learning Outcomes (ILOs)Program ILO (refer to programmatrix)

Course ILOs

A. KnowledgeandUnderstanding

a16–Outline the impact of systemicdisease on the blood and bonemarrow.

a17–Identify the role of thehematologist in management ofhaemostatic problems inpregnancy

a18–Identify haematologicalmanifestations of solid tumors

a1 –Identify basic facts in theHematological Manifestationsaccompanying liver, renal, endocrineand connective tissue diseases

a2 Describe treatment aspects of anaemiaof chronic disease

a3 –Identify the effect of pregnancy onperipheral blood and bone marrow

a4 Describe mode of treatment ofhaematological abnormalitiesaccompanying pregnancy

a5 -Identify haemostatic changesaccompanying solid tumor

a6 Describe causes and manifestations ofanaemia associating with solid tumors

B. Intellectualskills

1

C.Professionaland PracticalSkills

D. GeneralSkills

Course Content(Units/Topics)

Teaching/Learning MethodsLectures self

learningPractical/Clinical

Smallgroupdiscussion

Others

Hematological Manifestations ofConnective tissue disorders

Hematological Manifestations of liverdisease

Hematological Manifestations of renaldisease

Hematological Manifestations ofendocrine disease

Hematological Manifestations ofpregnancy

Hematological Manifestations of cancer Please check () the appropriate method.

Student AssessmentMethods of Assessment Essay Objective questions

Case OSCE/OSPE

Assignment Logbook fulfillment

Others

Schedule of Assessment Mid-term %

End of term 100 %Distribution of Marks Written Exam 100 %

Practical/Clinical Exam %Others %

List of Textbooks and ReferencesLecture Notes Print out of lectures

Course Text Books Postgraduate haematology

Suggested Extra Reading William haematology

Journals and Periodicals, others Bloodhaematologica

Course InstructorName: Nahla AM Hamed Signature:

Program CoordinatorName: Nahla AM Hamed Signature:

Program Director (Head of Department)Name: Tarek Thabet Signature:



Faculty: Medicine


Course InformationCourse Code: 050508151 Course Name: Laboratory Clinical Pathology

Program in which the Course is Given: Master Degree in Hematology


Course AimsBy the end of this course the students should be able to relevantly order hematological investigations,understand sampling conditions and precautions, to be able to interpret properly the results of differentinvestigations and correlate these results with the clinical condition of the patients to reach a properdiagnosis.


Course ILOs


a1 a1 Describe the indications andtechnique of performing bonemarrow aspirate and trephinebiopsy.

a4 Discuss presentation,complications, diagnosis andmanagement of different types ofanemia

a7 –Describe presentation, diagnosis,classification and management ofacute and chronic leukaemias inadults.

a11 –Outline the natural history,presentation and complications ofcongenital coagulation andplatelet disorders, the diagnosticmethods used in their assessmentand their management

a15 –Describe the pathophysiology

a1 –identify different indications and methodsof performing bone marrow aspirate.

a2 –identify different indications and methodsof performing trephine biopsy.

a3 Discuss investigations necessary fordiagnosing haemolytic anaemia

a4 Discuss required investigations required fordifferentiating different types of anemia

a3 –Describe the required diagnostic methodsof adults acute leukaemias

a4 .Discuss diagnostic approach to chronicleukaemia

a5 –describe the diagnostic methods forcoagulation and platelet disorders,

a6 Describe methods of assessment ofanticoagulant therapy

a7 Describe the required diagnostic methods

11

and classification ofmyeloproliferative disorders, therequired diagnostic methods andthe therapeutic options.

for myeloproliferative disordersa8 Describe the investigations required for

myelodysplatic syndrome


b3 Interpret laboratory testingresults and advise on the initialmanagement of commonhaematological disorders.

b1 Interpret laboratory testing results ofanaemia and bleeding disorder

b2 Interpret laboratory testing results ofmalignant blood disorders


c1 –Analyze and interpret bloodfilms and bone marrow smears

c3 –Select and evaluateappropriate laboratoryinvestigations to establishdiagnosis.

C15–Perform and interpret bloodfilm, marrow aspirate andtrephine biopsy undersupervision.

c1 ––interpret blood filmsc2 Interpret bone marrow aspirate

c3 –Select laboratory investigations forappropriate diagnosis of benign blooddiseases

c4 Select laboratory investigations for properdiagnosis of malignant blood diseases

C5-Perform blood picture under guideC6-perform bone marrow aspirate and

trephine biopsy under guide.

D. GeneralSkills

Course Content (Units/Topics)




Others

Sampling in hematology

How to approach a case of anemia

Investigations of Aplastic anemia

Investigations of Hemolytic anemia

Investigations of Iron deficiency andmegaloblastic anemia

Classification and diagnosis of Acuteleukemia

Chronic lymphoproliferative disorders I

Chronic lymphoproliferative disorders II

Principles of flow cytometry andimmunophenotyping I

Principles of flow cytometry andimmunophenotyping II

Classification and diagnosis ofMyelodysplastic syndromes

Chronic myeloproliferative disorders Plasma cell disorders

How to approach a case of bleedingdisorder

How to approach a case ofhypercoagulable state

Complete blood picture (normal pattern,anemias and malignancies)

Bone marrow aspirate and trephinebiopsy

Investigations of hemolytic anemias (Coomb’s test, osmotic fragility and ham’stest)

Electrophoresis

Investigations of bleeding disorders:PT,PTT, FDP’s, Factor assay

Cytochemistry and Iron stainSerology and blood transfusion

Please check () the appropriate method.


Case OSCE/OSPE


Others



Practical/Clinical Exam 30 %Others %

List of Textbooks and ReferencesLecture Notes

Course Text Books Dacie and Lewis Practical Haematology

Suggested Extra Reading

Journals and Periodicals, others

Course InstructorName: Prof. Nahla Farahat Signature:

Program CoordinatorName: Prof. Nahla A.M. Hamed Signature:

Program Director (Head of Department)Name: Prof . Tarek Thabet Signature:



Faculty: Medicine


Course InformationCourse Code: 05151807 Course Name: HaemostasisProgram in which the Course is Given Master Degree in Hematology


Course Aimsto provide candidates with the basic facts and skills that allow them to diagnose and manage

successfully haemostatic disorders

Intended Learning Outcomes (ILOs)Program ILO(refer to programmatrix)

Course ILOs


a11 –Outline the natural history,presentation and complications ofcongenital coagulation andplatelet disorders, the diagnosticmethods used in their assessmentand their management

a1 – Identify basic facts in the diagnosis andmanagement of haemostatic disorders

a2 – Outline basic data regarding the drugsused in treatment of haemostatic disorders

a3 Outline the complications ofhaemophilias


b1 Perform collection of entry andfollow up data.

b2 Conduct history and examinationcompetently.

b3 Interpret laboratory testingresults and advise on the initialmanagement of commonhaematological disorders.

b1 Collects data of patients on admissionb2 Collect follow up data.

b3 perform efficient history takingb4 Conduct full clinical examination.

b3 Analyze & evaluate laboratory informationto establish diagnosis and appropriatetreatment planning of haemostaticdisorders.

b4 solve problems related to haemostaticdisorders according to the available data

C.Professionaland Practical

c2 Interpret presenting featuresand conduct history and

C1- conduct full history takingC2- perform clinical examination competently

1/21/2

Skills examination competently


c4 –Interpret and apply laboratoryresults to patient management.

c9 Interpret and evaluatemonitoring of anticoagulationand advises appropriately

c3 –Select the investigations appropriate fordiagnosis in a systematic manner.

c4 Interpret laboratory results appropriately

c5 –interrelate results of laboratoryinvestigations to patient treatment.

c6 Select appropriate investigations for followup patients

C7-Evaluate methods and tools used inmanagement of haemostatic disorders

c8-evaluate anticoagulant monitoring

D. GeneralSkills

d4- Communicate effectively withcolleagues in other specialties forproper diagnosis and treatment ofthe patients.

d6- Refer the patient to seniorswhenever indicated.

d1- Communicate with colleagues in otherspecialties for data interpretationd2- know appropriate time for referral

d3- consult seniors in difficult cases.d4-get benefit from senior opinion





Others

Normal haemostasis: Blood vessels.Platelets. Coagulation factors. Naturallyoccurring inhibitors. Fibrinolysis.

Inherited bleeding disorders: Haemophilia A. Haemophilia B. Gene therapy. Von Willibrand disease. Congenital platelet disorders

Acquired coagulation, platelet & vascularbleeding:

Disseminated intravascularcoagulation.

Coagulopathy & massive bloodloss.

Vitamin K deficiency. Idiopathic thrombocytophric

purpura. vascularpurpuras.

Inherited thrombophilia. Acquired venous thrombosis. TTP. Please check () the appropriate method.


Case OSCE/OSPE


Others








Course InstructorName: Mohamed El-Dafrawy Signature:



Faculty: Medicine

Department:

Course InformationCourse Code:

05151811Course Name: integrated hematology 1

Program in which the Course is Given: master program of hematology


Course Aims to provide candidates with the skills that allow them to Diagnose and manage successfullycommon diseases of blood and bone marrow


Course ILOs


Interpret and correlate clinicaldata to make diagnostic andtherapeutic decisions based onbest evidence

Interact with patients in arespected and sympatheticmanner.

Cooperate appropriately withmembers of medical staff.

b3 Perform collection of entry and follow updata.


b5 Interpret laboratory-testing results andadvise on the initial management of commonhematological disorders.

b7 Correlate the examination, differentialdiagnosis and investigations to establish thediagnosis and appropriate treatmentplanning.

b8 Explain planned treatment clearly to thepatient

b9 Contribute to work of multidisciplinary teamfor managing complication through anappropriate writing of letter of referral

b10Apply evidence-based medicine fromupdated reference.


Apply specific maneuversrequired by haematologist

Perform laboratory tests andinterpret reports.

c1 –Analyze and interpret blood films andbone marrow smears

c2 –Interpret presenting features and conducthistory and examination competently

c3 –Select and evaluate appropriatelaboratory investigations to establishdiagnosis.

c4 –Interpret and apply laboratory results topatient management.

c5 –Formulate an appropriate managementplan and offer full explanation to patients.

c6 –Prescribe combination chemotherapyregimens appropriately.

c10 –Assess suitability for stem celltransplantation

D. GeneralSkills

Graduate should:

Perfect communication skillswith patients.

Integrate information fromdifferent sources.

d4-Communicate effectively with colleagues inother specialties for proper diagnosis andtreatment of the patients.d5-Perform leadership responsibilities in hisworkd6- Refer the patient to seniors wheneverindicated.d7- Write appropriate reports.d8-Recognize the value of continuous selflifelong learningd9-Upgrade his scientific information utilizing all

available printed and electronic sources.





Others

Case presentation



Case OSCE/OSPE


Others




Perquisites : 151801-810




Journals and Periodicals, others Bloodhaematological

Course InstructorName: Prof. Dr Manal sorady

Prof.Dr ashraf alghandour Signature:

Program CoordinatorName: Prof.Dr. Nahla A. Hamed Signature:

Program Director (Head of Department)Name: Prof . Dr. Hassan Nafea Signature:



Faculty: Medicine


Course InformationCourse Code: 05280833 Course Name: General PathologyProgram in which the Course is Given Master Degree in Hematology


Course Aims

1. Study the basics of general pathology that allow understanding the differentpathologic changes in the diseases that will be studied in the course.

2. Understanding the pathology of different lesions affecting the lymphoid systemincluding: etiology, pathogenesis, morphology, complications, clinical pictureand prognosis.

3. Acquiring skills needed to interpret pathologic findings in correlation with theclinical findings.


Course ILOs


a8 –Describe the classification,natural history, molecular biology,presentation, staging andtherapeutic modalities ofhematological malignancies.

a1Summarize the relevant anatomyand functional histology of thelymphoid system

a2. Illustrate the ontogeny of thelymphoid system

a3. Describe the changes that occurin a lymph node upon antigenicstimulation

a4. Recognize the normalimmunohistochemical profile ofdifferent lymphoid cells

a5. Identify the information thatshould be included in the requestfor a lymph node biopsy

a6. Recognize prerequisits for aproper diagnosis of a case oflymphoid disorder

a9 –Outline the most recenthistological classification oflymphomas approved by theWHO.

a7. Explain the importance of propergrossing of lymph node biopsy

a8. Identify the role ofimmunohistochemistry in thediagnosis of lymphoid disorders

a9. Explain the principles ofimmunophenotyping in detectingmolecules on the surface ofdifferent types of lymphoid cellsthrough antibodies that are givencluster designation or CD numbers

a10. Identify the three methods ofimmunophenotyping :Immunohistochemistry ,immunofluorescence and flowcytometry

a11. Appreciate common applicationsfor cytogenetics in NHL

a12. Identify the role of lymph nodeaspiration in diagnosis of lymphoiddisorder

a13. List the causes of leukocytosiswith examples

a14. Distinguish reactive fromneoplastic leukocytosis

a15. Relate these changes to variousetiologic factors

a16. Mention the causes ofenlargement of lymph nodes

a17. Classify inflammatory disordersof lymphoid tissue and discuss keypoints about the different types ofinflammatory lymphadenitis

a18. Classify granulomas. affectinglymph nodes

a19. Describe the microscopicpatterns of reactivelymphadenopathy and relate themto the etiology

a20. Mention the differentclassification schemes of lymphoma

a21. Explain the most recentclassification of lymphoma

a22. Identify different types oflymphoma

a23. Determine the lymphomacategory to which it belongs

a24. Determine and categorizeindolent and aggressive lymphomas

a25. Distinguish between NHL and HLa26. Distinguish between non-

Hodgkin’s lymphoma (NHL) andHodgkin's lymphoma (HL)

a27. Describe the morphologicalfeatures of NHL and HL

a28. State the staging system of NHLand HL

a29. Mention the causes ofenlargement of the spleen

a30. Discuss the pathology ofhistiocytosis X

a31. Classify anemiaa32. Summarize the pathologic

features of anemiaa33. Classify leukemiaa34. Summarize the principle

pathologic features of leukemiaa35. Outline a proper workup of a

case of lymphoid disorderA. Clinical PictureB. Laboratory InvestigationsC. RadiodiagnosisD. Tissue Biopsy : morphologicapproach , immunophenotypingE. CytogeneticsF. Molecular diagnosticG. Bone marrow biopsy


b5. Correlate the examination,differential diagnosis andinvestigations to establish thediagnosis and appropriatetreatment planning.

b1-Recognize the most importantcauses of lymph node enlargementb2.Evaluate the malignancy of alymphoid proliferationb3.Recognize the most common typesof lymphomas in Egyptb4. Select the proper situation to

recommend a lymph node biopsyb5. Formulate a logarithm for

diagnosis of a caseb6. Critically appraise the different

classification schemes of lymphoma

C.Professional C3–Select and evaluate appropriate

and PracticalSkills

laboratory investigations toestablish diagnosis.

C4–Interpret and apply laboratoryresults to patient management.

C1.Properly deal with a lymphnode biopsy and spleen

c2. Apply proper grossing techniquesof the lymph node and spleen.

C3. Properly Interpret a lymph nodebiopsy

c4. Use the proper tools for properdiagnosis of a lymphoid disorder

c5. Select the proper panel ofimmunohistochemistry fordiagnosing a specific condition.

c6. Practice proper interpretation ofimmunohistochemical stainingpatterns of the different cases.

c7. Properly utilize the WHOclassification of malignantlymphomas

D. GeneralSkills

d7 Write appropriate reports.

d8-Recognize the value ofcontinuous self lifelong learning

d1. Actively participate and interact ingroup discussions

d2. Develop self-directed learningabilities.

d3. Develop presentation skillsd4. Communicate effectively with

his/her colleagues and teachingstaff.

d5. Cooperate with colleagues toeffectively accomplish group workactivities.

d6. Develop decision making, andproblem solving skills (analyzing,evaluating evidence, logicalreasoning and synthesizing).

d7. Practice self and peer-to-peerappraisal and evaluation.

d8. Able to manage time effectively onpersonal and team basis.





assignments

Histology of the lymphoidsystem

Development and ontogeny ofthe lymphoid tissue

Define leukocytosis

Causes of leukocytosis withexamples

Causes of enlargement oflymph nodes

Causes of acute and chroniclymphadenitis

Gross and microscopicmorphology of acute andchronic lymphadenitis

Classification systems oflymphomas

Small lymphocytic lymphoma Mantle cell lymphoma MALT lymphoma Large cell lymphoma Burkitt’s lymphoma Lymphoblastic lymphoma Hodgkin's lymphoma T cell lymphoma Staging of lymphoma Causes of enlargement ofspleen

Pathogenesis of splenomegalyin different conditions.

Histiocytosis X Classification of leukemia Classification of anemia Pathologic aspects of anemia



Case OSCE/OSPE


Others



Practical/Clinical Exam %Others oral %

Assignment 30%


Course Text Books Robbins and Cotran: Pathologic Basis of Disease



Course InstructorName: Professor Nagwa Mashali Signature: Nagwa Mashali

Program CoordinatorName: Prof. Nahla A.M. Hamed Signature:

Program Director (Head of Department)Name: Prof. Tarek Thabet Signature:

quizDrills,quizzes

Drills,quizzes

Drills,quizzesDrills,quizzes

Drills,quizzes

Drills,quizzes

Drills,quizzes

Drills,quizzes

Drills,quizz



Faculty: Medicine

Department:


05151906Course Name lymphoma II

Program in which the Course is Given: doctorate program in hematology

Number of Credit Hours2 Theoretical Clinical/Practical

Course Aimsto provide candidates with the updated knowledge and skills that allow themtodiagnose and manage successfully Lymphomas


Course ILOs


a5 – Identify recent advances inthe classification, naturalhistory, molecular biology, andtherapeutic modalities ofhematological malignancies.

a6 – Identify recent advances in thehistological classification oflymphomas approved by theWHO.

a3 –update his knowledge in WHOclassification of lymphomaa4 Identify recent advances in the drugs used

in Lymphomas according to WHOclassification


b1 Analyze, deduce, extrapolate &evaluate laboratory testingresults for the initialmanagement of common andunusual hematologicaldisorders.

b2 Take decision in the diagnosisand appropriate treatmentplanning.

b5 Apply evidence based medicine

b1 Analyze & evaluate available laboratoryinformation to establish treatment planof Lymphomas.

b2 Analyze & deduce laboratory tests toestablish treatment of uncommon typesof Lymphomas.

b3 Take decisions in various professionalsituations in lymphoma

b5 Refer to evidence based medicine in

11

from updated printed andelectronic reference.

managing casesb6 Refer to updated reference in dealing with

difficult cases.

C.ProfessionalandPractical Skills

C1-Plan professional courses ofcombination chemotherapyregimens

C1-Evaluate and improve methods and toolsused in management of LymphomasC2–Plan professional courses to improve

practice and enhance performance ofjuniors as regards appropriate treatmentof Lymphomas

D. General Skills d1- perform full explanation of theside effects of chemotherapy topatients.

d1-Performleadership responsibilities inexplaining complications of chemotherapy topatientsd2- upgrade his scientific information utilizingall available printed and electronic sources tomanage side effects of chemotherapy





Others

Non Hodgkin's lymphomas. Classifications. Epidemiology. Aetiology. Cytogenetics& oncogenes. Clinical features. Investigations. Staging. Treatment. Specific types.

Hodgkin's lymphoma: Epidemiology. Classification. Pathogenesis. Presentation. Staging. Prognostic factors. Therapy.



Case OSCE/OSPE


Others








Course InstructorName: Prof.Signature: Prof. Nabil El-Halawani

Program CoordinatorName: Prof. Signature:

Program Director (Head of Department)Name: Prof . Signature: Yehia Ghanem



Faculty: Medicine

Department:


05151907Course Name:myeloma II

Program in which the Course is Given: MD in hematology


Course Aimsto provide candidates with the updated knowledge and skills that allow themtodiagnose and manage successfully Myeloma


Course ILOs


a1 – Identify Recent advances inthe field of molecular biologyin myeloma

a2 Identify recent advanes indiagnosis and management ofMyeloma

a5 – Identify recent advances in theclassification, natural history, molecularbiology, and therapeutic modalities ofhematological malignancies.


b1 Analyze & evaluate availablelaboratory information toestablish treatment plan ofMyeloma.

b2 Analyze & deduce laboratorytests to establish treatment ofuncommon types of Myeloma.

b4 Solve professional problemsrelated to Myeloma accordingto the available data

b5 Refer to evidence basedmedicine in managing cases

b6 Refer to updated reference indealing with difficult cases.

b1 Analyze, deduce, extrapolate & evaluatelaboratory testing results for the initialmanagement of common and unusualhematological disorders.

b2 Take decision in the diagnosis andappropriate treatment planning.

b5 Apply evidence based medicine fromupdated printed and electronic reference.

11

C.ProfessionalandPractical Skills

C1-Evaluate and improve methodsand tools used in management ofMyelomaC2–Plan professional courses to

improve practice and enhanceperformance of juniors asregards appropriate treatmentof Myeloma

C1-Plan professional courses of combinationchemotherapy regimens

D. General Skills d1-Perform leadershipresponsibilities in explainingcomplications of chemotherapy topatientsd2- upgrade his scientificinformation utilizing all availableprinted and electronic sources tomanage side effects ofchemotherapy

d1-perform full explanation of the sideeffects of chemotherapy to patients.





Others

Myeloma: Definition. Pathogenesis. Clinical features. Laboratory findings. Treatment. Monoclonal gammopathy of

uncertain significance.

Special types of myeloma: Plasma cellleukemia. Non-secretory myeloma.

Waldenstrommacroglobulinaemia. Heavy-chain diseases.



Case OSCE/OSPE


Others








Course InstructorName: Prof.Signature:Nahla AM Hamed

Program CoordinatorName: Prof. Signature:

Program Director (Head of Department)Name: Prof . Signature:YehiaGhanem



Faculty: Medicine


Course InformationCourse Code: 05151805 Course Name: Stem Cell DisordersProgram in which the Course is Given Master Degree in Hematology


Course Aimsto provide candidates with the basic data and skills that allow them to diagnose and manage

successfully stem cell disorders


Course ILOs


a15 –Describe the pathophysiologyand classification ofmyeloproliferative disorders, therequired diagnostic methods andthe therapeutic options.

a1 –outline the classification ofmyeloproliferative disorder

a2 describe basic facts in the field ofdiagnosis and management of stem celldisorders

a3 –describe fundamentals regarding the drugsused in treating stem cell disorders




b3 Interpret laboratory testingresults and advise on the initialmanagement of commonhematological disorders.

b1 Perform data collectionb2 Perform collection of follow up data.

b3 Perform history data and full examination ofmyelodysplastic syndrome.

b4 Perform history data and full examination ofmyeloproliferative disorders.

b5 solve problems related to stem celldisorders according to the available data

b6 Correlate the examination, differentialdiagnosis and investigations to establish thediagnosis and appropriate treatmentplanning.

C.Professional c2 Interpret presenting features C1- Interpret presenting clinical features

1/21/2

and PracticalSkills

and conduct history andexamination competently



C2 conduct history taking and clinicalexamination efficiently

C3-Select the appropriate investigations todiagnose myelodysplastic syndrome.

C4-Select the required investigations todiagnose myeloproliferative disorder.

C3– apply laboratory results to patientmanagement.C4-Evaluate methods used in management ofstem cell disorders

D. GeneralSkills

d1-Offer full explanation of the sideeffects of chemotherapy to patients.


d1- discuss side effects of chemotherapy topatients.d2- deal with side effects of chemotherapyefficiently

d3- Communicate effectively with colleagues inother specialtiesd4- refer cases to seniors in the appropriatetime for proper diagnosis and treatment of thepatients..





Others

Myelodysplastic syndromes. Cytogenetics. Investigations. Classifcation. Pathogenesis. Prognosis. Management.

Myeloproliferative disorders: The polycythaemia. Polycythaemiarubravera. Essential thrombocythaemia. Idiopathic myelofibrosis.



Case OSCE/OSPE


Others







Journals and Periodicals, others BloodHaematologica

Course InstructorName: Prof. Nahla AM Hamed Signature:

Program CoordinatorName: Prof. Nahla AM Hamed Signature:



Faculty: Medicine


Course InformationCourse Code: 051508151-1 Course Name: Internal Medicine for

Haematology ll

Program in which the Course is Given Master Degree in Hematology


Course AimsTo provide the students with data concerning clinical presentation and diagnosis of systemicdiseases characterized by haematological manifestations, Outline the impact of systemic disease onthe blood and bone marrow. in addition to study the effect of chemotherapy on different organs as wellsystemic paraneoplastic manifestations


Course ILOs



a1 Outline the effect of kidney on blooda2 Outline the paraneoplastic manifestationsa3 Describe haematological changes in the

elderlya4 Outline enteral and parenteral nutrition


b7 Contribute to work ofmultidisciplinary team formanaging complication throughan appropriate writing of letter ofreferral

b1 Contribute multidisciplinary team work forearly referral, diagnosing and treatingcomplications in other systems

b2 Write an appropriate letter of referral


c2 Interpret presenting featuresand conduct history andexamination competently

c1 Interpret clinical data appropriatelyc2 Conduct history taking and clinical

examination in the appropriate way

22


c3 –Select the appropriate investigations tothe patient situation for proper diagnosis.

c4 Interpret the laboratory results

D. GeneralSkills

d4-Communicate effectively withcolleagues in other specialties forproper diagnosis and treatment ofthe patients.

d1-Communicate with other specialtiesefficiently early in the course of the diseased2- knows the appropriate time of referal





Others

NephrologysymptomatologyCKDInvestigationsThe kidney in systemic diseasePrimary GNTubulointerstitial diseases + RTDAcid base balanceAcute kidney injuryAcute GNRenal replacement therapyHypertension & the kidneys

CardiologyCatheterization and angiographyInfective endocarditis (non mitralvalve lesions)Congenital heart disease in theadultPericardial diseaseIHD: acute coronary syndromesRheumatic fever & valvular heartdiseaseNuclear cardiology diagnosticThe cardiomyopathies andmyocarditisElectrocardiographyDisease of the aortaArrhythmiaHypotension & shock

PacemakersDisorders of blood pressure(hypertension)Ischaemic heart disease (chronicstable angina)Heart failureEchocardiographyCor pulmonale

NeurologyParaneoplastic syndromesCerebrovascular diseasesPeripheral neuropathySubacute combined degenerationof the spinal cordParaplegiaOpportunistic infections of thenervous system inimmunocompromized host

GITSymptomatology of GIT diseasesDiseases of the oesophagusDiseases of the stomachMal absorption syndromeMotility disorderes of GITInflammatory bowel disease (UC &Crohn’s disease)GIT neoplasms & polypsGIT in systemic diseasesGIT bleeding (upper, lower &obscure))Celiac diseaseVascular disorders of the gut &diseases of the peritoneumEsophageal manometry & pHmetryEnteral & parenteral nutritionGenetic GIT diseasesGIT proceduresDiverticular diseases & colonicpolyposis

GeriatricAgeing & antiageing measuresNutrition in the elderlyCerebrovascular disorders in theelderlyUrinary incontinence in elderlyDepression

Haematological disorders in theelderlyThyroid in elderlyCommon metabolic disorders inthe elderlyPrescribing for the elderlyImmunosenescence andsusceptibility to infectionGIT motility disorders in the elderlyDementia & deleriumosteoporosis



Case OSCE/OSPE


Others


End of term 100%Distribution of Marks Written Exam 70 %


List of Textbooks and ReferencesLecture Notes Print out

Course Text Books Davidson’s internal medicine

Suggested Extra Reading Harrison’s internal medicine

Journals and Periodicals, others www.emedicine.com

Course InstructorName: Prof Fathy Elsiwy Signature:



Faculty: Medicine


Course InformationCourse Code: 051508151 Course Name: Internal Medicine for

Haematology lProgram in which the Course is Given Master Degree in Hematology


Course AimsTo provide the students with data concerning clinical presentation and diagnosis of systemicdiseases characterized by haematological manifestations, Outline the impact of systemic disease onthe blood and bone marrow. in addition to study the effect of chemotherapy on different organs as wellsystemic paraneoplastic manifestations


Course ILOs



a1 Outline the effect of autoimmune liverdiseases on haematological profile of thepatient.

a2 Outline clinical presentation of connectivetissue diseases and their relation to blood.

a3 Describe systemic manifestations of TB


b7 Contribute to work ofmultidisciplinary team formanaging complication throughan appropriate writing of letter ofreferral

b1 Contribute to multidisciplinary team workfor early diagnosis and treatment ofcomplication

b2 writing letter of referral appropriately



c3 –Select and evaluate

c1 Conduct efficient history takingc2 interpret clinical presentation

appropriately

c3 –Select the suitable investigation to reach

11

appropriate laboratoryinvestigations to establishdiagnosis.

the correct diagnosis.c4 Select the appropriate laboratory

investigation for follow up

D. GeneralSkills


d1 select the appropriate time for referald2-Communicate with other specialties in theproper time fur early diagnosis and treatment.





Others

HepatologyAutoimmune liver diseaseHepatitisLiver cirrhosisPortal hypertensionPancreatitisHepatic tumorsPancreatic tumorsLiver transplantationFocal hepatic lesionsGall stones and cancer gall bladderAcute liver failureCholestatic liver diseaseVariceal bleeding

RheumatologyScore measurement rheumatologyCrystal induced arthritisVasculitisAPSRheumatoid arthritisSclerodermaSeronegative spondyloarthritisClinical examinationSLEInflammtory muscle disease

ChestCarcinomaCOPDPulmonary functionPulmonary embolism

TBAsthmaImaging



Case OSCE/OSPE


Others


End of term 100%Distribution of Marks Written Exam 70 %



Course Text Books Davidson’s internal medicine

Suggested Extra Reading Harrison’s internal medicine

Journals and Periodicals, others www.emedicine.com

Course InstructorName: Prof. Fathy Elsiwy Signature:





Faculty: Medicine


Course InformationCourse Code: 051608151 Course Name: Medical Biochemistry



Course Aims To provide the students with data concerning the role of carbohydrate, protein, lipid,vitamin and mineral metabolism in the human body, manifestations of vitamin and mineraldeficiency, mode of action of hormones as well as basic molecular pathology


Course ILOs


a2 Identify the underlying causes ofanemia.

a1.discuss the role of carbohydrate, protein,lipid, vitamin and mineral metabolism inthe human body

a2-describe the mode of action of hormonesa3- identify the basic of molecular biology



D. GeneralSkills

2





Others

Carbohydrate metabolism Energy production Lipid metabolism (cholesterol,

lipoprotein, triglycerides, ketone bodies

metabolism)

General protein metabolism

Vitamins

Mode of action of hormones

Iron and calcium metabolism

Molecular biology (replication,

transcription, protein biosynthesis,

mutation, recombinant DNA, DNA

technology & PCR)



Case OSCE/OSPE


Others



Practical/Clinical Exam %Others (Assignment) 20 %


Course Text Books

Suggested Extra Reading Devlin textbook of biochemistry with clinical

correlations

Lippincott’s illustrated reviews-Biochemistrys


Course InstructorName: Prof. Ahmed Nagdi Signature:



External Evaluation Report Page 1

External Evaluator Report for Post Graduate Studies

This report represents the Objective Scientific Assessment of Professor: Sameh Shamaa

Current job description:Prof of Medical Oncology & Hematology,Mansoura Faculty of Medicine

This evaluation was requested by: Prof. Dr. Nahla A. Hamed.

Department: Internal medicine ( Clinical Hematology Unit)

Program Title: Master Degree in Hematology

Date of evaluation:28/08/2010

Kindly use the following template for Program evaluation:I- Program Basic Information:

Item Fulfilled Not-fulfilledBasic Information Program Coordinator

Evaluator’s comments:

The.program.cover.very.well.the.necessary.basic.information.including………….Medical…………..Biochemistry,..Physiology,Microbiology,General.Pathology….,Clinical…………Pathology,Internal.Medicine for Hematology as.well.as.benign.and.malignant.Hematology.,

On.the.other.hand.prof.Nahla A.Hamed,the Program Coordinatoris.very.efficient,and.competent.in.the.field.of.Cinical.Hematology ,She can verywell.coordinate.this.program.successfuly.………………………………………………………………………………………………………

………………………………………………………………………………………………………

II- Academic Evaluation:

Program AimsPhrasing of Aims Clear Not ClearAims are Measurable Quantitative QualitativeEvaluator’s comments:

The.phrasing.of.the.program.aims.is.very.clear…and.the.aims.can.be.very.well.measured...in.……….qualitative.ways………………………………………………………………………………………………………


Intended Learning Outcomes (ILOs)Phrasing of ILOs Clear Not ClearILOs depict Program Aims Yes NoILOs represented in courses Yes NoILOs conform to graduate attributes in thedomain of:

Knowledge and Understanding Intellectual skills Professional and Practical Skills General and Transferable skills

Yes Yes Yes Yes

NoNoNoNo

ILOs reflect scientific advances in thespecialty

Yes No


…The Intended Learning Outcomes(ILOs).of.the.program.is.very.well.represented.in.the.differentcourses,.and.depicit..the.program.aims.and allow.the graduate .gain.of the different skillsneeded.……………………………………………………………………………………………………

Academic Reference Standards (ARS)Adopted ARS suitable for stated graduateattributes

Yes No

Program specifications fulfill ARS Yes No


…The. Academic Reference Standards (ARS).are.very.suitable..for.the graduate.attributes.On.the.other.hand.the.program.specifications fulfill.in.a.comptent.manar.the. AcademicReference Standards……………………………………………………………………………………………………


PROGRAM STRUCTURE AND CONTENTS:


………… … The program.sructure.is.very.well.designedand.the.contents.are.very.sufficientwithout.sofistication.…………………………………………………………………………………………

………………………………………………………………………………………………………

………………………………………………………………………………………………………

…………………………………………………………………………………………………….

III- Student Assessment:

Assessment methods are suitable for the stated ILOs Yes NoEvaluator’s comments:

……The.assessment.methods.are.very.suitable.for.the.quantitative.evaluation.of.the………student’s .Knowledge…and.skills.………………………………………………………………………………………………

………………………………………………………………………………………………………

………………………………………………………………………………………………………

…………………………………………………………………………………………………….

IV- Program Courses:

Based on review of the Course Specifications.

Course code 1 2 3 4 5Yes No Yes No Yes No Yes No Yes No

Course objectives clear Course objectives fulfill ProgramAims

ILOs measurable Course contents are up to date Teaching and Learning MethodsSuitable

Student Assessment Methodssuitable

Reference Books Recent


Further comments:

…All.the.courses.are.up.todate,with.clear.objectives.that.fulfills.the.program.aims.The.teaching..and.learning methods.ofthe.different.courses.are.suitable,as.well.as.the.students.assessment.metods.……………………………………………………………………………………………………

………………………………………………………………………………………………………

………………………………………………………………………………………………………

…………………………………………………………………………………………………….

Evaluator’s Total Assessment:

…… Program Basic Information is.up.to.date,clear.and.sufficient,.the.Program Aims areclear.and.quantitavely.measurable…The.Intended Learning Outcomes(ILOs)…are.very.well.represented,.also.the Program specifications fulfill ARS.

The Assessment methods are suitable for the stated ILOsand.the.different.courses.are.convenients,also.the.students.assessment.metods..aresufficient.and.quantitative.……………………………………………………………………………………………

………………………………………………………………………………………………………

………………………………………………………………………………………………………

…………………………………………………………………………………………………….

Name of Evaluating Professor: Prof Sameh Shamaa

Signature:



Faculty: Medicine


Course InformationCourse Code: 050608151 Pharmacology for HaematologyProgram in which the Course is Given Master Degree in Hematology


Course AimsTo provide the students with the essential knowledge concerning the pharmacological action, sideeffects and therapeutic uses of drugs commonly used in treatment of blood diseases


Course ILOs

A. Knowledgeand

Understanding

a4 Discuss presentation,complications, diagnosis andmanagement of different typesof anemia

a8 –Describe the classification,natural history, molecularbiology, presentation, stagingand therapeutic modalities ofhematological malignancies.

a12–Describe the pharmaceuticalsand blood products available forthe management of excessivebleeding, their indications andside-effects.

a20–Define the principles of

a1. classify drugs used in different types ofanemiaa2-Discuss iron metabolism and state drugsthat interfere with iron therapya3-Describe management of inherited andacquired bone marrow failure.

a4-Describe the principles of use ofantimicrobial drugsa5-Differentiate among different antimicrobial

drugs.a6-Discuss the pharmacokinetic and

pharmacodynamic for different analgesicdrugs

a8-Differentiate among different analgesic.

a9- Classify coagulant drugs, anticoagulantdrugs, antiplatelet drugs and thrombolyticdrugsa10- identify their pharmacological action,indications and side effectsa11-classify drugs used in treatment of shock

a12-Describe therapeutic modalities of cancer

2

chemotherapy regimens: modeof action, side effects andinteractions of agents used inthe management ofhematological malignancies.

a13. Describe therapy of acute leukaemia.


b6 Explain planned treatmentclearly to the patient

recall, describe, and apply the majorclassification of drugs, which are to includeuses, mechanism of action, side effects, andother pertinent information needed for thatparticular drug category (relevant to thecontent areas covered) by preparingassignments

C. Professionaland Practical

Skills

C5-Formulate an appropriatemanagement plan and offer fullexplanation to patients.

Prescribe the suitable drug according todifferent patient complaint

D. GeneralSkills

d9-Upgrade his scientificinformation utilizing allavailable printed and electronicsources.

Participate as a member of a team whendoing group activities.

negotiate to arrive at a clinical decision andprovide useful advice and alternative answersthrough critical thinking case studies





Others

Cancer chemotherapy Chemotherapy of leukaemia Treatment of anemia Antimicrobial drugs Anticoagulants Antiplatelets Fibrinolytic drugs Deep vein thrombosis Drug induced haematological

dysfunction

Immunomodulators

Antihypertensive drugs Shock Analgesic

Corticosteroids



Case OSCE/OSPE


Others



Practical/Clinical Exam %Others / Assignment 20 %


Course Text Books 1. Mycek MJ, Harvey RA. Lippincott'sIllustrated Reviews: Pharmacology, 8thed.Lippincott-Raven 2007

2.Katzung BG. Basic and Clinicalpharmacology 8th ed. Appleton & Lange 2008



Course InstructorName: Prof. Samia Mohammed Ali Signature: Prof. Samia M Ali


Program Director (Head of Department)Name: Prof Tarek Thabet Signature:



Faculty: Medicine


Course InformationCourse Code: 052008151 Course Name: Physiology for Haematology



Course AimsTo provide the students with basic knowledge concerning haematopoiesis, functions of normalblood cells and blood groupings


Course ILOs


a2– Identify the underlying causes ofanemia.

a3–Describe steps and regulation ofhematopoiesis.

a10–Describe normal hemostasis andfibrinolysis.

a11–Outline the natural history,presentation and complicationsof congenital coagulation andplatelet disorders, the diagnosticmethods used in theirassessment and theirmanagement

a14–Explain the use of blood productsupport, the principles of clinical

a1. Discuss different types of anaemiaa2. describe iron metabolism

a3. Classify and identify erythropoiesisa4. Describe function of RBCs, WBCs and

blood platelets

a5. Discuss mechanism of haemostasisa6. Identify natural anticoagulantsa7 Discuss cytokines and immunity.

a8. discuss the disorders resulting fromabnormalities in coagulation

a9.descrbe the disorders of plateletabnormalities

a9. Identify blood groupsa10. identify the indications and hazards of

2

blood transfusion and define thecomplications of long termtransfusion.

blood transfusion



b1. Correlate between structure and functionof blood cells.

b2. Differentiate between different types ofblood cells


D. GeneralSkills

d4 Communicate effectively withcolleagues in other specialties forproper diagnosis and treatment ofthe patients.

d1. Learn and teach in groupsd2. practice self evaluation





Others

Regulation of erythropoiesis

Anaemias

Functions of white blood cells and bodyimmunity

Functions of blood platelets and itsdisorders

Blood coagulation mechanisms and itsdisorders

Blood groups and blood transfusion

Anticoagulants

Cytokines



Case OSCE/OSPE


Others



Practical/Clinical Exam %Others assignment 25%


Course Text Books

Suggested Extra Reading Guyton. Textbook of Medical Physiology. 2008Oxford handbook of clinical haematology


Course InstructorName: Prof. Patrishia Sidrak Signature:



.Correlatebetweenstructureandfunction ofdifferentbloodcells.

b1.Analyzethegrossandmicroscopicfeatures



Faculty: Medicine


Course InformationCourse Code: 051808151 Course Name: Microbiology for Haematology



Course AimsTo provide the student with the basic knowledge concerning the cells of the immune system,cytokines as well as diagnosis and management of commonly encountered infections inimmunocompromised persons


Course ILOs


a14 Explain the use of blood productsupport, the principles ofclinical blood transfusion anddefine the complications of longterm transfusion.

a19–Outline complications of bonemarrow transplantation

a1 –Identify microbial worlda2 ––Describe natural history, presentation

and diagnosis of AIDS, hepatitis, infectionin immunocompromized host and hospitalacquired infection

a3 --Outline diagnostic microbiologya4 Describe the technique of sterilization and

disinfectiona5 -Describe inflammation

a6 define antigen antibody and complementa7 – Describe the innate and specific responsea8 -Identify the cells of immune response as

well as cytokines and chemokinesa9 -Identify hypersensitivity and

autoimmunityB. Intellectualskills

2


D. GeneralSkills





Others

Bacteriology (11 lectures)Introduction to microbial world

Antimicribial chemotherapy

Sterilization and disinfection(decontamination)

Hepatitis

AIDS

Infection in immunocompromized host

Hospital acquired infection

Diagnostic microbiology

Immunology (14 lectures)Innate response

Specific response

Cells of immune response

Cytokine

Chemokine

Inflammation

Antigen and antibody

Complement

Hypersensitivity and autoimmunity



Case OSCE/OSPE


Others





Course Text Books Microbiology for clinical practice



Course InstructorName: Prof. Mona Gamal Signature: Mona Gamal El Din Morsi





Faculty: Medicine

Department:Internal Medicine

Course InformationCourse Code: 05151801 Course Name: Acute LeukaemiasProgram in which the Course is Given Master Degree in Hematology


Course Aimsto provide candidates with the basic facts and skills that allow them todiagnose and manage

successfully acute leukaemic patients


Course ILOs


a7 – Describe presentation,diagnosis, classification andmanagement of acute and chronicleukemias in adults.

a19 ––Outline indications andcomplications of bone marrowtransplantation

a1 –Identify basic data in the diagnosis andmanagement of acute leukaemia

a2 –outline basic data regarding thecombination chemotherapy used intreatment of acute leukaemia

a3 –Outline indications of bone marrowtransplantation

a4 Outline complications of bone marrowtransplantation




b5 Correlate the examination,differential diagnosis andinvestigations to establish thediagnosis and appropriatetreatment planning.

b6 Explain planned treatment clearly

b1 Collect data entry of patients competentlyb2 Collect necessary data for follow up patients.

b3 Perform detailed history takingb4 Perform full clinical examination efficiently.

b5 Analyze & evaluate laboratory informationb6 Plan for diagnosis and appropriate

treatment of acute leukaemic patients.b7 solve problems related to acute leukaemia

according to the available data

b8 Explain plan of therapy to the patient

1/21/2

to the patient b9 Explain the expected side effects to thepatients





c5 –Formulate an appropriatemanagement plan and offer fullexplanation to patients.

c6 –Prescribe combinationchemotherapy regimensappropriately.

c7 –Practice appropriate use ofantibiotic regimens fortreatment and prophylaxis in theimmunosuppressed patient.

c10 –Assess suitability for stemcell transplantation

c11 -Diagnose & provide initialmanagement of hematologicalemergencies.

c12 –Practice appropriate use ofCentral lines.

c13 –Perform lumbar puncturecompetently and obtains CSFsample for analysis

C1- perform full history takingC2- practice detailed clinical examination

efficiently

c3 –select the appropriate investigationc4 Interpret the results of the selected

investigations for proper diagnosis.

c5 –modify the treatment of patientsaccording to results of his investigations

C4- Evaluate methods and tools used inmanagement of acute leukaemic patients

c5 Offer explanation of expected side effets topatients.

C6- offer supportive measure to the patients

c7 –formulate cycles of chemotherapyefficiently.

c8 Modify doses of chemotherapy

c9 –manage infections in theimmunosuppressed patient.

c10 Apply prophylaxix of infections

c11 –select indications of stem celltransplantation

c12 Apply contraindication totransplantation

c13 –select appropriate investigations fordiagnosing haematological emergencies

c14 provide initial treatment forhematological emergencies.

c15 –insert Central lines under supervisionc16 Use central line in the appropriate

indication

c17 –practice lumbar puncturec18 practice diagnostic CSF analysis

c14 Administer intrathecalchemotherapy under guide

c19 Administer methotrexate intrathecallyunder supervision

c20 Administer triple therapy intrathecallyunder supervision

D. GeneralSkills


d3- Manage effectively the use oftransplantation and its limitations topatient and family.


d5-Perform leadershipresponsibilities in his work


d7- Write appropriate reports.

d1- explain chemotherapeutic side effects topatients.d2- deal with chemotherapeutic side effectsefficiently

d3- explain the procedure of transplantation tothe patient and familyd4-explain complications of transplantation topatient and family.

d5-Communicate with seniors in interrrelatedspecialties to reach right diagnosisd6-select the appropriate time for referal

d7-guide nursing staff in their workd8-advise housekeepers about patients’treatment

d9- Refer complicated cases to senior staff.d10-get benefit from experience of senior staff

d11-Write reportsd12--appraise reports





Others

Acute myeloid leukemia. Epidemiology of disease. Pathophysiology. Disease classification. Cytogenetics. Treatment. Future developments.

Adult acute lymphoblastic leukaemia:

Introduction. Diagnosis. Clinical manifestations. Laboratory evaluation. Differential diagnosis. Initial evaluation and supportive

therapy. Chemotherapy. Stem Cell transplantation. Outcome of all subtypes and

prognostic factors. Minimal residual disease-practical

application in adult ALL. Treatment with monoclonal

antibodies. ABL tyrosine kinaseinhibitors in Ph/BCR-ABL-positiveALL.



Case OSCE/OSPE


Others








Course InstructorName: Prof. Hashim neanaa Signature:





Faculty: Medicine


Course InformationCourse Code: 05151802 Course Name: Iron Metabolism, Iron Deficiency

and Disorders of Haem Synthesis, MegaloblasticAnaemia, Haemolytic Anaemias, Aplastic Anaemia



Course Aimsto provide candidates with the basic facts and skills that allow them to Diagnose and manage

successfully anaemic patients


Course ILOs


a2 Identify the underlying causes ofanaemia.

a4 Discuss presentation,complications, diagnosis andmanagement of different types ofanaemia

a5 –Outline the molecular basis ofabnormal hemoglobins andthalassemia syndromes andexplain the laboratory methodsused in their screening anddiagnosis.

a6 –Describe pathology, diagnosisand management of inherited andacquired bone marrow failure.

a1 Describe the etiological factors of anemiaa2 Describe hereditary causes of anaemia

a3 Identify basic facts in the field of diagnosisand management of anaemia

a4 describe the drugs used in the field ofanaemia

a5 –Outline the genetic basis responsible forabnormal haemoglobins

a6 Describe management of thalassaemia

a7 –Describe in details the diagnostic approachto patient with bone marrow failure whetherinherited or acquired.

a8 Describe treatment of bone marrow failure

21

a13 –Describe the etiology, naturalhistory and classification ofpancytopenia

a9 Outline causes of pancytopeniaa10 Outline systematic method for diagnosis of

pancytopenia





b1 Perform data collection appropriatelyb2 Collect follow up data efficiently.

b3 perform detailed history takingb4 Perform full physical examination efficiently.

b5 Analyze & evaluate laboratory informationto establish diagnosis and appropriatetreatment planning of different types ofanaemia.

b6 solve problems related to anaemic patientsaccording to the available data


c2 –Interpret presenting featuresand conduct history andexamination competently


C1-––Interpret the available clinical dataC2-Conduct efficient detailed examination

C3 -interpret the results of blood films and bonemarrow smearsC4-Evaluate methods and tools used in

diagnosis of anaemic patients

D. GeneralSkills


d1- Communicate with colleagues in theinterrelated specialties for efficientmanagementd2- get benefit from experience of colleagues inother specialties





Others

Distribution of body iron. Cellular ironhomeostasis. Normal iron balance. Ironabsorption. Internal exchange. Diagnosticmethods for investigating iron metabolism.

Iron deficiency anaemia. Causes of iron deficiency. Management of iron deficiency.

Haem synthesis. Pathological alterations inhaem synthesis.

Megaloblasticanaemia: Introduction. Underlying basic science. Clinical features. Haematological findings. Cobalamin. Cobalamin analogues. Causes of cobalamin deficiency. Diagnosis of cobalamin deficiency.

Tests for the cause of cobalamindeficiency.

Folate. Causes of folate deficiency. Diagnosis of folate deficiency. General management of

megaloblasticanaemia.Prophylactic folic acid.

Megaloblasticanaemia not due tocobalamin or folate deficiency oraltered metabolism.

Other nutritional anaemias.

Haemolyticanaemias Disorders of red cell membrane. Inherited disorders of hemoglobin.

Sickle cell disease. Acquired haemolyticanaemias Immune haemolyticanaemias.

Warm-type autoimmunehaemolyticanaemias. Cold-typeautoimmune haemolyticanaemias.

The non-immune acquiredhaemolyticanaemias.

Inherited aplastic anaemia/bone marrowfailure syndromes:

Introduction. Fanconianaemia. Dyskeratosis

congenital. Shwachman-Diamondsyndrome. Diamond-Blackfananaemia.

Congenital and cyclicalneutropenias.

Thrombocytopenia with absentradii. Congenital amegakaryocytic

thrombocytopenia. PNH

Acquired aplastic anaemiaPlease check () the appropriate method.


Case OSCE/OSPE


Others








Course InstructorName: Prof. Hassan Nafea Signature:





Faculty: Medicine


Course InformationCourse Code: 05151808 Course Name: Blood Transfusion

Program in which the Course is Given Master Degree in Haematology


Course Aimsto provide candidates with the basic data in the field of blood transfusion


Course ILOs


a12 –Describe pharmaceuticals andblood products available for themanagement of excessivebleeding, their indications andside-effects.

a14 –Explain the use of blood productsupport, the principles of clinicalblood transfusion and define thecomplications of long termtransfusion.

a1 – Identify fundamentals in the field of bloodtransfusion.

a2 identify different components of blooda3 describe the main indication for their usea4 identify the complications of using blood

components

a5 –define early and late complications of bloodtransfusion

a6 update his knowledge regarding bloodtransfusion



C8-Manage complications of bloodtransfusion appropriately

C1- diagnose and manage theimmunological complications resulting fromblood transfusion

1

C2-deal with non immunologicalcomplications of blood transfusion

D. GeneralSkills

d2-Communicate effectively withblood donors

d1-advise about appropriate time of blooddonationd2-select those who can donate blood





Others

Blood component transfusion indications Complications of blood transfusion



Case OSCE/OSPE


Others




List of Textbooks and References

Lecture Notes Print out of lectures




Course InstructorName: Ass. Prof. Nadia Zaki Signature:





Faculty: Medicine


Course InformationCourse Code: 05151804 Course Name: Chronic LeukaemiasProgram in which the Course is Given Master Degree in Hematology


Course Aimsto provide candidates with the basic knowledge and skills that allow them to diagnose and manage

successfully chronic leukaemic patients


Course ILOs


a7 Describe presentation, diagnosis,classification and management ofacute and chronic leukemias inadults.

a1 – Identify prognostic factors in chronicleukaemia

a2 Outline basic facts in diagnosis of chronicleukaemia

a3 –describe the drugs used in treating chronicleukaemia






b1 Perform data collection accuratelyb2 Perform follow up data

b3 Conduct efficient taking history takingb4 Perform full clinical examination.

b5 Analyze & evaluate laboratory informationb6 Establish diagnosis according to

investigation results.

b7 Establish ppropriate treatment planningaccording to results of investigation.

b8 Solve problems related to chronicleukaemia according to the available data

1/21/2





c5 –Formulate an appropriatemanagement plan and offer fullexplanation to patients.

C1- Interpret available clinical data efficientlyC2- conduct efficient examination

c3 Select the appropriate investigationc4 –evaluate laboratory results used for

proper diagnosis.

C5 Evaluate methods and tools used inmanagement of chronic leukaemicpatients

C6-select appropriate investigation forfollow up

C7-Formulate a plan for appropriatetreatment

C 8-offer full explanation to patients

D. GeneralSkills


d1--Offer detailed explanation of thechemotherapeutic side effects to patients.d2- deal with chemotherapeutic side effects





Others

chronic myeloid leukaemia Introduction. Classification. Cytogenetics. Molecular biology. Clinical features. Haematology. Management :Treatment decisions

for newly diagnosed patients inchronic phase. Management ofchronic myeloid leukaemia inadvanced phase.

Variants of chronic myeloidleukaemia.

Chronic lymphocytic leukaemia and otherB-cell disorders:

Introduction. Methodology for diagnosis.

Chronic lymphocytic leukaemia.Management.

Prolymphocyticleukaemia.

Hairy cell leukaemia. The leukaemic phase of low-grade NHL. Please check () the appropriate method.


Case OSCE/OSPE


Others








Course InstructorName: Hashim Neanaa Signature:


Program Director (Head of Department)Name: tarek thabet Signature:



Faculty: Medicine


Course InformationCourse Code: 05151801 Course Name: Haemopoiesis



Course Aimsto provide candidates with the basic data in the field of stem cells research


Course ILOs


a3 Describe steps and regulation ofhaematopoiesis.

a1 – Identify basic facts in the field of stemcells.

a2 –describe fundamentals regarding growthfactors and cytokines

a3 Describe erythropoiesis, megakaryopoiesislymphopoiesis and monopoisis



D. General

2

Skills





Others

Introduction Sites of haemopoiesis The stromal microenvironment Stem cell trafficking Organization of haemopoiesis Haemopoietic growth factors andreceptors

Clinical applications of stem cellresearch.



Case OSCE/OSPE


Others








Course InstructorName: Manal Elsorady Signature:



2016 ) - Alexandria Faculty of Medicine · 1.4. Perform the main procedures required in hematology....

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