2015 Hopkins C.A.R.E.S Summer Symposium

July 30, 2015

Armstrong Medical Education Building

10:00-3:30 p.m.

Career Academic and Research Experiences for Students

Schedule

10:00- 11:00a.m. Welcome AMEB, 1st Floor Auditorium

Keynote Speaker Peter Agre, M.D.

Background Stories Branecia Bull, MERIT

Makayla Nicole Proctor, MCHC/RISE-UP

Andres Cordoba, Centro Sol Nadeen Ibrahim, SURE Kelcee Everette, INBT

11:00a.m. - 12:00p.m. Poster Session 1

AMEB, 2nd Floor Lobby

12:00p.m.

12:30p.m.-2:00p.m.

Lunch AMEB, 1st Floor Lobby

Oral Presentations

AMEB, 1st Floor Auditoriums (East and West)

2:00-3:00p.m. Poster Session 2

AMEB, 2nd Floor Lobby

3:00- 3:30p.m. Closing

AMEB, 1st Floor Auditorium

Outstanding Students Awards

Reception AMEB, 1st Floor Lobby

Keynote Speaker

Peter Agre, M.D.

Nobel laureate Peter Agre, MD became the second director of the Johns Hopkins Malaria Research Institute in January, 2008, succeeding founding director Diane E. Griffin, MD, PhD, who remains as chair of the department of Molecular Microbiology and Immunology.

Dr. Agre received his BA in chemistry from Augsburg College in 1970, and his MD from Johns Hopkins in 1974. Following an Internal Medicine Residency at Case Western Reserve University Hospitals of Cleveland and a Hematology-Oncology Fellowship at the University of North Carolina at Chapel Hill, Dr. Agre returned to Johns Hopkins as a postdoctoral fellow in cell biology. Dr. Agre joined the faculty in 1984 and has spent most of his professional life at Hopkins' School of Medicine, leaving in 2005 to go to become Vice Chancellor for Science and Technology at Duke University Medical Center. His return to Hopkins and JHMRI in 2008 gives Dr. Agre the opportunity to concentrate on an area in which he has always been interested - the problem of disease in the developing world.

Dr. Agre's research in red-blood-cell biochemistry led to the first known membrane defects in congenital hemolytic anemias (spherocytosis) and produced the first isolation of the Rh blood group antigens. In 1992, his laboratory became widely recognized for discovering the aquaporins, a family of water channel proteins found throughout nature and responsible for numerous physiological processes in humans— including kidney concentration, as well as secretion of spinal fluid, aqueous humor, tears, sweat, and release of glycerol from fat. Aquaporins have been implicated in multiple clinical disorders—including fluid retention, bedwetting, brain edema, cataracts, heat prostration, and obesity. Water transport in lower organisms, microbes, and plants also depend upon aquaporins. For this work, Dr. Agre shared the 2003 Nobel Prize in Chemistry with Roderick MacKinnon of Rockefeller University.

Not long after receiving the Nobel Prize, Dr. Agre was awarded a JHMRI pilot grant to extend his studies of aquaporins to malaria, addressing the question of whether or not aquaporins could be exploited as a means of treating or preventing the disease. Initial encouraging results have led to an NIH grant and a focus on malaria as the primary area of study in Dr. Agre's laboratory.

As President of the American Association for the Advancement of Science, Dr. Agre led science in diplomacy missions to Cuba, North Korea and Myanmar Burma. His honors include election to the National Academy of Sciences in 2000, the Institute of Medicine in 2005, the American

Academy of Arts and Sciences in 2003, and the American Philosophical Society in 2004. He has also received honorary doctorates from universities in Denmark, Japan, Norway, Greece, Mexico, Hungary, Poland and the United States.

2015 Hopkins C.A.R.E.S. Summer Programs

Biophysics Research for Baltimore Teens: Biophysics for Baltimore Teens (BRBT) is a new initiative, which will give Baltimore city teens a chance to do basic biomedical research in Johns Hopkins biophysics labs on both the Homewood and JHMI campuses. BRBT is offered through the Johns Hopkins Program in Molecular Biophysics (PMB) and PMB graduate students on both campuses will mentor BRBT interns. The interns’ exposure to laboratory research will be augmented with a weekly course in basic laboratory skills taught by graduate students and overseen by PMB faculty. CTY Center Scholars Program: The Center Scholars Program, developed by the Center for Talented Youth and Dr. Andrew Feinberg's Center for Excellence in Genome Science (CEGS) is designed to encourage academically advanced, historically under-represented minority high school students to explore careers in scientific research, particularly the field of genomics. CTY Summer Research Program: This program, sponsored by the Simons Foundation, invites high achieving, academically advanced high school students to participate in a residential research experiences across disciplines at both the Johns Hopkins University and School of Medicine. This six week residential program pairs students with research mentors through a highly selective process which considers both student and mentor skills and interests. Students attend career and research seminars and participate in a journal club sponsored by each host lab. Center for Computational Biology Summer Internship Program: The CCB internship program (http://ccb.jhu.edu/internship.shtml) will provide you with hands-on research experience as part of ongoing research projects with bioinformatics and genomics faculty in the Departments of Biomedical Engineering, Computer Science, Biostatistics, and Biology, and in the Institute of Genetic Medicine. Current areas of research include analysis of high-throughput DNA sequence data to characterize genes and their variations, studies of the microbiome, assembly of whole-genome shotgun data from various species, and the development of new computational and statistical methods for other genome analysis problems. The program involves full-time research for 8-12 weeks between May and August. Note that in 2015, for the first time, the CCB Summer Internships are being organized jointly with the Summer Research Expeditions in the Computer Science Department at JHU. The program is open to college undergraduates and to exceptional high school students. Centro SOL Programa de Verano para Jovenes: Summer program for Spanish/English bilingual high school students in Baltimore City. The program’s goal is to expose bilingual high school students to the medical field by offering meaningful opportunities to work with JHU School of Medicine faculty in clinical settings that serve Latino patients with limited-English proficiency. Patients with limited English proficiency (LEP) frequently have difficulties navigating the healthcare system, explaining their

illness, understanding their providers’ recommendations, and participating fully in the development of a treatment plan. In this project, we want to capitalize on the strength of bilingual youth in our community. Students who are fluent in both Spanish and English will be invited to apply to the program. Following orientation, students will be placed in various clinical settings, where they can utilize their Spanish language skills to assist Latino patients with limited-English proficiency in various scenarios, such as registering for care, guiding them to various places in the hospital, greeting them and providing information at the entrance or information desks throughout Bayview Hospital. In addition, students will shadow Johns Hopkins Hospital Spanish language interpreters for a day a week. This experience will allow them to appreciate the importance of professional medical interpretation during clinical encounters and give them an opportunity to pursue further training in this area if they are interested. Students will meet weekly with faculty preceptors to reflect on their experiences and provide feedback to our program. We see bilingual youth as a unique resource with enormous potential to succeed in STEM (Science, Technology, Engineering, and Math) careers under the right guidance. Through this pilot program, we will expose motivated Baltimore youth to careers in medicine, mentor them at a leading medical institution, and empower them to pursue further training that capitalizes on their Spanish language skills, while improving services to our Latino patients. Diversity and Academic Advancement Summer Institute (DAASI): The Diversity and Academic Advancement Summer Institute (DAASI) is a partnership between Johns Hopkins School of Medicine Office for Student Diversity and Thread (formerly Incentive Mentoring Program). The goals are to three fold: (1) Academic Assistance: Provide a comprehensive, engaging curriculum to bolster participants’ academic self-confidence and capabilities; (2) Service, Life Skills, and Team Work: Create opportunities for participants to learn important life and professional skills through work opportunities and service learning experiences; and (3) Visualizing Success: Expose them to science and health educational pathways so that they may visualize the possibility of pursuing careers in science. Institute for NanoBiotechnology Research Experience for Undergraduates (INBT): The Institute for NanoBiotechnology at Johns Hopkins University offers undergraduate students from colleges and universities around the country a chance to participate in research projects in the exciting and rapidly growing area of Nanobiotechnology, a place where biology, medicine, and nanotech meet. For more information, visit http://inbt.jhu.edu/education/undergraduate/reu/. The Johns Hopkins Internship in Brain Science Program (JHIBS): Project Pipeline Baltimore: The long-term goal of the JHIBS program is to significantly increase the pool of qualified under-represented professional candidates from Baltimore in the neurosciences and mental health medicine through an eight-week summer research and enrichment experience that targets high school juniors and seniors. The program will provide the necessary exposure, knowledge, and career-long mentoring, to help propel students toward a trajectory as a STEM professional. The program has been in existence for seven years funded by the Cohen Foundation and jointly this year with a grant from the National Institutes of Mental Health.

Maternal Child Health Careers/Research Initiatives for Student Enhancement Undergraduate Program (MCHC/RISEUP) at Kennedy Krieger Institute: The MCHC/RISE-UP is a 10-week summer public health leadership program designed for undergraduates in their junior and senior year and recent baccalaureate degree students (within 12 months of the MCHC/RISE-UP orientation) who are interested in learning more about preventing health disparities and promoting health equity and have a cumulative GPA of at least 2.5 on a 4-point scale. MCHC/RISE-UP is a national consortium of institutions including the Kennedy Krieger Institute (KKI; lead institution), Maryland Center for Developmental Disabilities, Johns Hopkins University School of Medicine, Nursing, and Public Health, University of Southern California, California State University-LA, and University of South Dakota Sanford School of Medicine Center for Disabilities. Three public health leadership tracks are offered: (1) clinical (KKI only), (2) research, and (3) community engagement and advocacy.

Medical Education Initiative for Teens (MERIT):

The Medical Education Resources Initiative for Teens (MERIT) aims to eliminate health care

disparities by transforming underrepresented high school students into health care leaders. To

accomplish these goals, MERIT provides seven years of academic, professional, and social

support. Scholars are selected during their sophomore year of high school and participate in

intensive MERIT programming until graduation including weekly Saturday sessions focused

on academic enrichment and college admissions guidance, paid summer internships in hospitals

and laboratories, and longitudinal mentoring. After high school, they become MERIT alumni

and receive continued guidance throughout college. Health care disparities will only be

eliminated if the workforce mirrors the communities we serve. MERIT Scholars’ voices are not

represented now, but one day, they will be poised to influence critical decisions. Psychiatry Summer Training and Research Program (P-STAR): The Psychiatry Summer Training and Research (P-STAR) program offers undergraduates interested in Behavioral and Biological Sciences the opportunity to work for ten weeks under the guidance of a faculty member at Johns Hopkins Medicine. Through one-on-one work with a faculty mentor, students gain hands-on experience in academic research and clinical environments. To provide in-depth exposure to Translational Psychiatry, especially that on schizophrenia and related disorders, we will have students work in both a laboratory setting and in clinical rotations. Pulmonary and Critical Care Medicine Summer Internship Program: The Division of Pulmonary and Critical Care Medicine hosts undergraduate students each summer as part of an NIH-funded program to enhance diversity in biomedical sciences. Students from around the United States and Puerto Rico join faculty for a ten-week, research-focused experience that extends from Memorial Day weekend through the first week of August. Students are matched with mentors based on their interests. Students work on specific research projects under the supervision of their mentor. Projects span a broad range of research, from the basic science of endothelial or epithelial cell biology to asthma epidemiology. In addition to the research experience, students participate in a weekly journal club, during which they present primary research articles to their peers and members of the faculty. Students also attend a seminar series featuring faculty members from Johns Hopkins and the NIH. This forum provides students with the opportunity to interact with faculty members and hear

different perspectives on issues related to career development. Students interested in clinical medicine are given the opportunity to “round” with the Johns Hopkins Medicine residents, providing a glimpse of life in clinical medicine as a resident at an academic institution. Stanley Summer Scholars Program: The goal of the Stanley Summer Scholars Program of the Stanley Division of Developmental Neurovirology, Dept. Pediatrics, is to foster enthusiasm for the study of the etiology, pathology, immunology, prevention and treatment of serious psychiatric diseases such as schizophrenia and bipolar disorder. By offering students the opportunity to gain laboratory experience while working closely with a mentor from the Stanley Division, we hope to encourage the pursuit of careers in basic, translational or clinical research focusing on major mental illnesses. Research performed in the Stanley Division is interdisciplinary and projects are available in a number of fields including molecular biology, immunology, virology, parasitology, cell culture, animal behavior and neuroscience. Summer Academic Research Experience (SARE): SARE is an 8-week outreach program that seeks to develop exceptional high school students from the greater Baltimore area by introducing them to academic research with a secondary emphasis on STEM and health-related professions. We provide our scholars with a unique exposure to modern scientific research, combined with additional tutoring to fortify basic academic skills. Students spend 70% of the time working in research labs and 30% of the time working on academic skills, including science, writing, and mathematics. This is a paid

internship and we request that ⅔ of the stipend be set aside for college. Summer Internship Program Basic Science Institute: The Summer Internship Program (SIP) provides experience in research laboratories to

students of diverse backgrounds, including underrepresented minority students, students from

economically disadvantaged and underserved backgrounds and students with disabilities that

have completed one - two or more years of college. The purpose of this exposure to biomedical

and/or public health research is to encourage students to consider careers in science, medicine

and public health.

Summer Urological Research Experience (SURE) at the Brady Urological Institute: As one of the leading urology departments in the world, the Brady Urological Institute plays a

key role in the advancement in the understanding and treatment of urological diseases and

cancer. As a part of the Department of Urology, the SURE Program is uniquely positioned to

allow students to experience a research opportunity that will allow them to understand how

advances at the bench can be translated to the bedside and how knowledge that can be gained

from treating patients can then be translated back to the bench. Research that occurs within

the department draws from a diverse list of expertise to elucidate answers for the current

paradigms in urologic oncology and other urologic diseases: cell biology, biochemistry,

molecular biology, oncology, biomedical engineering, genetics, cellular and molecular medicine,

and sexual dysfunction. During the 10 week program, students will conduct research related

to the overall goal of their mentoring laboratory while attending a series of seminars and

professional development workshops developed to provide the students with knowledge and

skills that will prepare them for post graduate education (MD, PhD, or similar) and a career in

biomedical research. Housed in a department in which the clinical operations are closely tied to

the ongoing research, students of the SURE Program are also offered an opportunity to view

live surgical procedures and shadow clinicians to obtain a better understanding of how the field

of urological medicine is practiced today. In a Department that utilizes a multidisciplinary

approach to its research missions, the SURE Program is able to provide research opportunities

in the areas of Cell biology, Biochemistry, Molecular biology, Oncology, Biomarker

development, Biomedical engineering, Genetics, Immunology, Pharmacology and molecular

sciences, Cellular and molecular medicine, and Sexual dysfunction. Additional information

about the SURE Program can be obtained by viewing the program

Oral Presentations

12:30p.m.-1:45p.m.

East Auditorium

West Auditorium

Time Name of Student Program Title 12:30pm Jennifer Mendez Centro SOL MIC & MBC Tuberculosis

Experiment

12:50pm Assefa Akinwole SARE Probing for Conformation Changes of DXP Synthase in the Presence of

Analogs 1:10pm Rosaura Garcia MCHC/RISE-UP Using a Template to Develop

Focused Health Education Communication

Time Name of Student Program Title 12:30pm Rachael Avidor and

Kayla McDaniel MERIT Increasing Awareness of Thyroid

Cancer in Women 12:50pm Chikaodi Nwanegwo BRBT IFI16 and autoimmunity

1:10pm Joseph Paggi CCB Graph-based alignment of DNA

sequence to a population of genomes 1:20pm Ashley Williams INBT Microfluidic devices to study effects

of varying levels of sheer stress on the proliferation and morphology of endothelial cells and derived brain

stem cells 1:40pm Thomas Valente SURE Visualization of androgen receptor

transcripts encoding discrete functional domains

1:20pm Christopher DaSilva PCCM Impact of environmental pollutants in a cohort of patients that have been diagnosed with chronic obstructive

pulmonary disease (COPD)

1:40pm Paige Greenwood SIP HIV/HCV coinfection leads to elevated expression of

proinflammatory cytokines compared to monoinfection

Poster Presentations

Session 1 (11:00-12:00)

# Name Program Title 1 BRBT BRBT Bootcamp

2 Chikaodi Nwanegwo

BRBT IFI16 and Autoimmunity

3 Shreya Bhatia CCB Meta-Analysis of miRNA Regulation, Abundance, and Target Genes in Brains of

Alzheimer’s Patients

4 Farhan Damani CCB "A Bayesian Network Approach to Identifying Functional Rare Variants"

5 Emily Herring Alison Samsel

CCB “Metagenomics classification with untranslated versus translated search”

6 Kevin Huang CCB "Improved Microbial Gene Finding Using Large Protein Sequence Data Sets"

7 Emma Jin CCB “Clustering of repetitive genomic sequences”

8 Nishika Karbhari Robert Phillips

CCB "SRA Trait Prediction using Genomic Data"

9 Jennifer Mendez Centro SOL MIC & MBC Tuberculosis Experiment

10 Caleb Akers INBT Cytotoxic Effect of Hyperthermia on Breast Cancer Cells

11 Kurt Castro INBT Multiplexed Color-coded Detection of Sexually Transmitted Diseases Based on Rolling Circle

Amplification

12 Alex Chavez INBT A microfluidic vessel for measuring intracellular uptake of cell-penetrating peptides

13 Nicolas Deshler INBT Biomechanics and Aerodynamics of Cricket Jumps

14 Alyssa Ertel INBT Self-Assembling Bioelectronic Materials

15 Franklyn Hall INBT Determination of the Optimal Oxygen Saturation for ECFC Network Formation Using

Layered Hydrogels

16 Athenia Jones INBT Observing the Effects of Substrate Stiffness on Brain Endothelial Cell Behavior

17 Briana Davis JHIBS Oxytocin and Vasopressin: Parallel Processing in the Social Brain

18 Rochinelle Dongmo

JHIBS Identification of HIV-infected Tissue Macrophages in Humanized Mice Part I

19 Osama Hassan JHIBS How does BACE1 inhibitor effect APP abundance in diabetic mice

20 Brittany Jones JHIBS NORT: Novel Object Recognition Test to Study Short-term Memory

21 Sabreenah Khan JHIBS The Don Project

22 Kayla Hall JHIBS Identification of HIV-infected Tissue Macrophages in Humanized Mice Part II

23 Brandon Addison MCHC/RISE-UP Kennedy Krieger Institute Behavioral Management Program

24 Mariah Barber Olivia Dure

MCHC/RISE-UP LIGHT Health Community Outreach and Transition

25 Stephanie Kwiatk MCHC/RISE-UP Mass communication in public health

26 Alesia Robinson MCHC/RISE-UP Kennedy Krieger Institute Phelps Center for Cerebral Palsy and Neurodevelopmental

Medicine

27 Samara Deleon MCHC/RISE-UP B'More 4 Healthy Babies

28 Monica Gapud MCHC/RISE-UP Integrating clinical practice with public health

29 Beverly Dahn MERIT Science of Medicine Internship: Autism

30 Kahlid Fowlkes MERIT Science of Medicine Internship: Autism

31 Christiona Harris MERIT Science of Medicine Internship: Tuberculosis

32 Karen Hernandez MERIT Science of Medicine Internship: Multiple Sclerosis

33 Lidia Hernandez MERIT Science of Medicine Internship: Fission Yeast

34 Elizabeth Cosby P-STAR Effect of Mutant DISC1 Expressed in Astrocytes on Cognitive Performance in the Radial Arm

Maze

35 Saarang Deshpande P-STAR Astrocytic ALDH7A1 Pathophysiology: Localization and Mechanism

36 Francisco Dominguez

P-STAR Social interaction and mTOR activity in Notch mouse models

37 Elizabeth Koplas P-STAR Developing Methods for Next Generation Sequencing to Examine Circulating miRNAs in

Psychiatric Disease

38 Serena Lao P-STAR Determining Off-Target Effects from the CRISPR/Cas9 Targeting of Schizophrenia-

Associated DPYSL2 Gene

39 Emily Merfeld P-STAR Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a

conditional neurodevelopmental mouse model of DISC1

40 Phillip Nantawisarakul

P-STAR Microglia Ablation and Reinfiltration During Rodent Brain Development

41 Madeline Pifer P-STAR Oxygen-independent upregulation of HIF1 in DISC1 knockdown models

42 Ali Abdel-Halim PCCM Quality Improvement for Intensive Care Unit Triage

43 Selom Avotri PCCM Lung Transplant Evaluation in Referred Outpatients

44 Jasmine Brown PCCM Antitussive Effects of Auranofin

45 Kathleen Carino PCCM Caspase Has a Role in the Recovery of Endothelial Barrier Integrity After Thrombin-

induced Disruption

46 Samantha Casimir PCCM Survival of Bacterial Cells with Misregulated Cell Wall Machinery

47 Shaquille Charles PCCM Idiopathic Pulmonary Fibrosis: Utilizing Electronic Health Records for Clinical Research

on Rare Diseases

48 Christopher DaSilva

PCCM Airway Macrophage Black Carbon as a Marker of Indoor Air Pollution

49 Maria Paula Hazbon

PCCM Academic Productivity of Interventional Pulmonology Training Programs

50 Rachel Howard PCCM Endothelial Nitric Oxide Synthase Involved in Early Right Ventricular Remodeling in

Pulmonary Hypertension

51 Brennan Boyle SIP The Role of ErbB2 and EGFR Kinase on Cardiac Hypertrophy Protein Expression

52 Prerana Chatty SIP The role of the hepatic estrogen receptor in regulating metabolism

53 Rachel de Barros Oliveira

SIP Genetic modifiers of congenital heart defects in a Down Syndrome model

54 Andrew Flatley SIP Impact of Sonic Hedgehog Agonist on Cerebellar Development in the Dp(16)1Yey/+ Mouse

Model of Down Syndrome

55 Marissa Gionet-Gonzales

SIP

56 Natalie Hamilton SIP Effects of S-palmitoylation on Neuropilin trafficking and localization

57 Kelsey Hopland SIP Characterization of neuron-specific proteasome

58 Errol Hunte, Jr. SIP Impact of Age on the Metabolism of the Anti-HIV Drug Maroviroc

59 Nikhil Adapa SURE Role of Mesenchymal Stem Cells in ASPN Expression

60 Kelly Humphreys SURE Expression Profile for Cancer/Testis Antigens in Prostate Cancer Cell Lines

61 Nadeen Ibrahim SURE HOXB13 Interactions with Androgen Receptors in Prostate Cancer - HOXB13 is a transcription factor that is specific to prostate development. It is also expressed in adults. To add, it was found

that it has the ability to interact with the androgen receptor, and the androgen receptor

signaling is an importance signaling pathway in prostate cancer. Characterizing the interaction between HOXB13 and androgen receptor will

offer new insight on the role of HOXB13 in prostate cancer carceniogenesis.

62 Cara Lang SURE Tissue-Specific Minicircle Gene Expression Vectors

63 Ashwin Monian SURE Genes differentially expressed in Prostate Cancer EMT

64 Zimuzoh Orakwue SURE Novel way of intratesticular testosterone production in sickle cell mice-effect on NO

signaling in the penis.

65 John Patterson SURE Silodosin inhibits cell growth of bladder and prostate cancers through down-regulation of

ELK1 in vivo

66 Kayla Prater SURE Role of STAT3 in prostatitis-induced epithelial proliferation and cancer cell growth and survival

67 Allison Reinhardt SURE TNF-α Is Increased Following Bilateral Cavernous Nerve Injury, Leading to Enhanced

Recruitment of Neurotoxic Macrophages

68 Sounak Roy SURE CXC Chemokine Receptors 4/7 in Prostate Cancer Bone Metastases

69 Thomas Valente SURE Visualization of Androgen Receptor Transcripts Encoding Discrete Functional Domains In

Metastatic Castration-Resistant Prostate Cancer Tumor Biopsies

70 Daphne Schlesinger

Individual Research

Shape Memory Effect of Anisotropic Poly(D,L-lactic acid) Microparticles.

71 Diana Hla CTY The Effect of Hydrophobic Domain Mutation on SARS CoV E Protein Oligomerization

72 Eunnie Lee CTY Question Complexity in Deductive Reasoning:The Impact of Number of

Propositions during Logic Processing

73 Caitlin Hogan CTY Post-Synthesis Surface Modification of PbS Colloidal Quantum Dot Optical Properties for

Solar Photovoltaics

74 Joshua Kasanjian CTY Effects of Exercise on Mitochondrial DNA Copy Number

75 Domenick Suarez CTY Human Opossum Epigenetic Similarities in DNA Methylation

76 Joseph Martin CTY Performance of Acutely Stressed C57/BL6 Mice in a Reversal Learning Task and Its Use for

Mouse Models of Schizophrenia

77 Ankur Sundara CTY Using Algorithms on Splice Graphs to Identify Splicing Events in Plants

78 Leonard Reid CTY Building a More Efficient Mechanism to test Memory Deficiency in Kabuki syndrome

Session 2 (2:00-3:00)

# Name Program Title 1 Shivani Pandey CCB "Methods for Aegilops tauschii BAC pool

assembly validation”

2 Rebecca Panitch CCB “Replication of Schizophrenia and Bipolar Disorder RNA Seq Analysis”

3 Shannon Rainsford CCB From A to B: An Enrichment Analysis of Subcompartments in Topologically Associated

Domains

4 Kayla Scharfstein CCB "Identifying Microbes from rRNA in Whole Genome Sequencing Experiments"

5 Dhruv Shankar CCB “Evaluating the accuracy of genome assembly with RNA-seq data”

6 Ankur Sundara CCB "Detecting Splicing Events in Plants Using Splice Graphs"

7 Sara Wang CCB "SRA sex prediction using genomic data"

8 Darren Davis DAASI

9 Alicia Lee INBT Bosutinib-Loaded Nanofibers for Inhibiting Cancer Cell Migration

10 Jaron Mackey INBT Self-Assembly Study of C12-FFEE, Ac-FFEE, and Ac-EEEE

11 Prathik Naidu INBT Towards the Rational Design of Potent Peptide Antibiotics

12 Jean Rodríguez Díaz

INBT Direct Reprograming of Fibroblast into Schwann cells

13 Joel Tyson INBT Mapping the Receptor JHA1's Role in the Endocytosis of Aplha-synuclein

14 Casey Vantucci INBT Multiple siRNA Delivery Using Bioreducible Polymeric Nanoparticles for Treatment of

Primary Human Brain Cancer Cells

15 Keclee evette INBT Effects of Shear Stress on the Proliferation and Morphology of HUVEC and dHBMEC Cell

Populations

16 Nahom Yimam INBT Effects of Shear Stress on the Velocity of HUVECand iPSC-Derived HBMEC Cell Lines

17 Shadora Robinson JHIBS Can Exosomes from ATP-Stimulated Astrocytes Reduce Neuronal Cell Death

18 Shamon Thomas-Green

JHIBS Sexual and Religious Obsessions and OCD

19 Montrell Vass JHIBS Isolating Skill Learning Using Point-to-Point Task Training

20 Daniel Gramling JHIBS Optimizing Exosome Purification from Serum and CSF

21 Sai Ruthwik JHIBS Correlation of Patient Perception of Gait and Balance with Validated Objective Measures

22 George Hseeh JHIBS The Neuroprotective Effect of Osteopontin on Cultured Neurons

23 Katherine Groesbeck

MCHC/RISE-UP Aftercare Clinic

24 Jalesa Hobson MCHC/RISE-UP Kennedy Krieger Institute cerebral palsy work

25 MCHC/RISE-UP Kennedy Krieger Institute Neuromotor Disorders work

26 Erika Castriz MCHC/RISE-UP Nutritional program for pre-teens

27 Cameron Wade MCHC/RISE-UP Native American Lifelines work

28 Jamia Marriott MERIT Science of Medicine Internship: Prostate Cancer

29 Josh Neal MERIT Science of Medicine Internship: Breast Cancer

30 Taylar Reed MERIT Science of Medicine Internship: HIV

31 Precious Tatum MERIT Science of Medicine Internship: Asthma

32 Savannah Tripp MERIT Science of Medicine Internship: Prostate Cancer

33 Wesley Godfrey PCCM Use of the Inspirotec as a Novel Sampler for Particulate Matter

34 Brittney Gordon PCCM The Effect of Heat and Humidity on Asthma Morbidity among Urban Children

35 Tiarra Joell PCCM Defining Asthma Pathology Associated with Airway Acidification through a Molecular Window of the Ovarian Cancer G Protein-

Coupled Receptor 1

36 Carolina Larrain PCCM The Regulation of NHE1 by Calpain in Pulmonary Arterial Smooth Muscle

37 Nichole Legaspi PCCM The Role of Angiotensin Type II Receptors in Oxidative Stress Injury

38 Jessica Nino de Rivera

PCCM The effect of healthcare satisfaction on medication adherence and blood pressure control

in adolescents with chronic kidney disease

39 Jose Reyes PCCM The role of CD36 and TRPV4 in reactive oxygen species induced calcium influx in human

lung microvascular endothelial cells

40 Arrix Ryce PCCM Histone H1-Lamin C Interactions

41 Abby Barger Stanley Scholars CMV and Associated Cognitive Decline: An In Depth Analysis of Antibody Binding Patterns

42 Nico Clarke Stanley Scholars Novel Exon Discovery in the Human Brain

43 Erika Glaubitz Stanley Scholars The effect of low-protein diet on chronic Toxoplasma gondii infection

44 Morgan Greene Stanley Scholars Optimizing PCR-based methods to assess neutralization of the latent HIV reservoir by

bNAbs in perinatal infection

45 Emily Krach Stanley Scholars Examining Novel Intergenic Transcripts Containing Repetitive Elements Dysregulated in

Psychiatric Disease

46 Cindy Louis Stanley Scholars Milk protein association with phases of bipolar disorder

47 Wei Feng Ma Stanley Scholars Innate Immune Response to An Intraperitoneally Administered Foodborne

Pathogen Changes Mouse Intestinal Morphology and Tight Junction Protein

Expression

48 Jamie Yang Stanley Scholars Toxoplasma affects dopamine neurotransmission: potential mechanisms

49 Stacey Alston SARE Investigating the Role of Neuropilin-2 in retinal ganglion cell projections to the dorsal lateral

geniculate

50 Grace Ayole SARE PALM Imaging of E. coli RNAP in different conditions

51 Adam Elsaidy SARE Role of Myosin II in defining the mechanics of Pancreatic Cancer

52 Siri Keyaka SARE Phenotypic Analysis of Murine Polycystic Kidney Disease (PKD)

53 Princess Massaquoi SARE Validation of histone H3K4 trimethylation of OPRM1 in persistent pain

54 Tashanna Sands SARE Investigating the effects of constituitively active RAS proteins on McF10A cell migration,

proliferation, and survival

55 Natalie Suarez-Perez

SARE Species Differences in metabolism of anti-HIV drug, maraviroc

56 Ayende Watson SARE Dual Specificity Phosphatase 19 (DUSP 19) is a newly discovered gene localized in the

centrosome that regulates cell migration and adhesion

57 Luis Milburn SIP Optimization of chromatin immunprecipitation for low cell numbers

58 Michelleine Modeste

SIP Evaluating the Effects of ECM Stiffness on C2C12 Myogenesis for Optimiazation and

Application to ASC's Myogenesis in a 2 Dimensional Culture

59 Daymond Parrilla SIP Monitoring Plk4 kinase activity in living cells

60 Diana Price SIP Adapting BioID to enable identification of host targets of Legionella viruence proteins

61 Mark Ren SIP A novel gene-environment mouse model for Parkinson's Disease using LRRD2G2019S and

MPTP

62 Daniella Rodriguez SIP Discovering novel kinases in the Hippo pathway

63 Bianca Romo SIP A Screen for Transmembrane Proteins that Promote Cell-Cell Fusion

64 Michaela Siver SIP Identifying Antibodies for Imaging of Copper Transporter CTR1 in Enteroids

65 Imani Williams SIP Optimizing CRISPR-Cas9 Genome Editing in Fission Yeast

66 Destiny Hines DAASI

67 Anthony Neville DAASI

68 Elizabeth Scriber DAASI

69 Juan Tucker DAASI

70 Joe Paggi CCB Graph-based alignment of DNA sequence to a population of genomes

71 Benjamin Aladejebi CTY Platelet Endothelial Interactions

72 Jessica Liu CTY Shape Analysis of the Auditory Cortex in Deaf Babies

73 Muriel Leung CTY Automated Processing of Tobacco News Articles

74 Angel Delgado CTY Generating Randomized DNA Pools of significant Protein Binding Regions

75 Alissa Johnson CTY Motivation as a Predictor of Success in Cognitive Training

76 Stefan Best CTY Effects of Lithium and Stress on Wnt Signaling in Bipolar Disorder Patients

77 Maya De La Torre

CTY Latent Cell Reversal in Ex Vivo Cell Cultures and HIV Patients: Predictive Computational

Models

78 Elsa Salido

CTY IncRNA Correlation with Leukemic Model Cells

79 Breanda Bzaringa JHIBS

Outstanding Students

Assefa Akinwole

Leadership Award Gilman High School

SARE

Alison Cruz

Professionalism Award Baltimore Polytechnic Institute

Centro SOL

Jose Dominguez

Community Involvement Award Current School

Centro SOL

Karen Hernandez

Leadership in Science Western High School

MERIT

Rafael Leon-Chavez

Passion for Learning Award Baltimore Polytechnic Institute

Centro SOL

Yaslin Machuca

Leadership Award Baltimore City College

Centro SOL

Natalie Suarez-Perez

Passion for Learning Award Roland Park County School

SARE

Yarnee Whitacker

Dedication to professional career pursuit REACH! Partnership School

MERIT

Anthony Neville

Passion for Learning DAASI

Diamond Eveline

Leadership DAASI

D'kai Vanlandingham

Professionalism DAASI

Sky Garner

Most Improved

DAASI

Acknowledgements

We are grateful our corporate sponsor, PNC Bank, for supporting the symposium, and for their

commitment to advancing education opportunities and academic programming for Baltimore

City youth.

Special thanks for the additional financial supports that made the Hopkins C.A.R.E.S. Summer

Symposium a success: Office of the Vice Dean for Education, Office for Student Diversity,

Summer Internship Program Basic Science Institute, The Johns Hopkins Internship in Brain

Science Program (National Institute of Mental Health R25-MH10071), and Pulmonary and

Critical Care Medicine Summer Internship Program.

Organizing Committee

Lori Brando, PhD: Assistant Professor and Program Coordinator for Stanley Summer Scholars Program

Amanda Brown, PhD: Director of Johns Hopkins Internship in Brain Science

Camille Bryant: Academic Program Administrator for Institute for NanoBioTechnology

Chiquita A. Collins, PhD: Associate Dean Office of Diversity and Cultural Competence

Ranice Crosby: Academic Program Administrator for Biophysics for Baltimore Teens

Frank Molina: High School Program Director, Thread, and Director for Diversity and Academic Advancement Summer Institute

Warren Grayson: Director of RISE (Reaching Inner city youth through Scientific Education)

Jasmine Griffin: Office Assistant for Office for Student Diversity

Tahirah Hall: Administrative Supervisor Summer Internship Program Coordinator for Pulmonary and Critical Care Medicine Summer Internship Program

Cathryn Kabacoff: Research Technologist for Summer Academic Research Experience

Stephanie Landicho: Program Director for Medical Education Resources Initiative for Teens

Eric Lee: Academic Service Specialist for Summer Internship Program

Yukiko Lema: Program Manager for Psychiatry Summer Training and Research Program

Stephanie Lechich: Research Program Assistant for Psychiatry Summer Training and Research Program

Rachelle Lott: Academic Program Assistant for Summer Internship Program

Tyler Mains: Founder and Adviser for Medical Education Initiative for Teens

Vicky Schneider: Center for Talented Youth Program Manager for Summer Research

Jungsan Sohn, PhD: Director of Biophysics Research for Baltimore Teens

Daniel Teraguchi, Ed.D: Chair, Hopkins C.A.R.E.S. Summer Symposium, Assistant Dean for Student Affairs, Director of Office for Student Diversity, Assistant Professor of Pediatrics,

Monica Guerrero Vazquez: Program Coordinator for Centro SOL

Ann Vukelich: Administrative Coordinator for Center for Computational Biology Summer Internship Program

Catherine L. Will: Program Manager for Summer Internship Program

David “Brandy” Yeater: Research Administrative Manager for Summer Urological Research

Experience at the Brady Urological Institute