2012 tus lecture 6
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Lecture 6. Nanotechnology Fuel Cells
Nano-composite materials
Nanoelectronics and photonic
Devices:
Chemical and Biological Detectors
Nanomedicine:
Disease Detection
Implants
Delivery of Therapeutics
Other nanomedicine
Applications
Risks
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Fuel Cells
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WHY FUEL CELLS?
Emission of toxic pollutants when fossil fuel burns
Build-up of CO2 & other greenhouse gases leading to global warming
Decline of world oil production
Deregulation of electricity supply industry
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Advantages of Fuel Cells
Modular Design
Cogeneration
Capacity to use different kinds of fuels
No moving parts
Fast response
High Efficiency
No emission of pollutants
More efficient and convenient than internal
combustion engines
•40-60% efficient
•Zero-emission
•Low maintenance costs
•No moving parts
More practical and cost effective than
batteries
High specific energy and power
Longer life (5-10 years vs. 1-3 for
batteries)
No long charging periods
Lower capital cost in mass production
No hazardous material disposal issues
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Polymer Electrolyte Membrane Fuel Cell (PEMFC)
http://www.celanesechemicals.us/index/about_index/innov-home/innov-fuelcell/fuel_cell_contacts/fuel_cell_pictures.htm
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2 mm 2 mm
FUEL CELL MATERIALS
Fuel cells will power the new hydrogen economy; and advances in materials science, especially nanomaterials will be key to enabling this.
MEMBRANES
A critical challenge is finding effective membrane materials. Membranes which can function without pressure, temperature, hydration may reduce the cost and complexity
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FUEL CELL MATERIALS
Fuel cells will power the new hydrogen economy; and advances in materials science, especially nanomaterials will be key to enabling this.
ELECTRODES AND CATALYSTS
CO tolerant catalysts based on nanostructured Pt alloys are presently the most utilized. Critical challenges are finding new nanostructured catalytic materials and cheap synthesis routes.
Nanostructured Pt-Ru catalyst
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• Composites
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Figure 8.1. Schematic representations of nanocomposite materials with
characteristic length scale: (a) nanolayered composites with nanoscale
bilayer repeat length L; (b) nanofilamentary (nanowire) composites
composed of a matrix with embedded filaments of nanoscale diameter d;
(c) nanoparticulate composites composed of a matrix with embedded
particles of nanoscale diameter d.
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• Nanoelectronics
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Fig. 1 Scanning-electron micrograph of a Silicon-on-insulator integrated-
phontonic Device. [2,3]
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Ballistic Nanotube MOS Transistors (Chen,Hastings)
Wd
D
L
SWNTSWNT
SiO2
Source
Al-Gate
Ti
HfO2
Drain
L
L~20 L~20 nmnm
Placement of Nanotubes by E-Field
(The first-demo) Nanotube Field-Effect Transistor(FET)
E-Beam Lithography
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Other Applications
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• Photonic Devices
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Figure 20.1. Schematic illustrations of 1D, 2D, and 3D photonic
crystals patterned from two different types of dielectric materials.
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Figure 20.3. (A) An illustration of the 3D woodpile lattice and (B) its
photonic band structure calculated using the PWEM method. The
filling fraction of the dielectric rods is 26.6%, and the contrast in
refractive index is set to be 3.6/1.0.(From Ref. 23 by permission of
Elsevier B.V.)
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• • Figure 1 With the disordered lattice set up, the
researchers launched a weak probe beam and imaged the intensity distribution in the x–y plane downstream as the light passed through the material (see the figure). In transverse localization, a narrow beam propagating through a disordered medium undergoes diffusive broadening until its width becomes comparable to the localization length. The greater the disorder, the faster the beam evolves into the localized state.
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• C. Chemical and Biological
Detectors
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Polymeric networks patterned onto silicon surfaces have potential
application as recognition elements in biosensor applications.
50 mm
Microarrays for Sensing Applications
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Fig. 4 (a) A capacitive sensor structure and (b) Response of the capacitive sensor using the vertically aligned MWNT’s in a template (Switch between 3% NH3 and pure N2).
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• Surface-plasmon resonance: – widely used for chemical sensing and for
investigating bio-molecular interactions
– high sensitivity, label free approach that measures refractive index changes near a metal-solution interface
– most often measures binding of the target analyte to a functionalized surface, but
• How can one differentiate between specific binding, non-specific binding, and changes in solution refractive index?
• How can one integrate SPR on chip for multi-channel self-referenced sensing?
Photonic Sensors: Self-Referencing Surface-Plasmon Resonance (SR-SPR)
Sensing Self-referencing Surface-Plasmon
Resonance Sensor
Students: R. Donipudi, P. Bathae Kumeresh; Funded by ORAU
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• Nanomedicine
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A nanofilter from LabNow gives a fast count of white blood cells
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Application as Functional Components of Novel Devices
• Nanomedicine
– Diagnosis • Imaging • Sensors • DNA Sequencing
– Arrays, Nanopore Sequencing
– Therapeutics • Surgery • Drug Development
– Arrays, Local Cellular Delivery
• Drug Delivery – Microchip, Microneedles, Micro-/Nano-sphere
• Tissue Engineering
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1.Disease detection
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Fig 3 Nanoscale Electrode for in-vivo neurological recording.
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Fabrication process is summarized. (a) Free-standing membranes are spin coated with positive e-beam resist, and e-beam lithography is performed. (b) The nanohole pattern is transferred to SiNx membrane through RIE processes. (c) Oxygen cleaning process results in a free-standing photonic crystal-like structure. (d) Metal deposition results in a free-standing optofluidic nanoplasmonic biosensor with no clogging of the holes. (e) Scanning electron microscope images of patterned SiNx membrane is shown before gold deposition. (f) Gold deposition result in suspended plasmonic nanohole sensors without any lift-off process. No clogging of the nanohole openings is observed (inset).
Published in: Ahmet A. Yanik; Min Huang; Osami Kamohara; Alp Artar; Thomas W. Geisbert; John H. Connor; Hatice Altug; Nano Lett. 2010, 10, 4962-4969. DOI: 10.1021/nl103025u Copyright © 2010 American Chemical Society
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(a) Immunosensor surface functionalization is illustrated in the schematics. Antiviral immunoglobulins are attached from their Fc region to the surface through a protein A/G layer. (b) Sequential functionalization of the bare sensing surface is illustrated (black) for the optofluidic nanohole sensors with a sensitivity of FOM ∼ 40. Immobilization of the protein A/G (blue) and viral antibody monolayer (red) result in the red shifting of the EPT resonance by 4 and 14 nm, respectively.
Published in: Ahmet A. Yanik; Min Huang; Osami Kamohara; Alp Artar; Thomas W. Geisbert; John H. Connor; Hatice Altug; Nano Lett. 2010, 10, 4962-4969. DOI: 10.1021/nl103025u Copyright © 2010 American Chemical Society
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Detection of PT-Ebola virus (a) and Vaccinia (c) viruses shown in spectral measurements at a concentration of 108 PFU/mL. (c, d) Repeatability of the measurements is demonstrated with measurements obtained from multiple sensors (blue). Minimal shifting due to nonspecific bindings is observed in reference spots (red). Here, the detection sensors are functionalized with M-DA01-A5 and A33L antibodies for capturing PT-Ebola and Vaccinia viruses, respectively.
Published in: Ahmet A. Yanik; Min Huang; Osami Kamohara; Alp Artar; Thomas W. Geisbert; John H. Connor; Hatice Altug; Nano Lett. 2010, 10, 4962-4969. DOI: 10.1021/nl103025u Copyright © 2010 American Chemical Society
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2.Implants
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3.Delivery of Therapeutics
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(Ehringer, Chien, Keynton, Walsh, Cohn, Hinds)
MEMS Based Detection and Drug Delivery for Treatment of Coronary Heart Disease
Early detection of sudden heart dysfunction using a micro-fabricated implantable device to monitor vital cardiac chemical changes
Rapid recovery from an ischemic attack by providing an efficient ATP delivery system to the heart.
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Drug Delivery into Neural Tissue (Cornell)
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Self-regulated Drug Delivery Devices • Micro- and nanofabricated devices have many potential applications in medicine
• For example, drug delivery devices can be combined with biosensors to create micro- and nanoscale self-regulated drug delivery devices
MicroCHIPS, Inc.
Drug Delivery Microdevice Micro-/nanoscale biosensor
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• Other Nanomedicine Applications
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Fig 3 Nanoscale Electrode for in-vivo neurological recording.
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Research Update III: Hippocampal Neuron Recordings in Awake Rats for up to 6
Months
Place Fields (after 30 min)
W4
20x150 µm
100 mm
61(15.1)
73(18.1)73(18.1)73(18.1)
Time →
Firing
Spike Waveforms Firing Rate Stripcharts
DSP03asig00312000
DSP01bsig00112000
Site 3 Site 4
6 months after implant
150 µV
200 µs
150 µV
200 μs
Site 3 Site 4
73(18.1)82(20.2)
4 9 ( 1 2 . 1 ) 6 1 ( 1 5 . 1 )
9 3 ( 2 3 . 1 ) 9 4 ( 2 3 . 2 )
7 3 ( 1 8 . 1 ) 8 1 ( 2 0 . 1 )
8 2 ( 2 0 . 2 )
Site 3
0 200 400 600 Time (sec)
0
5
Site 4
Firi
ng
Rat
e (H
z)
Site 3
0 200 400 600 Time (sec)
0
5 Site 4
Firi
ng
Rat
e (H
z)
1 month after implant
Courtesy of Dr. Sam Deadwyler and Dr. Rob Hampson, Wake Forest Univ.
1 month
6 months
1 month
6 months
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“Ceramic-based
Microarrays”
2.5 x 2.5 cm wafer
Side-by-Side
Serial
Research Update I: New Ceramic-Based Conformal Microelectrodes
Ceramic-based Microelectrodes
Al2O3 substrates 37.5 to 125 µm
1. Polyimide coatings
2. Pt or Ir recording sites
3. “Multi-purpose” tip and long shank designs
W2
20x150 µm
600 mm
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CA1
CA3
DG
1 2
4 3
Ceramic Probe
MRI of Macaque Brain
W4
20x150 mm
Co
un
ts/b
in
0 20 40 60 80 0
0.5 1
1.5 2
0 20 40 60 80 0
0.5 1
1.5 2 Site 1
0 20 40 60 80 0
0.5 1
1.5 2 Site 2
0 20 40 60 80 0
0.5 1
1.5 2 Site 3
Site 4
Hippocampus
Research Update IV:
Electrophysiological
Recordings in
Nonhuman Primates
150 µV
200 µs
1
2
4
3
Recording Sites
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Time (ms)
-10 -5 0 5 10
Firin
g R
ate
(H
z)
0
2
4
6
8
10
Time (ms)
-10 -5 0 5 10
0
2
4
6
8
10
Time (ms)
-10 -5 0 5 10
0
2
4
6
8
10
Time (ms)
-10 -5 0 5 10
0
2
4
6
8
10
Site 1
Site 2
Site 2a
Site 3
Site 3a
Site 4
Stim: 100 µA 250 μA 500 µA 1 mA W2
20x150 µm
600 mm
Record CA1
Stimulate CA3
Research Update II: Simultaneous Stimulation and Recordings
1
3
2
4
CA1
CA3
S S
Recording Sites
S = Stimulation Sites
150 µV
200 µs
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From: Patricia J. Cooper, Ming Lei, Long-Xian Cheng, and Peter Kohl J Appl Physiol 89: 2099-2104, 2000
10 mm
Diameter: 12 mm Compliance: 80 mm/mN, 4 mm/mN
Institute of Molecular Medicine
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NanoMedicine Project 3
Objective: To use hollow nanotubes as a delivery vehicle for
small interference RNA (RNAi) to silence specific gene products.
Institute of Molecular Medicine
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RNA injection via nanotubes
Institute of Molecular Medicine
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Force Transducer Step Motor
Carbon Fiber for manipulating single cell
Institute of Molecular Medicine
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• Other Nanomedicine Opportunities
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• RISKS
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A group of near-naked protestors demonstrate the invasion of nanotechnology (into clothing) in front of the Eddie Bauer flagship store in Chicago. The members of the group THONG (Topless Humans Organized for Natural Genetics) were upset the about the Nano-tex line of shirts and khakis. (Popular Science, August 2005)
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Andre Nel,1,2* Tian Xia,1 Lutz Ma¨dler,3 Ning Li1
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