2012 Annual Report - U-M Kellogg Eye Center

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UNIVERSITY OF MICHIGAN W.K. KELLOGG EYE CENTER 2 012 ANNUAL REPORT

LEADERSHIP

4 Dr. Paul Lee talks about new ways of working in a changing health care environment

PATIENT CARE

7 A patient with Graves’ eye disease has Kellogg’s multidisciplinary team on her side

8 A mother and daughter with a rare inherited eye disease come to Kellogg for treatment

EDUCATION AND GLOBAL REACH

10 Residents make the connection between research and clinical care

13 Advancing vision care worldwide through collaboration with our global partners

RESEARCH

16 Building a model to share the expertise of specialists in inherited eye disease

18 Expanding clinical research to evaluate new treatments

19 How often do patients with glaucoma need testing? A new tool could help.

20 New training grant will increase the pool of clinician-scientists

COLLABORATIVE RESOURCES

22 New initiatives spark innovation and foster interdisciplinary collaboration across U-M

23 Our faculty join a new Institute created to improve health care delivery and access

PHILANTHROPY

24 Grandnieces of Horace and Mary Rackham pay tribute to Kellogg cornea specialist

26 Kellogg’s new Taubman Scholars are recognized for innovative, treatment-driven research

front cover:

H. Kaz Soong, M.D., Donna Donato, Jonathan Trobe, M.D.,

Charlotte Bush, Brenda Bohnsack, M.D., Ph.D.

back cover:

Kristen Harris Nwanyanwu, M.D., Joshua Stein, M.D., M.S.,

Paul Lee, M.D., J.D., Thomas Gardner, M.D., M.S.,

Alan Sugar, M.D., Michael Smith-Wheelock, M.D.,

Shahzad Mian, M.D.

*This report covers the period

July 1, 2011, through June 30, 2012

Highlightsannual report 2012

82624 16 21

Dear Friends,

At what promises to be a time of significant change—and thus opportunity—

in health care, research, and education, I am heartened by the spirit, energy,

and values of our “Michigan family.” In this Annual Report, we are proud to

highlight the achievements of our faculty, trainees, and staff during the past

year. We are also pleased to share with you some of our new initiatives that

will help catalyze changes to meet national and global health care needs. We

believe that these examples of new approaches to how we work will not only

fundamentally enhance our knowledge of science and improve our care for

tomorrow’s patients but also empower all of us to realize a better future in

which we can truly cure or prevent visual disability.

The Department’s vision care initiatives hold great promise because

they reflect the guiding principles we all strive to honor: integrity, caring,

innovation, and teamwork. In addition, the stories behind the articles in

this report—representing the perspectives of our patients, faculty and staff—

demonstrate how we try each day to integrate these enduring principles into

our work. In fact, it is through stories about our experiences at Michigan that we know we are moving in the right

direction. Your stories are part of the Michigan and Kellogg experience as well. If you have one you’d like to share,

please send it to me at [email protected].

As a graduate of the University of Michigan School of Literature, Science, and the Arts and the Medical School,

my experience and stories reflect the strengths of our University and show why I am so confident that the future is

bright. Michigan’s support for individual passion and opportunities to work across disciplines was evident during

my student years; this dedication has only grown stronger with time. Future achievement will be built on multi-

disciplinary teamwork in research, education, and clinical care. Our faculty, trainees and staff have embraced this

approach, as you will see through stories of our work with the College of Engineering, School of Public Health,

the new Institute for Healthcare Policy and Innovation, and international colleagues. We look forward to forging

even more partnerships here and around the world.

Michigan’s greatest story is about our people: our alumni and friends, faculty and staff, patients and students,

and those we ask to join us in creating the future. From great mentors, starting with Paul Lichter, the Department’s

longtime chair, I have been fortunate to learn that our obligation is not to repay their kindness but instead to pass

their wisdom to others—our colleagues, residents, and fellows—to realize the better future that we all seek. On

behalf of the Kellogg family, I thank all of you who have so generously provided support toward our shared goal

of preserving vision and improving the lives of our patients.

Paul P. Lee, M.D., J.D.F. Bruce Fralick Professor and ChairUniversity of MichiganDepartment of Ophthalmology and Visual SciencesDirector, W.K. Kellogg Eye Center

Paul P. Lee, M.D., J.D.

“The third function of institutions of higher

learning is the creation of wisdom in our

students, trainees, staff, and faculty. Wisdom

is the multidisciplinary integration of knowl-

edge and experience resulting in the develop-

ment of new insights—the innovations that

improve our understanding of the world and

our ability to improve lives.”

— Paul P. Lee, M.D., J.D.

Curing, preventing, and treating eye disease

The Kellogg Eye Center has always upheld

the values of exemplary patient care and

dedication to our patients and their fami-

lies. Kellogg faculty and staff together have

developed a statement of purpose, a long-

term vision, and a set of guiding principles

that reaffirm these values.

PurPose: Improve lives through curing, preventing, and treating eye disease

VIsIon: We seek to improve lives around the world by enhancing vision

GuIdInG PrIncIPles

TeamWork: We are a collegial, productive, and collaborative community

carInG: We are respectful and compassionate

InnoVaTIon: our curiosity drives innovation and the quest for knowledge

InTeGrITy: our ethics are built on openness, honesty, and trust

university of Michigan kellogg eye center4

University of Michigan Provost Philip J. Hanlon, Ph.D., has noted that institutions of higher learning tradition-ally have three functions. The first is the transmission of information—the passing on of facts and discrete bits of data. Today, to varying degrees, information is free and readily accessible on the internet. The second function is the development of knowledge—of organiz-ing facts into coherent frameworks and perspectives. Knowledge is also increasingly available through the internet in ways that both resemble and complement the offerings of the traditional university. The third function, to which the University of Michigan is dedicated, is the creation of wisdom in our students, trainees, staff, and faculty. Wisdom is the mul-tidisciplinary integration of knowl-edge and experience resulting in the development of new insights—the innovations that improve our under-standing of the world and our ability to improve lives. At Kellogg, our passion for wisdom will drive the successes of tomorrow and will give us reason to be optimistic about the future, despite challenges such as empowering access to quality eye care for all; providing care with more limited resources while improving qual-ity; mitigating the growing epidemic of diabetes and the suffering of individuals with multiple health conditions; and meeting the growing demand for eye and health

care in the United States and abroad as societies around the world age. In the face of these and other issues, we should remind ourselves that innovation has resulted in the unprecedented progress of the last 100 years and will continue to be the key to better eye and health care. Our focus at Kellogg will not change: to provide our patients with the highest level of care. We seek to continuously implement the best and latest research and to create and refine new models for the delivery of care so that we may improve the lives of patients through the treatment, cure, and prevention of eye disease. What are some of the steps Kellogg is taking toward a better eye and health care system for tomorrow?

Understanding the “why” of diseases will enable us to create new therapies. Recent work on inflammatory pathways and early disease manifestations suggest new avenues of treatment for diabetic retinopathy and open-angle glaucoma that complement existing modes of therapy. Discoveries in thyroid eye disease mechanisms

are anticipated to lead to new clinical trials for thyroid eye disease within the next year.

Accelerating the pace of research that will have a direct impact on patient care will make these treat-ments available sooner. Across our campus, Michigan is a leader in many areas of translational research. One that holds great promise is person-alized medicine, which integrates many current concepts about disease. Better understanding of the relation-

ships among genes associated with eye disease, potential environmental factors, and clinical observations brings us closer to not only assessing a patient’s risk for a par-ticular disease, but also to targeting treatments to the individual’s profile. Similarly, new approaches to clinical research and trials will play a key role in speeding the availability of new therapies. Our faculty have formed companies to accelerate the movement of the discover-ies they have made in the lab to patient care settings.

“Our passion for wisdom

will drive the successes of

tomorrow and will give

us reason to be optimistic

about the future, despite

the challenges we face.”


The Chair’s Perspective

Wisdom and the Future

Paul P. Lee, M.D., J.D.

innovation in vision 5

Developing our technological expertise will enable us to develop new systems for creating care that are truly patient- and family-centered. In collaboration with the U-M College of Engineering, Kellogg faculty and staff are developing a computer model that will allow physicians in remote locations to tap the diagnostic expertise of a small number of specialists in inherited eye disease. Such a tool could help patients around the world receive emerging treatments for these rare dystro-phies. Our faculty have also developed an instrument that might one day be easily used by non-specialists to detect diseases like diabetic retinopathy and macular degeneration long before the first symptoms appear.

Health services research is a burgeoning field that brings together experts from many disciplines to ensure that patients can access the right care at the right time. Many faculty in this Department and the University are engaged in initiatives to improve the use of care by populations of individuals who are not receiving adequate care. Other studies seek to identify how to im-prove outcomes—how patients fare—after being treated with certain medications or procedures. Our potential for solving problems through these kinds of studies is greatly increased by the creation of the Institute for Healthcare Policy and Innovation that brings together over 400 of Michigan’s top health care researchers.

Taking the time to ask “why?” and to question our assumptions will drive our continuous quest for wis-dom. Asking what we can learn from other industries

and borrowing the best from among ourselves and others will be critical. Among physicians and trainees, we can encourage curiosity and innovation and resist the reflexive response to do things the same way “because we’ve always done it that way.”

Forming new structures adapted to the workforce of tomorrow will enable us to leverage new technolo-gies to enhance teaching and patient care. Collabora-tive, interactive learning will prepare our trainees for the very different health care environment they will work in as leaders of teams. We have also structured a leadership team at Kellogg (see photo) that integrates the strengths of our faculty to create a joint vision for what we hope to accomplish.

Keeping our focus on the patient will be our guide. How can we provide care that is faster, more accessible, and less demanding in terms of time and costs? How can patients participate in their own care to the extent they wish to be involved? These and other questions frame our opportunities. As we adapt to meet the challenges of our time, our traditional values and our passion for improving our patients’ lives will not change—but the way we achieve our goals will change. It is our responsibility to think about, encourage, and implement collaborative and innovative ways of improving our systems for delivering health and eye care. By so doing, we honor our respon-sibility to generate the wisdom that will guide the next generation in their quest for a brighter future.

Kellogg’s leadership team: Paul Lee, M.D., J.D., Thomas Gardner, M.D., M.S., Alan Sugar, M.D., Michael Smith-Wheelock, M.D., Shahzad Mian, M.D.

The kellogg eye center has enjoyed steady

growth, thanks, in part, to the recent

opening of our new facility with expanded

space for patients needing clinical and

surgical care. The new space has allowed

us to recruit additional faculty who are

developing innovative and treatment-directed

programs for patients suffering from debili-

tating eye disease. The department continues

to attract important federal grants and this

year achieved a ranking of #5 in funding

awarded to departments of ophthalmology

by the national Institutes of Health.

“Leaders and Best” in ophthalmology

1985

1995

2006

2011

2012

1,825 2,944 5,528 5,783 6,319

Surgeries

1985

1995

2006

2011

2012

36,853 57,081 120,954 129,127 138,812

Patient Visits

Patient Visits to the eye center

surgical Procedures PerformedFunding from the national Institutes of Health

$5.2 M $5.4 M $6.9 M $7.2 M $7.5 M

NIH Ranking

2008Number 10

2011Number 8

2010Number 10

2009Number 15

2012Number 5

innovation in Patient care 7

Ester M. Skutt, of Holt, Michigan, remembers vividly the day she was diagnosed with Graves’ disease in October 2009. “I was frightened,” says the former nurse. “I knew it was a pretty bleak situation. I had taken care of patients with the disease.” A complex autoimmune disorder, Graves’ disease results in the overproduction of thyroid hormones, or hyperthyroid-ism. The condition affects over 3 million Americans. One year later, in December 2010, Ms. Skutt devel-oped a cluster of “blisters” on her eyes. “I knew that with Graves’ disease there was a possibility that my eyes could be involved,” she says. Her greatest fear was that her symptoms could be related to Graves’ eye disease, a complication that results in swelling of the eyelids, a con-stant stare, eyelid retraction, and double vision. Left untreated, the disorder can lead to permanent vision loss. Ms. Skutt’s ophthalmologist in nearby Lansing started her on a regimen of steroid therapy to address the blistering. After two doses and strong drug intoler-ance, she found herself in the hospital with atrial fibrillation, an irregular heartbeat often associ-ated with congestive heart failure. Days later, she was referred to Kellogg’s Raymond S. Douglas, M.D., Ph.D., a specialist in Graves’ eye disease and renowned orbital, facial plastic and reconstructive surgeon. “Ms. Skutt’s inflammation and eye bulging had progressed rapidly and she was beginning to lose vision,” says Dr. Douglas. “Given her intolerance for steroids, we felt it would be reasonable to try alterna-tive anti-inflammatory therapies in conjunction with the care of a team of rheumatologists. After two infusions, her disease regressed and we were able to stabilize her thyroid function. Most of her pain also ceased.”

To help patients like Ms. Skutt receive expert care for this complex condition, the Kellogg Eye Center has formed its Thyroid Eye Disease Center, which brings together specialists from multiple disciplines to provide integrated care for individuals with thyroid disorders. Surgeons from Kellogg’s oculoplastics service are at the

core of the Center, coordinating clinical care as well as participat-ing in research aimed at discover-ing new therapies for Graves’ and thyroid disorders. In the months that followed, Ms. Skutt underwent orbital decompression surgery to move her eyes back into place followed by surgery to correct her double vision. “It was a terrific team ef-fort,” she says. “I saw specialists in orbital surgery, strabismus, and endocrinology at Kellogg—and a specialist in rheumatology at the

University of Michigan Health System. The communica-tion between doctors was fantastic.” Dr. Douglas’ office serves as a destination for patients with Graves’ eye disease. “If Ms. Skutt had to go through the normal referral channels, it would have been months of delay and time lost,” says Dr. Douglas. “With one appointment, her care was consolidated and she had a rapid treatment plan.” Ms. Skutt has returned to her normal life. “I’m doing fantastic,” she says. “My eyes look better than they did before I was diagnosed with Graves’ disease. The whole experience was just unbelievably good.”

Terry Smith, M.D., Monte Del Monte, M.D., and Raymond Douglas, M.D., Ph.D., coordinated care for their patient Ester Skutt

“Our office serves as a des-

tination for patients with

Graves’ eye disease. With

one appointment, Ms. Skutt’s

care was consolidated and she

had a rapid treatment plan.”

— raymond s. Douglas, M.D., Ph.D.

It Takes a Team How one patient benefited from a multi-

disciplinary approach to Graves’ eye disease


Charlotte Bush was just two years old when she made her first trip to the University of Michigan Kellogg Eye Center in 2009. A new experience for the toddler, such visits were more than familiar to her mother, Amanda Bush, of Marshall, Michigan, who has been treated at Kellogg for nearly 33 years for a condition known as Axenfeld-Rieger (A-R) syndrome—an inherited disease that predominantly affects the development of the eye. Ms. Bush suspected Charlotte might have the same disease and, if so, wanted to have it diagnosed and treated promptly; fifty percent of those with the disorder suffer from glaucoma. “Ever since I was a baby, I’ve been coming to Kellogg—it was just a nor-mal part of my life,” says Ms. Bush. “And, I’ve always had great experiences so it was natural to bring my daughter here.” Unfortunately, the mother’s keen instincts proved correct. At Charlotte’s first appointment she was di-agnosed with A-R by Paul R. Lichter, M.D., a highly respected glaucoma specialist and former Chair of the Department—and Ms. Bush’s childhood doctor. Once Charlotte’s vision and intraocular pressures were stabilized, she returned to her local ophthalmolo-

gist for routine check-ups. All went well until Charlotte failed a pre-kindergarten vision screening during the summer of 2012. When Ms. Bush took her daughter to the ophthalmologist to be fitted for eyeglasses, the pressure in her left eye was again elevated and it was recommended that she return to the Kellogg Eye Center. This time, Charlotte was seen by pediatric glau-coma specialist Brenda L. Bohnsack, M.D., Ph.D., who adds her expertise to that of two other faculty who are nationally recognized in pediatric glaucoma, Dr. Lichter and Sayoko E. Moroi, M.D., Ph.D. Dr. Bohnsack decided on surgery to place a glau-coma drainage tube in Charlotte’s left eye so that fluid build-up could be drained off the eye. “The pressure in both of Charlotte’s eyes was elevated, but the left eye showed signs of damage from the glaucoma,” says Dr. Bohnsack. At Charlotte’s one-month check-up, the pressure in her left eye was controlled, but her vision remained somewhat reduced to 20/50 after sustaining vision loss due to the glaucoma. With 20/20 vision in her right eye, she was doing fine visually, but Dr. Bohnsack decided to treat that eye with drops to control the pressure before Charlotte experienced loss of vision. In the future, Dr. Bohnsack anticipates Charlotte may need surgery on the right eye as well. In the meantime, Charlotte will be examined every few months to keep the eye pressure in check. Long term, she has a good prognosis. “In these types of cases, we look at how her mother has lived with the disease, and she has done well,” says Dr. Bohnsack. “This is a good indicator of how Charlotte will do.” Ms. Bush reports that Charlotte has handled surgery and subsequent follow-ups very well.

like Mother, Like daughterA rare inherited eye disease brings a mother and daughter to the Kellogg Eye Center for treatment

Charlotte Bush, at left, and with her mother, Amanda Bush, who was a patient of Paul Lichter, M.D.

innovation in Patient care 9

“Coming to Kellogg’s new pediatric eye clinic has been a good experience for Charlotte. She even asks when we can come back,” says Ms. Bush. “As for Dr. Bohnsack, she is a wonderful doctor who knows how to put Charlotte at ease.”

The Kellogg Eye Center and Carls Pediatric Ophthal-mology Clinic have a longstanding reputation for excel-lence in children’s eye care. Established in 1985 when Monte A. Del Monte, M.D., joined the Eye Center and was named the Skillman Professor of Pediatric Ophthalmology—the first endowed chair for pediatric ophthal-mology in the world—the Service now widens its scope with the addi-tion of two new subspecialists: Cagri G. Besirli, M.D., Ph.D., in pediatric retina, and Brenda L. Bohnsack, M.D., Ph.D., in pediatric glaucoma. These new faculty members join some 15 Kellogg physicians in providing children’s eye care throughout the Eye Center. Now, Dr. Del Monte, along with ocu-loplastics surgeon Christine C. Nelson, M.D., plans to create a center for visual development and pediatric eye disease to integrate both the clinical care for children and our research across the Michigan campus. As a clinician-scientist, Dr. Bohnsack navigates

easily between the clinic and laboratory with a clear sense of how her research will benefit her patients. She believes that understanding how the eye develops will shed light on the cause and possible prevention of congenital eye diseases. Dr. Bohnsack studies the function of genes that are important for the proper development of the front portion of the eye. “Zebrafish serve as a wonderful model because their embryos are transparent, allow-ing us to see development of the visual system as it happens,” she explains. She works closely with Alon Kahana, M.D., Ph.D., whose study of zebrafish focuses on the use of stem cells to regenerate eye tissue lost to injury or disease. Dr. Bohnsack is joining an area of research that has been supported for many years by senior scientists Peter F. Hitchcock, Ph.D., and Philip J. Gage, Ph.D.

Dr. Hitchcock’s laboratory investigates the function of molecules that govern development of the embryonic retina and the capacities of intrinsic stem cells in the adult retina. This work also utilizes zebrafish as a model. Dr. Gage’s laboratory studies mamma-lian models of congenital eye diseases and glaucoma, including Axenfeld-

Rieger syndrome, with the aim of further understanding the developmental events that lead to these diseases and eventually developing better treatments. Though they take different approaches to study the development of vision, these Kellogg researchers have a common goal: to make scientific discoveries that will improve care today and will cure and prevent eye disease in the future.

As a clinician-scientist,

Dr. Bohnsack has a clear

sense of how her research

will benefit her patients.

Brenda Bohnsack, M.D., Ph.D., with patient Charlotte Bush who, like her mother, has Axenfeld-Rieger syndrome.

l i n k i n g C h i L d r e n ’ s e y e C a r e and vision development research


Third-year resident Kristen Harris Nwanyanwu, M.D., M.B.A., earned an M.B.A. because she wanted to understand the business side of the health care system. The degree would provide the tools needed to help her fulfill her passion: helping people get the health care they need. It is this passion that led her to work with diabetic retinopathy specialist Thomas W. Gardner, M.D., M.S., and health services researcher Joshua D. Stein, M.D., M.S., on a project investigating factors that influence the progression of diabetic retinopathy, a complication of diabetes caused by changes in the blood vessels of the retina. The project involved examining medical claims from a large health care database in hopes of finding factors—such as hypertension, age, gender, duration of disease, and socioeconomic status—to determine a “score” that could help predict a patient’s risk for

developing diabetic retinopathy. Clinicians could then use this score as a tool in identifying and treating their high-risk patients as well as motivating them to change behaviors and reduce risk factors. During the second year of residency, Kellogg offers a research rotation that can be completed at the Eye Center or at any other institution in this country or around the world. Dr. Harris Nwanyanwu began her project during her first year and used the rotation to design, research, and write a grant. “The research rotation helps residents build something and see it to fruition,” says Dr. Harris Nwanyanwu. “We have the opportunity to learn about design protocols and research models, as well as writing the grant and navigating the application process. The rotation also allows us to see the value of collaboration within Kellogg and with other parts of the University.” Dr. Harris Nwanyanwu plans to join an academic medical center after completing a retina fellowship. “My goal is to ensure that patients not only have access to eye care but that they also receive the proper treatment for their condition,” she says.

Kellogg and iTs residenTs reaP The rewards

“My goal is to ensure that patients

not only have access to eye care but

that they also receive the proper

treatment for their condition.”

— Kristen Harris Nwanyanwu, M.D., M.B.A.

Kristen Harris Nwanyanwu, M.D., M.B.A.

innovation in education 11

When second-year resident Ira H. Schachar, M.D., began his residency, he was pleasantly surprised that so many members of the Kellogg faculty wanted him to be involved in their research. He opted to work on a project with retina specialist Thiran Jayasundera, M.D., and ocular pathologist Victor M. Elner, M.D., Ph.D., to quantify fundus autofluorescence (FAF) in age-related macular degeneration (AMD). FAF is an imaging method that targets the retinal pigment epithelial (RPE) cells—cells under the retina that nourish the rods and cones—and yields a higher detection rate for changes associated with vision-threat-ening diseases like AMD. FAF provides a topographic map of accumulated lipofuscin, the aging pigment, within the RPE. Normal accumulation of lipofuscin occurs with age, but accumulation is more pronounced in AMD. Lipofuscin will produce the majority of FAF when excited by blue light, and FAF that is emitted can be digitally recorded and analyzed. During his second-year research rotation, Dr. Schachar designed a method for quantifying the severity of disease seen in FAF images. By using a novel image analysis technique, it was possible to compare and quantify differences and changes in FAF images. This quantifica-tion process yields a single value—the Index of Retinal Autofluorescence—which can be used to assess AMD severity and its change over time. “Until this Index was developed, we did not have a quantitative tool for analyzing FAF images,” says Dr. Schachar. “With the help of Dr. Jayasundera and Dr. Elner, we designed an algorithm and took this project from ground zero to a point where we could create a pilot study,” says Dr. Schachar. When Dr. Jayasundera

recently presented this research at a national retina conference, he received an enthusiastic response. “Some researchers wanted to share their images with us so they could be analyzed,” says Dr. Schachar.

“This research is a hot topic in oph-thalmology, and the project has allowed me to tap into the scientific community much sooner than I would have other-wise,” he adds. “The project has also helped me learn the value of collabora-tion very early in my career.” Dr. Schachar presented his research at the Michigan Society of Eye Physi-cians and Surgeons’ annual conference

in the summer of 2012. “After speaking with physicians at the conference,” he says. “I realized how academic research can help clinicians in private practice.”

“The project has helped

me learn the value of

collaboration very early

in my career.”

— Ira H. Schachar, M.D.

of The researCh roTaTion

Ira Schacher, M.D.

Peter F. Hitchcock, Ph.D., Professor, Ophthalmology and Visual Sciences and Professor, Cell and Develop-mental Biology, has been appointed as an Associate Dean for Academic Programs and Initiatives at the University of Michigan Rackham Graduate School. He will serve the Dean of Rackham for the next four years toward the goal of ensuring excellence in gradu-ate education at the University of Michigan. In his new role, Dr. Hitchcock will undertake two broad tasks. The first is to provide administrative oversight for thirty-one Ph.D. and M.S. graduate programs in the biological, biomedical, and health sciences. The second is to direct initiatives and help craft policy decisions that impact graduate education at the University of Michigan.

During his tenure at Rackham, Dr. Hitchcock will continue to direct his NIH-funded laboratory, which investigates the molecular mechanisms govern-ing early development of the vertebrate retina and stem-cell-based neuronal regeneration in adult nervous tissue. Throughout his career, Dr. Hitchcock has also been dedicated to graduate and postdoctoral training at Michigan. In addition to current and past trainees mentored in his laboratory, Dr. Hitchcock was a former director of the U-M Neuroscience Graduate Program, founding director of the Office of Postdoctoral Stud-ies at the U-M Medical School, and currently serves as director of U-M’s Vision Research Training Grant. Among the many honors Dr. Hitchcock has re-ceived are the William and Mary Greve International Research Scholar Award, the Research Sabbatical Award, and the Senior Scientific Investigator Award from Research to Prevent Blindness. He has also re-ceived a Fogarty Senior International Research Scholar Award from the National Institutes of Health.

kellogg senior scientist named associate dean at rackham Graduate school

Medical innovation Fellows to develop “telehealth” conceptFour fellows from the U-M Medical Innovation Center (MIC) are stationed at Kellogg during the 2012–13 academic year in hopes of finding ideas that have potential for commercial development. The fellows have been on-site since July learning about Kellogg and the field of ophthalmology. They’ve met with personnel from Kellogg’s clinics, labs and satellite offices, have shadowed physicians during patient appointments, and have observed surgeries from the operating room. “It is important for us to know ophthalmology and be immersed in the culture at Kellogg,” says fellow Marius Tijunelis, M.D., M.B.A. (at left). “Although one year is a tight timeline, our team hopes to reach the goal of discovering a true need, developing a solution, and starting the com-mercialization process.” In the fall, the fellows narrowed their list of 10 ideas to 3 and presented them to a group of MIC advisors who helped the group select one concept. The fellows are finalizing an idea related to telehealth to improve patient care.

Peter Hitchcock, Ph.D.


Ophthalmic disease knows no boundaries. Worldwide, complex eye diseases—from glaucoma to age-related macular degeneration to cataract to diabetic retinopa-thy—steal the sight of millions of children and adults every year. According to the World Health Organiza-tion, more than 285 million people are significantly visually impaired and, of these, 246 million have low vision and 39 million are blind. Uncorrected refractive errors remain the major cause of visual impairment. To solve the puzzles of blinding eye disease, Kellogg clinicians and scientists have long believed that col-laboration with our global partners—in clinical care, research, and education—is central to the discovery of new treatments and cures that will improve the lives of patients here and abroad.

To this end, every year our faculty travel the globe with one objective in mind—to participate in the ex-change of knowledge about ophthalmology and vision sciences. And we leave our doors wide open to welcome our partners and peers from eye centers and health care institutions—from Beijing to Copenhagen to New Delhi—to do the same. In the past year, Kellogg faculty have led educa-tional courses on Graves’ eye disease in Guangzhou, China; on neuro-ophthalmology in Zurich, Switzerland; and on specialized uses of contact lenses in Shanghai and Taipei. Our clinicians also regularly participate in mission trips to provide basic eye care and surgical care to patients around the world. “We want to learn from others. And we want

H. Kaz Soong, M.D., Donna Donato, Jonathan Trobe, M.D.

global visionThe Center for International Ophthalmology is advancing

clinical care, education, and research worldwide


others to learn from us,” says Jonathan D. Trobe, M.D., Professor, Ophthalmology and Visual Sciences, and Professor, Department of Neurology. “We believe that it’s not a one plus one equals two, but a one plus one equals ten when we all get together—because everyone has different expertise to share.” Expanding partnerships are highlighted by a June, 2012, visit to the Kellogg Eye Center by Dr. Aravind Srinivasan, administrator of the internationally acclaimed Aravind Eye Hospital in Madurai, India, and a graduate of the U-M Ross School of Business, along with his architect, Israel Gnanaraj. Dr. Srinivasan is also the grandson of Aravind founder Dr. G. Venkataswamy. In preparation for an expansion of their operating facilities, Dr. Srinivasan and his team were eager to learn from Kellogg’s experience. Paul R. Lichter, M.D., who served as Chair during the recent expansion of the Eye Center, led the Aravind team on a tour of Kellogg’s state-of-the-art surgical suites. “The Aravind Eye Care System is unique,” says H. Kaz Soong, M.D., Professor, Ophthalmology and Visual Sciences. “The System, which encompasses 11 hospitals throughout India, performs 900 to 1200 ocular surgeries a day. Their complication rates are

as good as ours in this country and we can learn from their experience.” Since this visit, Kellogg faculty and staff have trav-eled to Aravind. Department Chair Paul P. Lee, M.D., J.D., participated in a strategic planning session for the Glaucoma Society of India hosted by Aravind. He also visited several sites within the eye care system. “The Aravind system is a remarkable realization of Dr. Venkataswamy’s vision to provide high quality eye care

to all and to eliminate needless blindness,” says Dr. Lee. “We hope to establish greater relationships with Aravind as part of Michigan’s expanding global health mission.” Growing collaborations be-tween Kellogg and its international partners have led to the formation of a new platform—the Center for International Ophthalmology, a co-ordinating agency for interchanges between ophthalmologists and vision scientists here and abroad. The Center is part of a larger

network of international initiatives under the University of Michigan Global Reach program. “We have our own projects and creativities,” says Dr. Trobe. “Yet we are integrated with the U-M Global Reach program, which seeks to unify all efforts across campus.”

“We believe that it’s not a

one plus one equals two, but

a one plus one equals ten

when we all get together—

because everyone has differ-

ent expertise to share.”

— Jonathan D. Trobe, M.D.

Christine Nelson, M.D., speaking with oculoplastic surgeons from China during a tour of the Kellogg Eye Center.

H. Kaz Soong, M.D., Paul Lee, M.D., J.D., Aravind Srinivasan, M.D., Israel Gnanaraj, and Paul Lichter, M.D., after a presentation by Dr. Srinivasan.


Raymond Douglas, M.D., Ph.D., with Fengyuan Sun, M.D., Tianjin, China

Sherry Day, O.D., top row, second from right, in Migori, Kenya with colleagues from Henry Ford Hospital and the University of Michigan Health System on a ten-day trip sponsored by Kenyarelief.org

The Department of Ophthalmology and Visual Sciences has initiated the Michigan Ophthalmology Trainee Career Development Award, a new academic grant pro-gram that encourages residents and trainees to pursue projects they are passionate about. Recipients of the award select faculty at Kellogg and throughout the cam-pus to partner with them in accomplishing their goals. Since its inauguration, two grants have been awarded to Kellogg residents. Crandall E. Peeler, M.D., second-year resident, will travel to Bhairawa, Nepal to evaluate whether a low-cost automated fundus camera can improve screening efforts in rural areas. A central question in his project is whether health care workers with little training in ocu-lar photography can use the portable camera to capture high-resolution fundus photographs used to diagnose eye disease. His goal is to help remote clinics identify patients who should be referred to larger medical cen-ters where higher level care for eye disease is available.

Abigail T. Fahim, M.D., Ph.D., also a second-year resident, received grant funding for her research in X-linked retinitis pigmentosa (XLRP), an inherited blinding disorder of the retina. Dr. Fahim is working to understand how lyonization, a process in which one X chromosome is silenced in every cell of a woman’s body, affects disease severity in women who carry a mutation for XLRP. All residents and trainees are eligible to apply for the award, and proposals are reviewed by the Kellogg Research and Therapeutics Committee.

inspiring innovationnew resident career development Grant

Abigail Fahim, M.D., Ph.D.Crandall Peeler, M.D.


Specialists in inherited retinal diseases—rare eye condi-tions that often lead to blindness or near blindness—are few and far between. Yet these physicians offer their patients a great deal of hope by identifying complex conditions and then confirming the diagnosis with genetic testing. To share the expertise of this small group of retina experts, Thiran Jayasundera, M.D., a specialist in reti-nal dystrophy at the Kellogg Eye Center, is collaborat-ing with faculty from the U-M College of Engineering. Together, they plan to create a computer model, RetDe-genDx, to help physicians arrive at a diagnosis for their patients—the first step in finding treatments for uncom-mon retinal diseases.

The Kellogg Eye Center is a natural starting point for such a system. John R. Heckenlively, M.D., the Paul R. Lichter Professor of Ophthalmic Genetics, has kept genetic profiles of his patients for years, creating a rich collection of clinical observations linked with genetic tests confirming the causative gene or genes. “It’s still very early in the development process,” observes Dr. Jayasundera, who completed a fellowship with Dr. Heckenlively before joining Kellogg’s faculty. “But we know that data like this could help direct at least a small group of patients to the correct therapeutic trial.” The engineering team will develop image recogni-tion software to identify indicators of disease that a specialist like Dr. Jayasundera would readily see in

sharing the expertisea computer model could help more patients know which genes—and

emerging treatments—are linked to their retinal disease

Kellogg’s retinal dystrophy team includes physicians, genetic counselors, and research scientists. Back row: Sarwar Zahid (medical student), Jillian Huang, M.S., David Zacks, M.D., Ph.D., Kari Branham, M.S., C.G.C., Naheed Khan, Ph.D. Front row: Debra Thompson, Ph.D., John Heckenlively, M.D., Thiran Jayasundera, M.D.

innovation in research 17

scans of his patients’ retinas. Added to the data are profiles of individual patients with confirmed diagnoses, including the causative genes that have been identified. As the tool grows with confirmed cases, it would allow another physician to enter a retinal scan and clinical data, triggering a search for near matches. In the best case, the physician would receive a probable diagnosis and a “short list” of genes to be tested. Besides offering patients and doctors a faster diag-nosis, RetDegenDx has economic advantages. Genetic testing is costly, and few clinics can afford the time or expense of testing for more than a few “suspect” genes among the 185 that have been identified in retinal diseases to date. “Developing this type of scan recognition, combining it with clini-cal data, and creating a diagnostic tool is a straightforward engineering problem,” says Gail Hohner, Man-aging Director of the U-M College of Engineering’s Multidisciplinary Design Program. “Our engineer-ing students will be part of a team developing algorithms to identify patterns and make predictions from a wide range of variables,” she says. “Because the system improves as more data are entered, the key is to collect as many cases as possible from clinics across the country.” Dr. Jayasundera observes that a few clinical trials for retinal dystrophies are beginning to emerge with gene therapies and stem cell treatments. “As new thera-pies are discovered, we want to make sure that patients

everywhere have a chance to learn about trials that could benefit them,” he says. “We hope that RetDegenDx is the tool that links patients with the treatments that can target their specific conditions.”

Tracking the progression of stargardt’s diseaseLearning about the progression of a disease may help researchers develop new treatments or direct patients to clinical trials. Thanks to a grant from the Midwest

Eye-Banks, Dr. Jayasundera and his team will monitor the vision of a group of Kellogg patients affected by Stargardt’s disease, an inherited eye disease that affects children and young adults, and results in the loss of central vision. Compared to macular degenera-tions that affect adults, Stargardt’s progresses at a relatively fast pace. Using an analysis algorithm devel-oped at the Kellogg Eye Center, the research team hopes to track the stages of vision loss at an earlier point

in the disease than is now possible. “This study should help us understand how young patients with similar characteristics will progress over time,” says Dr. Jayasundera. “That information could tell us who might benefit from therapies on the horizon or in newly emerging clinical trials.”

“As new therapies are

discovered, we want to

make sure that patients

everywhere have a chance

to learn about trials that

could benefit them.”

— Thiran Jayasundera, M.D.

Dr. Jayasundera is also involved in a new study on Stargardt’s disease.


Over the past year, Kellogg researchers and clinicians have been laying the groundwork for a new clinical trials center to meet the needs of patients who seek promising new treatments for eye disease. One of the driving forces behind the center is Grant M. Comer, M.D., M.S., a retina specialist and the Edward T. and Ellen K. Dryer Career Develop-ment Professor. “Clinical trials allow us to determine whether promising new medications are effective and safe in treating eye disease,” says Dr. Comer. “Our patients look to us for the latest advances in treatment, especially when they experience dis-eases for which there are less than optimal treatments—or none at all.” Renovations will soon begin to create a more con-venient setting for research volunteers. The new space will also accommodate the larger clinical staff needed to help manage compliance with federal regulations, study protocols, and increasing reporting requirements.

Highlighted studies and trials at Kellogg: Dr. Comer is currently recruiting volunteers for a two-year observational study to investigate functional and structural changes to the retina before and after treatment with anti-VEGF agents. His goal is to determine the source of vision loss in macular edema, a condition in which leaking blood vessels cause swelling of the retina. Victor M. Elner, M.D., Ph.D., and his team are using novel non-invasive imaging he developed in 2008 to assess severity and treatment of juvenile diabetes and age-related macular degeneration. These diseases are traditionally evaluated only by alterations in vision or ocular structure that occur late in the disease and only slowly respond to treatment. The new imaging is being used to assess metabolic status of retinal cells that changes early and rapidly in early disease and after treatment, giving researchers a more effective guide for dealing with these diseases. John R. Heckenlively, M.D., is helping to test whether the compound, valproic acid (VPA), would be a good candidate for treating retinitis pigmentosa (RP). To date there are no FDA-approved treatments for RP, a group of diseases in which damage to retinal cells leads to gradual loss of vision and eventual blindness. The trial will collect safety information and will evaluate the ability of VPA to slow or even reverse vision loss from RP.

Kellogg has also been awarded a National Eye Institute Clinical Trial Planning Grant to develop the infrastructure needed to carry out a large multi-center glaucoma trial. The proposed trial would evaluate whether statins, a class of drugs used to lower cholesterol, could prevent disease progression among individuals with mild to moderate open-angle glaucoma. David C. Musch, Ph.D., M.P.H., and Joshua D. Stein, M.D., M.S., will lead the effort.

Dr. Comer and the clinical research staff are optimistic about the impact the center could have on improving eye care. “We are hopeful that we can de-velop clinical studies to bring more treatments to more patients on a fast, safe, and effective timeline,” he says.

“Our patients look to us for

the latest advances in treat-

ment, especially when they

experience diseases for which

there are less than optimal

treatments —or none at all.”

— Grant Comer, M.D., M.S.

on Clinical researchKellogg is building a next-generation center to evaluate new treatments

FocusGrant Comer, M.D., M.S., is helping to lead Kellogg’s clinical research initiative.


How frequently should your ophthalmologist ask you to undergo testing for glaucoma? The answer is im-portant because patients with glaucoma who are not seen frequently enough are at risk of losing vision that cannot be restored. Yet too-frequent monitoring can be a burden for patients. A new computer modeling system could help physicians—especially non-specialists—predict which patients are likely to remain stable and which are likely to experience worsening disease over a relatively short time. The patient could then be advised when to return to the clinic for testing and treatment based on output from an algorithm. The project is a collaboration of Kellogg glaucoma specialist Joshua D. Stein, M.D., M.S., and epide-miologist David C. Musch, Ph.D., M.P.H., and colleagues in Industrial and Operations Engineering at the U-M College of Engineering, includ-ing Mariel S. Lavieri, Ph.D., and Mark P. Van Oyen, Ph.D. For specialists like Dr. Stein, the model provides one more tool to aid with decision making. “Technology of this sort is not a replacement for the judgment of the physician,” he says. “But taking advantage of computer modeling–based innovations can absolutely enhance our diagnostic abilities.” Over 2.2 million Americans have glaucoma, a lead-ing cause of visual impairment in the United States and worldwide. Because glaucoma often occurs without symptoms, a patient can experience irreversible vision loss before being diagnosed with the disease. Any delay in treatment can have significant consequences. “There are also costs to having patients return to

the clinic for testing more often than needed,” says Dr. Stein. “And patients can become anxious while under-going testing, which can lead to unreliable results and the need to repeat the test.” The computer model, which projects a personalized “time for next test,” is novel because it is updated each time a test has been performed. The algorithm is based on data from large clinical trials in combination with patient information—such as eye pressure and visual field test results—that accumulates as more tests are completed.

The research team has filed a patent for the model, which has applications beyond glaucoma or even eye disease. “An algorithm like this can be applied to any chronic disease that requires test-ing over time,” says Dr. Stein. “It could help physicians manage diabetes and high blood pressure, or any condition requiring repeated measurements.” The research team has validated the model by testing it against data from national clinical studies. One such trial,

the Collaborative Initial Glaucoma Treatment Study, led by investigators at the Kellogg Eye Center, provided 10 years of test results on over 600 patients with newly di-agnosed glaucoma. “When we compared our algorithm to currently accepted testing practices represented in the trial, it demonstrated better accuracy and decreased de-lay in identifying disease progression,” says Dr. Lavieri. “Our work is based on foundational systems en-gineering models that also allowed us to put a man on the moon,” says Dr. Van Oyen. “This research will lead to more efficient use of resources with more effective patient care.”

Mark Van Oyen, Ph.D., Mariel Lavieri, Ph.D., and Joshua Stein, M.D., M.S.

“Our work is based on

foundational systems

engineering models that

also allowed us to put

a man on the moon.”

— Mark Van Oyen, Ph.D.

Joining Forces to develop a new diagnostic Tool

A computer model could help determine

how often to test for progression of

glaucoma and other chronic conditions


Fostering repair processes in diabetic retinopathy

Steven F. Abcouwer, Ph.D., Associate Professor, Oph-thalmology and Visual Sciences, has been awarded a National Institutes of Health grant (R01). Under the grant, Bone Marrow Neuropathy Drives Diabetic Retinopathy, Dr. Abcouwer and colleagues at Michigan State University and the University of Florida will study repair processes that may prevent the progression of retinal tissue damage and inflammation that results in loss of sight during diabetic retinopathy. “Our work is based on the observation that

diabetes impedes nerve commu-nication with the bone marrow, which is necessary for the release of stem-cell-derived precursor cells that travel to sites of tissue damage and aid in their repair,” says Dr. Abcouwer. “Previous studies have focused on processes that lead to retinal damage, rath-er than restoration. This research is significant because it could lead to ways of preventing diabetic retinopathy by fostering the bod-ies’ own repair processes.”

Kellogg is awarded an nei Training granT

grant highLights

kellogg will train clinician-scientists under a new neI k12 Training Grant

The Kellogg Eye Center has been awarded a grant to recruit, train, and mentor ophthalmologists who plan to develop research programs in tandem with their clinical practice. Kellogg is one of six ophthalmology departments in the nation to have received this award from the National Eye Institute, whose goal is to increase the number and effectiveness of clinician- scientists in ophthalmology and vision sciences. Newly trained ophthalmolo-gists, who have had years of medi-cal education, often find it difficult to invest additional time acquiring the skills needed to develop successful research pro-grams. Under the grant, Kellogg is recruiting candidates to the Michigan Vision Clinician-Scientist Development Program and will provide them with mentoring, pro-tected time for research, core instruction, and a range of skills that will enable them to manage a major research enterprise. The program is designed to help trainees

make the transition from participating in mentored research projects to serving as investigators for indepen-dently funded projects. “The K12 grant provides an avenue for the Depart-ment to recruit and train outstanding clinician-scien-tists,” says Thomas W. Gardner, M.D., M.S., Associate Chair for Research. “We expect to attract candidates who are extremely bright, inquisitive and mindful that

research discoveries arising from clinical practice can help us elimi-nate preventable vision loss and improve the lives of our patients.” Dr. Gardner and Department Chair Paul P. Lee, M.D., J.D., will serve as co-principal investigators for the grant. In their proposal they cited the tremendous re-sources of the U-M Health Sys-tem, which was awarded $368.7

million in research grants from the National Institutes of Health in 2011, as well as the Kellogg Eye Center’s research strengths in areas such as retinal stem cells and regeneration, diabetic retinopathy, epidemiology and biostatistics, and thyroid eye disease. In 2012, Kellogg was ranked 5th in NIH funding awarded to depart-ments of ophthalmology.

“The K12 grant provides an

avenue for the Department to

recruit and train outstanding

clinician-scientists.”

— Thomas W. Gardner, M.D., M.S.

Steven Abcouwer, Ph.D.


preventing retinal cell death associated with diabetes

Patrice E. Fort, Ph.D., M.S., Research Assistant Profes-sor, recently received a National Institutes of Health grant (R01) for his project, Progressive Impact of Dia- betes on Retinal Neuroprotection by Alpha-Crystallins. Dr. Fort is studying how the natural adaptive mecha-nisms for protection of the retina are impaired by diabetes—which leads to cell death and ultimately loss of vision. “Understanding how the protective abilities of alpha-crystallins [neuroprotective proteins] are af-fected in disease states will enable us to develop novel approaches to manipulate these pathways and provide therapeutic benefit to preserve vision in persons with diabetes,” says Dr. Fort. “This research is significant because it could lead to the development of new thera-peutic strategies for diabetic retinopathy and other chronic retinal neurodegenerative disorders such as age-related macular degeneration.”

Finding the optimal gLauComa treatment for each patient

Sayoko E. Moroi, M.D., Ph.D., Professor and glaucoma specialist, is also a recent recipient of a National Institutes of Health award (R01). Under the four-year collaborative research investigation, Aqueous Humor Dynamic Components that Determine Intraocular Pressure Variance, Dr. Moroi seeks to identify biomark-ers associated with fluctuation in eye pressure and variation in response to glaucoma treatment that will make it possible to predict the optimal treatment for each patient. “If there are biomarkers that are linked to a poor response, then we may be able to avoid unneces-sary treatment and wasted office visits,” says Dr. Moroi. “Using these profiles to determine in advance the best treatment could have a major impact in preventing the most severe effects of the disease.”

Plus diabeTes and glauComa granTs

grant highLights

Patrice Fort, Ph.D., M.S.

Sayoko Moroi, M.D., Ph.D.


Kellogg researcher Kwoon Y. Wong, Ph.D., investigates retinal neurons that drive subconscious physiological responses to light—such as pupil reflex, the synchroni-zation of the sleep-wake cycle with environmental light-dark cycles, and the modulation of hormone secretion. Dr. Wong believes this research would benefit from collaboration with other departments at the University. “We could partner with architects to study how lighting conditions might influence subconscious vision or with engineers to develop novel lighting technologies that optimally stimulate these subconscious visual neurons,” says Dr. Wong. “But lack of fund-ing has been an issue.” Such collaboration is a reality thanks to MCubed—a new U-M program designed to fund pilot studies that spark innovation and foster multidisciplinary teamwork. To qualify, researchers form teams of three, representing at least two disciplines. Funded projects receive $60,000. The first 50 projects were selected in November. Kellogg epidemiologist David C. Musch, Ph.D., M.P.H., along with faculty from the Department of Otolaryn-gology-Head and Neck Surgery and the College of Engi-neering, received funding for a project on the potential benefit of using antacids to treat skin cancer of the head and neck. Retina specialist Thiran Jayasundera, M.D., and colleagues from the College of Engineering won funding to create a computer model for patients with inherited retinal diseases (read more on page 16). MCubed plans to select 200 additional projects, and more than 20 Kellogg faculty members—like Dr. Wong—are hopeful their projects will be chosen.

Fast Forward to tomorrow’s curesAnother initiative to support research at Michigan is the Strategic Research Initiative—a $100 million com-mitment over three years from the Medical School Dean’s Office. Its goal is to “fast forward” research around a common vision to develop tomorrow’s cures. As a first step, the Health System’s research strengths were identified—cancer, inflammation, meta-bolic diseases, vascular diseases, and nervous system

disorders. From there, the goal was to discover opportunities at the intersections of 10 research strengths, including drug development, person-alized medicine, and aging. U-M researchers, including 15 Kellogg faculty members, have formed interdisciplinary teams to develop proposals. Winners will be announced in early 2013. “Research in the visual sciences

fits quite naturally at the intersections defined by the Dean’s initiative,” says Paul P. Lee, M.D., J.D., Chair and F. Bruce Fralick Professor of Ophthalmology. “Our faculty are currently working on aging and eye disease, drugs targeted at retinal disease, and personal-ized therapies for glaucoma—to name a few areas that could yield new treatments for eye disease.” The initiative began with a large investment in infrastructure, the purchase of the North Campus Research Complex in 2009. The facility, designed to foster multidisciplinary collaboration among research-ers, houses biomedical research core facilities with DNA sequencing technologies and centralized data storage, as well as a biorepository and space for clinical trials.

Kwoon Wong, Ph.D., who investigates subconscious vision, sees potential for collaboration with architects on lighting technologies.

“Research in the visual

sciences fits quite naturally

at the intersections defined

by the Dean’s initiative.”


u-m initiatives to spur researchTwo new programs will help fund collaborative

research throughout the university


400 health services researchers will work together to make health care better, safer, and more cost effective

Joshua D. Stein, M.D., M.S., a clini-cian and health services researcher at the University of Michigan Kellogg Eye Center, uses large health care databases to study utilization patterns and patient outcomes of eye care in the United States. Now, Dr. Stein will have access to even more resources—as well as more opportunities to collaborate with U-M faculty and others—as a mem-ber of the newly created U-M Institute for Healthcare Policy and Innovation (IHPI). IHPI is one of the nation’s largest communities of physicians, scientists, and policy analysts studying how health care works and, more importantly, how to improve it. To date, IHPI is comprised of approximately 400 health services researchers at U-M, as well as non-profit and private sector organizations. “The idea behind IHPI is to gather talented individuals from different disciplines and university programs and give them the shared space and support they need to successfully understand the changing health care system, advance beneficial health-related policies, and inform efforts to improve patients’ well-being through health services research,” says Dr. Stein. “Although IHPI members come from many different departments and programs throughout the University, we are now positioned to pool our resources and learn from one another in a highly collaborative environment.” In addition to facul-ty from the U-M Medical School, IHPI members include faculty from the U-M School of Public Health, the Ford School of Public Policy, and the U-M Institute for Social Research. Founded in 2011, the Institute is an initiative

of the U-M Medical School. According to Department Chair and IHPI member Paul P. Lee, M.D., J.D., the Institute will tap the expertise of specialists in health care data analy-sis, among them Marie Lynn Miranda, Ph.D., Dean of the U-M School of Natural Resources and Environment. “Dean Miranda has made ground-breaking use of geospatial mapping in health care,” he says. “We are fortunate that her team will be applying those tools to the new W.K. Kellogg Founda-tion grant to improve utilization of eye care services by children throughout

the state of Michigan, especially in disadvantaged communities.” Geospatial mapping allows researchers to visualize data related to the locations of patients, patterns of health care, and social and community resources for a given area. “Through affiliation and partnerships with other centers and institutes at Michigan, we can begin to

link changes in public policies to improvements in the health of people in Michigan and around the United States,” adds Dr. Lee. In addition to Dr. Lee and Dr. Stein, Kellogg is represented by Paul R. Lichter, M.D., David C. Musch, Ph.D., M.P.H., Roni M. Shtein, M.D., M.S., and fellow Paula Anne Newman-Casey, M.D. “Establishing this institute shows U-M’s commitment and dedication to supporting researchers and creating an

environment for us to achieve our potential as health care innovators,” says Dr. Stein. “We now have an exciting opportunity to come together, share ideas, and learn from each other. Through our synergy, we hope to make substantial contributions to the practice of health care and the health of patients here in Michigan and around the globe.”

Joshua Stein, M.D., M.S.

“We hope to make sub-

stantial contributions to

the practice of health

care and to the health

of our patients.”

— Joshua D. stein, M.D., M.s.

Sharing Resources and Collaborating on tough health Care issues


Last year, Joanne Rackham, 81, and Katherine Rackham, 80, of Plymouth, Michigan, grandnieces of U-M benefactors Horace H. and Mary A. Rackham, widened the reach of their extraordinary family legacy with their bequests to the Kellogg Eye Center in support of cornea research. The planned gifts celebrate their special relationship with Alan Sugar, M.D., Professor and Vice Chair, Ophthalmology and Visual Sciences, who has cared for Joanne for over 25 years. The gifts will establish an endowment to support cornea research in perpetuity. “We want Dr. Sugar to have what he needs to do his research. My work and Katherine’s work always meant everything to us, and now Dr. Sugar’s work is

the future we care most about. He will change the world for so many people,” says Joanne. “Dr. Sugar is the greatest guy in the world. He’s been a savior to me. There are people who come along once in a lifetime who are irreplaceable. Dr. Sugar is one of them.” With full agreement and gratitude, her sister Katherine adds, “The man is remarkable.” The sisters’ longstanding relationship with the University of Michigan Kellogg Eye Center began in 1987 when Joanne was diagnosed with Fuchs dystro-phy, an inherited corneal degeneration that required her to have a first corneal transplant in her right eye in 1987 and a second in her left eye in 1993. “I would sit in the waiting room and see children and ladies who

Katherine (left) and Joanne (right) Rackham visit the plaque honoring their late uncle in the rotunda of his namesake Horace H. Rackham School of Graduate Studies.

a Legacy of sightgrandnieces of u-m benefactors horace and mary rackham honor a beloved Kellogg cornea specialist with their bequests to advance ophthalmic research


were also dealing with this condition. I wanted to help them. This is something I can do as a service, because I didn’t have any children myself.” Retinal specialist, Andrew K. Vine, M.D., also assisted in Joanne’s care when she needed treatment for a detached retina. Affecting four percent of the population, Fuchs disease destroys the thin layer of cells that line the back part of the cornea and is the leading indication for corneal transplantation. More common in women than in men, the disorder typically affects individuals in their 50s or 60s—although occasionally appears earlier in adulthood. Dr. Sugar admits he was greatly surprised when he learned of the bequests. “The generosity of the Rackham sisters is remarkable,” he says. “It shows a willingness to create a lasting legacy that will help patients for decades to come. I am deeply honored.” The cornea service will use this gift for generations to gain better understanding of the physiology of Fuchs disease and its genetics, advance surgical techniques, and improve donor cornea preparation and eye banking. “I don’t think that we will end corneal dystrophies and degenerations, but we will lessen the blindness they can cause and improve the lives of those with these conditions,” says Dr. Sugar. The sisters—and last remaining heirs to carry the Rackham name—continue the family legacy in support of intellectual exploration that began in 1935 when trustees of the Horace and Mary Rackham Fund gave the University of Michigan $6.5 million for the con-struction of the Rackham Graduate School and an

endowment for graduate education. At the time it was the largest gift ever given in support of graduate education in the United States, and without a doubt in the world. The Rackham Graduate School continues today as the home of graduate and professional education at the University of Michigan and as a major center of cultural and intellectual exchange. Paul P. Lee, M.D., J.D., Chair of the Department of Ophthalmology and Visual Sciences, says, “Dr. Sugar’s

research has advanced our under-standing of corneal transplanta-tion and degenerative diseases like Fuchs dystrophy. With this gift, Dr. Sugar and his team will be able to carry their work forward to have an enduring impact on patients who suffer from corneal disease. It is a fitting tribute to one of our most distinguished and respected faculty members.” For the past thirty years, Dr. Sugar has provided a small white card with his office phone number,

home phone number, and paging number to all his surgical patients. “Something as simple as this card reflects Michigan’s philosophy of patient-centered care, of thinking what would most help our patients when they encounter problems, even if it’s in the middle of the night,” he explains. Over the years, Joanne was one of many patients who benefited from Dr. Sugar’s uncom-mon kindness. “One of my girlfriends needed eye care recently, so I called Dr. Sugar to ask if he accepted refer-rals,” says Joanne. “Then I gave her his home phone number. She still sees him and is doing very well.”

“The generosity of the

Rackham sisters is remark-

able. It shows a willingness

to create a lasting legacy

that will help patients for

decades to come.”

— Alan Sugar, M.D.

Joanne (left) and Katherine Rackham have made plans to establish an endowment for cornea research. Joanne is a longtime patient of Dr. Alan Sugar (right).


foCus on TranslaTing researCh inTo

Dr. Gardner is the Taubman Healthy Eyes Scholar

Thomas W. Gardner, M.D., M.S., Professor of Ophthal-mology and Visual Sciences and of Molecular and Integra-tive Physiology, has long been recognized for his research to find novel treatments for diabetes-related eye disease. Dr. Gardner was named the first Healthy Eyes Scholar by the A. Alfred Taubman Medical Research Institute and JDRF, formerly the Juvenile Diabetes Research Foundation, the leading global organization focused on type 1 diabetes research. JDRF and the Taubman Institute will support a three-year grant for Dr. Gardner to study novel treat-ments and biomarkers—indicators that can measure the progress of disease and the effectiveness of treatments — for diabetic retinopathy, the most common complica-tion of diabetes and the leading cause of legal blindness among adults aged 20 to 74 years in the United States. “Dr. Gardner’s focus on detection of preclinical diabetic eye disease—that is, before individuals or their physicians realize that eye function is deteriorating—would allow people with diabetes to be treated at an earlier stage of the disease when therapy is more likely to be effective,” says Helen Nickerson, Ph.D., JDRF’s senior scientific manager of complications. “Validated methods of early detection would also reduce the time needed to conduct clinical trials and speed the develop-ment of new therapies for diabetic eye disease.” Dr. Gardner will receive $150,000 for each of three

years from the Taubman Institute’s endowment and JDRF. The JDRF grant is supported by the Ford Mo-tor Company Fund as part of JDRF’s Healthy Eyes Project, an initiative to ensure that ad-vances in retinopathy science are translated into treatments for people with diabetes. “This research offers promise for those facing or living with blindness caused by diabetes,” says James G. Vella, president of the Ford Motor Company Fund and Community Services. “This investment is made possible by

the thousands of Ford employees around the world who together with Ford Motor Company have raised tens of millions to support JDRF and diabetes research.” The collaboration with JDRF marks the first time an outside organization has co-sponsored a Taubman Scholar. “This exciting alliance will make it possible for us to accept yet another eminent researcher into the program,” says Eva L. Feldman, M.D., Ph.D., Director of the Taubman Institute. “We’re proud of our relation-ship with JDRF and delighted to welcome Dr. Gardner and his colleagues to our pool of scientists who are working on cutting-edge cures and treatment.” “I’m thrilled and honored,” says Dr. Gardner. “We hope to not only understand what causes retinopathy and how to prevent it, but perhaps even to restore the vision in patients who have lost it,” he says. “Right now we truly have nothing to offer those people, but our goal is to change that. The Taubman Institute likes bold and audacious ideas, and we’ve given them one.”

Thomas Gardner, M.D., M.S., Kate Durak, JDRF, and Paul Lee, M.D., J.D.


new TreaTmenTs for eye disease

Dr. Kahana is a Taubman Emerging Scholar

Alon Kahana, M.D., Ph.D., Assistant Professor and Helmut F. Stern Career Devel-opment Professor of Ophthalmology and Visual Sciences, directs a research program investigating the use of stem cells to regenerate eye tissue. Now he has been named the Mrs. William Davidson Emerging Scholar by the Taubman Emerg-ing Scholars Program

at the A. Alfred Taubman Medical Research Institute. The Emerging Scholars Program, created to support early career physician-scientists whose laboratory work aims to translate basic research into new treatments for disease, connects University of Michigan Medical School faculty members at the as-sistant professor level with philan-thropists who pledge to support the physicians’ research for three years—at $50,000 per year. “We urgently need the best and brightest doctors who are motivated by the patient suffering they witness each day to continue to develop new therapies,” says Eva L. Feldman, M.D., Ph.D., Director of the Taubman Institute. Dr. Kahana’s research focuses on the use of stem cells to regenerate eye tissue lost to injury or disease.

“We believe that regenerative medicine will play a key role in the future of medical care,” says Dr. Kahana. “Our work on eye muscles has identified stem cells and pathways that could one day be used to facilitate regen-eration as therapy for muscle disorders affecting vision, as well as for degenerative disorders such as Duchene muscular dystrophy. In addition, greater understanding of the role of stem cells in driving tissue repair versus scarring could help us develop new approaches to the treatment of complex eye conditions, such as thyroid eye disease.” Karen Davidson will tell you that what struck her most when she first met Dr. Kahana was his enthusiasm for research. “He has such passion to grow our under-standing of disease and directly affect treatment. If there’s anyone who can do it, he can. And I really hope he does,” says Mrs. Davidson. “My family has been personally impacted by the type of orbital eye diseases that Dr. Kahana studies. I want to do what I can to help others who struggle with these diseases—they deserve to have hope. Finding meaningful treatments could

significantly improve outcomes for these patients.” “I’m honored to be the recipi-ent of Mrs. Davidson’s trust and generosity,” says Dr. Kahana. “This gift provides the oppor-tunity to have an impact on the lives of patients, colleagues, and

trainees. And, it connects us with some of the most ac-complished scientists and physicians at the University of Michigan. Her belief in our research has motivated us to work even harder to develop new treatments and cures to blinding and debilitating diseases. We are very grateful to Mrs. Davidson, as well as Mr. Taubman and Dr. Feldman, for their support and leadership.”

“We believe that regenerative

medicine will play a key role

in the future of medical care.”

— Alon Kahana, M.D., Ph.D.

Alon Kahana, M.D., Ph.D.


annual honor roll of donorsWith heartfelt thanks to donors

who made gifts from July 1, 2011,

through June 30, 2012. Included in

this listing are contributors whose

donations are part of multi-year

pledges.

$500,000 to $999,999Lynn H. and Robert W. BrowneJuvenile Diabetes Research Foundation

$100,000 to $499,999Anonymous Donor The Carls FoundationArnold and Mabel Beckman FoundationJerome Jacobson FoundationEdwin E. Meader EstateJoel and susan MindelElsa U. Pardee FoundationResearch to Prevent BlindnessThe Harry A. and Margaret D. towsley foundation

$50,000 to $99,999Anonymous Donors (2) The Foundation Fighting BlindnessLois M. Mcclain estateMickey and Karen ShapiroTimothy and Laurie G. Wadhams

$10,000 to $49,999American Diabetes Association, Inc.BCBSM FoundationBirkhill Family FoundationMichael and Joanne BissonThomas W. BreakeyEric and Sara ConnSandra and David DetrisacRuth Dixon Ann S. EdwardsFrances and David H. GrossmanRichard F. and Susan GutowCharles S. and Ann S. HutchinsWilliam and Gina KeoughAl and Colette KesselDrs. Vik and Bithika KheterpalRonald Kurtz and Jennifer SimpsonCarolyn and Paul LichterKeith and Della McKenzieThe Meijer FoundationLarry G. MillerBruce and Roberta OliverGilbert S. Omenn and Martha A. Darling Michael PachtmanMildred E. Swanson FoundationDavid and Jayne VerLeeMargaret F. Vezina EstateThe Honorable Nancy C. Wheeler

$5,000 to $9,999Carol A. BallJason M. Burgett, M.D.Don and Betts ChisholmMark and Judith CohenScott M. Corin and Nina Blumenthal

Dow chemical company foundationMichael G. and Deborah L. Harrison Tarek S. Hassan and Diana M. Gomez-HassanHelen and Richard Kerrsusan J. LaneCorey MillerCarol StandardiGerald and Joyce TrocchioDanny D. Wang and yili WangW. Scott and Jill Wilkinson

$1,000 to $4,999Anonymous Donors (2) Gerald and Gloria AbramsAnthony and Mary AdamisAmjad Z. Ahmad, M.D.Steven and Carol Archer Dr. and Mrs. Robert C. ArendsEverton and Saundrett ArrindellBetty Baier and Mark KessonHarry and Patricia BashAnne and Terry J. BergstromRhoda L. and Roger M. BerkowitzDonald and Christine BeserRohit and Shakti BhatnagarGeorge F. BlassEleanor E. BrownellElizabeth A. CallawayBruce D. Cameron, M.D.Keith D. and Cheryl D. CarterJanet and Bill CassebaumDr. William S. CliffordPaul Cochranclaude M. colemanglen copeland

“Generous donor support has allowed

us to follow hunches and explore new

ideas that are outside the scope of

NIH-funded research. This has resulted

in exciting discoveries and new avenues

of research that otherwise may not

have been possible.”

— Bret a. Hughes, Ph.d. Professor

WITH GRATITUDE FOR GIFTS MADE FROM JULy 1, 2011, THROUGH JUNE 30, 2012


Wayne T. and Barbara M. CornblathDr. and Mrs. Morton S. CoxKatherine and Ralph CrewDamon’s GrillGloria P. and William E. Dean, Jr.Jane and Irwin Deister, Jr.Monte A. and Kristen G. Del MonteRosemarie DeLandJames R. DevineMary Hunter DobsonJ. McGregor and Christine DoddsMagdalen Skuba EdwardsMichael and Elizabeth EichlerMeelad ellisthomas f. and susan W. essmanHal and Donna EstryMurray J. and Lynda L. FeiwellJoe and Beth Fitzsimmonsh. halladay and Jean e. flynnVictor P. and Mary E. FreligaDasa and Nalini GangadharTom and Maureen Grace GardnerRichard and Lisa GarfinkelSunir J. Garg, M.D., and stella Luo, M.D.Larry and Mary GerbensJames and Charlene GlerumMartin R. and Rise GoodeMr. Waleed K. GosaynieJoanne R. GradowskiGrand Lodge of Michigan Kathryn G. GrayDaniel and Norma GreenRobert and Teresa GrosserodeEugene R. and Phoebe M. HarcumTheodore and Naomi Harrison David S. Hemmings, M.D.Myron HepnerBarry and Mary Ann HoffmanRobert O. and Carolyn S. HoffmanHelen W. Holmes TrustJames and Kathy HolmesWalter L. and Barbara J. HungerfordJewish community foundation of Ann ArborJoja Hospitality, LLCProfessor Judy M. JuddMr. Leslie Kahn and Ms. Irene WatcherRita Barbour KernNancy and Jeffrey Khan, M.D.James G. and Carolyn KnaggsPaul and Jennifer LeeJohn and Suzanne LeyKim Lindenmuth and Matthew BuecheWilliam W. LoveFrode and Marilyn MaaseidvaagJames Albert MaraldoDonald and Jacqueline MccullochJudge Joe B. McDade and Mrs. Mary W. McDadeCarolyn E. Mesara

Dr. and Mrs. P. Anthony MezaDean and Lynn Mitchellnicholas and shannon MitticaCruse W. MossAndrew MoyesKen and Pat MussonJohn and Phyllis napleyMark and Susan OrringerPam W. ParrishAllen and Kathy PearceMichael Petersen and Elizabeth BinasioJeffrey A. PikeScott M. Pinter, M.D.Sally J. PryceJames and Nancy RavinRebekah Assembly of MichiganJonathan and robin roweEllajane S. RundlesStephen J. and Kim R. SaxeDavid W. Schmidt, M.D. Dr. and Mrs. Gregory L. SkutaFrancis Soans, M.D.Mark and Romana SolentPeter K. and Faye B. SpeertAlan and Gail SugarErrol R. and Berry SweetMichele Tameris-CookEdward and Karen TennerJames B. Thompson and Mary Ann BrandtVictoria TkachTriford FoundationAdele and Peter VaculikAndrew Vine and Caroline BlaneRichard L. and Kay E. WatnickLee S. and Stephen T. WebsterJohn and Carol WeigelDrs. Adrienne West and Mark HemmilaHerbert E. WestonGeorge C. and Cindy WhitakerMarina V.N. and Robert F. WhitmanAlfred and Carol WickMary June WilkinsonThe Lawrence and Sylvia Wong FoundationFuxiang and Fenfen ZhangKate and Jeffrey Zink

$500 to $999Roger D. ArnettLana L. BerryRobert D. Biggs, M.D.Steven A. Boskovich, M.D.James and Jacqueline BowenArlene R. CaonRichard and Enid CarlinHideki and Tomomi ChumanGrant and Alicia Comer Mr. Frank and Dr. Theresa Cooney

“All of us at Kellogg are dedicated

to integrating our clinical care,

research, and educational missions.

Grateful patients and donors are

essential in helping us realize

our goal of treating, curing, and

preventing eye disease.”

— michael W. smith-Wheelock, m.d. assistant Professor associate chair for clinical affairs



Arnold and Susan CoranEvonne DamianosRoland and Louise W. DeMartinRoberta Demott-FribergGayle D. DickersonJohn s. DunnDeborah EadieCheryl and Bruce ElliottThe Estate of Emily Joslin Robert and Cassandra EstesSharon A. FoxHarry C. Gibson, M.D.Mark and Mary HetrickMillicent higgins, M.D.ada sue hinshawCheryl Huey, M.D.ida L. iacobucciChristine G. JamesJames a. JohnsonMark and Linda Johnson Daniel and Rose KachnowskiDr. Alon and Heidi KahanaMichael A. Kipp, M.D.James and Carolyn KnaggsJoseph KrajcikSam and Marilyn KrimmDr. Stuart P. Landay and Ms. Susan L. BathkeProfessor Emeritus Myra A. LarsonRobert C. Leland, Jr.Richard Alan Lewis and Patricia N. Lewishugh LoganShahzad I. Mian and Uzma AhmadDr. Michel and Alice NasifBetsy and Ken NisbetPatrick J. Parden, M.D.Alexander E. and Diane L. PogrebniakDonald and Debra PuroIva Jean RoeJames Michael RosenfieldDr. Siv B. SaetreDonald and Jane Schriveryamina Sebihi and Brian P. RowanMarvin and Marci ShulmanBecky and Doug SpalyJames P. and Dorothy SymonsSusan and David ThomsTina D. Turner, M.D.David R. WagnerJoseph Brennan Walsh, M.D.Elise WeisbackKatherine A. WhitneyDr. and Mrs. Keith M. WilliamsJung and chiung yao WuXi Chapter of Delta Gamma foundationDr. Tetsuya TamamotoThaddeus and Joanne Zolty

$100 to $499Anonymous Donors (19) Joshua B. Albertson and roslyn M. stahlAnn T. AlexanderLyle and Margaret AllisDr. Krista AndersonPeter and Patricia AntonacopoulosAssumption Greek Orthodox ChurchSamuel and Mary BackosRichard and Madalynn BairBeverly and George BakerLawrence A. BarnesLois and David BaruTheodore and Patti BashAnne and Donald F. Baty, Jr.Harry E. BeesonStanley and Joy BerentLois BerezaDr. and Mrs. Werner G. BergenCagri and Sheila BesirliRalph H. BeuhlerMichael and Clarita BishelJustin Gottlieb and Barbara BlodiEdward L. and Martha Boggs, Jr.Stephen and Danielle BoorsteinFrances R. BoselDaniel L. BradenWilliam and Julie BromleyMargaret BrownHenry J. and Jean L. BrownWilbur and Carolyn BurkettJ. Scott and Nancy BurnsChristine R. BuseNorman and Maureen CampbellHelen CargasJ.R. and Elaine J. Carsonclaudette J. caselloSherry Changanne M. chaseChristina and Nick CheolasRobert and Kay ChesebroBenjamin and Deborah ChongMary and Raymond ChristlMarilyn CitronJohn and Carolyn ClarkMartha and James ClearyShirley CoeBeck and David BeckMs. alice s. cohenCarl and Maria ConstantPatrick and Laura CoppensEllen L. CoulthardDonald R. CoxMargaretAnn Cross and James Van FleterenAlicia CurleyCathleen A. CurleyWilliam and Carol CutlerLarisa and Arthur CzabaniukLyubica Dabich, M.D.

“As a young investigator in the process

of developing a research program,

I am grateful for early funding and

awards from individual donors

and privately funded organizations.

Such generosity allows me to study

retinal diseases and their mecha-

nisms—with the goal of developing

new treatments to prevent or reverse

associated vision loss.”

— Patrice e. Fort, Ph.d., m.s. assistant Professor



Barbara DalasinskiJohn and Elizabeth DallasDave and Marsha DarrahDolores D. DaudtJames E. DaviesProf. William and Virginia DawsonCecelia and Homer DeatonMary Jo and William DemopoulosDr. M. Kenneth and Arvene DicksteinRichard and Joann DionneJohn a. DoddsMarlene and Paul DodgeMr. and Mrs. Kenneth R. DornbrookDow Corning CorporationBlake and Melba DoyleDeborah DrousJoyce P. DukeMr. and Mrs. Wilbert L. EhmannRichard L. Ellisnancie entenmannMichael J. fanolaDr. and Mrs. Robert FazioBryn A. and Suzanne M. FickEsther M. FloydFood Services, Inc.Randee FreedmanRalph N. FunkJeannine M. galettiPatricia M. Gardnerthomas and Melissa gauntlettge foundationMichael J. geiss iii, M.D.James and Patricia GiftosJacqueline and Richard GilbertHilary Grabe and Michael MayerRichard L. GreerMark W. and Susan S. GriffinNorman GrigsbyTerry A. Gromacki and Cassie Lyn BarnhardtMrs. Adele Gudes

Geza L. and Elizabeth F. GyoreySteven and Iris HaakMargaret HagenMr. Kenneth HallerMichael W. and Molli hallumHugh and Janet HarnessTimothy C. HarrisLarry and Jocelyn HarwoodNoriko and Dr. Ken HashimotoGerald and Mignon HepplerDavid and Phyllis Herzigruth heyn, M.D.Jeanne and Conrad HeynerFrederick J. Heynertom s. hillPeter J. HirthRichard and Jane HissProf. Emer. Gerald P. HodgeJonell HollingerDeborah HollowayMary M. HowreyMargaret M. and James E. Hughessungmin hyung, M.D., Ph.D.Illinois Tool Works FoundationDr. and Mrs. James D. IzerRichard and Anne JacksonJim and Valorie JalsovskyRobert J. JampelMr. and Mrs. Kenneth B. JohnsonDr. Mark E. JohnstonNorma JohnstonArtie Jones and Kimberly DulimbaS. Preston and Dr. Betty B. JonesMr. and Mrs. Francis J. JoyceLeo Kalyvas, Jr.Charlene and Leo KayRosemary S. KayeHelen D. KellamRalph and Priscilla KinneyPhillip and Frances KishAlexandra Klos

Mary Jo KnightFrank J. KonkelJ. David and Grace KotreDrs. Teresa and Norman KriegerSusan and James KruckiGerald and Dorothy KurtzMarie Lanestephen P. and candis M. LangLouis and gail LaricheKurt K. Lark, M.D.Lucille LeflerMr. and Mrs. F. R. LehmanGary Lelli and Kelly BottgerCheryl L. and J. Paul LemieuxJoanne r. Leonihelios LeungDanute M. Leveckis, M.D., and Timothy Van Every, M.D.Bobbie and Myron LevineRobertson A. LewisSeymour and Betty LichterSherry L. LindahlMark and Carol LoesselThomas Longworth and Carol CramerA. Letitia LovelessLonnie and Melissa LoySandra Dee LukschJane G. MaddoxJoseph L. MagginiCarol L. Makielski and Charles D. LakeRichard and Barbara MannisLinda Manoogian-FingerleCarl F. Marrs and Julia E. RichardsRegent Olivia P. Maynard and S. Olof KarlstromRoderick A. McDonaldLloyd and Helen Mc KeeKathy A. McMenemy-WilliamsLaurie and Fredrick MetzgerElaine J. MickelsonMyrna and Newell Miller

“The Dryer Career Development Professorship has provided

the resources needed to build a clinical studies infrastructure

that will serve as the foundation for the next generation of

clinical research we are building at Kellogg. These studies

will enable us to more quickly bring new, more effective

treatments to our patients.”

— Grant m. comer, m.d., m.s., assistant Professor edward T. and ellen k. dryer career development Professor



Alphonse J. Miskohelen L. MitchellMs. Marlene M. MoleskiJohn and Linda MorrisonDonald and Ann MunroAlphonsus C. MurphyMr. and Mrs. Albert NedoffChristine Nelson and Willis LillardLawrence and Rebecca NewmanJonathon P. NiemczakHarry and Leeta NistelConstance and David OslerMark E. and Barbara C. OverlandJoseph PalmMary ParisiNicola and Deborah ParravanoShirley and Ara PaulCarol M. PaullJoseph and Betty PavkaGordon E. Peckham, Sr.Keith and Janet Lee PerkinsJames and Nancy PflastererSheryl and Douglas PodlewskiLinda M. PodojilJoe and Mary PousakRebecca and Eric PriebeRobert RappCharles Schmitter and Allyn RavitzWilliam RedfieldMr. and Mrs. Walter F. Redmondann M. reedWilliam and Charlotte ReesRita and Robert ReskeMs. ann M. riceRichard K. RobertsBarbara and Art RoccoDavid and Ann RogersRichard Z. and Edie W. Rosenfeld

Dennis A. and Olivia S. Rossrennie and Michael rothMichael c. roustemisCarol and Dave RundleDonald R. and Barbara ScavardaLinda and Thomas SchalekMrs. Helen F. SchaperPerry and Faith SchechtmanMichael R. SchleifNorma and Ray SchmickJudith and Willard Schneidereileen schottJohn and Karen SchultzMarc Alan SchwartzFrances C. ScottGarrett R. and Emily K. ScottWoodrow and Loulease SellersBrahm Shapiro and Lorraine Fig ShapiroDavid and Elvera ShappirioRohit ShastryCharles ShermanMax and Roni ShteinTed and Mary Ann SimonSandra R. SingerDaniel and Julie sinnottGrace M. SmithKenneth S. Smith and Donna GeneseoIrene Solent-Field and Matthew g. fieldSt. Paul Lutheran SchoolJohn and Alexandra StarrVirginia and Eric SteinThomas and Jane StratfordS. Stephen StreeterDr. Charles Shun SuMargaret A. SullivanWesley Szpunar

Duane TarnackiFrank D. Tennenttom thomasDebra Thompson and William Strong elaine J. thompsonA. Richard TischlerPeter and Barbara TorriceKaren and Arthur TousignantDr. and Mrs. Steve S. TsangaliasRoula and Fereniki TsaprailisHerbert and Anne UptonLois van houtenRonald VanderlugtMichael and Tina VarlamosGeorge Verrassue vitousLampros (Louis) VlahantonesGeorge and Chrisanthy VolisSusan WabekeRichard and Edith WacksmanClaudia M. WagnerP. Steven Wainess, D.D.S.Arthur and Renata WassermanChristian and Ella WeberCarolyn Jean WeigleDr. and Mrs. William W. WellsAvis L. WhiteDr. Patrick T. and Mary WhiteMarallyn M. WightJohn WilliamsJeneane WiseDavid and Phyllis WittrockFord L. WrightMichael and Kathleen yangGloria yffErnest ZacharyAllan C. ZanderThomas and Delle ZurSchmiede

“Support for education enables us to provide our

future ophthalmologists and vision scientists with

the tools, technologies, and skills needed to make

real contributions in a changing health care and

scientific environment.”

— shahzad I. mian, m.d. associate chair for education and residency Program director



In Memory Of

The Kellogg Eye Center is honored

to have received gifts in memory of

the following individuals.

Margaret BaierNorbert BerezaDavid BerryIdelle BinderSylvia BreakstoneEdmund M. BrownellGertrude CallawayJim caonRuth M. ClarkePaul and Kate ColemanKenneth CosbyHoward CourtneyMildred Dillard George Duke, Jr.Harold F. Falls, M.D.Pearl A. FitzpatrickAnn Flaherty MurphyJ. scott flemingF. Bruce Fralick, M.D.Bartley R. Frueh, M.D.Dr. Henry GrayGeorge HarrisJean D. Harrison Kathleen HattDr. Sivana T. HellerC. Theodore Larson, FAIAWilliam LeoniSusan LichterLucille MagginiRichard MartinLinn ann Masonagnes McMenemyMinnie MenskeyJack MorrisCharles MuleJoAnne NedoffErnestina ParravanoHarry PiperHeinz Prechter Gordon RiehlPeggy RobertsCarl RoeDr. Walter Z. Rundles, Jr.

Earl SchaperJulianna simonDavid M. Smith, M.D.Eric SteinMarguerite W. Sullivanrandall WallachDr. Edwin WightElizabeth WilhoffTheodore WoehrleGeorge Zissis

In Honor Of

The following individuals were

honored through gifts to the Kellogg

Eye Center.

Steven Bisson Edith BrownDeborah Dayton Jane Griffith ElliottVictor M. Elner, M.D., Ph.D.Frances and David H. GrossmanBrendan HeppnerJoseph and Lori HymesDr. Frank D. JohnsonMark W. Johnson, M.D.David JudeAlon Kahana, M.D., Ph.D.Noah KotrePaul R. Lichter, M.D.Paul and Carolyn Lichterconnie MannRoger F. Meyer, M.D.Shahzad I. Mian, M.D.Mark MilazzoSayoko E. Moroi, M.D., Ph.D.Richard A. Pittsley, M.D.Stephen J. Saxe, M.D.roni M. shtein, M.D.Michael W. Smith-Wheelock, M.D.H. Kaz Soong, M.D.Alan Sugar, M.D.Clare Van FleterenLillian Weiglerebecca a. Wu, M.D.David N. Zacks, M.D., Ph.D.

Bequests and Other Planned Gifts

It is with deep gratitude that we

recognize the following individuals

for making the Kellogg Eye Center

a part of their estate plans.

Frank J. and Helga ArnoldNancy BenderAnne S. BenninghoffRhoda L. and Roger M. BerkowitzRobert D. Biggs, M.D.Gloria P. and William E. Dean, Jr.Ralph M. FoxHelen A. (Poorbaugh) FreedmanLarry and Mary GerbensConrad L. Giles Ed and Sue Gorneyida Lucy iacobucciMrs. Harry KrashenEdward and Duffy LadenbergerHarry and Eva McGeeM. Joseph and Beverly McKenneyBruce L. and Roberta OliverAlvin PerkissSally J. PryceJoanne A. RackhamKatherine M. RackhamMrs. Shirley M. SchaibleAlice and Ronald ShanklandE.H. Newel and Rosemary Smithrussell a. stephens and Phyllis a. capognaJames B. Thompson and Mary Ann BrandtDavid and Jayne VerLee

Only those who gave their

permission are included above.

The Kellogg Eye Center greatly

values our donors, and we make

every effort to ensure the accuracy

of the honor roll. Please call us at

734.615.0243 if you note any errors.



Steven F. Abcouwer, Ph.D. editorial board, American Journal of Physiology: Endocrinology & Metabolismeditorial board, Journal of Clinical & Experimental Ophthalmologystudy section, research grant review Committee, american diabetes association research funding Program

David A. Antonetti, Ph.D.study section, national institutes of health diseases and Pathophysiology of the Visual system editorial board, Tissue Barriers

Steven M. Archer, M.D.best doctors in americaU.S. News & World Report Top doctorguest of honor, 736th meeting of the new england ophthalmological society, boston, marobb-Peterson lecture, Children’s hospital Pediatric ophthalmology fellowship alumni meeting, boston, maeugene r. folk, m.d., Visiting Professorship, illinois eye and ear infirmary, Chicago, ilarthur w. stickle lecture, washington university, st. louis, molifetime honor award, american association for Pediatric ophthalmology and strabismus

Cagri G. Besirli, M.D., Ph.D.heed fellow, heed ophthalmic foundationfellow, society of heed fellowsronald g. michels fellowship award15th fellow research award, The retina society

Brenda L. Bohnsack, M.D., Ph.D.heed fellow, heed ophthalmic foundationfellow, society of heed fellowsresident and fellow research forum, association of university Professors of ophthalmologyresearch to Prevent blindness Career development award

Theresa M. Cooney, M.D.board member and delegate to the michigan state medical society for the michigan society of eye Physicians and surgeons

Wayne T. Cornblath, M.D.best doctors in americaeducation liaison Committee, north american neuro- ophthalmology society - american academy of ophthalmology

Monte a. Del Monte, M.D.best doctors in americaU.S. News & World Report Top doctorTop doctor, hour detroitnorth american Chair, Program Committee, sub-specialty day in Pediatric ophthalmology, Pan american association of ophthalmology, buenos aries, argentinainvited scientific advisor and lead faculty, webmdCentral

Monte a. Del Monte, M.D. (cont.)member and grant reviewer, scientific advisory Committee, Knight’s Templar eye research foundation, schaumburg, ilspecial invited international Keynote speaker, 3rd Chinese Pediatric ophthalmology society meeting, Xiamen, ChinaChair, Program Committee, american orthoptic Council

Hakan Demirci, M.D.best doctors in america

raymond s. Douglas, M.D., Ph.D.best doctors in americaThe endocrine society international award for excellence in Published Clinical research

Susan G. Elner, M.D.best doctors in americaexecutive editor, American Journal of Ophthalmology

Victor M. Elner, M.D., Ph.D.best doctors in americaU.S. News & World Report Top doctorstudy section C grant reviewer, national eye instituteChair, asoPrs awards Committee

Jerome I. Finkelstein, M.D., FACSbest doctors in america

Bruce A. Furr, C.O., M.S.P.H.Past President, american association of Certified orthoptistsmember, executive Committee, american association of Certified orthoptistsCo-host, american academy of ophthalmology/american orthoptic Council/american association of Certified orthoptists strabismus symposium, american academy of ophthalmology annual meetingmember, international affairs Committee, american association for Pediatric ophthalmology and strabismus editorial board, American Orthoptic Journal

Christopher Gappy, M.D.Peer reviewer, Journal of American Association for Pediatric Ophthalmology and Strabismus

Thomas W. Gardner, M.D., M.S. healthy eyes Taubman scholar, a. alfred Taubman medical research institute, university of michigan medical school and Jdrfresearch to Prevent blindness Physician-scientist awardassociate editor, Diabetes and Acta Ophthalmologicaeditorial board, Journal of Ocular Biology, Diseases, and Informaticsscientific advisory board, diabetic retinopathy Clinical research networkscientific review Committee, T1d exchange biobank

facuLty honors anD recognition


Thomas W. Gardner, M.D., M.S. (cont.)external scientific advisory board, european Consortium for the early Treatment of diabetic retinopathyJuvenile diabetes foundation international medical science review Committee: Clinical affairs advisory Committeesteering Committee, lasker foundation/international retina research foundation initiative on diabetic retinopathy

Richard E. Hackel, M.A., C.R.A., F.O.P.S.member, board of education, ophthalmic Photographers’ society

John R. Heckenlively, M.D.best doctors in americaU.S. News & World Report Top doctorassociate editor, eye

Peter F. Hitchcock, Ph.D.associate dean for academic Programs and initiatives, rackham graduate schoolChair, retinal Cell biology Programming Committee for the association for research in Vision and ophthalmology academic editor, PLoS ONE

ida L. iacobucci, c.o.lifetime achievement award for 54 years’ service, american association of Certified orthoptists

Thiran Jayasundera, M.D., FRCSC, FRANZCOassociate editor, BMC Ophthalmology

Mark W. Johnson, M.D. best doctors in americanamed one of 135 leading ophthalmologists in america by becker’s asC reviewelected to membership in the gass fluorescein ClubChair, Committee on Programs, american ophthalmological societyTreasurer and executive Committee, The retina societymember, nominating Committee, The retina societyeditorial board, American Journal of Ophthalmologyeditorial board, Retinaeditorial board, Retinal Physician

Alon Kahana, M.D., Ph.D.best doctors in americaalliance for Vision research awardTaubman emerging scholar, a. alfred Taubman medical research institute, university of michigan medical schoolmichael blumenthal Keynote lecture, israel microsurgical Convention, eilat, israelresearch to Prevent blindness Career development award

Paul P. Lee, M.D., J.D.best doctors in americaU.S. News & World Report Top doctoreditorial board, Archives of Ophthalmologyboard of directors, american board of ophthalmologyboard of directors, arVo foundationboard of advisors, hoskins Center for Patient safety and Quality, american academy of ophthalmologyg. Victor simpson, m.d., lecture, washington hospital Center (georgetown university), washington, d.C.ernest K. goodner lecture, university of California at san franciscoKnapp symposium, american ophthalmological societyacademia ophthalmologica internationalis

Paul R. Lichter, M.D., FACSbest doctors in americaU.S. News & World Report Top doctorPresident, academia ophthalmologica internationalis board of Trustees, international Council of ophthalmologyChair, Clinical and educational Conflict of interest Committee, university of michigan medical school

Shahzad I. Mian, M.D.best doctors in americaPatrick regan o’Connor, m.d., memorial lecture, university of louisvilleralph and sophie heintz lecture, 38th annual h. bruce ostler association of Proctor fellows meetingeditorial board, CorneaCornea editor for the ophthalmic news and education networkboard of directors, Cornea societyPolicy and Position review Committee, eye bank association of americaaccreditation board, eye bank association of americaProgram director’s Council, association of university Professors in ophthalmologydeputy section leader, Council, american academy of ophthalmologyCornea representative, ophthalmology leadership advocacy group

Sayoko E. Moroi, M.D., Ph.D.best doctors in americaarVo foundation for eye research, Certificate of appreciation for service as a developing Country eye researcher Travel fellowship mentor Planning Committee and glaucoma subcommittee, national eye health education Program, national eye institute, national institutes of healthad hoc member, study section, diseases and Pathophysiology of the Visual system, national eye institute



David C. Musch, Ph.D., M.P.H.editorial board, Ophthalmologyeditorial board, RetinaPreferred Practice Patterns Committee, american academy of ophthalmologyadvisory board, Cochrane eyes and Vision group data and safety monitoring board appointments: •CornealPreservationTimeStudy,NEI,NIH(chair) •HydrusIVPhase3study,Ivantis,Inc.,Irvine,CA(chair) •SirolimusTreatmentofGeographicAMDPhase2study, nei, nih (member) •LeberCongenitalAmaurosisTreatmentPhase3study, Children’s hospital of Philadelphia (member)

Christine C. Nelson, M.D., FACSbest doctors in americaTop doctor, hour detroitadvisory board, women in ophthalmology

Donald G. Puro, M.D., Ph.D.best doctors in america

Julia E. Richards, Ph.D.fellow, association for research in Vision and ophthalmologyleague of research excellence, university of michigan medical schoolTextbook award: “outstanding academic Title” award from the journal Choice: Current Reviews for Academic Libraries for “The human genome: a user’s guide” third edition, by Julia e. richards and r. scott hawley

roni M. shtein, M.D., M.s.young Physician leader, eye bank association of americaoutstanding research mentor award, university of michigan undergraduate research opportunities Program achievement award, american academy of ophthalmology

Terry J. Smith, M.D. best doctors in americaThe endocrine society international award for excellence in Published Clinical research league of research excellence, university of michigan medical school research to Prevent blindness Physician-scientist awardboard of directors, national graves’ disease foundationChief medical and scientific officer, national graves’ disease foundationboard of scientific advisors, guthy-Jackson foundation

Michael W. Smith-Wheelock, M.D.best doctors in america

H. Kaz Soong, M.D.best doctors in americaassistant editor, Cornea

Joshua D. stein, M.D., M.s.secretariat award, american academy of ophthalmology research to Prevent blindness Physician-scientist awardfellow, Center for health Care research and Transformationeditor in Chief, Evidence-Based Ophthalmology

Alan Sugar, M.D.best doctors in americaCo-Chair, institutional review boards of the university of michigan medical schooleditor in Chief, Corneasecretariat award, Clinical education, american academy of ophthalmologyr. Townley Paton award lectureship, eye bank association of americaroger f. meyer Cornea lectureship

Debra A. Thompson, Ph.D.executive editor, Experimental Eye Researchfellow, association for research in Vision and ophthalmology

susan s. thoms, M.D.best doctors in america

Jonathan D. Trobe, M.D.best doctors in americaU.S. News & World Report Top doctorsection editor, Ophthalmology, UpToDateassociate editor (neuro-ophthalmology), Medlinkadvisory board, Korean Journal of Ophthalmology

Maria A. Woodward, M.D.basic and Clinical science Course Committee, american academy of ophthalmology

Jennifer S. Weizer, M.D.best doctors in america

Dongli yang, M.D., Ph.D.reviewer, Molecular Vision reviewer, BMC Ophthalmology

David N. Zacks, M.D., Ph.D.best doctors in americaTerry J. bergstrom Teaching award

* Only peer-selected “Best Doctors” and “Top Doctors” rankings are noted



antonetti Da, Klein r, Gardner TW. diabetic retinopathy. N Engl J Med. 2012;366(13):1227-39.

antonopoulos C, stem m, Comer GM. acute anterior uveitis following intravitreal bevacizumab but not subsequent ranibi-zumab. Clin Ophthalmol.2011;5:1659-62.

apkarian ao, garton hJ, wesolowski J, Trobe JD. relapsing dorsal midbrain syndrome following interventions for hydrocephalus in aqueductal stenosis. J Neuroophthalmol.2012;32(2):124-7.

Archer SM. are amblyopia treatments really all equal? is that even the right ques-tion? Am Orthopt J.2012;62:1-3.

Archer SM. arguing with success: pulley surgery versus conventional surgery for convergence excess esotropia. J AAPOS. 2012;16(2):110-1.

bajenova nV, Vanderbeek bl, Johnson MW. Change in choroidal thickness after chemotherapy in leukemic choroidopathy. Retina.2012;32(1):203-5.

Besirli CG, Johnson MW. Traction-induced foveal damage predisposes eyes with pre-existing posterior vitreous detach-ment to idiopathic macular hole formation. Eye.2012;26(6):792-5.

Besirli CG, sudhakar P, wesolowski J, Trobe JD. serous retinal detachment in hypertensive posterior reversible encepha-lopathy syndrome. AJNR Am J Neurora-diol.2011;32(11):E203-5.

bian Zm, Elner SG, Khanna h, murga-Zamalloa Ca, Patil s, Elner VM. expres-sion and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci.2011;52(12):8646-56.

Bohnsack BL, bhatt r, Kahana A. nonophthalmic symptoms secondary to ocular torticollis from severe blepharop-tosis: an underappreciated but treatable condition. Ophthal Plast Reconstr Surg. 2012;28(2):e36-9.

Bohnsack BL, gallina d, Kahana A. Phe-nothiourea sensitizes zebrafish cranial neu-ral crest and extraocular muscle develop-ment to changes in retinoic acid and igf signaling. PLoS One.2011;6(8):e22991.

Bohnsack BL, gallina d, Thompson h, Kasprick ds, lucarelli mJ, dootz g, nel-son cc, mcgonnell im, Kahana A. de-velopment of extraocular muscles requires early signals from periocular neural crest and the developing eye. Arch Ophthalmol. 2011;129(8):1030-41.

Bohnsack BL, Kasprick ds, Kish Pe, gold-man d, Kahana A. a zebrafish model of axenfeld-rieger syndrome reveals thatpitx2regulationbyretinoicacidis essential for ocular and craniofacial development. Invest Ophthalmol Vis Sci. 2012;53(1):7-22.

briceno C, Douglas rs. orbital and periorbital infections. Arch Ophthalmol. 2012;130(2):233-4.

Chaki m, hoefele J, allen sJ, ramaswami g, Janssen s, bergmann C, Heckenlively Jr, otto ea, hildebrandt f. genotype-phenotype correlation in 440 patients with nPhP-related ciliopathies. Kidney Int. 2011;80(11):1239-45.

Chen C, thompson Da, Koutalos y. reduction of all-trans retinal in vertebrate rod photoreceptors requires the combined actionofRDH8andRDH12. J Biol Chem. 201213;287(29):24662-70.Epub2012May23.

Cheng h, Khan NW, roger Je, swaroop a. excess cones in the retinal degeneration rd7 mouse, caused by the loss of function oforphannuclearreceptorNr2e3,origi-nate from early-born photoreceptor precur-sors. Hum Mol Genet. 2011;20(21):4102-15.

Cho ri, Elner VM, nelson cc, frueh br. The effect of orbital decompression surgery on lid retraction in thyroid eye disease. Ophthal Plast Reconstr Surg. 201;27(6):436-8.

Clark a, Zhu a, sun K, Petty hr. Cerium oxide and platinum nanoparticles protect cells from oxidant-mediated apoptosis. J Nanopart Res.2011;13(10):5547-55.

Comer GM, stem ms, Saxe SJ. suc-cessful salvage therapy of fusarium endophthalmitis secondary to keratitis: an interventional case series. Clin Ophthal-mol.2012;6:721-6.

cooney tM, wu a, wilkes g, Finkel-stein Ji, Musch Dc. The effects of sys-temic alpha1-adrenoreceptor antagonists on pupil diameter. Br J Ophthalmol. 2012;96(4):490-3.

Cornblath WT. neuro-ophthalmology: five new things. Neurol Clin Pract. 2012;2:129-33.

day s, acquah K, Lee PP, mruthyun-jaya P, sloan fa. medicare costs for neovascular age-related macular degen-eration,1994-2007.Am J Ophthalmol. 201;152(6):1014-20.Epub2011Aug16.

day s, acquah K, mruthyunjaya P, gross-man ds, Lee PP, sloan fa. ocular com-plications after anti-vascular endothelial growth factor therapy in medicare patients with age-related macular degeneration. Am J Ophthalmol. 2011;152(2):266-72.Epub2011Jun12.

FACULTy PUBLICATIONS


de Paula fh, Khairallah Cg, niziol lm, Musch Dc, shtein rM. diffuse lamellar keratitis after laser in situ keratomileusis with femtosecond laser flap creation. J Cataract Refract Surg.2012;38(6):1014-9.

dolman PJ, Cahill K, Czyz Cn, Doug-las rs, Elner VM, feldon s, Kazim m, lucarelli m, sivak-Collcott J, stacey aw, strianese d, uddin J. reliability of estimat-ing ductions in thyroid eye disease: an international Thyroid eye disease soci-ety multicenter study. Ophthalmology. 2012;119(2):382-9.

Douglas rs, gupta s. The pathophysiolo-gy of thyroid eye disease: implications for immunotherapy. Curr Opin Ophthalmol. 2011;22(5):385-90.

fausett bV, Trobe JD. Paralysis of accom-modation with preserved pupillary function as the initial manifestation of guillain-barre syndrome. J Neuroophthalmol. 2012;32(2):148-9.

fernando r, atkins s, raychaudhuri n, lu y, li b, Douglas rs, smith tJ. human fibrocytes coexpress thyroglobulin and thyrotropin receptor. Proc Natl Acad Sci U S A.2012;109(19):7427-32.

field mg, yang D, bian Zm, Petty hr, Elner VM. retinal flavoprotein fluores-cence correlates with mitochondrial stress, apoptosis, and chemokine expression. Exp Eye Res.2011;93(4):548-55.

Fort PE, losiewicz mK, reiter Ce, singh rs, nakamura m, Abcouwer SF, barber aJ, Gardner TW. differential roles of hyperglycemia and hypoinsulinemia in dia-betes induced retinal cell death: evidence for retinal insulin resistance. PLoS One. 2011;6(10):e26498.

frey T, antonetti Da. alterations to the blood-retinal barrier in diabetes: cytokines and reactive oxygen species. Antioxid Redox Signal.2011;15(5):1271-84.

fukumoto m, nakaizumi a, Zhang T, lentz si, shibata m, Puro DG. Vulner-ability of the retinal microvasculature to oxidative stress: ion channel-dependent mechanisms. Am J Physiol Cell Physiol. 2012;302(9):C1413-20.

gillespie ef, Papageorgiou Ki, fernando r, raychaudhuri n, Cockerham KP, Char-ara lK, goncalves aC, Zhao sX, ginter a, lu y, smith tJ, Douglas rs. increased expression of Tsh receptor by fibrocytes in thyroid-associated ophthalmopathy leads to chemokine production. J Clin Endocrinol Metab.2012;97(5):E740-6.

Grabe HM, bapuraj Jr, wesolowski Jr, Parmar h, Trobe JD. homonymous hemianopia from infarction of the optic tract and lateral geniculate nucleus in deep cerebral venous thrombosis. J Neurooph-thalmol.2012;32(1):38-41.

Heckenlively JR. new concept: treating nonproliferative diabetic retinopathy with light adaptation of rods during sleep. Eye. 2011;25(12):1533-4.

hegedus l, bonnema sJ, smith tJ, brix Th. Treating the thyroid in the presence of graves’ ophthalmopathy. Best Pract Res Clin Endocrinol Metab.2012;26(3):313-24.

heise ea, Fort PE. impact of diabetes on alpha-crystallins and other heat shock proteins in the eye. J Ocul Biol Dis Inform. 2011;4(1-2):62-9.

heitor de Paula f, Kamyar r, shtein rM, Sugar A, Mian si. endothelial kerato-plasty without descemet stripping after failed penetrating keratoplasty. Cornea. 2012;31(6):645-8.

hoa n, Tsui s, afifiyan nf, sinha hikim a, li b, Douglas rs, smith tJ. nuclear target-ing of igf-1 receptor in orbital fibroblasts from graves’ disease: apparent role of adam17. PLoS One.2012;7(4):e34173.

huang T, Cui J, li l, Hitchcock PF, li y. The role of microglia in the neurogenesis of zebrafish retina. Biochem Biophys Res Commun.2012;421(2):214-20.

hwang CJ, Khadavi nm, Papageorgiou K, said J, Chong K, lee d, smith tJ, goldberg ra, Douglas rs. histopathol-ogy of brow fat in thyroid-associated orbitopathy. Ophthal Plast Reconstr Surg. 2012;28(1):27-9.

Jackson gr, scott iu, Quillen da, wal-ter le, Gardner TW. inner retinal visual dysfunction is a sensitive marker of non-proliferative diabetic retinopathy. Br J Ophthalmol.2012;96(5):699-703.

Jarsky T, Cembrowski m, logan sm, Kath wl, riecke h, Demb JB, singer Jh. a synaptic mechanism for retinal adaptation to luminance and contrast. J Neurosci. 2011;31(30):11003-11015.

Kahana A, Bohnsack BL, Cho ri, maher Co. subtotal excision with adjunctive scle-rosing therapy for the treatment of severe symptomatic orbital lymphangiomas. Arch Ophthalmol.2011;129(8):1073-6.

Kaiser Jm, imai h, haakenson JK, bruck-lacher rm, fox Te, shanmugavelandy ss, unrath Ka, Pedersen mm, dai P, willard mf, bronson sK, Gardner TW, Kester m. nanoliposomal minocycline for ocular drug delivery. Nanomedicine.2012Mar28.[Epubaheadofprint]

Kamyar r, Weizer JS, de Paula fh, stein JD, Moroi SE, John Da, Musch Dc, Mian si. glaucoma associated with boston type i keratoprosthesis. Cornea. 2012;31(2):134-9.

Kang Jh, loomis s, wiggs Jl, stein JD, Pasquale lr. demographic and geograph-icfeaturesofexfoliationglaucomain2united states-based prospective cohorts. Ophthalmology.2012;119(1):27-35.



Kasprick ds, Kish Pe, Junttila Tl, ward la, Bohnsack BL, Kahana A. microanatomy of adult zebrafish extraocular muscles. PLoS One.2011;6(11):e27095.

Kim w, argento a, Rozsa FW, mallett K. Constitutive behavior of ocular tissues over a range of strain rate. J Biomech Eng. 2012;134(6):061002.

Kokkinopoulos i, Colman a, hogg C, Heckenlively JR, Jeffery g. age-related retinal inflammation is reduced by 670 nm light via increased mitochondrial mem-brane potential. Neurobiol Aging.2012May15.[Epubaheadofprint]

Koreen l, yoshida n, escariao P, niziol lm, Koreen iV, Musch Dc, Chang s. incidence of, risk factors for, and com-bined mechanism of late-onset open-angle glaucoma after vitrectomy. Retina. 2012;32(1):160-7.

Kowalski Jw, rentz am, walt Jg, lloyd a, lee J, young Ta, Chen wh, bressler nm, Lee PP, brazier Je, hays rd, revicki da. rasch analysis in the development of a simplified version of the national eye Institutevisual-functionquestionnaire-25for utility estimation. Qual Life Res. 2012;21(2):323-34.Epub2011Aug4.

Kramer bC, Musch Dc, niziol lm, Weizer JS. reliability of simultaneous visual field testing. Ophthalmology. 2012;119(2):304-7.

Kymes sm, lambert dl, Lee PP, Musch Dc, siegfried CJ, Kotak sV, stwalley dl, fain J, Johnson C, gordon mo. The de-velopment of a decision analytic model of changes in mean deviation in people with glaucoma: the Coa model. Ophthalmol-ogy.2012;119(7):1367-74.Epub2012Apr25.

lambert sr, Archer SM, wilson me, Trivedi rh, Del Monte Ma, lynn m. long-term outcomes of undercorrection versus full correction after unilateral intraocular implantation in children. Am J Ophthalmol. 2012;153(4):602-8.

lass Jh, beck rw, benetz ba, dontchev m, gal rl, holland eJ, Kollman C, mannis mJ, Price f, Jr., raber i, stark w, stulting rd, Sugar A. baseline factors related to endothelial cell loss following pen-etrating keratoplasty. Arch Ophthalmol. 2011;129(9):1149-54.

lee bJ, Elner SG, Douglas rs, Elner VM. island pedicle and horizontal advance-ment cheek flaps for medial canthal re-construction. Ophthal Plast Reconstr Surg. 2011;27(5):376-9.

lee bJ, gupta s, flint a, singer Tr, Elner vM. Pigmented orbital mass due to remote pencil trauma. Ophthal Plast Reconstr Surg.2012;28(3):e67-8.

lee bJ, nelson cc, lewis Cd, Perry Jd. external dacryocystorhinostomy outcomes in sarcoidosis patients. Ophthal Plast Reconstr Surg.2012;28(1):47-9.

lee bJ, nelson cc. intralesional interferon for extensive squamous papilloma of the eyelid margin. Ophthal Plast Reconstr Surg.2012;28(2):e47-8.

Lee PP, dzau J. emergency department use for eye care services and future directions in care. Arch Ophthalmol. 2012;130(1):106-7.

lee s, Douglas rs. systemic malToma with presumed choroidal involvement. Arch Ophthalmol.2012;130(3):379.

liu y, gibson J, wheeler J, Kwee lC, santiago-Turla Cm, akafo sK, Lichter Pr, gaasterland de, Moroi SE, Challa P, herndon lw, girkin Ca, budenz dl, Richards JE, allingham rr, hauser ma. galC deletions increase the risk of pri-mary open-angle glaucoma: the role of mendelian variants in complex disease. PLoS One.2011;6(11):e27134.

LoftusJV,SultanMB,PleilAM;Macugen1013 study group. Changes in vision- and health-related quality of life in patients with diabetic macular edema treated with pegaptanib sodium or sham. Invest Oph-thalmol Vis Sci.2011;52(10):7498-505.[Lee P–Collaborator]

losiewicz mK, Fort PE. diabetes impairs the neuroprotective properties of retinal alpha-crystallins. Invest Ophthalmol Vis Sci.2011;52(9):5034-42.

louttit md, Kopplin lJ, igo rP, Jr., fondran Jr, Tagliaferri a, bardenstein d, aldave aJ, Croasdale Cr, Price mo, RosenwasserGO,LassJH,IyengarSK;feCd genetics multi-Center study group. a multicenter study to map genes for fuchs endothelial corneal dystrophy: baseline characteristics and heritability. Cornea. 2012;31(1):26-35.[Sugar A, Mian s, Soong HK–Collaborators]

luttrull JK, sramek C, Palanker d, spink CJ, Musch Dc. long-term safety, high-resolution imaging, and tissue temperature modeling of subvisible diode micropulse photocoagulation for retinovascular macu-lar edema. Retina.2012;32(2):375-86.

morse ar, Lee PP. Comparative effective-ness: insights on treatment options for open-angle glaucoma. Arch Ophthalmol. 2012;130(4):506-7.



muir Kw, Ventura a, stinnett ss, enfiedji-an a, allingham rr, Lee PP. The influence of health literacy level on an educational intervention to improve glaucoma medi-cation adherence. Patient Educ Couns. 2012;87(2):160-4.

murakami T, frey T, Lin c, antonetti Da. Protein kinase Cbeta phosphorylates oc-cludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo. Diabetes. 2012;61(6):1573-83.

Musch Dc, gillespie bw, niziol lm, Lichter PR, Varma r. intraocular pres-sure control and long-term visual field loss in the Collaborative initial glau-coma Treatment study. Ophthalmology. 2011;118(9):1766-73.

Musch Dc, niziol lm, stein JD, Kamyar rm, Sugar A. Prevalence of corneal dystrophies in the united states: estimates from claims data. Invest Ophthalmol Vis Sci.2011;52(9):6959-63.

nakaizumi a, Puro DG. Vulnerability of the retinal microvasculature to hypoxia: role of polyamine-regulated K(aTP) channels. Invest Ophthalmol Vis Sci. 2011;52(13):9345-52.

nakaizumi a, Zhang T, Puro DG. The electrotonic architecture of the retinal microvasculature: diabetes-induced altera-tion. Neurochem Int.2012Feb13.[Epubaheadofprint]

nallasamy s, anninger wV, Quinn ge, Kroener b, Zetola nm, nkomazana o. survey of childhood blindness and visual impairment in botswana. Br J Ophthalmol. 2011;95(10):1365-70.

neveling K, Collin rw, gilissen C, van huet ra, Visser l, Kwint mP, gijsen sJ, Zonneveld mn, wieskamp n, de ligt J, siemiatkowska am, hoefsloot lh, buckley mf, Kellner u, Branham KE, den holland-er ai, hoischen a, hoyng C, Klevering bJ, van den born li, Veltman Ja, Cremers fP, scheffer h. next-generation genetic testing for retinitis pigmentosa. Hum Mutat. 2012;33(6):963-72.

newman-Casey Pa, Talwar n, nan b, Musch Dc, stein JD. The relationship be-tween components of metabolic syndrome and open-angle glaucoma. Ophthalmol-ogy.2011;118(7):1318-26.

Papageorgiou Ki, hwang CJ, Chang sh, Jarullazada i, Chokron garneau h, ang mJ, King aJ, mancini r, Douglas rs, goldberg ra. Thyroid-associated periorbitopathy: eyebrow fat and soft tissue expansion in patients with thyroid-associated orbitopathy. Arch Ophthalmol. 2012;130(3):319-28.

Papageorgiou Ki, mancini r, garneau hC, Chang sh, Jarullazada i, King a, forster-Perlini e, hwang C, Douglas rs, goldberg ra. a three-dimensional construct of the aging eyebrow: the illusion of volume loss. Aesthet Surg J. 2012;32(1):46-57.

Patel ss, lee bJ, Elner VM. Painful traumatic neuroma after orbital decom-pression surgery. Arch Ophthalmol. 2012;130(4):530-1.

Pattnaik br, Hughes BA. effects of KCnQ channel modulators on the m-type potas-sium current in primate retinal pigment epithelium. Am J Physiol Cell Physiol. 2012;302(5):C821-33.

Plageman Tf, Jr., Zacharias al, gage PJ,LangRA.Shroom3andaPitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis. Dev Biol. 2011;357(1):227-34.

Puro DG. retinovascular physiology and pathophysiology: new experimental ap-proach/new insights. Prog Retin Eye Res. 2012;31(3):258-70.

runkle ea, antonetti Da. The blood-retinal barrier: structure and functional signifi-cance. Methods Mol Biol. 2011;686:133-48.

runkle ea, sundstrom Jm, runkle Kb, Liu X, antonetti Da. occludin localizes to centrosomes and modifies mitotic entry. J Biol Chem.2011;286(35):30847-58.

schneider ew, geraets rl, Johnson MW. Pars plana vitrectomy without adjuvant procedures for repair of primary rheg-matogenous retinal detachment. Retina. 2012;32(2):213-9.

schneider ew, Johnson MW. emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review. Clin Ophthalmol.2011;5:1151-65.

shtein rM, Elner SG, bian Zm, Elner vM. il-8 and mCP gene expression and production by lPs-stimulated hu-man corneal stromal cells. Int J Inflam. 2012;2012:714704.

shtein rM, Kelley Kh, Musch Dc, Sugar a, Mian si. in vivo confocal microscopic evaluation of corneal wound healing after femtosecond laser-assisted kerato-plasty. Ophthalmic Surg Lasers Imaging. 2012;43(3):205-13.

shtein rM, raoof-daneshvar d, lin hC, Sugar A, Mian si, nan b, stein JD. Keratoplasty for corneal endothelial disease,2001-2009.Ophthalmology. 2012;119(7):1303-10.Epub2012 apr 17.

shtein rM. Post-lasiK dry eye. Expert Rev Ophthalmol.2011;6(5):575-82.



sloan fa, acquah Kf, Lee PP, sangvai dg. despite ‘welcome to medicare’ ben-efit, one in eight enrollees delay first use of part b services for at least two years. Health Aff.2012;31(6):1260-8.

smith tJ, Douglas rs. Pharmacotherapy: does selenium supplementation improve graves’ ophthalmopathy? Nat Rev Endo-crinol.2011;7(9):505-6.

smith tJ, hegedus l, Douglas rs. role of insulin-like growth factor-1 (igf-1) pathway in the pathogenesis of graves’ orbitopa-thy. Best Pract Res Clin Endocrinol Metab. 2012;26(3):291-302.

smith tJ, Padovani-Claudio da, lu y, raychaudhuri n, fernando r, atkins s, gillespie ef, gianoukakis ag, miller bs, gauger Pg, doherty gm, Douglas rs. fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in graves’ disease. J Clin Endocrinol Metab. 2011;96(12):3827-37.

sofat r, Casas JP, webster ar, Branham KE, hingorani ad. Complement factor h genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype. Int J Epide-miol.2012;41(1):250-62.

stanton Cm, yates Jr, den hollander ai, seddon Jm, swaroop a, stambolian d, fauser s, hoyng C, yu y, atsuhiro K, Branham KE, othman m, Chen w, Kortvely e, Chalmers K, hayward C, moore aT, dhillon b, ueffing m, wright af. Complement factor d in age-related macular degeneration. Invest Ophthalmol Vis Sci.2011;52(12):8828-34.

stein JD, grossman ds, mundy Km, Sugar A, sloan fa. severe adverse events after cataract surgery among medicare beneficiaries. Ophthalmology. 2011;118(9):1716-23.

stein JD, Kim dd, Peck ww, giannetti sm, hutton dw. Cost-effectiveness of medications compared with laser trabecu-loplasty in patients with newly diagnosed open-angle glaucoma. Arch Ophthalmol. 2012;130(4):497-505.

stein JD, Kim ds, mundy Km, Talwar n, nan b, Chervin rd, Musch Dc. The as-sociation between glaucomatous and other causes of optic neuropathy and sleep ap-nea. Am J Ophthalmol. 2011;152(6):989-98.

stein JD, newman-Casey Pa, Talwar n, nan b, Richards JE, Musch Dc. The relationship between statin use and open-angle glaucoma. Ophthalmology. 2012Oct;119(10):2074-81.Epub2012Jun21.

stein JD, Pasquale lr, Talwar n, Kim ds, reed dm, nan b, Kang Jh, wiggs Jl, Richards JE. geographic and climatic fac-tors associated with exfoliation syndrome. Arch Ophthalmol. 2011;129(8):1053-60.

stein JD, Talwar n, laverne am, nan b, Lichter PR. Trends in use of ancillary glau-coma tests for patients with open-angle glaucomafrom2001to2009.Ophthal-mology.2012;119(4):748-58.

stein JD, Vanderbeek bl, Talwar n, nan b, Musch Dc, Zacks DN. rates of nonexu-dative and exudative age-related macular degeneration among asian american ethnic groups. Invest Ophthalmol Vis Sci. 2011;52(9):6842-8.

stein JD. serious adverse events after cataract surgery. Curr Opin Ophthalmol. 2012;23(3):219-25.

sudhakar P, rodriguez fr, Trobe JD. mri restricted diffusion in lymphomatous optic neuropathy. J Neuroophthalmol. 2011;31(4):306-9.

sudhakar P, shah gV, saponara f, fullen dr, Trobe JD. Central retinal artery occlu-sion secondary to orbital inflammation in lupus erythematosus profundus. J Neur-oophthalmol.2012;32(1):93-4.

Sugar A, montoya mm, beck r, Cowden Jw, dontchev m, gal rl, Kollman C, malling J, mannis mJ, Tennant b. impact of the cornea donor study on acceptance of corneas from older donors. Cornea.2012Jan18.[Epubaheadofprint]

Tash br, bewley mC, russo m, Keil Jm, sundstrom Jm, antonetti Da, Tian f, flana-gan Jm. The occludin and Zo-1 complex, defined by small angle X-ray scattering and nmr, has implications for modulating tight junction permeability. Proc Natl Acad Sci USA.2012Jul3;109(27):10855-60.Epub2012Jun18.

Taylor s, Chen J, luo J, Hitchcock PF. light-induced photoreceptor degeneration in the retina of the zebrafish. Methods Mol Biol2012;884:247-54.

Thomas Jl, ochocinska mJ, Hitchcock Pf, Thummel r. using the Tg(nrd:egfp)/albino zebrafish line to characterize in vivo expression of neurod. PLoS One. 2012;7(1):e29128.

thompson Da, Khan NW, othman mi, Chang b, Jia l, Heckenlively JR, swaroop A.Rd9isanaturallyoccurringmousemodel of a common form of retinitis pigmentosa caused by mutations in rPgr-orf15. PLoS ONE.2012;7(5):e35865.

Todorich b, scott iu, flynn hw, Jr., Johnson MW. evolving strategies in the management of submacular hemorrhage associated with choroidal neovasculariza-tion in the anti-vascular endothelial growth factor era. Retina. 2011;31(9):1749-52.



Tranos Pg, moore a, Pavesio C, acha-rya nr, Johnson MW. diagnostic and therapeutic challenges. Retina. 2012;32(1):191-6.

Tsui s, fernando r, Chen b, smith tJ. divergent sp1 protein levels may underlie differential expression of udP-glucose dehydrogenase by fibroblasts: role in sus-ceptibility to orbital graves’ disease. J Biol Chem.2011;286(27):24487-99.

ulmer m, li J, yaspan bl, ozel ab, Richards JE, Moroi SE, hawthorne f, budenz dl, friedman ds, gaasterland d, haines J, Kang Jh, lee r, Lichter PR, liu y, Pasquale lr, Pericak-Vance m, realini a, schuman Js, singh K, Vollrath d, weinreb r, wollstein g, Zack dJ, Zhang K, young T, allingham rr, wiggs Jl, ashley-Koch a, hauser ma. genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the neighbor and glaugen consortia. Invest Ophthal-mol Vis Sci.2012;3;53(8):4468-74.Epub2012Jun1.

Van herle K, behne Jm, Van herle a, blaschke Tf, smith tJ, yeaman mr. integrative continuum: accelerating therapeutic advances in rare autoimmune diseases. Annu Rev Pharmacol Toxicol. 2012;52:523-47.

Van hook mJ, Wong Ky, berson dm. dopaminergic modulation of ganglion-cell photoreceptors in rat. eur J Neurosci. 2012;35(3-4):507-18.

Vanderbeek bl, Johnson MW. The diversity of traction mechanisms in myopic traction maculopathy. Am J Ophthalmol. 2012;153(1):93-102.

Vanderbeek bl, Zacks DN, Talwar n, nan b, Musch Dc, stein JD. racial differences in age-related macular degeneration rates in the united states: a longitudinal analysis of a managed care network. Am J Oph-thalmol. 2011;152(2):273-82.

warden Kf, alizai am, Trobe JD, hoff JT. short-term continuous intraparenchymal in-tracranial pressure monitoring in presumed idiopathic intracranial hypertension. J Neuroophthalmol. 2011;31(3):202-5.

weick m, Demb JB. delayed-rectifier K channels contribute to contrast adapta-tion in mammalian retinal ganglion cells. Neuron.2011;71(1):166-79.

Weizer JS, Musch Dc, niziol lm, Khan nW. multifocal visual evoked potentials for early glaucoma detection. Ophthalmic Surg Las Imaging 2012;43:335-40.

wiggs Jl, yaspan bl, hauser ma, Kang Jh, allingham rr, olson lm, abdrabou w, fan bJ, wang dy, brodeur w, budenz dl, Caprioli J, Crenshaw a, Crooks K, del-bono e, doheny Kf, friedman ds, gaas-terland d, gaasterland T, laurie C, lee rK, Lichter PR, loomis s, liu y, medeiros fa, mcCarty C, mirel d, Moroi SE, Musch Dc, realini a, Rozsa FW, schuman Js, scott K, singh K, stein JD, Trager eh, Vanveldhuisen P, Vollrath d, wollstein g, yoneyama s, Zhang K, weinreb rn, ernst J, Kellis m, masuda T, Zack d, richards Je, Pericak-Vance m, Pasquale lr, haines JL.Commonvariantsat9p21and8q22are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet.2012;8(4):e1002654.

wilkinson Je, burmeister l, brooks sV, Chan CC, friedline s, harrison de, hejtmancik Jf, nadon n, strong r, wood lK, Woodward MA, miller ra. rapamy-cin slows aging in mice. Aging Cell. 2012;11(4):675-82.Epub2012Jun4.

wissinger b, schaich s, baumann b, bonin m, Jagle h, friedburg C, Varsanyi b, hoyng Cb, dollfus h, Heckenlively JR, rosenberg T, rudolph g, Kellner u, salati r, Plomp a, de baere e, andrassi-darida m, sauer a, wolf C, Zobor d, bernd a, leroy bP, enyedi P, Cremers fP, lorenz b, Zrenner e, Kohl s. large deletions of theKCNV2genearecommoninpatientswith cone dystrophy with supernormal rod response. Hum Mutat.2011;32(12):1398-406.

Woodward MA, Titus m, mavin K, shtein rM. Corneal donor tissue preparation for endothelial keratoplasty. J Vis Exp. 2012;64:e3847.

yang D, Elner SG, Chen X, field mg, Petty hr, Elner VM. mCP-1-activated monocytes induce apoptosis in human reti-nal pigment epithelium. Invest Ophthalmol Vis Sci.2011;52(8):6026-34.

yao J, Jia l, Khan NW, Zheng Qd, moncrief a, hauswirth ww, thompson Da, Zacks DN. Caspase inhibition with XiaP as an adjunct to aaV vector gene-replacement therapy: improving efficacy and prolonging the treatment window. PLoS One.2012;7(5):e37197.

Zaidi aa, brucker aJ, Johnson MW. diag-nostic and therapeutic challenges. Retina. 2011;31(10):2125-8.

Zhang l, sun y, Johnson MW, Richards Je, Moroi SE. Combined cilioretinal artery and central vein occlusions in juvenile glaucoma. Arch Ophthalmol. 2011;129(9):1231-4.

Zhang X, yang d, Hughes BA. KCnQ5/K(v)7.5 potassium channel expression and subcellular localization in primate retinal pigment epithelium and neural retina. Am J Physiol Cell Physiol. 2011;301(5):C1017-26.



Zhao sX, Tsui s, Cheung a, Douglas rs, smith tJ, banga JP. orbital fibrosis in a mouse model of graves’ disease induced by genetic immunization of thyrotropin receptor cdna. J Endocrinol. 2011;210(3):369-77.

Zhu a, romero r, Petty hr. an enzymatic colorimetric assay for glucose-6-phosphate. Anal Biochem. 2011;419(2):266-70.

Zhu a, sun K, Petty hr. Titanium doping reduces superoxide dismutase activity, but notoxidaseactivity,ofcatalyticCeO(2)nanoparticles. Inorg Chem Commun. 2012;15:235-237.

Books/Book chaPters

Cho, r.i., Kahana, A. orbital exentera-tion. in: black eh, nesi fa, gladstone gJ, levine mr, Calvano CJ, eds, Smith and Nesi’s Ophthalmic Plastic & Reconstructive Surgery, 3rd edition. new york:springer, 2012,pp1033-44.

de la Parra P, Sugar A, Mian si. Conjunc-tival flaps for Corneal disease. in: Tasman w, Jaeger ea, eds, Duane’s Clinical Ophthalmology. Philadelphia:Jb lippincott, 2012,vol6,chap33.

Del Monte Ma. neurocutaneous syn-dromes. in: wright Kw, strube yJ, eds, Pediatric Ophthalmology and Strabismus, 3rd edition. new york, ny: oxford univer-sityPress,2012,pp1167-97.

Del Monte Ma. ocular anatomy and Physiology. in: rudolph C, lister g, ger-shon a, first l, rudolph a, eds, Rudolph’s Pediatrics,22ndedition.NewYork,NY:McGraw-Hill,2012,chap579,pp2273-5.

Douglas rs, gupta s, smith tJ. Pathogen-esis and medical management of Thyroid eye disease. in: black eh, nesi fa, glad-stone gJ, levine mr, Calvano CJ, eds, Smith and Nesi’s Ophthalmic Plastic & Reconstructive Surgery, 3rd edition. new York:Springer,2012,pp1213-23.

enzenauer r, hoehn me, Del Monte Ma. strabismus. in: rudolph C, lister g, gershon a, first l, rudolph a, eds, Rudolph’s Pediatrics,22ndedition.NewYork,NY:McGraw-Hill,2012,chap586,pp2293-8.

gupta s, Demirci H, lee bl, Elner VM, Kahana A. orbital inflammatory diseases. in: black eh, nesi fa, gladstone gJ, levine mr, Calvano CJ, eds, Smith and Nesi’s Ophthalmic Plastic & Reconstructive Surgery, 3rd edition. new york:springer, 2012,pp933-58.

Hackel RE. ophthlamic Photography. in: stein ha, stein rm, freeman mi, eds, Ophthalmic Assistant: A Text for Allied and Associated Ophthalmic Personnel,9thedi-tion.NewYork:Elsevier,2012.

John Da, Weizer JS. selective laser Trabeculoplasty. in: Kahook m, ed, Es-sentials of Glaucoma Surgery. Thorofare, NJ:SLACKInc.2012,chap21,pp185-196.

Kahana A. Transcranial approach to the orbit. in: black eh, nesi fa, glad-stone gJ, levine mr, Calvano CJ, eds, Smith and Nesi’s Ophthalmic Plastic & Reconstructive Surgery, 3rd edition. new York:Springer,2012,pp807-10.

Kahana, A. orbital Vascular anomalies. in: black eh, nesi fa, gladstone gJ, levine mr, Calvano CJ, eds, Smith and Nesi’s Ophthalmic Plastic & Reconstructive Surgery, 3rd edition. new york:springer, 2012,pp993-1004.

raoof d, Mian si. femtosecond laser-assisted astigmatism correction. in: goggin m, ed, Astigmatism - Optics, Physiol-ogy and Management, new york, new York:InTechPublishing,2012,chap13.

rumery TC, Musch Dc, stein JD. review of glaucoma surgery Clinical Trials. in: Kahook my, ed., Essentials of Glaucoma Surgery.Thorofare,NJ:SLACKInc.,2012,chap43,pp.351-72.

saponara f, stein JD. Comparison of argon laser Trabeculoplasty and selective laser Trabeculoplasty. in: Kahook m, ed, Essentials of Glaucoma Surgery. Thoro-fare,NJ:SLACKInc.2012,chap22,pp197-201.

stein JD. Preoperative evaluation for glaucoma drainage device surgery. in: Kahook m, ed, Essentials of Glaucoma Surgery.Thorofare,NJ:SLACKInc.2012,chap 6, pp 61-71.

stein JD. standard Technique for implant-ing glaucoma drainage devices. in: Kahook m, ed, Essentials of Glaucoma Surgery.Thorofare,NJ:SLACKInc.2012,chap8pp81-94.

stratton r, hauswirth w, Gardner TW. Studies on Retinal and Choroidal Disor-ders.NewYork:Humana,2012.

Szymarek TN, Moroi, SE, eisengart Ja. glaucoma surgery in the nanophthalmic eye. in: Kahook m, ed, Essentials of Glau-coma Surgery. Thorofare, nJ:slaCK inc. 2012,chap33,pp285-291.

Tombran-Tink J, barnstable CJ, Gardner tW. Visual dysfunction in diabetes: The Science of Patient Impairment and Im-provement.NewYork:Springer,2012.

Trobe JD. The Physician’s Guide to Eye Care, 4th edition. san francisco:american AcademyofOphthalmology,2012.



faCulTy name sourCe id ProJeCT TiTle

eXternaL grants anD funDingJuly 1, 2011 — June 30, 2012

S.Abcouwer,Ph.D. NIH R01-EY020582-04 RegulationofRetinalCellDeathinDiabetes;Co-I Jdrf Jdrf Center for mechanisms and intervention ofDiabeticRetinopathy;Project2Co-PI

D.Antonetti,Ph.D. NIH R21-EY-019392-03 InductionoftheBlood-RetinalBarrier NIH R01-EY-012021-15 MechanismsofRetinalVascularPermeabilityinDiabetes NIH R01-EY-021165 TheRetinalMicroenvironmentinDiabeticRetinopathy subcontract with northwestern university, Pi: robert linsenmeier, Ph.d. Jdrf developing atypical PKC inhibitors to Treat diabetic retinopathy Jdrf Jdrf Center for mechanisms and intervention ofDiabeticRetinopathy;Project2Co-PI Jdrf PolyChromatic angiography for grading retinal Vascular leakage rPb Jules and doris stein rPb Professorship

g. Comer, m.d., m.s. lowy medical research institute/ a natural history study of macular Telangiectasia — Clinical Trial The macTel study ocuscience Phase ii/iii study of the efficacy and safety of macuclear mC-1101 1% Tid in the Treatment of nonexudative amd ocuscience reproducibility and Tolerability of Visual Tests used to evaluate nonexudative amd

w. Cornblath, m.d. iCon Clinical research/Pfizer Case-Crossover study of Pde5 inhibitor exposure as a Potential “Trigger factor” for acute naion

h. demirci, m.d. midwest eye-banks roles of inflammation and angiogenesis in Conjunctival melanoma: Progression and metastasis

R.Douglas,M.D.,Ph.D. NIH R01-EY211197-02 RoleofCD40+FibrocytesinThyroid-Associated ophthalmopathy rPb lew r. wasserman merit award

s. elner, m.d. nih/Clinical Trial u10-ey014660-06 multicenter uveitis steroid Treatment (musT) Trial Coordinating Center: Johns hopkins university SantenPharmaceutical IntravitrealInjectionsofDE-109fortheTreatment of active, non-infectious uveitis

P. fort, Ph.d. fight for sight detailed analysis of Crystallins Cellular and sub-Cellular upregulation during diabetic retinopathy midwest eye-banks Characterization of Crystallin Proteins expression in human retina: effect of diabetes



P.Gage,Ph.D. NIH R01-EY014126-09 Pitx2:MolecularMechanismsinEyeDevelopment and disease

T.Gardner,M.D.,M.S. NIH R01-EY020582-04 RegulationofRetinalCellDeathinDiabetes NIH DP3-DK094292-01 MetabolicReprogramminginDiabeticComplications; subaccount with frank C. brosius, m.d., department of nephrology, university of michigan NIH/ClinicalTrial U10EY14231 PromptPanretinalPhotocoagulation(ProtocolS), Coordinating Center: Jaeb NIH/ClinicalTrial U10EY01423 GenesinDiabeticRetinopathy,CoordinatingCenter:Jaeb american diabetes association regulation of akt activity in diabetic retinopathy Jdrf Jdrf Center for mechanisms and intervention of diabetic retinopathy Jdrf evaluation of retinal sensory neuropathy study midwest eye-banks a diabetic retinopathy risk of Progression Calculator rPb Physician-scientist award

J.Heckenlively,M.D. NIH R01-DC009606-03 OlfactorySignaling,Cilia,andSensoryDisorders subaccount with Jeffrey martens, Ph.d., department of Pharmacology, university of michigan NIH R01-EY016862-05 GeneticVariationsinAge-RelatedMacularDegenerations NIH R21-EY-022172-01 InvestigationofAutoimmuneAnti-RetinalAntibodiesinDiabetes ffb Center for the study of retinal degenerative diseases ffb Consortium Treatment grant: assessment of Therapies NNRI NNSP-CL-0212- APhaseIIMultipleSite,Randomized,Placebo-Controlled 0061-miCh-ner Trial of oral Valproic acid ocuscience ocusciences Photography Project sramek foundation interactive and integrated genetic databases for the study of age-related macular degeneration

P.Hitchcock,Ph.D. NIH R01-EY007060-23 NeuronalDevelopment,InjuryandRepairinRetina NIH T32-EY013934-10 VisionResearchTrainingProgram midwest eye-banks regulation of retina-specific gene expression

B.Hughes,Ph.D. NIH P30-EY007003-26 CoreCenterforVisionResearch(fivecoremodules) NIH R01-EY008850-20 IonConductancesintheRetinalPigmentEpithelium

m. Johnson, m.d. midwest eye-banks student stipend award for natalia bajenova, m.d.

A.Kahana,M.D.,Ph.D.NIH K08-EY018689-05 ZebrafishModelforStudyingOrbitalDevelopment and disease alliance for Vision research biological signals Controlling extraocular muscle regeneration alliance for Vision research Chemical genomic screen for modifiers of axenfeld-rieger syndrome: a Pilot study to identify novel Therapeutics of anterior segment dysgenesis




a. Kahana, m.d., Ph.d. alliance for Vision research investigating the role of extracellular matrix factors and(cont.) Collective Cell migration in extraocular muscle repair and regeneration using a Zebrafish model AllianceforVisionResearch InvestigatingtheRolesofTwist1andTwist2inExtraocular muscle biology and orbital rhabdomyosarcoma alliance for Vision research Thyroid-related eye disease: a Preclinical study investigating the role of retinoid receptors in mediating orbitopathy fight for sight developing genomic Technologies to study extraocular muscle OrganizationandStrabismusUsingaZebrafishModel; award for brenda bohnsack, m.d., Ph.d. fight for sight development and regeneration of extraocular muscles in Zebrafish - student stipend award for u-m medical student daniel Kasprick rPb Career development award

P. lichter, m.d. rPb unrestricted grant VisionCare ophthalmic Technologies/ VisionCare ophthalmic Technologies implantable Clinical Trial miniature Telescope for Central Vision impairment associated with age-related macular degeneration and other maculopathies

m. lipson, o.d. eyeVis, l.l.C. stabilizing myopia by accelerated reshaping Technique synergeyes, inc. duette Versus biofinity Toric: Visual acuity and Vision-related Quality of life

s. mian, m.d. alliance for Vision research Cost-effectiveness of endothelial Keratoplasty Compared with Penetrating Keratoplasty bausch & lomb, inc. Treatment of ocular graft-versus-host disease (gVhd) with Topical loteprednol etabonate 0.5% midwest eye-banks outcomes of refractive surgery Performed by Trainees

S.Moroi,M.D.,Ph.D. NIH R01-EY-022124-01 AqueousHumorDynamicComponentsthatDetermine intraocular Pressure Variance MerckandCompany,Inc. MerckIISP#31911Study:EffectofMyocilinGenetic Variants on intraocular Pressure and Pressure Variation in sitting and supine Positions

D.Musch,Ph.D.,M.P.H. NIH R21-EY-020912-02 ClinicalandQualityofLifeInsightsonGlaucoma from analyses of CigTs data NIH RC1-EY020140-01 ComparativeEffectivenessandMedicalInterventions forPrimaryOpen-AngleGlaucoma;Subcontractwith Johns hopkins university m-CasTl a survey of Vision Care Providers for older drivers Pfizer Value estimation Project in glaucoma (Phase iii)




C.Nelson,M.D. NIH R01EY019497-03 GeneticBasisofCongenitalAnophthalmia; subaccount with Thomas glaser, Ph.d., departments of internal medicine and human genetics, university of michigan midwest eye-banks economic factors that influence blepharoplasty and ectropion repairs

H.Petty,Ph.D. NIH R21EY019986-01A1NovelImmunofluorescenceMethodsforRetinalResearch elsa u. Pardee foundation Pilot studies on the anti-Tumor Capacity of novel Catalytic nanoparticles

D.Puro,M.D.,Ph.D. NIH R01-EY012507-13 RetinovascularPhysiologyandPathobiology

J. richards, Ph.d. nih r01-ey011671-11 molecular genetics of Primary open-angle glaucoma NIH R21EY021000-02 OcularEffectsofMetformin NSF CMMI1130275 MechanicsofIntraocularPressureIncreaseAssociatedwith genetic factors subaccount with alan argento, Ph.d., department of mechanical engineering, university of michigan dearborn

R.Shtein,M.D.,M.S. NIH K23-EY017885-04 NeovascularizationPatternsinCornealGraftRejection NIH P60-DK020572-34 InVivoCornealConfocalMicroscopyforNon-invasive AssessmentofDiabeticPeripheralNeuropathy;Subaccount with michigan diabetes research and Training Center, university of michigan, Co-Pi midwest eye-banks diagnostic imaging for intraoperative floppy iris syndrome u-m medical school Clinical sciences scholars Program award

T.Smith,M.D. NIH R01-DK063121-05 ImmunoglobulinActivationofFibroblasts NIH R01-EY008976-18 RegulationofRetroocularConnectiveTissue nih r01-ey011708-16 functional diversity of orbital fibroblasts howard hughes fibrocytes as a Potential biomarker for Thyroid-associated MedicalInstitute Ophthalmopathy;ResearchTrainingFellowshipfor u-m medical student erin gillespie rPb Physician-scientist award

J.Stein,M.D.,M.S. NIH K23-EY019511-03 AssociationbetweenCataractSurgeryandProgression of diabetic retinopathy NIH P60-DK020572 Cost-EffectivenessofDifferentTreatmentsforClinically SignificantDiabeticMacularEdema;Subcontractwith michigan diabetes research and Training Center, university of michigan alliance for Vision research a diabetic retinopathy Progression risk Calculator american glaucoma society mentoring for advancement of Physician-scientist enabling award Program




J. stein, m.d., m.s. blue Cross blue shield of michigan longitudinal rates of Postoperative adverse outcomes (cont.) after glaucoma surgery among medicare beneficiaries 1994–2005 rPb Physician-scientist award

A.Sugar,M.D. NIH/ClinicalTrial U10-EY012358 CorneaDonorStudy,CoordinatingCenter:Jaeb NIH/ClinicalTrial U10-EY020797-01 CornealPreservationTimeStudy,CoordinatingCenter:Jaeb

D.Thompson,Ph.D. NIH R21-EY020967-01 ChromophoreEffectsinGeneticallyDiverseForms of retinal dystrophy ffb Consortium Treatment grant: small molecular interventions ffb gene-replacement Therapy for XlrP due to rPgr mutations - Continuation midwest eye-banks Chromophore Therapy in retinal degeneration RDH12FundforSight Gene-ReplacementTherapyforRDH12Mutations

K. wong, Ph.d. nih r00-ey018863-05 Cross-Talk between ganglion-Cell Photoreceptors and other neurons in the retina midwest eye-banks functional Characterization of developmental Changes in nmda receptor subunit Composition of retinal ganglion Cells rPb Career development award

D.Zacks,M.D.,Ph.D. NIH R01-EY020823-03 AutophagyandControlofPhotoreceptorApoptosis beckman foundation autophagy and age-related macular degeneration ffb Center for the study of retinal degenerative diseases ffb Consortium Treatment grant: Transplantation of Photoreceptor Precursors lincy foundation Preventing Photoreceptor Cell death in age-related macular degeneration

Source Abbreviations

FFB..................... Foundation Fighting Blindness JDRF ................. Juvenile Diabetes Research Foundation International M-CASTL ........Michigan Center for Advancing Safe Transportation throughout the lifespan nIH ...................national Institutes of Health nnRI ................national neurovision Research Institute nSF ...................national Science Foundation RPB ....................Research to Prevent Blindness


leadersHIP

Paul P. lee, m.d., J.d.chair

alan sugar, m.d.Vice chair

michael W. smith-Wheelock, m.d.associate chair for clinical affairs

shahzad I. mian, m.d.associate chair for education

Thomas W. Gardner, m.d., m.s.associate chair for research

secTIon cHIeFs

Jill e. Bixler, m.d.comprehensive ophthalmology

donna m. Wicker, o.d., Faaocontact lens, low Vision and Visual rehabilitation

H. kaz soong, m.d.cornea and external disease, cataract and refractive surgery

christine c. nelson, m.d., Facseye Plastic, orbital and Facial cosmetic surgery

sayoko e. moroi, m.d., Ph.d.Glaucoma, cataract and anterior segment disease

Jonathan d. Trobe, m.d.neuro-ophthalmology

monte a. del monte, m.d.Pediatric ophthalmology and adult strabismus

mark W. Johnson, m.d.retina and uveitis

adrienne l. West, m.d.at large

FaculTy

steven F. abcouwer, Ph.d.Vision research

James l. adams, m.d.eye Plastic, orbital and Facial cosmetic surgery

david a. antonetti, Ph.d.Vision research

steven m. archer, m.d.Pediatric ophthalmology and adult strabismus

Terry J. Bergstrom, m.d.comprehensive ophthalmology

donald s. Beser, m.d., Facscomprehensive ophthalmology

cagri G. Besirli, m.d., Ph.d.retina and uveitis

Brenda l. Bohnsack, m.d., Ph.d.Pediatric ophthalmology and adult strabismus

kari Branham, m.s., c.G.c.Genetic counseling

Grant m. comer, m.d., m.s.retina and uveitis

Theresa m. cooney, m.d.cornea and external disease, cataract and refractive surgery

Wayne T. cornblath, m.d.neuro-ophthalmology

sherry H. day, o.d.contact lens, low Vision and Visual rehabilitation

karen s. deloss, o.d.contact lens, low Vision and Visual rehabilitation

Hakan demirci, m.d.orbital and ocular oncology

courtney a. dewey, o.d.Pediatric ophthalmology and adult strabismus

raymond s. douglas, m.d., Ph.d.eye Plastic, orbital and Facial cosmetic surgery

elizabeth du, m.d.comprehensive ophthalmology

susan G. elner, m.d.retina and uveitis

Victor m. elner, m.d., Ph.d.eye Plastic, orbital and Facial cosmetic surgery

Jerome I. Finkelstein, m.d., Facscomprehensive ophthalmology

Patrice e. Fort, Ph.d.Vision research

carlton J. Foster, o.d.Pediatric ophthalmology and adult strabismus

Bruce a. Furr, c.o., m.s.P.H.Pediatric ophthalmology and adult strabismus

Philip J. Gage, Ph.d.Vision research

christopher Gappy, m.d.Pediatric ophthalmology and adult strabismus

Hilary m. Grabe, m.d.neuro-ophthalmology

daniel G. Green, Ph.d.Vision research

Paul J. Grenier, o.d.comprehensive ophthalmology

richard e. Hackel, m.a., c.r.a.ophthalmic Photography

John r. Heckenlively, m.d.retina and uveitis

Peter F. Hitchcock, Ph.d.Vision research

christopher T. Hood, m.d.cornea and external disease, cataract and refractive surgery

Bret a. Hughes, Ph.d.Vision research

Ida l. Iacobucci, c.o.Pediatric ophthalmology and adult strabismus

diane m. Jacobi, o.d.contact lens, low Vision and Visual rehabilitation

Thiran Jayasundera, m.d., Frcsc, FranZcoretina and uveitis

denise a. John, m.d., FrcscGlaucoma, cataract and anterior segment disease

alon kahana, m.d., Ph.d.eye Plastic, orbital and Facial cosmetic surgery

ariane d. kaplan, m.d.comprehensive ophthalmology

Harjeet kaur, m.d., Frcs(I)comprehensive ophthalmology

naheed W. khan, Ph.d.Vision research

Jennifer a. kozak, m.d.Pediatric ophthalmology and adult strabismus

amy l. lagina, o.d.contact lens, low Vision and Visual rehabilitation

Helios T. leung, Ph.d., o.d., Faaocontact lens, low Vision and Visual rehabilitation

Paul r. lichter, m.d., FacsGlaucoma, cataract and anterior segment disease

cheng-mao lin, Ph.d.Vision research

michael J. lipson, o.d., Faaocontact lens, low Vision and Visual rehabilitation

Xuwen liu, m.d., Ph.d.research Investigator

david c. musch, Ph.d., m.P.H.Vision research

arivalagan muthusamy, Ph.d.research Investigator

Gale a. oren, m.I.l.s.library

Hemant Pawar, Ph.d.Vision research

Howard r. Petty, Ph.d.Vision research

donald G. Puro, m.d., Ph.d.comprehensive ophthalmology

Julia e. richards, Ph.d.Vision research

Frank W. rozsa, Ph.d.research Investigator

Gary s. sandall, m.d., FacsPediatric ophthalmology and adult strabismus

roni m. shtein, m.d.cornea and external disease, cataract and refractive surgery

Terry J. smith, m.d.eye Plastic, orbital and Facial cosmetic surgeryendocrinology

Joshua d. stein, m.d., m.s.Glaucoma, cataract and anterior segment disease

Bradley W. Taylor, o.d., m.P.H.contact lens, low Vision and Visual rehabilitation

debra a. Thompson, Ph.d.Vision research

susan s. Thoms, m.d.comprehensive ophthalmology

Joshua P. Vrabec, m.d.comprehensive ophthalmology

Jennifer s. Weizer, m.d.Glaucoma, cataract and anterior segment disease

kwoon y. Wong, Ph.d.Vision research

maria a. Woodward, m.d.cornea and external disease, cataract and refractive surgery

rebecca a. Wu, m.d.comprehensive ophthalmology

dongli yang, m.d., Ph.d.research Investigator

david n. Zacks, m.d., Ph.d.retina and uveitis

FaCuLty oF the department oF ophthalmology and Visual sciences

w.K. Kellogg eye Center

Faculty2012Faculty of the department of

ophthalmology and Visual sciences

1st Row: Thomas W. Gardner, M.D., M.S., Shahzad I. Mian, M.D., Paul P. Lee, M.D., J.D., Alan Sugar, M.D.

2nd Row: Jonathan D. Trobe, M.D., Jill E. Bixler, M.D., H. Kaz Soong, M.D., Mark W. Johnson, M.D., Monte A. Del Monte, M.D., Christine C. Nelson, M.D., Sayoko E. Moroi, M.D., Ph.D., Denise A. John, M.D.

3rd Row: John R. Heckenlively, M.D., James L. Adams, M.D., Kwoon Y. Wong, Ph.D., Steven M. Archer, M.D., Gary S. Sandall, M.D., Susan S. Thoms, M.D., Alon Kahana, M.D., Ph.D., Joshua P. Vrabec, M.D., Elizabeth Du, M.D.

4th Row: Hilary M. Grabe, M.D., Theresa M. Cooney, M.D., Wayne T. Cornblath, M.D., Peter F. Hitchcock, Ph.D., Debra A. Thompson, Ph.D., Donald G. Puro, M.D., Ph.D., Bruce A. Furr, C.O., David C. Musch, Ph.D., M.P.H., Roni M. Shtein, M.D., M.S., Grant M. Comer, M.D., M.S., Jennifer A. Kozak, M.D., Rebecca A. Wu, M.D.

5th Row: Joshua D. Stein, M.D., M.S., Patrice E. Fort, Ph.D., M.S., Jerome I. Finkelstein, M.D., Terry J. Bergstrom, M.D., Amy L. Lagina, O.D., Bradley W. Taylor, O.D., M.P.H., Karen S. DeLoss, O.D., Christopher T. Hood, M.D.

6th Row: Richard E. Hackel, M.A., C.R.A., Steven F. Abcouwer, Ph.D., Michael J. Lipson, O.D., Philip J. Gage, Ph.D., Bret A. Hughes, Ph.D., Christopher Gappy, M.D., Sherry H. Day, O.D., Courtney A. Dewey, O.D., Donna M. Wicker, O.D., Gale A. Oren, M.I.L.S., Brenda L. Bohnsack, M.D., Ph.D.

7th Row: Thiran Jayasundera, M.D., David A. Antonetti, Ph.D., Paul J. Grenier, O.D., Susan G. Elner, M.D., Hakan Demirci, M.D., David N. Zacks, M.D., Ph.D., Raymond S. Douglas, M.D., Ph.D., Maria A. Woodward, M.D., Helios T. Leung, Ph.D., O.D., Cheng-mao Lin, Ph.D.

1sT year resIdenTs

courtney kauh, m.s., m.d.m.d. university of Toledo m.s. ohio state university

mehnaz khan, m.s., m.d.m.d. Vanderbilt universitym.s. Johns Hopkins university

lee m. kiang, m.d., Ph.d.m.d., Ph.d. Weill cornell, rockefeller, sloan ketteringPh.d. The rockefeller university

monica m. michelotti, m.d.m.d. university of michigan

melisa nika, m.d.m.d. university of michigan

andrew W. stacey, m.d., m.s. m.d. ohio state university m.s. Brigham young university

2nd year resIdenTs

nicholas d. chinskey, m.d.m.d. university of michigan

abigail T. Fahim, m.d., Ph.d.m.d. Baylor university Ph.d. university of michigan

ryan J. Fante, m.d.m.d. university of colorado denver

denise s. kim, m.d.m.d. university of michigan

crandall e. Peeler, m.d.m.d. dartmouth college

Patricia a. Ple-plakon, m.d.m.d. university of michigan

Ira H. schachar, m.d.m.d. Washington university in st. louism.sc. oxford university

3rd year resIdenTs

alexandra o. apkarian, m.d.m.d. university of michigan

s. asha Balakrishnan, m.d.m.d. Washington university in st. louis

michael l. Bullard, m.d.m.d. university of Iowa

Blake V. Fausett, m.d., Ph.d.m.d. university of michiganPh.d. university of michigan

molly l. Fuller, m.d., Ph.d.m.d. case Western reserve university Ph.d. case Western reserve university

kristen Harris nwanyanwu, m.d., m.B.a.m.d. university of Pennsylvaniam.B.a. university of Pennsylvania

duna raoof-daneshvar, m.d.m.d. university of michigan

Travis rumery, d.o.m.d. des moines university, college of osteopathic medicine

clInIcal FelloWs

cesar a. Briceno, m.d.eye Plastic, orbital and Facial cosmetic surgerym.d. - Johns Hopkins universityresidency - doheny eye Institute, university of southern california

lindsey B. delott, m.d.neuro-ophthalmologym.d. - ohio state universityresidency - university of michigan

nadeem H. Fatteh, m.d.cornea and external disease, cataract and refractive surgerym.d. - medical college of Georgiaresidency - Georgia Health sciences university

Jonathan B. Greene, m.d.cornea and external disease, cataract and refractive surgerym.d. - university of michiganresidency - university of california

shivani Gupta, m.d., m.P.H.eye Plastic, orbital and Facial cosmetic surgerym.P.H. - university of michiganm.d. - ohio state universityresidency - university of Illinois at chicago

nieraj Jain, m.d.Vitreo-retinal surgicalm.d. - duke universityresidency - duke university

Partho s. kalyani, m.d.Vitreo-retinal surgicalm.d. - northeastern ohio universities college of medicine residency - university of arizonaFellowship - Jules stein eye Institute, university of california los angeles

allison n. mccoy, m.d., Ph.d.eye Plastic, orbital and Facial cosmetic surgerym.d. - duke university residency - Wilmer eye Institute

Paula anne newman-casey, m.d.research / comprehensive ophthalmologym.d. - university of michiganresidency - university of michigan

shreya s. Prabhu, m.d., m.P.H.Pediatric ophthalmology and adult strabismusm.d. - Boston universityresidency - university of michigan

Jasleen k. singh, m.d.Pediatric ophthalmology and adult strabismusm.d. - medical college of Georgiaresidency - northwestern university

Jeffrey m. sundstrom, m.d., Ph.d.medical retina Fellowm.d. - Pennsylvania state university residency - Pennsylvania state university

linda Zhang, m.d.Glaucoma, cataract and anterior segment diseasem.d. - university of michigan residency - university of michigan

researcH FelloWs

alma rosa Barajas-espinosa, Ph.d.Ph.d. universidad autonoma de san luis Potosi, mexico

edith arnold Hernandez, Ph.d.Ph.d. national autonomous university of mexico

caiping Hu, m.d., Ph.d.Ph.d. Wayne state universityPh.d. sun yat-sen university, Guangzhou, Guangdong, Peoples republic of china

Bin li, m.d., Ph.d.Ph.d. ohio state university

Jibiao li, Ph.d.Ph.d. kent state university

nupur raychaudhuri, Ph.d.Ph.d. Bose Institute, calcutta, India

shameka J. shelby, Ph.d.Ph.d. university of michigan

Benjamin k. stafford, Ph.d.Ph.d. university of california, santa cruz

scott m. Taylor, Ph.d.Ph.d. Florida Institute of Technology

Wei Zhang, Ph.d.Ph.d. Institute of developmental Biology, shandong university, Peoples republic of china Xiwu Zhao, Ph.d.Ph.d. Institute of Biophysics, chinese academy of sciences, Beijing, china

Our residents, clinical fellows, and research fellows

are an important part of the Kellogg community,

where they have the opportunity to forge close

working relationships with faculty. At Kellogg we

are committed to bringing new technologies and

approaches to education to help our graduates

meet the challenges of changing health care and

research environments.

eduCaTing The neXT generaTion of oPhThalmologisTs and Vision sCienTisTs

Executive Officers of the University of Michigan Health System Ora Hirsch Pescovitz, M.D. Executive Vice President for Medical Affairs

Douglas L. Strong, M.B.A. Chief Executive Officer, U-M Hospitals and Health Centers

James O. Woolliscroft, M.D. Dean, U-M Medical School

The Regents of the University of Michigan

Julia Donovan Darlow, Laurence B. Deitch, Denise Ilitch, Olivia P. Maynard, Andrea Fischer Newman, Andrew C. Richner, S. Martin Taylor, Katherine E. White, Mary Sue Coleman (ex officio)

Editor: Betsy Nisbet

Writers: Aimee Bergquist, Barbara Sefton

Editorial Assistant: Lisa Burkhart

Design and Art Direction: David Murrel

Photographers: Eric Bronson, Scott Soderberg, Austin Thomason, U-M Photo Services; Lin Goings, U-M Department of Ophthalmology and Visual Sciences; Leisa Thompson, Leisa Thompson Photography

FOR addiTiOnal cOpiES, plEaSE cOnTacT US: University of Michigan Department of Ophthalmology and Visual SciencesW.K. Kellogg Eye Center1000 Wall StreetAnn Arbor, Michigan 48105

734.763.4660 • www.kellogg.umich.edu

FOR PATIENT qUERIES, please call 734.763.8122

The W.K. Kellogg eye CenTer aT

The UniversiTy of MiChigan has

again been naMed one of The

Top ophThalMology prograMs in

The CoUnTry by U.S. NewS & world

report. in This sUrvey, ophThal-

MologisTs seleCT The prograMs

Where paTienTs reCeive The besT

Care for The MosT CoMplex or

diffiCUlT CondiTions.

CARINGI n t eg r i t y

Teamwork

2012 Annual Report - U-M Kellogg Eye Center

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Transcript of 2012 Annual Report - U-M Kellogg Eye Center