2011년 사업계획 목차 - zist,fara CANVAS SF Catalog...FSBC-SF-S05 In-situ Sterilizable...

Copyright © 2016 Centrion Science. All rights reserved. www.centrion.co.kr

INNOVATIVE BIOTECHNOLOGY SCIENCE COMPANY

BIOTECHNOLOGY SCIENCE

INNOVATIVE BIOTECHNOLOGY SCIENCE COMPANY

BIOCANVAS SF

In Touch With Life Science

IN-SITU STERILIZABLE FERMENTATION SYSTEMS

Pilot SIP(Sterilization-in-place) Fermentor

The CENTRION brand offers pilot and profuction scale bioreactor/fermentation systems for all of your large scale fermentation needs. BIOCANVAS SF Fermentor designs order-made equipment that is designed to best fit the culture conditions, culturing the object you want. stainless steel vessel and in situ Automatic sterilization System and how to use a separate sterile devices do not need to be used, in large fermentation scale-up is possible equipment. BIOCANVAS SF of sterile fermentation system (in situ automatic sterilization system) is designed to be easy to use as a lab scale fermentor. Heater has been installed on the jacket of the vessel can raise the temperature to a level to sterilize the vessel, as well as temperature control of the vessel does not require a separate sterilization system. Culturing cells and microbes could not be any easier with our full automation control of sterilization and fermentation process. BIOCANVAS SF Fermentor can be used to develop new products in the company's laboratory or university.

Features • Intelligent 17" wide touch screen Industrial PC fermentation controller • PLC Controller is applied for minimizing size and making simple set-up process • CPU and sensor board into One-board solve problems immediately • High density fermentation : DO-stat, pH-stat, Exponential feeding, etc • DO Cascade function and automation control • Remote control by PC software Data Logging system • Automatic head lift system built-in to move Top plate easily • Everything on one skid frame : Easy to install and move additional vessels and vessel controllers • Accurate temperature control with cooler and heater • Automatic flow control: mass flow controller • All-in-one system including seed fermentor and main fermentor • Applied stainless pipe transfer line for perfect sterilization and user’s convenience • Top Plate approach adopted in the European Design • The level of cGMP IQ / OQ compliance

Head Lifting System • Head plate is lifted by air cylinder and guided by the two sets of linear motion guide • Safety pin is used to hold the lifted head plate • Lifting system is made of stainless steel(SUS 304) that it is rustles • Basic system with the 50L-500L capacity

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Pilot Production Scale Fermentation System

Pilot Fermentor

Vessel volume

Total Capacity(L) 30L 50L 70L 100L 150L 300L 500L 1000L

Working Volume(L) 21L 35L 50L 70L 100L 210L 350L 700L

Agitation

Drive & Range 30L ~500L : AC motor Top drive(mechanical seal driving) 50~1,000 ±1 RPM(In the condition of no load)

Control Manual or automatic control of agitation speed

Impellers Rushton turbine impeller, Foam breaker(SUS 316L)

Sensor & Control Magnetic hall sensor, PID control

Agitation Type Top Drive(Mechanical Seal) or Bottom Drive(Magnetic Coupling)

Head Lift The head lift system is powered by air cylinder and guided by two sets of linear motion guide

Materials & Finish Vessel/Piping SUS 316L, SUS 304(electrolytic polishing)

Sterilization Heat exchanger or inject steam into jacket.(105℃~130℃)

Aeration Sparger Ring sparger(SUS 316L)

Filter Inlet(0.2㎛), Outlet filter(0.2㎛)

pH Range / Electrode 2.0~12.0 pH of set point, PID control / Gel Type

DO Range / Electrode 0~200% or 0~20ppm, PID control / Polarographic Type

Temperature Range & Sensor Ambient + 3℃~80℃ (0.1℃), RTD(Pt-100), PID control

Pressure Control The back pressure is controlled manually and/or automatically

Control Panel 17” Touch Screen Color LCD

Control program Process, Trend, Calibration Mode control display. all the programmed setting values will be automatically stored into the built-in memory.

Processor PLC system

Setting Automated sterilization process Automated fermentation program Valve control

Communications Memory stick, printer, computer, etc with the RS-232C communication protocol

Data Storage pH, DO, Pressure, Temperature and Agitation speed

• According to customer requirements and the intended use by changing some standards it can be produced. • The control software also can be produced according to customer requirements.

Pilot scale bioreactor standard specifications



In-situ Sterilizable Fermentor BIOCANVAS SF Series



• Vessel Ratio (H/D) - 2:1 - Total Vol. L / Working Vol. L • Vessel Pressure Certification Stamp - No Stamp / ASME Stamp • Vessel Surface finish - Inside / outside : 0.8㎛ / 1.2㎛ • Sight glass 1 ea : Oblong type

• Top Plate - Exhaust/Port/Pressure Gauge with diaphragm /Pressure Transmitter/Foam Sensor/Septum Port 4ea/ Inoculum Port • Upper Port - Aeration/Aeration by pass/Circle Light/ Rupture Disk

• Lower Port - Sampling / pH / DO / Temp / Etc. • Harvest



Inner Vessel design pressure : -1~ 4 bar(g)

Inner Vessel working pressure : 2 bar(g)

Inner Vessel Material: SUS 316 L

Inner Vessel Design temp : 150˚C

Inner Vessel Working temp : 10 ~ 65˚C

Inner Vessel SIP temp : 121˚C

Jacket design pressure : Max. 6 bar(g)

Jacket working pressure : Max. 4bar(g)

Jacket Material : SUS 304

Vessel Temp, Pressure

BIOCANVAS SF Series (30L~1000L)

Main Controller

Peristaltic Pump

Agitator

Sampling Port

Aeration Air Filter Housing

Heat. Exchanger

Vessel

Frame

Harvest

Reagent Bottle

Sensor Port

Sight Glass

Cat. NO. Description

FSBC-SF-S01 In-situ Sterilizable Fermentor 30L




Ordering information







Head Lift

Control Valve



• The control software also can be produced according to customer requirements.



Main Control System Specification

* LG PLC CONTROLLER.

▪ Control Cabinet : Body case with touch screen display

▪ 17” Resistive touch color LCD panel for, data input and display/Touch Screen Industrial PC unit

▪ On/Off diaphragm valves with air solenoid valves

▪ Automation program & software

▪ Functions: pH, DO, Foam, Temperature, Agitation, Peristaltic pump control,Calibration & Recalibration, Etc.

▪ Real time data as a graphs for rpm, temp, DO, pH, and foam

▪ Existing data will be graphed with its own real-time system

▪ Displays and saves date, time, rpm, temperature, DO, pH, and foam

▪ Data logging software for PC: Spread sheet format & Graph type of parameters

▪ View Excel: Accumulated data in Excel format

▪ Fed Batch

- pH stat, DO stat, user feeding profile, and exponential feeding On/Off & Auto Mode setting

▪ Automatic DO control

- Feed pump

▪ Alarm Function

- All measured and control parameters: alarm low/high limits

- Screen display

▪ Automatic/Manual sterilization system

▪ Operation mode: Stop/Sterilization/ Cooling/Culture

▪ Set cooling temp

▪ User setting and programmable / Security: password protected

▪ SCADA functionality can be added(optional)

(Remote monitoring the system operation via internet)



SCADA SYSTEM


* Introduction to SCADA SYSTEM Focus on remote monitoring and control system or SCADA monitoring and control system, also known as a data acquisition system for monitoring and control functions says. SCADA systems are analog or digital signals on the communication path to the remote device, the status information data to the remote small device (remote terminalunit) to collect, receive, record and display on the remote device to the central control system which monitors control. * SCADA SYSTEM control practices They are connected by a relay module local controllers PC 1 as Each local controller to the remote control. The local controller of P / V, S / V, Valve ON / OFF, Control State collects data in real time. The data collected is DB (Data Base) is stored in Graph, the report output. -The central control room at System Run / Stop, Valve On / Off, S / V, Control Command and set the remote control. User Login grading to enhance the security features. This is connected to the separate program SCADA communication protocol matched DLL files are also provided.


Lighting Pilot Photo Bioreactor

Light intensity control range

10 – 100%

Light module Fluorescent LED Lamp

Light Color White, RED, Blue

Max. Lux Max. 10000lux

Control Mode On/off or set of the lighting Controller

Power Voltage 110V-220V, 50/60Hz, 15A

Specification Features

Adjustable light intensity Fluorescent light source Expendable up to 3 lighting modules Scales-up Ideal for Pilot Custom

Fabrication Easy operation and Long life


FSBC-PP-PB01 Photo Bioreactor Autoclavable Fermentor

30L – 200L

Ordering information

PBR (Photobioreactor: photobioreactor) is The particular microorganisms that require light from microorganisms and microorganisms such as that just Chlorella growing in the sea water of the proper amount of light, temperature and carbon dioxide because the photosynthetic this microorganism as plant haejumyeon supply are self-culture well and so may reduce the carbon dioxide for photosynthesis by giving the current supplied to the carbon dioxide in accelerating the global warming on the photobioreactor effectively the advantage of producing a material by culturing a nutrient and via Chlorella. Photobioreactor will be a gas which is supplied carbon dioxide to the fermentor, unlike normal culturing marine microalgae of different culture conditions than are many different Chlorella production design the device in the structures of each micro algae culture well. Is attached to the vessel with a source of light, LED light, and light intensity depending on the culture conditions and the culture medium to adjust the lighting time, and so on. It is possible to precisely measure the growth of biomass, cleaning materials and health food, cosmetics (chlorella) and is used to cultivate a lot. - LED illumination with Full spectrum imitates natural sunlight as closely as possible by emitting light peaks at 430nm and 630nm, without NDIR and ultraviolet spectrum - Remote` control by PC software Data Logging system components


Lighting Module Items

Temp. Range & sensor Ambient 3℃~80℃, RTD(Pt-100), PID control

Sparger & Gas mode Micro sparger, 2 gas and 4 gas mixer(option)

Inlet Filter 0.2㎛ air filter cartridge

Filter & Condenser 0.2㎛ air filter cartridge, SUS 316

pH Range 0~14.0 pH of set point, PID control

pH Electrode Gel Type

DO Range 0~20ppm or 0~100%, PID control

Heating System Cartidge heater

Light sourse Device Selectable - Fluorescent lamp or LED

LED Lighting Intensity adjustable from 0 to 100 %, Maximum light intensity1000 µmol(photon)/m2/s

Light Regime Static or dynamic (sinus, daylight, pulse form)

Peristaltic pump Control 4 constant speed pumps each assignable to a wide variety of function for control of acid, base, foam and feed

Recording pH, DO, Temp., Foam, etc.

Pilot PBR Fluorescent LED lamp Case


Lighting Pilot Photo Bioreactor

Lighting Module Items

• According to customer requirements and the intended use by changing some standards it can be produced.


Agitator – Top Driving Specification

▪ AC motor / Inverter ▪ Direct coupling ▪ Double mecanical seal / Standard Supply system ▪ Shaft ▪ 380V, 50/60Hz, 3Phase ▪ RPM: 100 ~ 800 (in water) ▪ Impeller 1: SUS 316L Rushton impeller(33%), 2 stage ▪ Impeller 2: SUS 316L impeller for anti-foam, 1 stage ▪ 316L Removable vertical baffle plates - 3 wings

Single Mechanical Seal

(Chesterton)

Double Mechanical Seal

(Chesterton)

Turbine Impeller Marine Impeller Foam Breaker



• According to customer requirements and the intended use by changing some standards it can be produced..


Agitator – Bottom Drive (Magnetic Coupling)

Fermentor Bottom Magnetic

Coupling

Max. Volume : 500Liter

Tank(Feeding, Harvest)

Bottom Magnetic Coupling

Turbine Impeller Marine Impeller Foam Breaker






Aeration system Specification

▪ Accommodate flow rate quantity: 2VVM

▪ Inlet air filter- filter element: PTFE, 0.2 micron

▪ Filter area: 0.2m2

▪ Inlet airfilter housing: design-sanitary, material- 316L

▪ Sterilization: 121C, 30min

▪ Air flow control: Manual

▪ Diaphragm Valve : 4ea

▪ Steam Trap

▪ 316L Ring type sparger

30L~100L 150L~1000L

MFC(Mass flow controller)

Gas flow control, such as Air

option

4 Gas Mixer(ON/OFF Type)

option






Feeding System

Feeding Peristaltic Pump Reagent Chamber

102R

Peristaltic Pump

(Watson Marlow)

BOXER 15QQ

Peristaltic Pump

(BOXER)

313

Peristaltic Pump

(Watson Marlow)

option

Peristaltic Pump Feeding System Reagent Chamber


In-situ Sterilizable Fermentor BIOCANVAS SF

Series


Sampling Valve System Harvest Valve

Tank Valve Novaseptic Valve

Select valve operation of the automatic / manual


Pneumatic / Manual Valve

Manual Diaphragm Valve Pneumatic Diaphragm Valve

Check Valve Steam Trap

Pneumatic angle seat

globe valve

Ball Valve

Safety Valve

(Yoshitake)

Steam Regulator

(Yoshitake)

Optional part


Head Lift system

• SP50~500Liter Standard

• SP1Ton No longer apply

• Stroke : 0~400mm

Optional Items

Utility part


Utility (Steam Boiler, Air Compressor, Chiller)

Steam Boiler

(Sterile and temperature

controlled)

Air Compressor

(Vessel Internal supply

Pneumatic Diaphragm Valve Control)

Chiller

Low Temperature control

Fermentor depends on the specifications.

Optional Accessory Items

Documentation


Scope of Documentation

1 Vessel Drawing

2 Strength Calculation Sheet

3 MDR

(Manufacturer’s Data Report for Pressure Vessels)

4 Material Inspection Report

5 Mill Test Certificate

6 IR (Inspection Report)

7 Head Plate Inspection Report

8 Dimensional Inspection Report(for Cylinder)

9 Visual and Dimensional Inspection Report

10 Pressure Test

11 Report of Radiographic Examination(R.T)

12 Name Plate Rubbing Sheet

13 Internal Buffing Inspection Sheet(RA 0.8㎛)

14 Sight Glass Certificate

15 ISO Certificate

16 Welding procedures

17 ASME Certificate of Eligibility

( ABSG Consulting Inc)

IQ, OQ Documentation

FAT

SAT

Welding Documentation

(Install additional cost foreign products and documents)

ASME Documentation



Japan's B.E Marubishi Co.,Ltd with a suitable fermentor with international standards and

quality standards in technology partnership

We continue to export to the completion of product development.

Cooperation Partners

HEAD OFFICE

Bucheon Techno Park Ssangyong 3cha 397, Seokcheon-ro, Ojeong-gu, Bucheon-si, Gyeonggi-do, Rep, of KOREA

Tel : +82_32_624_2060

Fax : +82_32_624_2059

www.centrion.co.kr / Email : [email protected]

Copyright © 2016 Centrion Science. All rights reserved. V1.0

BIOCANVAS Customers want and diverse culture will be drawn correctly.

http://www.centrion.co.kr/

2011년 사업계획 목차 - zist,fara CANVAS SF Catalog...FSBC-SF-S05 In-situ Sterilizable...

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