2009 CSBB LAB 新生訓練
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Transcript of 2009 CSBB LAB 新生訓練
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新生訓練基礎生物 /生化
馬誠佑
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Biomaterial• Nucleotide (DNA, RNA)• Protein• Saccharide• Lipid
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ATP(Adenosine TriPhosphate)
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DNA (DeoxyriboNucleic Acid)
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DNA
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RNA (RiboNucleic Acid)
• mRNA (messenger): protein translation• tRNA (transfer)• rRNA (ribosome)• snRNA (small nuclear): regulation
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Protein
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Lipid
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Summary
• DNA: blue print of life.• RNA: transcription, translation, regulation.• Protein: functional unit, enzyme, signal
molecule.• Saccharide: energy fuel, cell recognition.• Lipid: energy fuel, membrane, signal
molecule.
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Central Dogma
Transcription
DNA
mRNA Translation
Protein
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Transcription
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Translation
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Cell StructureEukaryote
Prokaryote
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Virus
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Cell Structure
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單細胞生物的生活哲學是
“ Every cell for itself”
多細胞生物的生活哲學是
“ No one is an island”
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1. Communication via gap junction
2. Communication via cell surface proteins, ex. Cell adhesion molecules
3. Communication via extracellular chemical messengers and receptor system
synchronous
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Mitosis/Meiosis
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DNA Replication
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Metabolism
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Summary
• Central dogma: DNA => RNA => Protein• Cell structure• Mitosis/Meiosis• DNA Replication• Metabolism
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Protein Sturcture• Primary structure: ….ATTQKLVSSC….
• Secondary structure: Regularly repeating local structures. Ex: α-helix, β-sheet….
• Tertiary structure: The overall shape of a single polypeptide chain.
• Quatemary structure: multi-polypeptide chains complex.
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Secondary Structure: α-helix
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Secondary Structure: β-sheet
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Backbone Conformation
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Tertiary/Quatemary structure
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Cooperativity
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Disulfide Bond
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Disulfide Bond
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Protein Structure/Function
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Sequence/Structure
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Summary• Protein structure: 1, 2, 3, 4.
• Protein regulation: Cooperative, feedback.
• Structure/function: Function depends on structure.
• Sequence/structure: Structure is more conserve than sequence.