2005 Anatomic Pathology Exam Microscopic Slide Review Presented at the 57 th Annual Meeting of the...
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2005 Anatomic Pathology ExamMicroscopic Slide Review
Presented at the57th Annual Meeting of the ACVP
December 3, 2006Tucson, AZ
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2005 Microscopic Slide Exam Reviewpreparing the microscopic exam
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1. Nov/Dec- initial committee meeting @ annual ACVP
2005 Microscopic Slide Exam Reviewpreparing the microscopic exam
![Page 4: 2005 Anatomic Pathology Exam Microscopic Slide Review Presented at the 57 th Annual Meeting of the ACVP December 3, 2006 Tucson, AZ.](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfac1a28abf838c9b9c4/html5/thumbnails/4.jpg)
1. Nov/Dec- initial committee meeting @ annual ACVP
2. Mid-Apr- contributions to section leader
2005 Microscopic Slide Exam Reviewpreparing the microscopic exam
![Page 5: 2005 Anatomic Pathology Exam Microscopic Slide Review Presented at the 57 th Annual Meeting of the ACVP December 3, 2006 Tucson, AZ.](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfac1a28abf838c9b9c4/html5/thumbnails/5.jpg)
1. Nov/Dec- initial committee meeting @ annual ACVP
2. Mid-Apr- contributions to section leader
3. Section leader prepares draft exam-matrix: process/tissue/species
2005 Microscopic Slide Exam Reviewpreparing the microscopic exam
![Page 6: 2005 Anatomic Pathology Exam Microscopic Slide Review Presented at the 57 th Annual Meeting of the ACVP December 3, 2006 Tucson, AZ.](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfac1a28abf838c9b9c4/html5/thumbnails/6.jpg)
4. May/Jun- 2nd committee meeting,
review of draft exam, keys prepared
2005 Microscopic Slide Exam Reviewpreparing the microscopic exam
![Page 7: 2005 Anatomic Pathology Exam Microscopic Slide Review Presented at the 57 th Annual Meeting of the ACVP December 3, 2006 Tucson, AZ.](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfac1a28abf838c9b9c4/html5/thumbnails/7.jpg)
4. May/Jun- 2nd committee meeting,
review of draft exam, keys prepared
5. Mid-Aug- slides, exam questions completed
2005 Microscopic Slide Exam Reviewpreparing the microscopic exam
![Page 8: 2005 Anatomic Pathology Exam Microscopic Slide Review Presented at the 57 th Annual Meeting of the ACVP December 3, 2006 Tucson, AZ.](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfac1a28abf838c9b9c4/html5/thumbnails/8.jpg)
4. May/Jun- 2nd committee meeting,
review of draft exam
5. Mid-Aug- slides, exam questions completed
6. Sep- exam time
2005 Microscopic Slide Exam Reviewpreparing the microscopic exam
![Page 9: 2005 Anatomic Pathology Exam Microscopic Slide Review Presented at the 57 th Annual Meeting of the ACVP December 3, 2006 Tucson, AZ.](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfac1a28abf838c9b9c4/html5/thumbnails/9.jpg)
1. rat, brain, astrocytoma
2. horse, artery, strongylosis
3. dog, skin, ceruminous gland carcinoma
& dirofilariasis
4. dove, liver, amyloidosis
5. sea lion, kidney, leptospirosis
2005 Microscopic Slide Exam Review
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6. ox, lung, atypical interstitial pneumonia
7. cat, intestine, panleukopenia & FIP
8. marmoset, bone, fibrous osteodystrophy
9. dog, salivary gland, infarct
10.ox, spinal cord, fibrocartilaginous embolus
2005 Microscopic Slide Exam Review
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11. cat, kidney, lily toxicosis
12. dog, eye, phthisis bulbi
13. rhesus, lung, SIV & CMV
14. walleye, skin, fibrosarcoma
15. ox, heart, ionophore toxicosis
2005 Microscopic Slide Exam Review
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16. dog, bone, metastatic carcinoma
17. horse, placenta, aspergillosis
18. dog, liver, autoimmune hemolytic anemia
19. rat (panel), thoracic mass, hibernoma
20. ox (TEM), oral mucosa, MCF
2005 Microscopic Slide Exam Review
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Case 7: Tissue from a cat.
• Histopathologic description (12 points)
• Morphologic diagnosis(es) (4 points)
• Cause(s) (4 points)
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Case 7: Tissue from a cat.
• Histopathologic description (12 points)– Intestine
• Mucosa– Blunting of villi– Collapse of lamina propria– Dilated crypts with necrotic debris
• Muscularis, serosa, mesentery– Perivascular accumulations of PMNs, macrophages
and fibrin
– O/C• Logical and clear presentation of features
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Case 7: Tissue from a cat.
• Morphologic diagnosis(es) (4 points)– Necrotizing enteritis– Pyogranulomatous perivasculitis/peritonitis
• Cause(s) (4 points)– Feline parvovirus (Feline panleukopenia virus)– Feline infectious peritonitis virus
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Case 9: Tissue from a dog.
• Histopathologic description (14 points)
• Morphologic diagnosis(es) (6 points)
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Case 9: Tissue from a dog.
• Histopathologic description (14 points)– Salivary gland (ID)
• Vasculature– Thrombosis
• Acini– Coagulative necrosis– Inflammation– Granulation tissue
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Case 9: Tissue from a dog.
• Histopathologic description (14 points)– Salivary gland (ID)
• Septa– Inflammation– Hemorrhage– Fibrosis
• Ducts– Inflammation– Necrosis– Squamous metaplasia
– O/C• No points allotted
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Case 9: Tissue from a dog.
• Morphologic diagnosis(es) (6 points)
– Necrotizing sialoadenitis with thrombosis (infarction) and squamous metaplasia
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Case 11: Tissue from a cat.
• Histopathologic description (13 points)
• Morphologic diagnosis(es) (4 points)
• Most likely cause (3 points)
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Case 11: Tissue from a cat.
• Histopathologic description (13 points)– Distribution
– Tubular epithelium• Degeneration • Necrosis• Regeneration
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Case 11: Tissue from a cat.
• Histopathologic description (13 points)– Casts
• Granular• Protein
– Mineralization
– O/C • Logical and clear presentation of features
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Case 11: Tissue from a cat.
• Morphologic diagnosis(es) (4 points)– Diffuse tubular necrosis with casts
• Most likely cause (3 points)– Lily toxicosis– Aminoglycoside antibiotic toxicosis
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Case 16: Tissue from a dog.
• Histopathologic description (14 points)
• Morphologic diagnosis(es) (6 points)
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Case 16: Tissue from a dog.
• Histopathologic description (14 points)– Bone
• Neoplasm: location, pattern, cell morphology, cell borders, cytoplasm, nuclear morphology, nucleoli, mitoses, anisokaryosis, necrosis
• Proliferation of new bone • Resorption of trabecular bone
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Case 16: Tissue from a dog.
• Histopathologic description (14 points)– Muscle degeneration and atrophy
– O/C• Logical and clear presentation of features• Primary vs. secondary processes
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Case 16: Tissue from a dog.
• Morphologic diagnosis(es) (6 points)– Metastatic transitional cell carcinoma in bone– Hyperostosis– Muscular atrophy and degeneration
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Case 19: Tissue from a rat.
• Microscopic description (16 points)
• Morphologic diagnosis (4 points)
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Case 19 (panel): Tissue from a rat.
• Microscopic description (16 points)– A. H&E
• Description: pattern, cell morphology, cell borders, cytoplasmic vacuoles (fat), nuclear morphology, multinucleated cells, nucleoli, no mitotic figures
– B. Oil-Red-O• Positive cytoplasmic staining = lipid
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Case 19 (panel): Tissue from a rat.
• Microscopic description (16 points)
– C. Mitochondrial uncoupling protein-1 immunohistochemistry
• Reactivity indicates presence of numerous mitochondria
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Case 19 (panel): Tissue from a rat.
• Microscopic description (16 points)– D. TEM
• Many mitochondria• Some mitochondrial swelling• Fat droplets• Morphology consistent with brown fat
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Case 19 (panel): Tissue from a rat.
• Morphologic diagnosis (4 points)– Hibernoma
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2005 Microscopic Slide Exam Reviewscoring
Proportion (%) Passed Mean Score Range of Scores
2003 2004 2005 2006 2003 2004 2005 2006 2003 2004 2005 2006
45 72 47 61 57 63 57 62 71-37 82-11 75-31 83-7