Identifying differentially expressed genes from RNA- seq data
20,000 GENES IN HUMAN GENOME; WHAT WOULD HAPPEN IF ALL THESE GENES WERE EXPRESSED IN EVERY CELL IN...
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Transcript of 20,000 GENES IN HUMAN GENOME; WHAT WOULD HAPPEN IF ALL THESE GENES WERE EXPRESSED IN EVERY CELL IN...
20,000 GENES IN HUMAN GENOME; WHAT WOULD HAPPEN IF ALL THESE GENES WERE EXPRESSED IN EVERY CELL IN YOUR BODY?
WHAT WOULD HAPPEN IF THEY WERE EXPRESSED IN THE WRONG CELLS?
WARM-UP # 5 1/13/2015
Why is control of gene expression important?
Antennapedia
How do cells know which genes to use?98% of human genome does NOT code for
proteins!RNA polymerase – enzyme that produces
mRNA
Promoter Region of DNA that begins transcription
TRANSCRIPTION FACTORSo Proteins that control transcription
o Bind to enhancer DNA
o Always present in cell, but most likely have to be activated before they will bind to DNA
Transcription Factors• Essential for the transcription of all
protein-coding genes• Can either repress or enhance
transcription