2

High Resolution T2 ImagingRat versus Mouse

T1 MP-RAGE

Dark CSF

Resolution Rat: 156 x 156 x 700 µm3

Mouse: 138 x 117 x 400 µm3

Coil setup:Transmit: Integrated body coilReceive: Dedicated brain 2x2 array

3

T2 Imaging

Rat brain

TSE, magnetization restoreTR: 2000 msTE: 38 msTot. scan time: 3 min 10 sFoV: 35 x 35 mm² Slice thickness: 0.8 mmMatrix: 240 x 320Resolution: 146 x 109 µm2

Coil setup:Transmit: Integrated body coil Receive: Rat brain

quadrature coil

T2 imaging

Bright CSF

BGA12S

T2 Map T2

1.2 x 0.182 x 0.182 mm3

Traumatic Brain Injury

T2 image of injured Rat spine

Spine Injury

Rat Thoracic Spine

Fiber tracking rat spine – T2 backgroundpost injury

Diffusion Tensor Imaging

Fiber tracking mouse brain

Pre injury

Post injury

Gadolinium-tagged drug in Nasal Passage fMRI

segmentationMouse spine

angiography

Rat knee

9

Mouse Spine with the MRI CryoProbe™

Turbo-RARE-T2TR: 1000 ms Slice thickness: 0.5TE: 12.6 ms Res.: 46 x 46 µm²Matrix: 384 x 384 NA: 2Total time 6 min. 24 sec.

10

• Specific animal beds:rat, mouse, rabbit

• Integrated animal warming

• Stereotactic fixation

Animal handling

Cryocoil bed

Mouse Cardiac Coil Rat Body/Cardiac Coil

Mouse and Rat Beds

Attached to bed

Dr Edward Hall

ADC

DWIRATSingleCoronalSlice117um x 238um x 1500um

“Qualitative” Analysis - T2 map, T1 map, ADC (DTI)

Rat Body/Cardiac CoilMouse Body Coil

Cryo-probe images – mouse brain• FLASH T2 * weighted• TE/TR: 22/350ms• Res.: 30x30x500µm• Scantime 6min• 9.4 T

2Cb

3Cb

5&4Cb6Cb

7Cb

8Cb

10Cb

9Cb

Gray matter:molecular layer

White matter

Gray matter:granular layer

Purkinje cell layer