1687-9856-2013-S1-P2.pdf
1
POSTER PRESENTATION Open Access Characteristics of ketoacidosis diabetic at Fatmawati Hospital Bina Akura 1* , Ibnu Sastrawigoena 2 From 7th APPES Biennial Scientific Meeting Nusa Dua, Bali. 14-17 November 2012 Background Diabetic ketoacidosis (DKA) is the most common compli- cation of diabetes mellitus. DKA results from absolute or relative deficiency of circulating insulin and from com- bined effects of increased counter regulatory hormone levels. The combination of low serum insulin and high counter regulatory hormone concentrations accelerate catabolic state with increased glucose production by liver and kidneys (by glycogenolysis and gluconeogenesis), impair peripheral glucose utilization causing hyperglyce- mia and hyperosmolality, and increase lipolysis and keto- genesis, resulting in ketonemia and metabolic acidosis. Most of Indonesian children with diabetes mellitus (DM) came for the first time with diabetic ketoacidosis. Aims To describe the characteristics of diabetes mellitus type 1 cases presenting with ketoacidosis symptoms at fatmawati hospital. Methods A retrospective survey was conducted during June 2012. Data was collected by using questionnaire. Subjects with ketoacidosis complication were included. Results Of 20 children with diabetes mellitus type 1 at fatmawati hospital, only 13 subjects were included. Subjects were included had ketoacidosis event. Ratio between male to female almost equal (male 46.2% vs female 53.8%). Most subjects were 5-9 years old (46.1%) and 10-14 years old (38.4%). All subjects were not obese (100%) with body weight are 28.9±13.8 kg and body height are 134.8±16.4 cm. Most subject were severe ketoacidosis (53.8%) and small subjects were mild (23.1%), moderate (23.1%). Median glucose concentration is 339 (203-577)mg/dL and keton concentraton is 2.88±1.0 mg/dL. Hemoglobin A1c (HbA1c) is 11.1±1.9 % from all subjects. All subjects survived. Conclusions Subjects were almost equal between male to female. Most subjects were aged 5-9 years old. Most subjects were severe ketoacidosis with median glucose concentration 339 (203-577) mg/dL and keton concentration 2.88±1.0 mg/dL. Most subjects were not obese with HbA1c 11.1±1.9%. Authors’ details 1 Pediatric endocrinology division, Fatmawati hospital, Jakarta, Indonesia. 2 Registrar of pediatric department, Fatmawati hospital, Jakarta, Indonesia. Published: 3 October 2013 doi:10.1186/1687-9856-2013-S1-P2 Cite this article as: Akura and Sastrawigoena: Characteristics of ketoacidosis diabetic at Fatmawati Hospital. International Journal of Pediatric Endocrinology 2013 2013(Suppl 1):P2. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit 1 Pediatric endocrinology division, Fatmawati hospital, Jakarta, Indonesia Full list of author information is available at the end of the article Akura and Sastrawigoena International Journal of Pediatric Endocrinology 2013, 2013(Suppl 1):P2 http://www.ijpeonline.com/content/2013/S1/P2 © 2013 Akura and Sastrawigoena; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transcript of 1687-9856-2013-S1-P2.pdf
POSTER PRESENTATION Open Access
Characteristics of ketoacidosis diabetic atFatmawati HospitalBina Akura1*, Ibnu Sastrawigoena2
From 7th APPES Biennial Scientific MeetingNusa Dua, Bali. 14-17 November 2012
BackgroundDiabetic ketoacidosis (DKA) is the most common compli-cation of diabetes mellitus. DKA results from absolute orrelative deficiency of circulating insulin and from com-bined effects of increased counter regulatory hormonelevels. The combination of low serum insulin and highcounter regulatory hormone concentrations acceleratecatabolic state with increased glucose production by liverand kidneys (by glycogenolysis and gluconeogenesis),impair peripheral glucose utilization causing hyperglyce-mia and hyperosmolality, and increase lipolysis and keto-genesis, resulting in ketonemia and metabolic acidosis.Most of Indonesian children with diabetes mellitus (DM)came for the first time with diabetic ketoacidosis.
AimsTo describe the characteristics of diabetes mellitus type 1cases presenting with ketoacidosis symptoms at fatmawatihospital.
MethodsA retrospective survey was conducted during June 2012.Data was collected by using questionnaire. Subjects withketoacidosis complication were included.
ResultsOf 20 children with diabetes mellitus type 1 at fatmawatihospital, only 13 subjects were included. Subjects wereincluded had ketoacidosis event. Ratio between male tofemale almost equal (male 46.2% vs female 53.8%). Mostsubjects were 5-9 years old (46.1%) and 10-14 years old(38.4%). All subjects were not obese (100%) with bodyweight are 28.9±13.8 kg and body height are 134.8±16.4cm. Most subject were severe ketoacidosis (53.8%) andsmall subjects were mild (23.1%), moderate (23.1%).
Median glucose concentration is 339 (203-577)mg/dL andketon concentraton is 2.88±1.0 mg/dL. Hemoglobin A1c(HbA1c) is 11.1±1.9 % from all subjects. All subjectssurvived.
ConclusionsSubjects were almost equal between male to female. Mostsubjects were aged 5-9 years old. Most subjects weresevere ketoacidosis with median glucose concentration339 (203-577) mg/dL and keton concentration 2.88±1.0mg/dL. Most subjects were not obese with HbA1c11.1±1.9%.
Authors’ details1Pediatric endocrinology division, Fatmawati hospital, Jakarta, Indonesia.2Registrar of pediatric department, Fatmawati hospital, Jakarta, Indonesia.
Published: 3 October 2013
doi:10.1186/1687-9856-2013-S1-P2Cite this article as: Akura and Sastrawigoena: Characteristics ofketoacidosis diabetic at Fatmawati Hospital. International Journal ofPediatric Endocrinology 2013 2013(Suppl 1):P2.
Submit your next manuscript to BioMed Centraland take full advantage of:
• Convenient online submission
• Thorough peer review
• No space constraints or color figure charges
• Immediate publication on acceptance
• Inclusion in PubMed, CAS, Scopus and Google Scholar
• Research which is freely available for redistribution
Submit your manuscript at www.biomedcentral.com/submit1Pediatric endocrinology division, Fatmawati hospital, Jakarta, Indonesia
Full list of author information is available at the end of the article
Akura and Sastrawigoena International Journal of Pediatric Endocrinology 2013, 2013(Suppl 1):P2http://www.ijpeonline.com/content/2013/S1/P2
© 2013 Akura and Sastrawigoena; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of theCreative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, andreproduction in any medium, provided the original work is properly cited.
