HORMONAL INFLUENCE IN

ENDOMETRIOSIS

ENDOMETRIOSIS presence of endometrial tissue outside

the uterine cavity endometrial tissue is misplaced and

grows in other places outside the uterus 10% of the female population of

reproductive age The exact cause of endometriosis is still

unknown.

THEORIES Even though the exact cause of

endometriosis is still unknown there are some theories that could explain the reason of it

1) Retrograde Menstruation2) Coelomic Metaplasia3) hereditary disease

SYMPTOMS 1)Sever pain in the abdominal and pelvic

areas

2) Infertility About 30% of woman who suffer from

endometriosis will have infertility

HORMONES RELATED TO ENDOMETRIOSIS

1) Oestrogen ● group of hormones that promotes the

reproductive system and the secondary characteristic in females

●simulate the production of Follicle Stimulating Hormone.

●endometriosis is an oestrogen- dependant disease.

2) Growth hormone and Growth- Hormone releasing hormone

●Growth hormone is a protein hormone

●Regulates growth and development

● involved in the process of sexual differentiation, pubertal maturation

● Growth- Hormone Releasing Hormone is produced by the hypothalamus and stimulates the release of Growth Hormone.

Slater’s study (2003) indicate that Growth hormone releasing hormone (GHRH) and GH hormone promote endometrial proliferation and endometrial carciroma.

During this study 1) banked tissue : normal uterine sample

and endometriosis samples 2) Immunochemistry of each tissue was

analyzed using different antibodies 3) Immunolabeling of both samples were

performed

Results show that endometriotic tissue showed increase in immunolabeling of GH compared with normal tissue.

Slater (2003) concluded that GH may play a role in the progression of both endoetriosis and endometrial canciroma

GONADOTROPIC HORMONES

● stimulate the production and development of the human reproductive system

● kinds of gonadotropic hormones: Luteinizing Hormone (LH) and Follicle stimulating hormone (FSH)

● LH stimulates sex steroid secretion● FSH stimulates the growth and

maturation of the ovarian follicles.

PRODUCTION OF GONADOTROPIC HORMONE

RELATIONSHIP WITH ENDOMETRIOSIS

Gonadotropin releasing hormone is used in form of an agonist, called Gonadotropin releasing hormone agonist, to treat endometriosis pain

most used and effective clinical treatment for endometriosis pain.

TREATMENTS FOR ENDOMETRIOSIS

Apart from surgery, the treatments administered for endometriosis are mostly to reduce pain.

Hormones had been used to control the thickening and bleeding of the tissue and are proved to be the most effective in pain reduction.

HORMONAL TREATMENTS

1. Growth hormone releasing hormone agonist

● GnRH agonist inhibits the secretion of GnRH to the gonadotrophs

● These hormones work by turning off the ovaries causing a pseudo-menopause.

●They inhibit the effect of hormones that cause ovulation, especially estrogen, and leads to inflammation and pain

● GnRH agonist therapy consists of several injections or nasal spray during approximately three months

Meresman’s (2003) study indicate that GnRH play an important role in the reduction of cell proliferation in endometriosis.

During this study:1) Tissue were selected: 16 with

untreated endometriosis and 14 control2) Tissue was planted and incubated 3) Cells were washed and different agents

(including LA, as a GnRH) were added 4) Tissue was inclubated for 48 additional

hours

Meresman (2003) concluded that GnRH-a appear to have a direct effect in decreasing the cell proliferation in endoetrial cells.

CONCLUSION GH and GhRH may play a role in

endometrial proliferation. It may also play a role in the progression of both endoetriosis and endometrial canciroma. As more proliferation occurs, more misplaced tissue is found, increasing the pain prdoduce by this condition.

While GnRH was been proven to decrease cell proliferation in endometrial tissues. As proliferation is reduced, the patient experiences less pain due to a decrease of the amount of the misplaced tissue.

SCIENTIFIC IMPORANTCE

Studies about how Growth hormone and Growth hormone releasing hormone work in the progression of cell proliferation during endometriosis, could be related to the cause of this condtition.

Studing this hormone can give a cause of why is this condition produced.

REFERENCES Meresman G, Bilotas M,Buquet R,Baraño

R,Sueldo C,Tesone M.2003.“Gonadotropin- releasing hormone agonist induces apoptosis and reduces cell proliferation in eutopic endometrial cultures from women with endometriosis”. Fertility and sterility. [Internet];[revised 2002 May 17] Vol 80: Available in: http://www.s ciencedirect.com/science/article/pii/S0015028203007696

National Institute of Health [Internet].[unknown].USA: National Institute of Health;[unknown]. Available in:http://www.nichd.nih.gov/health/topics/Endometriosis.cfm

Slater M,Copper M,Murphy CR. 2006. Human Growth Hormone and Interleukin-6 are Unregulated in Endometriosis and Endometriod Adenocarcinoma.Acta Histochemica [internet];[revised 2005 Oct 5];[cited 2008 Jan 18].108,13-18:Available in: http://www.sciencedirect.com/ science /article/pii/S0065128106000158

The hormone foundation [Internet].[2011].Connecticut: The hormone foundation;[cited unknown]. http://www.hormone.org/Endo101/page2.cfm

Rose G.2005.What is endometriosis.Women’s Health Medicine [Internet];[unknown].Available in:Science Direct

Mona.Endometriosis-what is it [video].USA:icyou, A Benefitfocus Company. Available in: http://www.youtube.com/user/icyouhealth#p/search/0/pVrKiBUPoL4

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