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GENERIC NAME: Furosemide BRAND NAME: Lasix, FreticRoute of Administration: IV Dosage: 40 mg q8 with BP precaution

DRUG CLASS MODE OFACTION

INDICATIONS/CONTRAINDICATIONS

ADVERSEREACTIONS TOWATCH OUT

FOR

DRUGINTERACTIONS

NURSINGCONSIDERATIONS

HEALTHTEACHINGS

Loop Diuretics Inhibits sodiumand chloridereabsorption atthe proximaltubules, distaltubules andascending loppof henleleading toexcretion ofwater together

with sodium,chloride andpotassium.Diuretic,hypertensive

I:Treatment toedema associatedwith hepaticcirrhosis,hypertension

CI:Hypersensitivitytosulfonylureas;anuria

Orthostatichypertension,vertigo,headache,dizziness,paresthesia,jaundice,hyperuricemia,hyperglycemia,hypokalemia,muscle spasm,

weakness,anorexia, nausea,vomiting.

Aminoglycosides,digitalisglycosides,lithium, NSAIDs,phenytoin,salicylates,thiazide diuretics.

Assess patientsunderlying conditionbefore starting therapy.Monitor weight, edema,breath sounds, bloodpressure, fluid intakeand output,electrolytes, potassium,sodium,glucose, uricacid and BUN.

Assess fluid volumestatus:urine: color,quality and specificgravity, intake outputratio, weight, skinturgor,edema,pulses.Dehydration symptoms.

Instruct the patient totake with food or milkif GI symptoms ofnausea and anorexiaoccur

Inform the patient thatthis drug causes aloss of potassium,therefore food rich inpotassium should be

added in the diet.

Instruct the patient tolie down slowly ifdizziness occurs

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GENERIC NAME: Oxacillin BRAND NAME: Prostaphlin, Wydox

Route of Administration: IV Dosage: 500 mg q6 ANST




FOR

DRUGINTERACTIONS


HEALTHTEACHINGS

Anti infectives Interferes withcell wallreplication ofsusceptibleorganisms;osmoticallyunstable cellwall swells,bursts fromosmoticpressure

I: treatment ofinfections causedby penicillinase-producingstaphylococci;initial therapy ofsuspectedstaphylococcalinfection

CI:hypersensitivity

to penicillins

Lethargy,hallucinations,anxiety,twitching,coma,seizures, nausea.Vomiting,diarrhea,increased AST,ALT, abdominalpain, anemia

Increasedoxacillin levelswith probenecid.Impairedbactericidaleffects of oxacillinin tetracyclines.Incompatible withaminoglycosides

Assess results ofculture and sensitivitytests and patientsallergy history prior tobeginning therapy.

Monitor blood studies:AST, ALT, CBC, Hct,bilirubin if patient is onlong term therapy

Assess bowel patterneveryday.

Evaluate results oflaboratory test,therapeuticeffectiveness andadverse reactions atregular intervals duringthe treatment

Do not take any newmedication duringtherapy unlessapproved by thephysician.

This medication canbe only administeredby infusion orinjection( rapidadministration can

result to seizures)

Report immediatelyany redness, swelling,burning or pain atinjection/infusion site;respiratory difficulty orswallowing; chestpain; rash

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GENERIC NAME: Metronidazole BRAND NAME: Dazolex, Frotin, Tricomycin, TriconexRoute of Administration: IV Dosage: 500mg q8 ANST


INDICATIONS/CONTRA

INDICATIONS

ADVERSEREACTIONS TO

WATCH OUTFOR

DRUGINTERACTIONS


HEALTHTEACHINGS

Anti- infectives Direct actingamebicide. Itbinds tobacterial andprotozoal DNAto cause loss ofhelicalstructure,strandbreakage ,

inhibition ofnucleic acidsynthesis andcell death

I: infections in theintra abdominal,skin and skinstructure, boneand joint.

CI:Blooddyscrasias. ActiveCNS diseases.Hypersensitivity to

imidazole

Convulsiveseizures,peripheralneuropathy, rash,pruritus, GIdiscomfort,anorexia, nausea,furred tongue, drymouth andunpleasant

metallic taste,headache, lessfrequentlyvomiting,diarrhea,weakness anddarkening of theurine

Alcohol.Rifampicin,clindamycin,tetracyclines.Disulfiram,lithium,cyclosporin,phenytoin orPhenobarbital.

Obtain baselineinformation on patientsinfection: fever, woundcharacteristics

Obtain C & S beforebeginning therapy toidentify if correcttreatment has beeninitiated.

Assess for allergicreactions

Monitor renal function

Assess for overgrowthof infection

Advice patient tocomplete full courseof therapy even if hefeels betterInstruct patient not totake alcohol or drugsthat contain alcoholduring therapybecause of a

disulfiram likereaction to alcoholingestion

Inform the patientthat drug can causemetallic taste andmay darken urine

Advise patient tohave sips of water,sugarless gum or

hard candy to relievedry mouth

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GENERIC NAME: Paracetamol BRAND NAME: Biogesic, TylenolRoute of Administration: Oral Dosage: 500 mg tab, 1 tab q4 for fever




FOR

DRUGINTERACTIONS


HEALTH TEACHINGS

Analgesics Decreasesfever byinhibiting theeffects ofpyrogens onthehypothalamicheat regulatingcenters and bya hypothalamicaction leading

to sweatingandvasodilatation.

I: treatment offever; relief of mildto moderate pain

CI:hypersensitivity,intolerance totartazine, alcohol,table sugar,saccharin

Stimulation,drowsiness,nausea, vomiting,abdominal pain,hepatoxicity,hepatic seizure,renal failure,leucopenia,neutropenia, ras,jaundice,convulsions,

coma, death

Toxicity may beincreased inpatients receivingother potentiallyhepatoxic drugs.Absorption maybe accelerated bydrugs such asmetoclopramide.Excretion may beaffected and

plasmaconcentrationsaltered whenadministered withprobenecid

Assess patientsfever or pain: type ofpain, location,intensity, duration,temperature anddiaphoresis

Assess for allergicreactions

Assess for

hepatoxicity:darkurine, clay coloredstools, yellowing ofskin or sclera,itching, abdominalpain, diarrhea

Monitor renal andliver functions. AST,ALT, BUN, CREA

Advise patient to avoidalcohol; acute poisoningwith liver damage mayresult; acute toxicityincludes symptoms ofnausea, vomiting andabdominal pain.

Advise patient to avoidtaking more than oneproduct containing

paracetamol at one timeas this may causetoxicity

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GENERIC NAME: Amlodipine BRAND NAME: Amvasc, NorvascRoute of Administration: Oral Dosage: 5g tab OD

DRUGCLASS

MODE OFACTION

INDICATIONS/CONTRA

INDICATIONS

ADVERSEREACTIONS TO

WATCH OUT FOR

DRUGINTERACTION

S


HEALTHTEACHINGS

ANTIHYPERTENSIVE:CALCIUMANTAGONIST

Inhibits influx ofcalcium ion acrosscell membranes toproduce relaxationof coronaryvascular smoothmuscle anddecreaseperipheral vascularresistance ofsmooth muscle

and increasesmyocardial oxygendelivery in patientswith vasospasticangina

I: Hypertension;chronic stableangina;vasospasticangina

CI: sick sinussyndrome, 2nd or3rd degree AVblock, except witha functioning

pacemaker

Palpitations,peripheral edema,tachycardia,bradycardia,arrhythmias,headache,dizziness, fatigue,lethargy, dermatitis,rash, cramps,shortness of breath,dyspnea, flushing

Beta blockers:may causeincreasedadverse cardiaceffects as aresult ofmyocardialdepression.Fentanyl:severehypotension or

increased fluidvolumerequirementshave occurredwith similardrugs

Assesscardiorespiratory status:Anginal pain, BP, pulse,respiration ,ECG

Assess hydration andfluid volume status: Iand O ratio, presenceof edema, distendedneck veins, lungcrackles, adequate

pulses and skin turgor

Monitor liver function

Teach patient to useas directed even iffeeling better;may betaken with othercardiovascular drugs,food helps decreasestomach upset

Advice patient toavoid hazardousactivities until

stabilized on drugand dizziness is nolonger a problem.

Report symptoms ofchest pain, swellingof extremities,irregular pulse,altered vision,shortness of breath,hypotension

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GENERIC NAME: Clonidine BRAND NAME: CatapresRoute of Administration:SL Dosage: 75mg tab, q6 PRN

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GENERIC NAME: Losartan BRAND NAME: Angiocard, Bepsar Route of Administration: Oral Dosage: 50mg tab OD Am




FOR

DRUGINTERACTIONS


HEALTH TEACHINGS

Angiotensin IIAntagonista

Selectivelyblocks thebinding ofangiotensin IIto receptorsites in manytissues,especially thevascularsmoothmuscles and

adrenal glands.This preventsthevasoconstricting andaldosterone-secretingeffects ofangiotensin IIon thesetissues.

I: treatment ofhypertension; inheart failure andmyocardialinfarction, it maybe used alone orin combinationwith other antihypertensiveagents. Renalprotection in Type

II diabetic patientswith proteinuria.CI: renal arterystenosis,hyperkalemia.Hypersensitivity.Anuria.

Dizziness anddose-relatedorthostatichypotension.Impaired renalfunction andrarely rash,angioedema.Hyperkalemia,facial edema,fever, angina

pectoris, 2nd

degree AV block,arrhythmias,diarrhea, drymouth, anemia,gout, musclecramps,.severemigraine.

Potassiumsparing diuretics,K supplements,salt substitutes,Alcohol,barbiturates,narcotics, Antidiabetic drugs,otherhypertensives.ACTH, NSAIDs.

Rifampicin

Assess patientsblood pressurebefore startingtherapy and regularlythereafter. Obtainbaseline liver andrenal function beforetherapy and regularlyassess kidneyfunction.

Monitor for possibleadverse drugreaction. Assess forhydration status.

Advice patient tocomply with dosageschedule even if feelingbetter. Tell patient toavoid sodiumsubstitutes becausethey may containpotassium which cancause hyperkalemia.Inform patient that drugmay cause dizziness

and light-headedness.

Instruct patient to reportdrug induced adverseeffects.

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GENERIC NAME: Clindamycin BRAND NAME: Anerocon, Clindal, KlindexRoute of Administration: IV Dosage: 3mg q8




FOR

DRUGINTERACTIONS


HEALTH TEACHINGS

lincosamines Inhibitsbacterialproteinsynthesis bybinding to the50s subunit ofthe ribosomes

I:Seriousanaerobicinfections.altenative to penicillin insome severestaphylococcaland streptococcalinfections. Biliaryandstaphylococcalbone and joint

infections. Skininfections involvingheavy colonizationwith anaerobes.CI: hypersensitivitytolincosamides.patients with colitis anddiarrhea. Severerenal and hepaticimpairment.

Adverse: GIdisorders. Rarelyhepaticimpairment.agranulocytosis

Erythromycin,cholestryamine,generalanesthetics,polymyxins,aminoglycosides,narcotic analgesic

Assess patient forsigns and symptomsof infection includingcharacteristics ofwound, urine andstool.

Assess completeculture and sensitivitytesting before start ofdrug therapy

Assess for allergicreaction

Monitor urine output

Monitor blood studies:AST, ALT, CBC, HCT,Biliburin

Teach patient aspectsof drug therapy

Culture maybe takenafter medicationcourse has beencompleted

Advice patient to reportsore throat, fever,fatigue; may indicate

super impose infection

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GENERIC NAME: rani tid ine BRAND NAME: ZantacRoute of Administration: IV Dosage: 500g




FOR

DRUGINTERACTIONS


HEALTH TEACHINGS

Histamine2antagonist

Competitivelyinhibits theaction ofhistamine atthe H2 receptorsof the parietalcells of thestomach,

inhibiting basalgastric acidsecretion andgastric acidsecretion that isstimulated byfood, insulin,histamine,cholinergicagonists,gastrin, andpentagastrin

Indicationsshort termtreatment of activeduodenal ulcer

Treatment of heartburn, acidindigestion, sourstomachContraindications:Contraindicatedwith allergy toranitidine,lactation.

Use cautiouslywith renal orhepatic function,pregnancy.

CNS: HeadacheMalaise,dizziness,somnolence,insomnia,vertigo.

CV: tachycardia,bradycardia

GI: constipation,diarrhea,nausea,vomiting,abdominal pain.

Local Pain:At IM site, localburning or itchingon IV site.

Increasedeffects ofwarfarin; monitorpatient closelyand adjusteddosage asneeded

Decreased doses inrenal and liver failure.

Report sore throat,fever, unusualbleeding or bruising,severe headache,and etc.

Ranitidine is to beused only by thepatient for whom itis prescribed. Donot share it withother people.

Do not useRanitidine if itcontains particles,

is cloudy ordiscolored, or if thevial is cracked ordamaged.

Ranitidine mayinterfere withcertain lab tests,including urineprotein tests. Besure your doctorand lab personnelknow you are taking

Ranitidine.

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GENERIC NAME: Tramadol BRAND NAME: HemarateRoute of Administration: IV Dosage: 100mg Q8



ADVERSEREACTIONS TOWATCH OUT FOR

DRUGINTERACTIONS


HEALTH TEACHINGS

Analgesic Binds co opioid receptorsInhibits reuptake ofserotonin andnorepinephrine in theCNS

Moderate tomoderately severepain

Contraindications:Not recommendduring pregnancy

Patients who areacutely intoxicatedon alcohol.

Hepatic impairment

Patients with historyof Opioiddependence.

CNS: SEIZURES,dizziness, headache,somnolence, anxiety,CNS stimulation,confusion, coordinationdisturbance,euphoria, malaise,nervousness, sleepdisorder, weakness,EENT: visualdisturbances,

CV: vasodilation,GI: constipation,nausea, abdominalpain, anorexia,diarrhea, dry mouth,dyspepsia, flatulence,vomiting,GU: menopausalsymptoms, urinaryretention/frequency,Derm: pruritus,sweating,

Neuro: hypertonia,Misc: physicaldependence

Coumadin Oral

and Darvocet-N100 Oral mayinteract basedon the potentialinteractionbetweenSELECTEDANTICOAGULANTS andPROPOXYPHENE;TRAMADOL.SELECTED

ANTICOAGULANTS/ACETAMINOPHENCoumadin Oral

and Darvocet-N100 Oral mayinteract basedon the potentialinteractionbetweenSELECTEDANTICOAGULANTS and

ACETAMINOPHEN.

Assess type, location,and intensity of painbefore administratingtramadol.

Assess bowelfunction routinely toprevent constipation.

Monitor for seizures.May occur within therecommended doserange.

Assess for allergicreaction to tramadol.

Instruct patient on how andwhen to ask for painmedicationMay cause dizziness anddrowsiness. Caution patienavoid driving orher activities requiringalertness until response tomedication is knownAdvise patient to changepositions slowly to minimizeorthostatic hypotensionCaution patient to avoid

concurrent use of alcohol oother CNS depressant withthis medication
http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720

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GENERIC NAME: cilostazol BRAND NAME: PletaalRoute of Administration: PO Dosage: 50mg BID



ADVERSEREACTIONS TOWATCH OUTFOR

DRUGINTERACTIONS


HEALTH TEACHINGS

therapeutic:antiplateletagentsPharmacologic:plateletaggregationinhibitors

Inhibits the enzymecyclic adenosinemonophosphate(cAMP)phosphodiesterase III(PDE III), which resultsin increased cAMP inplatelets and bloodvessels, producinginhibition of plateletaggregation andvasodilation.

Indications:Reduction of thesymptoms ofintermittentclaudication asmeasured byincreased walkingdistan

Contraindications: Hypersensitivity

CNS: headache,

dizziness

CV: palpitations,

tachycardia

GI: diarrhea

Do not takethis medicinewith any of thefollowingmedications:grapefruit

juiceThis medicinemay alsointeract withthe followingmedications:

agents thatprevent ortreat bloodclots like enoxaparin orwarfarin

aspirindiltiazemerythromycin orclarithro

mycinomeprazolesome

Assess for theFollowingConditions:

bleedingdisorderorhemophiliahistoryofheartfailure, heartattack, orother heartdiseasean unusualorallergicreaction tocilostazol,othermedicines,foods, dyes, orpreservativespregnant ortrying to getpregnantbreast-feeding

Use cautiously in pregnancy or child

(safety not established).

Pregnancy Risk Category: C
http://health.yahoo.net/adamcontent/blood-clotshttp://health.yahoo.net/adamcontent/blood-clotshttp://health.yahoo.net/goldcontent/enoxaparinhttp://health.yahoo.net/goldcontent/enoxaparinhttp://health.yahoo.net/goldcontent/warfarinhttp://health.yahoo.net/goldcontent/warfarinhttp://health.yahoo.net/goldcontent/aspirinhttp://health.yahoo.net/goldcontent/diltiazemhttp://health.yahoo.net/goldcontent/erythromycinhttp://health.yahoo.net/goldcontent/erythromycinhttp://health.yahoo.net/goldcontent/clarithromycinhttp://health.yahoo.net/goldcontent/clarithromycinhttp://health.yahoo.net/goldcontent/omeprazolehttp://health.yahoo.net/adamcontent/bleeding-disordershttp://health.yahoo.net/adamcontent/bleeding-disordershttp://health.yahoo.net/adamcontent/hemophiliahttp://health.yahoo.net/adamcontent/hemophiliahttp://health.yahoo.net/adamcontent/heart-failurehttp://health.yahoo.net/adamcontent/heart-failurehttp://health.yahoo.net/adamcontent/allergic-reactionshttp://health.yahoo.net/adamcontent/allergic-reactionshttp://health.yahoo.net/galecontent/pregnancy-3http://health.yahoo.net/galecontent/breastfeedinghttp://health.yahoo.net/adamcontent/blood-clotshttp://health.yahoo.net/adamcontent/blood-clotshttp://health.yahoo.net/goldcontent/enoxaparinhttp://health.yahoo.net/goldcontent/enoxaparinhttp://health.yahoo.net/goldcontent/warfarinhttp://health.yahoo.net/goldcontent/warfarinhttp://health.yahoo.net/goldcontent/aspirinhttp://health.yahoo.net/goldcontent/diltiazemhttp://health.yahoo.net/goldcontent/erythromycinhttp://health.yahoo.net/goldcontent/erythromycinhttp://health.yahoo.net/goldcontent/clarithromycinhttp://health.yahoo.net/goldcontent/clarithromycinhttp://health.yahoo.net/goldcontent/omeprazolehttp://health.yahoo.net/adamcontent/bleeding-disordershttp://health.yahoo.net/adamcontent/bleeding-disordershttp://health.yahoo.net/adamcontent/hemophiliahttp://health.yahoo.net/adamcontent/hemophiliahttp://health.yahoo.net/adamcontent/heart-failurehttp://health.yahoo.net/adamcontent/heart-failurehttp://health.yahoo.net/adamcontent/allergic-reactionshttp://health.yahoo.net/adamcontent/allergic-reactionshttp://health.yahoo.net/galecontent/pregnancy-3http://health.yahoo.net/galecontent/breastfeeding

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medicationsfortreating depression like fluoxetine, fluvoxamine,nefazodone

somemedicationsfortreating fungalinfections like ketoconazole,fluconazole, itraconazole
http://health.yahoo.net/adamcontent/depressionhttp://health.yahoo.net/adamcontent/depressionhttp://health.yahoo.net/goldcontent/fluoxetinehttp://health.yahoo.net/goldcontent/fluoxetinehttp://health.yahoo.net/goldcontent/fluvoxaminehttp://health.yahoo.net/goldcontent/fluvoxaminehttp://health.yahoo.net/goldcontent/nefazodonehttp://health.yahoo.net/goldcontent/nefazodonehttp://health.yahoo.net/galecontent/fungal-infections-1http://health.yahoo.net/galecontent/fungal-infections-1http://health.yahoo.net/galecontent/fungal-infections-1http://health.yahoo.net/goldcontent/ketoconazolehttp://health.yahoo.net/goldcontent/ketoconazolehttp://health.yahoo.net/goldcontent/fluconazole-2http://health.yahoo.net/goldcontent/fluconazole-2http://health.yahoo.net/goldcontent/itraconazolehttp://health.yahoo.net/goldcontent/itraconazolehttp://health.yahoo.net/adamcontent/depressionhttp://health.yahoo.net/adamcontent/depressionhttp://health.yahoo.net/goldcontent/fluoxetinehttp://health.yahoo.net/goldcontent/fluoxetinehttp://health.yahoo.net/goldcontent/fluvoxaminehttp://health.yahoo.net/goldcontent/fluvoxaminehttp://health.yahoo.net/goldcontent/nefazodonehttp://health.yahoo.net/goldcontent/nefazodonehttp://health.yahoo.net/galecontent/fungal-infections-1http://health.yahoo.net/galecontent/fungal-infections-1http://health.yahoo.net/galecontent/fungal-infections-1http://health.yahoo.net/goldcontent/ketoconazolehttp://health.yahoo.net/goldcontent/ketoconazolehttp://health.yahoo.net/goldcontent/fluconazole-2http://health.yahoo.net/goldcontent/fluconazole-2http://health.yahoo.net/goldcontent/itraconazolehttp://health.yahoo.net/goldcontent/itraconazole

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GENERIC NAME: Vit. K BRAND NAME: Kalium DuruleRoute of Administration: Dosage: AMP OD 3x Doses




DRUGINTERACTIONS

NURSINGCONSIDERATION

HEALTH TEACHINGS

Electrolytes Replace potassiumand maintainpotassium level

To preventhypokalemia,prophylaxis duringtreatment w/diuretics

Contraindicated inpatient with

oliguria,

anuria,; patient

with

untreated

Addisons

disease or with

acute

dehydration ,heat

cramps,

Use cautiouslywith

patient with

cardiac

disease and renal

impairment

Watch out forlevels of

potassium

electrolyte level

to prevent

hyperkalemia.

Observe 10 rights

of giving

medication.

Watch out for

possible adverse

reaction of the

patient.

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GENERIC NAME: Ceftazidime BRAND NAME: ZeptrigenRoute of Administration: IV Dosage: 1gm Q8




DRUGINTERACTIONS


HEALTH TEACHINGS

Anti-infective

Cephalosporin

Thirdgenerationcephalospirin thatinhibits itscell wallsynthesis,promotingosmoticinstability; usually

bactericid

Indication:management ofedema associatedwith excessivealdosteroneexcretion,hypertension,primaryhyperaldosteronism,hypokalemia,treatment ofhirsutism, cirrhosis ofliveraccompanied byedema or ascites

Contraindications:acute renalinsufficiency, anuria,hyperkalemia.pregnancy

gynecomastia; GIsymptoms;drowsiness;lethargy;headache; mentalcondusion; ataxia;impotence;menstrualirregularities; postmenoposebleedidng; rarelyagranulocytosis;usticaria; fever

Aminoglycosid

es

Increased risk of

nephrotoxicity.

Incompatibility

Aminoglycosid

es

Do not add

aminoglycosides

to ceftazidime

solutions

because

inactivation of

both drugs may

result;

administer at

separate sites if

concurrenttherapy is

Assess for

liver and renal

dysfunction.

Obtain CBC,

renal function

studies; reduce

dose with

dysfunction.

Culture

infection, and

arrange

sensitivity tests

before and

during therapy if

expected

response is not

seen.

Store at

temperatures not

exceeding 30C.

Have Vit. K

available in case

hypoprothrombi

nemia occurs.

Discontinue if

hypersensitivity

occurs.

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indicated.

Sodium

bicarbonate

Do not dilute

ceftazidime with

sodium

bicarbonate.

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GENERIC NAME: Tazocin BRAND NAME: ZeptrigenRoute of Administration: IV Dosage: 1gm Q8




DRUGINTERACTIONS


HEALTH TEACHINGS

Anti-infective

Cephalosporin

Thirdgenerationcephalospirin thatinhibits itscell wallsynthesis,promotingosmoticinstability; usuallybactericid

Indication:management ofedema associatedwith excessivealdosteroneexcretion,hypertension,primaryhyperaldosteronism,hypokalemia,treatment ofhirsutism, cirrhosis ofliveraccompanied byedema or ascites

Contraindications:acute renalinsufficiency, anuria,hyperkalemia.pregnancy

gynecomastia; GIsymptoms;drowsiness;lethargy;headache; mentalcondusion; ataxia;impotence;menstrualirregularities; postmenoposebleedidng; rarelyagranulocytosis;usticaria; fever

Coumadin Oraland Darvocet-N100 Oral mayinteract basedon the potentialinteractionbetweenSELECTEDANTICOAGULANTS andPROPOXYPHENE;TRAMADOL.SELECTEDANTICOAGULANTS/ACETAMINOPHENCoumadin Oral

and Darvocet-N100 Oral mayinteract basedon the potentialinteractionbetweenSELECTEDANTICOAGULANTS and

Assess for

liver and renal

dysfunction.

Obtain CBC,

renal function

studies; reduce

dose with

dysfunction.

Culture

infection, and

arrange

sensitivity tests

before and

during therapy if

expected

response is not

seen.

Instruct the patient to store

the medication at

temperatures not

exceeding 30C.

Have Vit. K

available in case

hypoprothrombi

nemia occurs.

Discontinue if

hypersensitivity

occurs.
http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720http://www.medscape.com/druginfo/druginteractions?drug_4069=Coumadin%20Oral&drug_4998=Darvocet-N%20100%20Oral#inter_1720

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