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11. Mendelian Genetics II- Extensions
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Transcript of 11. Mendelian Genetics II- Extensions
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2006-2007
Beyond Mendel’s Lawsof Inheritance
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Extending Mendelian genetics Mendel worked with a simple system
peas are genetically simple most traits are controlled by a single gene each gene has only 2 alleles, 1 of which
is completely dominant to the other The relationship between
genotype & phenotype is rarely that simple
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Incomplete dominance Heterozygote shows an intermediate,
blended phenotype example:
RR = red flowersrr = white flowersRr = pink flowers
make 50% less color
RR
RRWWRW
WWRW
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Incomplete dominance
true-breedingred flowers
true-breeding white flowers
XP
100%
100% pink flowersF1
generation(hybrids)
self-pollinate
25%whit
eF2generation
25%
red1:2:
1
50%pink
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Co-dominance 2 alleles affect the phenotype
equally & separately not blended phenotype human ABO blood groups 3 alleles
IA, IB, iIA & IB alleles are co-dominant glycoprotein antigens on RBC IAIB = both antigens are produced
i allele recessive to both
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Genetics of Blood typepheno-
typegenotype
antigenon RBC
antibodiesin blood
donationstatus
A IA IA or IA itype A antigens
on surface of RBC
anti-B antibodies __
B IB IB or IB itype B antigens
on surface of RBC
anti-A antibodies __
AB IA IBboth type A &
type B antigens on surface
of RBC
no antibodies universal recipient
O i ino antigens on surface
of RBC
anti-A & anti-B antibodies
universal donor
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Pleiotropy Most genes are pleiotropic
one gene affects more than one phenotypic character 1 gene affects more than 1 trait dwarfism (achondroplasia) gigantism (acromegaly)
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Acromegaly: André the Giant
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Aa x aa
Inheritance pattern of Achondroplasia
a a
A
a
A a
A
a
Aa x Aa
Aa
aa aa
Aa
50% dwarf:50% normal or 1:1
AA
aa
Aa
67% dwarf:33% normal or 2:1
Aa
lethal
dominantinheritance
dwarf dwarf
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Epistasis
B_C_B_C_bbC_bbC__ _cc_ _cc
One gene completely masks another gene coat color in mice = 2 separate genes
C,c: pigment (C) or no pigment (c)
B,b: more pigment (black=B) or less (brown=b)
cc = albino, no matter B allele
9:3:3:1 becomes 9:3:4
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Epistasis in Labrador retrievers 2 genes: (E,e) & (B,b)
pigment (E) or no pigment (e) pigment concentration: black (B) to brown (b)
E–B–E–bbeeB–eebb
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Polygenic inheritance Some phenotypes determined by additive
effects of 2 or more genes on a single character phenotypes on a continuum human traits
skin colorheightweight intelligencebehaviors
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enzyme
Skin color: Albinism Johnny & Edgar Winter
albinoAfricans
However albinism can be inherited as a single gene trait aa = albino
melanin = universal brown color
tyrosine melaninalbinism
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OCA1 albino Bianca Knowlton
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Sex linked traits Genes are on sex chromosomes
Discovered by T.H. Morgan at Columbia U. Drosophila breeding
good genetic subject prolific breeders/2 week generations 4 pairs of chromosomes XX=female, XY=male
1910 | 1933
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autosomal
chromosome
s
sexchromosome
s
Classes of chromosomes
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F2generation
100%red-eye female
50% red-eye male50% white eye male
Discovery of sex linkage
P X
F1generation(hybrids)
100%red eye
offspring
true-breeding white-eye male
true-breedingred-eye female
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In humans & other mammals, there are 2 sex chromosomes: X & Y 2 X chromosomes
develop as a female: XXgene redundancy,
like autosomal chromosomes an X & Y chromosome
develop as a male: XYno redundancy
Genetics of Sex
X Y
X
X
XX
XY
XY
50% female : 50% male
XX
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XRXR XrY
Let’s reconsider Morgan’s flies…
x
Xr Y
XR
100% red eyes
XR
XRXr XRY
XRYXRXr
x
XRXr XRY
XR Y
XR
Xr
XRXr
XRYXRXR
XrY100% red females50% red males; 50% white males
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Genes on sex chromosomes Y chromosome
few genes other than SRYsex-determining region: master regulator for
maleness turns on genes for production of male
hormones many effects = pleiotropy!
X chromosome other genes/traits beyond sex determination
mutations: Hemophilia, Duchenne muscular dystrophy,
color-blindness
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Sex-linked usually means
“X-linked” more than
60 diseases traced to genes on X chromosome
Duchenne muscular dystrophyBecker muscular dystrophy
Ichthyosis, X-linkedPlacental steroid sulfatase deficiencyKallmann syndromeChondrodysplasia punctata, X-linked recessive
HypophosphatemiaAicardi syndromeHypomagnesemia, X-linkedOcular albinismRetinoschisis
Adrenal hypoplasiaGlycerol kinase deficiency
Incontinentia pigmentiWiskott-Aldrich syndromeMenkes syndrome
Charcot-Marie-Tooth neuropathyChoroideremiaCleft palate, X-linkedSpastic paraplegia, X-linked, uncomplicatedDeafness with stapes fixation
PRPS-related gout
Lowe syndrome
Lesch-Nyhan syndromeHPRT-related gout
Hunter syndromeHemophilia BHemophilia AG6PD deficiency: favismDrug-sensitive anemiaChronic hemolytic anemiaManic-depressive illness, X-linkedColorblindness, (several forms)Dyskeratosis congenitaTKCR syndromeAdrenoleukodystrophyAdrenomyeloneuropathyEmery-Dreifuss muscular dystrophyDiabetes insipidus, renalMyotubular myopathy, X-linked
Androgen insensitivity
Chronic granulomatous diseaseRetinitis pigmentosa-3
Norrie diseaseRetinitis pigmentosa-2
Sideroblastic anemiaAarskog-Scott syndrome
PGK deficiency hemolytic anemia
Anhidrotic ectodermal dysplasia
AgammaglobulinemiaKennedy disease
Pelizaeus-Merzbacher diseaseAlport syndrome
Fabry disease
Albinism-deafness syndrome
Fragile-X syndrome
Immunodeficiency, X-linked,with hyper IgM
Lymphoproliferative syndrome
Ornithine transcarbamylase deficiency
Human X chromosome
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Map of Human Y chromosome?
< 30 genes on Y chromosome
Sex-determining Region Y (SRY)
linked
Channel Flipping (FLP)Catching & Throwing (BLZ-1)
Self confidence (BLZ-2)note: not linked to ability gene
Devotion to sports (BUD-E)
Addiction to death &destruction movies (SAW-2)
Scratching (ITCH-E)Spitting (P2E)
Inability to express affection over phone (ME-2) Selective hearing loss (HUH)
Total lack of recall for dates (OOPS)
Air guitar (RIF)
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X-inactivation Female mammals inherit 2 X chromosomes
one X becomes inactivated during embryonic development
condenses into compact object = Barr bodywhich X becomes Barr body is random in each cell
patchwork trait = “mosaic”
XH
Xh
XHXh
patches of black
patches of orange
tricolor catscan only befemale
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Environmental effects Phenotype is controlled by
both environment & genes
Color of Hydrangea flowers is influenced by soil pH
Human skin color is influenced by both genetics & environmental conditions
Coat color in arctic fox influenced by heat sensitive alleles
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2006-2007
Any Questions?
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Review Questions
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1. Three babies were recently mixed up in a hospital. After consideration of the data below, which of the following represent the correct baby/parent combinations?
A. I-3, II-1, III-2 B. I-1, II-3, III-2 C. I-2, II-3, III-1 D. I-2, II-1, III-3 E. I-3, II-2, III-1
Couple #Blood groups
IA and A
IIA and B
IIIB and O
Baby #Blood groups
1B
2O
3AB
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2. A mother with type B blood has two children, one with type A blood and one with type O blood. Her husband has type O blood. Which of the following could you conclude from this information?A. The husband could not have fathered either child.
B. The husband could have fathered both children.
C. The husband must be the father of the child with type O blood and could be the father of the type A child.
D. The husband could be the father of the child with type O blood, but not the type A child.
E. Neither the mother nor the husband could be the biological parent of the type A child.
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3. Vermilion eyes is a sex-linked recessive characteristic in fruit flies. If a female having vermilion eyes is crossed with a wild-type male, what percentage of the F1 males will have vermilion eyes? A. 0% B. 25% C. 50% D. 75% E. 100%
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4. Barring in chickens is due to a sex-linked dominant gene (B). The sex of chicks at hatching is difficult to determine, but barred chicks can be distinguished from nonbarred at that time. To use this trait so that at hatching all chicks of one sex are barred, what cross would you make? A. barred males barred females B. barred males nonbarred females C. nonbarred males barred females D. nonbarred males nonbarred females
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5. A recessive allele on the X chromosome is responsible for red-green color blindness in humans. A woman with normal vision whose father is color-blind marries a color-blind male. What is the probability that this couple’s son will be color-blind? A. 0 B. 1/4 C. 1/2 D. 3/4 E. 1
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6. An achondroplastic dwarf man with normal vision marries a color-blind woman of normal height. The man's father was six feet tall, and both the woman's parents were of average height. Achondroplastic dwarfism is autosomal dominant, and red-green color blindness is X-linked recessive.
How many of their female children might be expected to be color-blind dwarfs? *A. all
B. none
C. half
D. one out of four
E. three out of four
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7. An achondroplastic dwarf man with normal vision marries a color-blind woman of normal height. The man's father was six feet tall, and both the woman's parents were of average height. Achondroplastic dwarfism is autosomal dominant, and red-green color blindness is X-linked recessive.
How many of their male children would be color-blind and normal height? A. all B. none C. half D. one out of four E. three out of four
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8. In cats, black color is caused by an X-linked allele; the other allele at this locus causes orange color. The heterozygote is tortoiseshell. What kinds of offspring would you expect from the cross of a black female and an orange male? A. tortoiseshell female; tortoiseshell male B. black female; orange male C. orange female; orange male D. tortoiseshell female; black maleE. orange female; black male
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9. Red-green color blindness is a sex-linked recessive trait in humans. Two people with normal color vision have a color-blind son. What are the genotypes of the parents? A. XcXc and XcY B. XcXc and XCY C. XCXC and XcY D. XCXC and XCY E. XCXc and XCY
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10. A color-blind son inherited this trait from hisA. mother.
B. father.
C. mother only if she is color-blind.
D. father only if he is color-blind.
E. mother only if she is not color-blind.
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11. In cattle, roan coat color (mixed red and white hairs) occurs in the heterozygous (Rr) offspring of red (RR) and white (rr) homozygotes. When two roan cattle are crossed, the phenotypes of the progeny are found to be in the ratio of 1 red:2 roan:1 white. Which of the following crosses could produce the highest percentage of roan cattle? *A. red whiteB. roan roanC. white roanD. red roanE. All of the above crosses would give the same percentage
of roan.
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12. You think that two alleles for coat color in mice show incomplete dominance. What is the best and simplest cross to perform in order to support your hypothesis?A. a testcross of a homozygous recessive mouse with a
mouse of unknown genotypeB. a cross of F1 mice to look for a 1:2:1 ratio in the offspringC. a reciprocal cross in which the sex of the mice of each
coat color is reversedD. a cross of two true-breeding mice of different colors to
look for an intermediate phenotype in the F1
E. a cross of F1 mice to look for a 9:7 ratio in the offspring