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![Page 1: 10/18/2015 Rad Bio: Radionuclides p. 1 of 70 Illinois Institute of Technology Physics 561 Radiation Biophysics, Lecture 10 Deposited Radionuclides; Exposures.](https://reader035.fdocuments.in/reader035/viewer/2022062719/56649ecf5503460f94bdd916/html5/thumbnails/1.jpg)
04/20/23 Rad Bio: Radionuclides p. 1 of 70
Illinois Institute of Technology
Physics 561 Radiation Biophysics, Lecture 10
Deposited Radionuclides;Exposures to Radiation
1 July 2014Andrew Howard
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Class Overview Radionuclides, continued
– Routes of entry– Physics & chemistry of
nuclides– Dosimetry and activity– Tritium, noble gases– Alkali metals– Alkaline earths– Halogens– Uranium & plutonium
Exposure from natural and man-made sources
– Population dosimetry– Dose equivalent and
equivalent dose– Radiation weighting
factors– Natural sources– Man-made sources
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Internally deposited radionuclides
Why radionuclides are studied in the context of internal deposition
• Exposure works differently from external exposure: acts over shorter length scales
• Often involves high-LET forms that would never have biological effects if they were external
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How do they get in?
Ingestion - intake in food & water though GI tract & tracheal clearance
Inhalation - breathed-in radionuclides traveling through nasopharyringeal passages to the lung
Injection - only intentional(except in bad Hollywood movies)-only relevant in a few therapeutic contexts
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Ingestion Intake through digestive system Various fates:
– Excretion Urine Feces
– Incorporated into blood,e.g. via glutathione conjugation
– Incorporation into lymph– Bile with radionuclides that have
collected into the liver out of the circulatory system can be secreted back into the digestive system
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Inhalation
Respiratory system:3 compartments:– Nasopharyngeal (NP)– Tracheobronchial (TB)– Deep-lung parenchyma (P)
Deposition (graph sideways from book-fig. 15.2):)
% d
ep
osi
tion
Activity mean aerodynamic diameter, µm0.1 0.2 0.5 1.0 2.0 5.0 101
510
203050
7090
DT-B
DP DN-P
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Inhalation: Fate of Radionuclides
Radionuclides enter respiratory system via nose & mouth
Travel through trachea Either travel farther down to bronchi & lungs or
are sent back up to be exhaled or swallowed Physical fate primarily function of size & shape Size Matters!
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What happens to nuclides if they get into the deep lung?
Fate depends on chemistry If particles are moderately to very water-soluble,
they pass into the bloodstream readily– There’s a lot of surfactant (detergent) lining the lung
surface that helps to solubilize things– once in the blood, the compounds get metabolized
or cleared or both If the material is very insoluble it gets gobbled
up by macrophages– Particles go to lymph nodes inside macrophage– Ultimately the lymph empties into the blood
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Physics and Chemistry of Inhaled Radionuclides
Shape matters, too! Biological response depends substantially
on shape because cells react very differently to needles as compared to cubes
– Asbestos: caused mostly by needle-shaped fibers, independent of their chemical nature
– Spheres of the same compounds would be harmless
– Macrophages respond peculiarly to needle-shaped particles
Surface area to volume ratios influence biological fate!
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Chemistry of Radionuclides: General
Chemistry is neutron-independent, i.e. every isotope behaves identically (exception: 3H) . . . (until decay occurs)
Nuclides of elements without ordinary biological function are metabolized approximately like their nearest vertical neighbors in the periodic table
– Not entirely successful substitutions– Sometimes: Very small discrimination ratio
Alkali metals: Li, Na, K, Rb, Cs, Fr Elaborate mechanisms for handling K; none for Rb
so Rb tends to behave like K (but not like Na).
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Chemistry and Metabolism
Periodic Table of the Elements
Actinide Series
Lanthanide Series
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Dose to Specific Organs
Distribution over time can be complex It takes some time for each organ to receive
its dose, and as things clear (both physically and biologically) the concentrations will diminish
Note in fig. 15.3 that the 131I dose to the thyroid is not predominant over the others because it’s such a small organ
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Fig.15.3, my version
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Complex Case: 99mTc
Three emissions with different activities and energies
Effective value depends on tabulating individual contributions
Absorbed dose depends on applying this value in a Monte Carlo analysis of deposition in various organs: see tables 15.2 and 15.3 in the text
Further variability (beyond limitations of these models) come from the fact that real people aren’t identical to the “standard man”
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Dosimetry of specific nuclides
We describe equivalent dose asHT,R = wRDT,R
where DT,R is the absorbed dose in tissue T from radiation type R, wR is the radiation weighting factor for this radiation type, and HT,R is the equivalent dose actually experienced by the tissue
This is similar to the concept of RBE except that it emphasizes that tissues respond differently to different types of radiation.
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Tritium TP=12.3y Mostly in the form of water Turnover: TB = 10 days, like ordinary water Low-energy beta and it’s cleared quickly so
the hazard is pretty low. Some 3H can get incorporated into
macromolecules—that could be more severe. Hydrogens in different organic molecules
have different exchange rates; T~10-10s for hydrogens attached to N or O; T ~ minutes or forever for C-H hydrogens.
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Example from Amino Acids
Serine has C-H, N-H, and O-H bonds in it.
Hydrogens attached to carbons are essentially non-exchanging
Hydrogens attached to N and O exchange in microseconds or faster
Exchange lives of some NH and OH are longer because they’re solvent-protected.
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Exchangeable Hydrogens in DNA
The hydrogens on the ribose ring of DNA are not exchangeable: in fact, there are very few exchangeable H’s in DNA!(e.g. amine H’s)
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Noble Gases: Krypton and Radon
85Kr common in nuclear power– Not incorporated in the body much
because it’s not very reactive– Therefore not a serious biological hazard
Radon is important:we’ll talk about it in chapter 16.
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Alkali Metals Sodium isotopes are used in diagnostics 40K is an important background irradiator: see
chapter 16 Cesium (and rubidium) are produced in fission.
– 137Cs ended up in the atmosphere as a component of fallout
– Behave like potassium– TB ~ 50-150 days– TP ~ 30 y so biological clearance dominates– excretion has 2-component model
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Two-Component Model
Model looks likeA(t) =A0[p1exp(-1t) +p2exp(-2t)]
Withp1 + p2 = 1
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Alkaline Earths
These are typically divalent (2+) Be, Mg, Ca not very important except as research
subjects Sr has practical significance
– 90Sr is major component of fallout from nuclear weapons testing.
– Tp = 28 y (- to 90Y90Zr) so it’s dangerous
– 89Sr is important too (Tp = 50.5 d, - to 89Y)
– Sr is a Ca analog and tends to concentrate in tissues where Ca2+ is supposed to concentrate
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Alkaline earths, concluded
140Ba (Tp =12.8d, - to 140La140Ce) common in fallout and reactor output; but it has a short half-life
226Ra (Tp=1600Y, to 222Rn218Po214Pb214Bi214Po210Pb210Bi206Tl206Pb) is important too
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Sr and Ra retention and effects
Ra retained somewhat less than Sr,but a reasonable amount stays around for years
Did childhood leukemias increase in the US because of fallout in the 1950’s? Unclear; it’s hard to get unambiguous evidence of environmental effects on human health for anything except smoking.
Radium dial painters got sarcomas of bone and carcinomas of the sinus epithelium
224Ra was used in treatments after WWIIIt can be used to quantitate Pu carcinogenicity
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Halogens: Iodine
Iodine is concentrated in the thyroid 131I is an important fission product
– Short physical half-life (8 days, - to 131Xe)
– Moves quickly through the food chain via milk
125I used in imaging & brachytherapy:Td=59.4 d, EC to 125Te
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Iodine, concluded
Major releases of 131I:– Chernobyl (1986)– Windscale nuclear
plant in England (1957)– Flawed episode of West
Wing, season 7(“Duck & Cover”)
Radioactive iodine can be competed away with iodine in table salt
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Uranium
Naturally occuring even though all its isotopes are radioactive
Precursor of other high-Z elements 238U is common— long half-life 235U is 0.7% of natural mixture
– percentage can be reduced (“depleted”)– Or enhanced (“enriched”)– Undergoes fission when bombarded with slow
(“thermal”) neutrons
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Uranium, continued
Plentiful in reactors and weapons Toxic to kidney, independent of radioactivity Decay modes:
– 235U: emitter to 231Th … 207Pb, T1/2 = 7*108 y
– 238U : much more common (99.3%) emitter to 234Th … 206Pb, T1/2 = 4.5*109 y
In one year, 1g of 238UO2 produces 5.70*10-13 moles of 234ThO2 = 0.295 ng, generating 3.44*1011 depositions along the way = 1090 dps = 0.295 µCi.
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Plutonium Two common isotopes:
238Pu: T1/2 = 86.4yand 239Pu : T1/2 = 24890 y
Inhaled Pu in lung:cancer, some lymphatic-system damage
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Is Pu the most toxic substance? Is it the most toxic substance in the world?
– Available exposure routes limited– I wouldn’t want to eat it, but there are worse
toxicants even among metals; and biohazardous substances (e.g. aflatoxin) are much nastier on a per-g or per-mole basis
Exposure through fallout: 400 megacuries worldwide.But it still has to get inside us to do damage.
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How nasty is Pu, really?
It’s probably about as carcinogenic as radium if it’s deposited in the skeleton
Lung tumors are likely with inhalation of large quantities;possibility of lavage exists as a mitigation
Depositions of Pu elsewhere might be cancerous if they stay around long enough
Kidney toxicant, like Uranium? Probably:the actinides have chemistries that are similar one to the other
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Important nuclides, Z ≤ 80Nuclide mode product final T1/2 comment
3H - 3He 3He 12.33y reactor byproduct40K EC 40Ar 40Ar 1.28*109y naturally occurring85Kr - 85Rb 85Rb 10.8 y reactor byproduct87Rb - 87Sr 87Sr 4.75*1010y naturally occurring89Sr - 89Y 89Y 50.5d fallout90Sr - 90Y 90Zr 28.8y significant in fallout99m Tc 99Tc 99Ru 6h medical imaging125I EC 125Te 125Te 59.4d imaging reagent131I - 131Xe 131Xe 8.0d fallout: found in milk137Cs - 137Ba 137Ba 30.1y weapon byproduct140Ba - 140La 140Ce 12.8d* weapons, reactors
* Misstated in Alpen as 128d
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Important radionuclides, Z > 80
Nuclide mode product final T1/2 comment219Rn 215Po 207Pb 4.0s gas; see next chapter222Rn 218Po 206Pb 3.8d gas; see next chapter223Ra 219Rn 207Pb 11.4d on 235U chain224Ra 220Rn 208Pb 3.66d on 232Th chain226Ra 222Rn 206Pb 1600y on 238U chain232Th 228Ra 208Pb 1.4*1010y pseudo-stable!233U 229Th 209Bi 1.59*105y detectable235U ,SF 231Th 207Pb 7.04*108y detectable; fissionable238U 234Th 206Pb 4.47*109y predominant U isotope238Pu 234U 206Pb 87.7y fallout; space vehicles239Pu , SF 235U 207Pb 24110y fallout, reactorsSF= spontaneous fission
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Human exposures to ionizing radiation This is the last chapter in Alpen, but clearly it’s not the
final part of what we will discuss in this course We want to offer you a fuller understanding of some
special topics, including hormesis, as well as a brief introduction to general biochemistry.
Those additional lectures are intended to provide you with a better context for the material that Alpen offers.
Anyway …the point of the remainder of this lecture is to consider human exposures to ionizing radiation, whether they’re natural or anthropogenic.
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What can and can’t we control?
Significant sources of risk from exposure to ionizing radiation to the population as a whole
– Natural background– Diagnostic applications of ionizing radiation
Anything else?– Therapeutic X-rays and isotopes:
few people so population dose is tiny– Consumer applications (e.g. Cathode Ray
Tube TV receivers): tiny per-person dose
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The Meta-question:Are low doses worse than zero doses?
Clearly most people don’t get exposed to distinctly high doses of ionizing radiation
We’re going to spend some time thinking about how to quantitate and how to assess risk from various sources, particularly as part of natural and man-made background
But:Do we really know that these background levels pose a net risk; or is the hormesis concept operating here?
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Population Dosimetry Biologically effective dose from n different sources:
We can describe the dose equivalent as H = i=1n DiQiNi
– Di is dose from source or radiation type i– Qi corrects for LET-dependent biological effectiveness– Ni corrects for nonuniformities in distribution and anything else
This is an old way of doing things... Reference source of exposure:
Whole-body exposure to rays Adjustments to dose depend on
– Type of radiation– Portion of person irradiated
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Why Consider Equivalent Dose?
It enables us to compare radiation types & exposure modalities on a quasi-equal footing
Unit of equivalent dose: Sievert corresponds to the Gray for dose. Rem corresponds to rad.
1 Sv = 1 Gy if using reference exposure
Equivalent dose HT = RwRDT,R
(Might underestimate health risks of the reference source!)
High LET sources have high radiation weight factors, up to a point (see last week’s lectures)!
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Radiation Weight Factors, wR
Radiation type wR
Xrays, rays 1e-, e+, µ 1Neutrons
– <10keV 5– 10-100keV 10– 100-2000 keV 20– 2-20MeV 10– > 20 MeV 5
Protons (non-recoil), > 2MeV 2 particles, fission fragments 20Relativistic heavy ions 20
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Effective Dose
Effective dose E is defined so that the probability of cancer and genetic effects is the same no matter where and how uniformly the deposition occurs:E = TwTHT = TRwTwRDT,R
Implicit here is the concept that wR is independent of wT, which isn’t completely true; but it’s close enough given how vague the values are!
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Tissue Weight Factors, wT
wT=0.01 wT=0.05 wT=0.12 wT=0.20
Bone surface Bladder Bone Marrow Gonads
Skin Breast Colon
Liver Lung
Esophagus Stomach
Thyroid
Remainder
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What are we trying to do here?
These tissue weighting factors are taking into account the portion of the radiation that ends up in the relevant tissue
That, in turn, depends on the tendency to concentrate certain atoms in particular organs
But it also depends on the actual size (fraction of total body weight) associated with that organ
Consider iodine in the thyroid and calcium in bone; but most other nuclides are more promiscuous in their distribution.
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Committed Equivalent Dose
ICRP idea looking at time-integral over time of equivalent dose rate in a specific tissue T following intake
Thus for a single nuclide absorbed at time t0,
HT() = ∫t0t0+ (dHT(t)/dt)dt
Usually is taken as 50 years for occupational exposures and 70 years for general public
Smaller values apply to already-aged populations
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Committed Effective Dose
Add up the committed equivalent dosesover all the tissues irradiated
E() = T wTHT() =
T wT∫t0t0+ (dH(t)/dt) dt
Units for all of these are Sieverts wR is like Q in the dose equivalent definition
wT is like the N value in the dose equivalent definition
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Collective Dose Collective Dose S: the aggregate dose associated with
an exposure received by a population of N individuals Thus if we know <E> and N then
(collective dose) S = <E>Nis proportional to expected number of cases of disease (assuming linear response and 0 threshold).
Multiple populations (subgroups i = 1, . . . N):S = iHiPi
Thus if at collective dose level E, the probabilityP(cancer) = 10-5, then in a population N = 106 we expect ~10 cancer cases
This notion works well with stochastic endpoints
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Risk Factors
Weighting factor for any organ is the ratio of the risk for that organ to the total risk
These estimates involve– Fatal cancers– Genetic risk– Life shortening
Purpose:risk-weighted dose estimate for a mixture of types of radiation or for radiation of parts of the body
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Total Stochastic Detriment, part I
Lifetime risk coefficients, 10-2 Sv-1
Organ Popu- wT Rad wT
lation WorkersBladder 0.29 0.040 0.23 0.042Bone Marrow 1.04 0.143 0.83 0.150Bone Surface 0.07 0.010 0.06 0.011Breast 0.36 0.050 0.29 0.052Colon 1.03 0.142 0.82 0.148Esophagus 0.24 0.033 0.19 0.034Liver 0.80 0.110 0.64 0.116
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Total Stochastic Detriment, Concluded
Organ Popu- wT Rad wT
lation WorkersOvary 0.15 0.021 0.12 0.022Skin 0.04 0.006 0.03 0.005Stomach 1.00 0.138 0.80 0.145Thyroid 0.15 0.021 0.12 0.022Remainder 0.59 0.081 0.47 0.085Gonads (genetic) 1.33 0.183 0.80 0.145Grand Total 7.25 1 5.53 1
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So let’s look at specifics Up to now we’ve been arming you with a
few analytical tools. Now we’ll look at actual sources of
background– Natural– Anthropogenic
Medicinal Occupational
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A few natural sources matter: Soil-borne radionuclides Airborne radionuclides Cosmic rays from deep space
Total Exposure from these sources:
around 0.7 - 3 millisieverts per year Dominated by U-Th series (mostly Rn),
40K, 87Rb, Cosmic rays Varies significantly with altitude
External Natural Sources
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Why 40K and 87Rb? Very long half-lives 40K:
– T1/2 is 1.3*109y, i.e. about 0.25* age of the earth– K common in earth’s crust so there’s a lot of 40K– 40K is only 0.01% of total K, though– 2 decay modes: EC or + + to 40Ar or - to 40Ca
87Rb (- to 87Sr)– even longer T1/2: 5.0*1010y (3* age of universe)– 27.2% of the natural abundance– But there isn’t much Rb in the soil
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Radon as a natural source
Substantial concern in recent years about radon such that wR = 20 for Rn alphas and
decay products. n.b.: should we actually consider indoor
radon a natural source? Pay attention to fig. 16.1!
– Nuclear industry, consumer products, air travel are
trivial for the general population– Most of the natural background is Rn daughters
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Distribution of Doses Natural background and
medical dose dominate This is a redrawing of Alpen’s
fig. 16.1, corrected.
An
nua
l dos
e, m
Sv
2.4
NaturalBack-ground
Medical
Fallout
NuclearIndustry
ConsumerProducts Air Travel
1
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What are the natural sources?
Series Primordial radionuclides starting mostly from 238U, 232Th, and 235U;especially 222Rn from 226Ra
Nonseries primordial radionuclides: 40K, 87Rb Cosmogenic radionuclides:
Elements in earth’s crust or in atmosphere interact with cosmic ray: mostly 14C, 3H, 22Na (and 7Be)
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Outdoor, Extracorporeal Sources
Mostly uranium-thorium seriesbut also some 40K
Varies widely from place to place:150-1400 µGy per year,depending on where you are
What matters is gamma emitters here: wR=1 because nothing else gets into the skin
Typical 222Rn exposure is 232µGy per year; with wR=20, that’s almost 5 millisieverts—high compared to Alpen’s published totals
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How variable is the background? An extreme case:
Ramsar, Iran: 260 mGy (not mSv!) natural
background Mostly 226Ra in hot springs Some U, Th in minerals No evidence that the local
population is suffering from this exposure
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Indoor, Extracorporeal Sources
Depend slightly on the method of construction– What is the source of the building material?– How leaky is the building (especially for 222Rn);
Well-insulated buildings deliver a high body burden because we’re trying not to have to heat them so much--so the gas stays in the house
– Therefore, as building practices improve, the Rn exposure increases
Almost all uranium-thorium series stuff
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Inhaled Radionuclides
222Rn is the inhalation culprit Study in New York gave some big numbers
for total body burdens received:1.9-3 mGy/year, I.e. around 38-60 millisieverts!
This is actually equal to the occupational limit, so something is wrong: either we need to get radon out of our houses or we need to revise the occupational limits upward.
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Nonseries Radionuclides
40K and 87Rb get into the body through ordinary metabolism. Beta emitters, wR=1.
Typical doses for 40K:– 180 µSieverts/year to gonads– 60 µSieverts/year to bone– 270 µSv per year to bone marrow
Typical doses for 87Rb:– 10 µSieverts/year to gonads– <10 µSieverts/year to bone– 10 µSv per year to bone marrow
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Cosmic Rays and Cosmogenic Radionuclides
Varies a lot by location– The higher in altitude you are,
the more you get– Also, the portion contributed by neutrons
goes up as you go higher in altitude– Some variation by latitude and longitude
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Cosmic Radiation and AltitudeDose and equivalent dose rate
go up with altitude
Tis
s ue
Do s
e E
q ui v
a le n
t R
ate
mS
v/y
1
2
0.5
Altitude, Kilometers0
0.25 0.25
0.5
1.0
2
Abs
orbe
d do
se r
a te
in a
ir, m
Gy/
y
4 km
SeaLevel
Chicago
Albu-querque
Mt. Whitney
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World Summary (cf. fig. 16.4)
All but 5% of U-Th series is 222Rn daughters
An
nua
l equ
iva
len
t
dos
e, m
Sv
Cosmogenic nuclides
Cosmic rays 40K + 87Rb U-Th internal
U-Th external
1
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Human exposures, worldwide
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Artificial sources
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Another perspective
Courtesy Emory University Radiation Protection program
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Effective Dose, mSv Yr-1, US+Canadafrom natural sources
Source Lung Gonads Bone Marrow OtherTotal
WT value 0.12 0.25 0.03 0.03 0.03 1.0
Cosmic rad 0.03 0.07 0.008 0.03 0.13 0.27
Cosmogenic 0.001 0.002 — 0.004 0.003 0.01radionuclides
Terrestrial:
External 0.03 0.07 0.008 0.03 0.14 0.28
Inhaled 2.00 — — — — 2.00
Nuclides 0.04 0.09 0.03 0.06 0.17 0.40In the body
Totals 2.1 0.23 0.05 0.12 0.44 2.96
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Man-Made Sources Major contributors to population dose are:
– Medical diagnostic procedures– Smoking (!) 210Pb, 210Po
Individual burdens:– Diagnostic– Smoking– Therapeutic use of x-rays,
Recall discussion ofadditive vs. multiplicative risk
I encourage you to read the details about anthropogenic sources, but I won’t test you in detail
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Diagnostic X-rays
US bone marrow dose ~ 1mGy = 1 mSv US genetically significant dose ~ 0.3 mGy Methods getting better but more procedures are done Weighted annual effective dose ~ 0.36 mSv Age and gender-specific adjustments bring that down
to about 0.23 mSv. Values in 3rd-world countries are lower in spite of the
patients’ experience of higher doses per treatment
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Nuclear medicine
US value ~ 140 µSv; lower elsewhere Includes nuclides for cardiac function tests, PET Effective dose is about 0.6 * diagnostic X-ray value
Dose,mGy or mSv
0 0.2 0.4 0.6 0.8
Genetically significant dose, mGy
Effective Dose Equivalent, HE, mSv
Bone marrow dose, mGy
Nuclearmedicine
DiagnosticX-Ray
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Nuclear Power
Fuel cycle: mining, milling, refining, UF6,enriched UF6 (sublimes at 56.5ºC)
Fuel fabrication, power generation, reprocessing,waste disposal, fuel storage, transportation
These are different from medical background in that they’re regional rather than global
A sub-population is particularly at risk: namely, miners and neighbors of the facilities that handle these compounds