10. Wilson Disease - More Med, Refer Rasa
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Transcript of 10. Wilson Disease - More Med, Refer Rasa
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7/27/2019 10. Wilson Disease - More Med, Refer Rasa
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Wilsons disease
Wilson disease (also known as hepatolenticular degeneration) is a genetic disorder thatprevents the body from getting rid of extra copper.
A small amount of copper obtained from food is needed to stay healthy, but too much
copper is poisonous. In Wilson disease, copper builds up in the liver, brain, eyes, and
other organs. Over time, high copper levels can cause life-threatening organ damage.
Causes
Wilson disease is caused by a buildup of copper in the body.
Normally, copper from the diet is filtered out by the liver and released into bile, which
flows out of the body through the gastrointestinal tract. People who have Wilson disease
cannot release copper from the liver at a normal rate, due to a mutation of the ATP7Bgene. When the copper storage capacity of the liver is exceeded, copper is released intothe bloodstream and travels to other organsincluding the brain, kidneys, and eyes.
Hepatic fibrosis develops, ultimately producing cirrhosis. Copper diffuses out of the liver
into the blood, then into other tissues. It is most destructive to the brain but also damages
the kidneys and reproductive organs and causes hemolytic anemia. Some copper isdeposited in Descemet's membrane of the cornea, causing Kayser-Fleischer rings.
Symptoms
Wilson disease first attacks the liver, the central nervous system, or both.
A buildup of copper in the liver may cause ongoing liver disease. Rarely, acute liver
failure occurs; most patients develop signs and symptoms that accompany chronic liver
disease, including
swelling of the liver or spleen
jaundice, or yellowing of the skin and whites of the eyes
fluid buildup in the legs or abdomen
a tendency to bruise easily
fatigue
Kayser-Fleischer rings result from a buildup of copper in the eyes and are the most
unique sign of Wilson disease. They appear in each eye as a rusty-brown ring around the
edge of the iris and in the rim of the cornea.
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A buildup of copper in the central nervous system may result in neurologic symptoms,
including
problems with speech, swallowing, or physical coordination
tremors or uncontrolled movements
muscle stiffness behavioral changes
Motor deficits are common, including any combination of tremors, dystonia, dysarthria,
dysphagia, chorea, drooling, and incoordination.
Diagnosis
Wilson disease is diagnosed through a physical examination and laboratory tests.
In case of physical examination, Kayser-Fleischer rings are present in almost all people
with Wilson disease who show signs of neurologic damage but are present in only 50percent of those with signs of liver damage alone.
Laboratory tests measure the amount of copper in the blood, urine, and liver tissue.
Most people with Wilson disease will have a lower than normal level of copper in theblood and a lower level of corresponding ceruloplasmin, a protein that carries copper in
the bloodstream. In cases of acute liver failure caused by Wilson disease, the level of
blood copper is often higher than normal. A 24-hour urine collection will show increasedcopper in the urine in most patients who display symptoms.
A liver biopsya procedure that removes a small piece of liver tissuecan show if theliver is retaining too much copper.
Genetic testing may help diagnose Wilson disease in some people, particularly those with
a family history of the disease.
In Ayurvedic perspective
Drugs that possess properties such as rakta prasadana and yakrit visesha should be
selected.
Tikta rasa
ShophaghnaMutrala
Vishahara
The following medicines can be given in this case
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Kashayam and Paneeyam
Guduchyadi Kashayam 60 ml twice daily before food (A.H)
Punarnavadi kashayam 60 ml twice daily before food (Bhaishajya
Ratnavali)
Nimbatvagadi kashayam 60 ml twice daily before food (S.Y) Patolakaturohinyadi kashayam 60 ml twice daily before food
Laghu Panchamoola Paneeyam 500 ml daily
Jambeeradi Paneeyam 20 ml twice daily
Tablets
Dashanga Agadam 2 tablets twice daily after food
Dushi Vishadi Agadam 2 tablets twice daily after food
Chandraprabha vati 2 tablets twice daily after food
Lehyam
Drakshadi Lehyam 1 teaspoon twice daily after food
Dashamoola harithaki 10 grams at night after food (A.H)
Rasayanam
Tippili Rasayanam
Choornam
Pippili choornam 1 teaspoon twice daily with honey after food
Bhrungaraja Choornam 1 teaspoon twice daily with honey after food
Neeli Choornam 1 teaspoon twice daily with honey after food
Nimba Tvak Choornam 1 teaspoon twice daily with honey after food
Guda Pippali 1 teaspoon twice daily with milk after food
External application
In case of tremors, Sahacharadi tailam can be used for external application
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