1 Zoonoses Intro Dunne
Transcript of 1 Zoonoses Intro Dunne
Epidemiology Epidemiology and Control of and Control of Zoonotic Zoonotic InfectionsInfections
Epidemiology Epidemiology and Control of and Control of Zoonotic Zoonotic InfectionsInfections
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1 – Zoonosis Intro & TSE
2 – Rabies
3 – Classic Zoonoses
4 – Bioterrorism
5 – Vector-borne Diseases
6 – Parasitic Zoonoses
7 – Emerging Zoonoses
8 – Foodborne Illnesses
Epidemiology and Control of Epidemiology and Control of Zoonotic InfectionsZoonotic Infections Epidemiology and Control of Epidemiology and Control of Zoonotic InfectionsZoonotic Infections
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Part I: Introduction to Zoonoses
Part II: Transmissible Spongiform Encephalopathies
Intro to ZoonosesIntro to Zoonoses• Definition
• Importance
• Etiologies
• Animal Examples
• Transmission Routes
• Life Cycles
ZoonosesZoonoses
From the Greek:
Zoon: Animal
Noson: Disease
Diseases and infections which are naturally transmitted between vertebrate animals and humans
- WHO 1959
ZoonosesZoonoses
• Does NOT include
– Fish and reptile toxins
– Allergies to vertebrates
– Diseases in which animal-derived food serves as a vehicle (e.g. hepatitis A contaminated deli meat)
– Experimentally transmitted diseases
ZoonosesZoonoses
• > 250 zoonotic diseases
• 60% of US Household have ≥1 pet
• Multiple pets in the home
• Human-animal bond
• Exotic species as pets
Zoonoses: Common DiseasesZoonoses: Common Diseases
Frequency – (CDC, 2003)
Salmonella 39,919
Lyme disease 18,991
West Nile (CNS) 2,862
Trichinosis 4
ZoonosesZoonoses
Spectrum of Disease Severity
Death = rabies
Severe illness = plague
Chronic illness = Q-fever
Mild illness = psittacosis
Zoonoses: ImportanceZoonoses: Importance• Economics
– Zoonotic disease are expensive• Rabies post-exposure prophylaxis
• GI illness due to Salmonella or Campylobacter – lost productivity, medical costs
– Import/Export• BSE – restriction on cattle
• Avian Influenza – restriction on chicken
• Travel/Globalization• Decreased transit time - SARS
• Remote area accessibility
Zoonoses: ImportanceZoonoses: Importance
• Surveillance– Animals are sentinels
• Prevention and Control– Animal = key component– Complications (e.g. Lyme disease)– Unknown reservoirs (e.g. Ebola)
Zoonoses: Etiologic Classification
Zoonoses: Etiologic Classification
• Viral
• Bacterial
• Parasitic
• Mycotic
Zoonoses: Viral ExamplesZoonoses: Viral Examples
Colorado tick fever Japanese encephalitis
Ebola Monkeypox*
Equine encephalitides (WEE, EEE, VEE)
Nipah*
Hantaviruses Rabies*
Hendra* Rift Valley fever
Herpesvirus B West Nile virus*
Influenza Yellow fever* indicates covered in lectures
Zoonoses: Bacterial ExamplesZoonoses: Bacterial Examples
Anthrax* Plague*
Brucellosis* Psittacosis*
Campylobacteriosis* Q fever*
Cat-scratch disease* Relapsing fevers
Leptospirosis* Salmonellosis*
Listeriosis* Tularemia*
Lyme disease* Yersiniosis* indicates covered in lectures
Zoonoses: Parasitic ExamplesZoonoses: Parasitic Examples
PROTOZOAL HELMINTHIC
Trypanosomiasis Baylisascariasis*
Babesiosis Cysticercosis
Cryptosporidiosis* Hydatidosis
Leishmaniasis Schistosome dermatitis
Giardiasis* Trichinosis*
Toxoplasmosis* Visceral larva migrans and toxocariasis*
* indicates covered in lectures
Zoonoses: Mycotic ExamplesZoonoses: Mycotic Examples
Aspergillosis
Blastomycosis
Cryptococcosis*
Dermatophytosis*
Histoplasmosis
Sporotrichosis
* indicates covered in lectures
Zoonoses: Animal SpeciesZoonoses: Animal Species
• Dogs & Cats– Rabies– Roundworm– Ringworm – Lyme Disease (dogs only)– Cat Scratch Disease (cats only)
• Food Animals– Salmonella– E.coli– Brucellosis
Zoonoses: Animal SpeciesZoonoses: Animal Species
• Birds: – Psittacosis– West Nile– Cryptococcus
• Reptiles, Fish, & Amphibians– Salmonella– Mycobacterium
• Wild Animals– Hantavirus– Plague– Tularemia
Routes of TransmissionRoutes of Transmission
• Direct– Droplet or Aerosol– Oral – Contact
• Indirect – Foodborne– Water-borne– Fomite– Vector-borne– Environmental
Zoonoses - Life CycleZoonoses - Life Cycle
ORTHOZOONOSES
– May be perpetuated in nature by a
single vertebrate species
– E.g. rabies, brucellosis, anthrax
Zoonosis: Rabies Life CycleZoonosis: Rabies Life CycleVirus inoculation (bite)
Salivary gland excretion
Zoonoses - Maintenance CycleZoonoses - Maintenance Cycle
CYCLOZOONOSES
– Requires more than one vertebrate species but no invertebrate host
– Most are cestodiases (tapeworm diseases)
• Taenia saginata and T. solium require man to be one of vertebrate hosts
• Others, such as hydatidosis, man is accidentally involved
Life Cycle:
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Zoonoses - Life CycleZoonoses - Life Cycle
METAZOONOSES– Require both vertebrates and
invertebrates to complete transmission– All arboviral infections
• West Nile virus, Saint Louis encephalitis
– Some bacterial diseases• Plague, many rickettsia
– Some parasitic diseases• Leishmaniasis, schistosomiasis
Zoonoses: MetazoonosesZoonoses: Metazoonoses• Invertebrate Host: Mosquitoes
• Vertebrate Host: Birds
• Incidental Hosts: – HUMANS, horses, amphibians, other mammals
Risk FactorsRisk Factors
• Companion Animal – Dogs & roundworm
– Rats & Rat Bite Fever
• Occupational – Animal control workers & rabies
– Wildlife biologists & hantavirus
• Foodborne – Raw meat & E.coli
– Unpasteurized dairy & Listeria
Risk FactorsRisk Factors
• Recreational Activities
– Camping & Lyme disease
• Farm Settings
– Sheep & Q-fever
– Cattle & Cryptosporidium
• Travel
– Maylasia & Nipha
– Australia & Hendra
Reportable Diseases of Animals
Reportable Diseases of Animals
• By veterinarian or other individual• Reported to CA Department of Health Services
– Plague – Rabies
• Reportable to the CA Department of Food and Agriculture – Anthrax– Brucellosis– Glanders– Listeriosis– Rabies in livestock– Venezuelan equine encephalomyelitis– West Nile– And more…