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CTC Analyticals AG Support TrainingPage 1CTC Training 2-091February 2009IntroductionsName?Where are you from?How long with Agilent/Channel Partner?Are you Service Engineer or other job?Chemistry or Electronics background?Experience withGC, GC-MS, LC-LC-MS or CTC?How is your English?

1 - CTC-Agilent OverviewPage 2CTC Analyticals AG Support TrainingforGC, GC-MSLC, LC-MSusingMulti Technique ChemstationMS ChemstationEZ ChromOpenLab CDS Chemstation EditionOpenLab CDS EZChrom EditionMass HunterPage 3CTC Training 2-093February 20091 - CTC-Agilent OverviewPage 5CTC Sample Injection TechnologyFounded 1987 in Basel SwitzerlandStarted with GC OEM Autosamplers Model A200SPittcon 1996 Launch of PAL SystemsPrivate owned ISO 9001 registered companyDedicated to gas- and liquid handling systemsInhouse R&D and QC / Outsourced productionNo direct sales and marketing organisationAll systems tested in house prior to shipmentCTC Training 2-095February 20091 - CTC-Agilent OverviewPage 6Why CTC Autosamplers?

CTC Training 2-096February 20091 - CTC-Agilent OverviewPage 7Multipurpose Injection System

Liquid mode with large volume injection up to 500lHeadspace without sample loop or heated transfer lineSPME extraction for heated and agitated samplesITEX (In Tube Extraction) sample enrichment mode

SPME

HeadspaceLiquidNEW CTC Training 2-097February 20091 - CTC-Agilent OverviewPage 8Sample Capacity

Sample capacity up to:

600 1ml vials294 2ml vials 96 10ml vials 96 20ml vials 8 96 well microplates 8 384 well microplates 8 96 deepwell plates

CTC Training 2-098February 20091 - CTC-Agilent OverviewPage 9Sample Cooling Options

Tray Cooler 4C 70C(Peltier version)

Tray Cooler 2 4C 70C(Peltier version)200 1ml vials 98 2ml vials

200 1ml vials 98 2ml vials 32 10ml vials 32 20ml vials

CTC Training 2-099February 20091 - CTC-Agilent OverviewPage 10Multi Purpose GC Injectors/Samplers forGas ChromatographyPAL Gas Chromatography Applications

CTC Training 2-0910February 2009

1 - CTC-Agilent OverviewPage 11GC-PAL and Combi-PAL OverviewMounting Hardware for 6850/6890/7890 Upgrade Options for up to 4 different Sample Prep Injection Modes

Mounting Hardware for 6850/6890/7890Liquid Injections only, no upgrade

LHS2Injector 80Sampler 120Sampler 80CTC Training 2-0911February 20091 - CTC-Agilent OverviewPage 12 Non Upgradable Configuration

Liquid mode standard configuration10l syringe kit for liquid injection 1 Tray for 98 2ml vials / 78 1ml vials1 WashStation for two different solvents and 1 standard liquidInjector 80G6502-CTC GC PAL, CTC ColorsG6502B GC PAL, Agilent Injector 80, Agilent branded

CTC Training 2-0912February 20091 - CTC-Agilent OverviewPage 13Upgradable Configurations

Sampler 120Sampler 80Liquid mode standard configuration (shipped with all Systems)10l syringe kit for liquid injection 1 Tray for 98 2ml vials / 78 1ml vials1 WashStation for two different solvents and 1 standard liquidHeadspace mode standard configuration (Option 111, or G6503B)2.5 ml syringe kit with heated syringe holder1 Tray for 32 10 or 20ml vials6 Position Heated Agitator

G6500-CTC Combi-PAL w/ Headspace, CTC ColorsG6501-CTC Combi-PAL w/o Headspace, CTC ColorsG6501B Combi-PAL w/o Headspace, Agilent Sampler 80, Agilent branded

G6509-CTC Combi-PAL 120 cm rail w/o Headspace, CTC ColorsG6509B Combi-PAL 120 cm rail w/o HS, Agilent Sampler 120, Agilent brandedCTC Training 2-0913February 2009

1 - CTC-Agilent OverviewPage 14Model G6501B/G6509B Upgrade Path Liquid Syringe

Headspace ITEX SPMELiquid1. Starting with Liquid Injection (G6501B or G6509B)2. Add Headspace Option (G6503B)3. Add SPME (G6504B)HS OptionITEX TrapsSPME Option4. Add ITEX II (soon)CTC Training 2-0914February 2009Review: Three Basic GC SystemsLiquid Injections Only, Non Upgradable, 80 cm X RailGC-Pal, G6502-CTC, G6502B Agilent GC Injector 80

Liquid Injections, Supports Headspace, SPME & ITEX II, 80 cm RailCombi-Pal, LHS0, LHS2, G6500-CTC, G6501-CTC, G6501B Agilent GC Sampler 80

Liquid Injections, Supports Headspace, SPME & ITEX II, 120 cm RailLHSX, LHS9, G6509-CTC, G6509B Agilent GC Sampler 120

1 - CTC-Agilent OverviewPage 15

1 - CTC-Agilent OverviewPage 16PAL Liquid Chromatography Applications

Liquid Chromatography

High Throughput LC InjectorsCTC Training 2-0916February 20091 - CTC-Agilent OverviewPage 17

PAL Liquid Chromatography Systems

CTC Training 2-0917February 20091 - CTC-Agilent OverviewPage 18Entry Level System LC PALFixed configurationno options availableSample Capacity 216 2ml vials4 x 96/384 Deepwell plates4 x 96/384 Shallow well plates

Injection Valve Single 2 position 6-port valveBench Space 50 cm width

50 cmCTC Training 2-0918February 20091 - CTC-Agilent OverviewPage 19Mid range System HTC PAL

50 cmFlexible Configuration

Max. Sample Capacity 648 2ml vials 12 96/384 Deepwell plates 24 96/384 Shallow well plates

Cooled Sample Storage Option

Max. Injection Valves One 2 position 6-port valveOptional 2 and 3 Valve OperationMultiposition Valve DrivesBench Space 50 cm width

High Throughput CompactCTC Training 2-0919February 20091 - CTC-Agilent OverviewPage 20High Throughput System HTS PAL

80 cmFlexible ConfigurationMax. Sample Capacity 972 2ml vials 18 96/384 Deepwell plates 24 96/384 Shallow well plates

Cooled Sample Storage Option Max. Injection Valves Two 2 position 6-port valvesOptional 2 and 3 Valve OperationMultiposition Valve DrivesPAL Dilutor OptionBench Space 80 cm width

High Throughput StandardCTC Training 2-0920February 20091 - CTC-Agilent OverviewPage 21

IFC PAL FractionCollector 120 cmPrep Version

Injection Side 98 2ml vials or 32 10/20ml vialsCollection SideTube sizes 1092pcs. 13x100mm (9ml) 700pcs. 16x100mm (12ml) 700pcs. 16x150mm (20ml)504pcs. 18x150mm (27ml) 504pcs. 20x150mm (34ml) 294pcs. 25x150mm (55ml)optional Gilson 215 rack holderInjection / Wash6-port VICI Valco prep valve up to 50ml/min2 different wash solventsInjection volume up to 5000lCTC Training 2-0921February 20091 - CTC-Agilent OverviewPage 22HPLC PALs Injection volumes

Syringes / CTC label

9 different SizesSize Injection range10l 1 - 10l25l2.5 - 25l50l 5 - 50l 100l10 - 10l250l 25 - 250l 500l50 - 500l 1000l 100 - 1000l 2500l 250 - 2500l 5000l 500 - 5000l

CTC Training 2-0922February 20091 - CTC-Agilent OverviewPage 23Sample Storage for HTS / HTC PAL

TrayholdersStack 4C 40C (Peltier Cooling)Microplate StackDeepwell Stack Trays 1/2/10/20mlTray 4C 70C (Peltier Cooling)CTC Training 2-0923February 20091 - CTC-Agilent OverviewPage 24Agilent Products and Instrument Description1290 Infinity LC Injector HTC(G4278A)1290 Infinity LC Injector HTS(G4277A)50 cm wideUp to 12 well plates cooled40 ppm or 0.004% typical carryoverInjection volume up to 100 L with DLW, and up to 5 mL* with Fast wash80 cm wideUp to 24 well plates cooled40 ppm or 0.004% typical carryoverInjection volume up to 100 L with DLW, and up to 5 mL* with Fast wash

CTC Training 2-0924February 2009Review: LC Systems and ConfigurationsHTC/HTS PAL High Throughput LC Injection Systems (2006-2010)600 bar Injection valve, fast/active wash station, Generic Pal designHTC, G4270-CTC: 50cm, compact system, medium capacityHTS, G4271-CTC: 80cm, standard system, high capacity

1290 Infinity LC Injector HTS/HTC (since 2010)Proprietary 1200 bar Injection valve, Dynamic Load and Wash DLW, xt-electronics,faster cycles times, lower carryover, Agilent DesignHTS, G4277A: 80cm, standard system, high capacityHTC, G4278A: 50cm, compact system, medium capacity1 - CTC-Agilent OverviewPage 251 - CTC-Agilent OverviewPage 26

GC PAL / Combi-PAL / HTS / HTC / LC PAL Local control Control by handheld terminal without PC(standalone contact closure remote start operation)

Instrument access for

Local setup and teach functionMethod parametersSample ListUtility Functions

CTC Training 2-0926February 20091 - CTC-Agilent OverviewPage 27OptionsCTC Training 2-0927February 20091 - CTC-Agilent OverviewPage 28

PAL Dilutor Option for HTS PALExternal Dilutor module

Feeds liquid directly through the injection syringe into samplesNot compatible with DLWCTC Training 2-0928February 20091 - CTC-Agilent OverviewPage 29PAL Barcode Reader (with B.01.0x only)

Laser scanner reads barcode labels on 2, 10 and 20ml vials

Transfers data into Sample List

Requires steel caps for magnetic vial transport

Barcode types UPC versions A and E EAN 8 and EAN 13Code 39Interleaved 2 of 5 Discrete 2 of 5 Code 128Code 93CodabarCTC Training 2-0929February 20091 - CTC-Agilent OverviewPage 30PAL Option Flow Through CellOnline Analysis Application

Stainless steel flow cell body

Internal Volume 1ml

Flow rate up to 100ml/min

inch Swagelok connectors

Sample aspiration through Teflon coated Septum

Cleaning port for easy maintenance

CTC Training 2-0930February 2009