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1 of 15
Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Congressionally Directed Medical Research Programs (CDMRP)
Presented to National Institutes of Health
Peer Review Advisory Committee
Presented byJanet Harris, Ph.D., R.N.
Colonel, US Army Nurse CorpsDirector
23 January 2006
US Army Medical Research and Materiel Command (USAMRMC)
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
CDMRP Philosophy
Vision: Find and fund the best research to eradicate diseases and support the warfighter for the benefit of the American public
Mission: We provide hope by promoting innovative research, recognizing untapped opportunities, creating partnerships, and guarding the public trust.
THE CENTRAL THEME IS INNOVATION
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
CDMRP History
1992: Grassroots advocacy heightened political awareness of breast cancer
1993: Congress appropriated $210M to the Department of Defense (DOD) budget for breast cancer research, managed by the CDMRP, after consultation with the Institute of Medicine (IOM) in fiscal year 1993 (FY93) and re-reviewed the program in FY97.
1996-2002: Additional research programs added: 1996: Neurofibromatosis
1997: Prostate Cancer and Ovarian Cancer
1999: Peer Reviewed Medical Research Program
2002: Prion, Tuberous Sclerosis, and Chronic Myelogenous Leukemia.
These and other programs are managed by the CDMRP
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Funds added to the DOD budget by Congress [generally as DHP(RDT&E)]*
Respond to targeted guidance from Congress
Two-tier formal review of proposals – IOM Model
Consumer advocate participation throughout process
Vision is adapted yearly to facilitate rapid change and address research gaps
Highly flexible management processes
CDMRP Unique Features
*Defense Health Program (Research Development, Test and Evaluation)
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
0
50
100
150
200
250
300
350
400
FY92 FY93-94
FY95 FY96 FY97 FY98 FY99 FY00 FY01 FY02 FY03 FY04 FY05
Institutionally BasedProgramsOsteoporosisResearch Program Defense Women'sHealth Res. Prog. National PrionResearch ProgramCooperative DOD/VAMedical Res. Prog.Tuberous SclerosisResearch ProgramMyeloproliferativeDisorders ResearchChronic MyelogenousLeukemia Res. Prog.Ovarian CancerResearch ProgramNeurofibromatosisResearch Program Peer ReviewedMedical Res. Prog.Prostate CancerResearch Program Breast CancerResearch Program
CDMRP Funding History
0
50
100
150
200
250
300
350
400
FY92 FY93-94
FY95 FY96 FY97 FY98 FY99 FY00 FY01 FY02 FY03 FY04 FY05
Institutionally BasedProgramsOsteoporosisResearch Program Defense Women'sHealth Res. Prog. National PrionResearch ProgramCooperative DOD/VAMedical Res. Prog.Tuberous SclerosisResearch ProgramMyeloproliferativeDisorders ResearchChronic MyelogenousLeukemia Res. Prog.Ovarian CancerResearch ProgramNeurofibromatosisResearch Program Peer ReviewedMedical Res. Prog.Prostate CancerResearch Program Breast CancerResearch Program
Awards 26 445 366 313 524 435 661 746 664 726 721 566 ~650
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Training and Research Resources
Innovation-Based Research
ClinicalResearch
Traditional Research(e.g., R01-, P50-type awards)
FY06 Investment Strategy
TranslationalResearch
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Program Cycle
VisionSetting
Release of ProgramAnnouncement
ProposalReceipt
Peer Review
ProgrammaticReview
Candidate Award List
CongressionalAppropriation
Receipt of
Funds
CGApproval Integration
Panel
Science evaluationBudget evaluation
Programmatic relevanceBudget evaluation
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Electronic Proposal/Grant Management
CDMRP eReceipt System Web-based proposal submission system Includes modules for Principal Investigators and Office of
Sponsored Research Representatives Information collected in fields, text boxes, and PDF files
Program and Peer Review Management Information System™ (P²RMIS™) Proprietary web-base system owned and used by Constella
Health Sciences, our peer review contractor
Electronic Grants System Custom designed, state of the art database and business
system for the paperless management of medical research proposals and grants.
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Advantages of Electronic Processes
Reduced Applicant Cost: Uploading PDF files is less costly than copying and shipping proposal
Reduced Program Cost: Reduction in labor during receipt and savings in reviewer shipping exceed cost of printing proposal copies
Increased Communication: Reviewers, Chairperson, and Scientific Research Administrator can review critiques in advance of the meeting
Time Savings: Compliance (administrative review), referral, and summary statement writing all streamlined through use of web-based tools
Increased Efficiency: Allows for collaboration between organizations by implementing
electronic workflows and virtual files
Allows for real-time data transfer, multiple users, standardization of processes and unprecedented secure access to data
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Standard Peer Review Scoring
Criteria Global Adjectival
10, 9 1.0 - 1.5 Outstanding
8,7 1.6 - 2.0 Excellent
6, 5 2.1 - 2.5 Very good
4,3 2.6 - 3.5 Good
2,1 3.6 - 5.0 Fair
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Regular
(Idea Awards)Concept
Era of Hope
InnovatorClinical Trial Award
Referral Discipline-Focused Discipline-FocusedMechanism-Focused
Mechanism-Focused
Distribution Paper/CD-ROM P²RMIS™ (Web) Paper Paper/CD-ROM
CollectionCritique and Preliminary Scores
Brief Comment and Score
NothingCritique and Preliminary Scores
Pre-MeetingPanel-Wide Access to Comments
None NonePanel-Wide Access to Comments
Meeting Traditional Discussion NoneComparative Discussion
Dual Discussion: Proposal & Protocol
Global Score Numeric: 1.0 – 5.0 Adjectival Only: Outstanding - Fair
NoneSingle Numeric Global Score
Evaluation Criteria
10 – 1 NoneText Only: No Scoring
Separate Criteria for Proposal and Protocol
Summary Statements
Concatenated; Sent to Applicants
Sequential; Internal Use Only
Text Only: No Scoring
Separated Sections for Proposal and Protocol
Peer Review Processes
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Correlations Between Final Global Scores and Final Criteria Scores for Idea Awards
Scores Correlated with Final Global Score
Pearson’s R Correlation
(Interval by Interval)
Research Strategy -0.886
Relevance -0.820
Innovation -0.876
Investigator -0.701
Environment -0.639
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Lessons Learned
Consumers are integral to peer review
Efficiencies of cradle to grave electronic management
Need to maintain dynamic flexible processes
Tailor peer review processes to:
Mechanism goals
Time constraints
Funding limitations
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Ongoing Challenges
Identifying Innovation
Keeping Peer Reviewers engaged during panel discussions
Congruency among narrative, criteria scores, and global score
Optimizing panel size, reviewer workload, and length of panel discussion
Meeting needs of multiple end users of critique
Programmatic Review
Applicant
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Department of Defense Congressionally Directed Medical Research Programs
U.S. Army Medical Research & Materiel Command
Web Site – http://cdmrp.army.mil