1 Neurobiology of Laughter By Silvia Helena Cardoso Lecture presented in Royal Institution, London.
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Transcript of 1 Neurobiology of Laughter By Silvia Helena Cardoso Lecture presented in Royal Institution, London.
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Neurobiology of Laughter
By Silvia Helena Cardoso
Lecture presented in Royal Institution, London
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During vigorous laughter
You must get unobstructed upper airways in order to laughTherefore a spasm occurs, so that neck and head are
thrown back to provide a free respiratory intake.
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NormalRespiration
Laughter
“Laughter is a good aerobic exercice that ventilates the lungs”
Dr. William Fry Jr.
Laughter is accompanied by a strong increase of amplitude and frequency of respiratory movement with a consequent increase in the intake of oxigen and output of carbon dioxide
OO22
COCO22
Compare the contrast between waves of sound during
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Blushing
Jugular vein
Arterioles in the face dilate provoking an increase in the blood flow
The venous return from the face by the jugular veins is partially blocked due to a strong contraction of neck muscles
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Shedding of tears
The repeated contraction of the muscles around the eyes compressess the lacrimal glands provoking the outflow of
tears.
Lacrimal glands
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Pressure in the abdomen
Repeated short, strong contractions of the muscles of thoracic wall, abdomen, and diafragm increase blood flow into our internal organs
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“Being weak with laughter”
Muscleweakness
Muscle tension decreases, and we may temporarily lose control of our limbs.
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Laughter activates the cardiovascular system, so heart rate and blood pressure increase
The arteries then dilate, causing blood pressure to fall
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Loss of control of urinary sphincterLoss of control of urinary sphincter
Wetting oneself
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Laughter promotessocial bonding
“Shared laughter creates a bond of friendship. When people
laugh together, they cease to be young and old, master and
pupils. They have become a single group of human beings,
enjoying their existence."
W. Grant Lee
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Laughter is contagious
“Laughter is a powerful sound”Dr. Joseph M. Mercola
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???
“If we see someone laughing
alone he or she would seem to be crazy”
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Contagious laughter:Contagious laughter: Roots in the neurological mechanism of laugh detection and Roots in the neurological mechanism of laugh detection and
replicationreplication
Auditory Auditory feature feature detectordetector
LaughLaughgenerationgeneration
Wave ofSound
LaughLaughgenerationgeneration
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Congenitally blind, Congenitally blind, deaf, and dumbdeaf, and dumb
child child
Premature babyPremature baby
Evidences point to an innate, preprogrammed basis for laughter
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Do animals also laugh?Do animals also laugh?
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Laughter is not unique to humans
Apes open their mouths wide, expose their teeth, retract the corners of their lips, and emit loud and repetitive
vocalizations
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Playful BehaviourLaugh and fun
"The true origins of laughter lie in the rough-and-tumble play of our primate ancestors”
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Playful Behaviour
Fighting in make-believe aggression is not for real. Laughter indicates that aggressive
play is just fun
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Laughter even evolved long before higher mammals appeared on the scene.
Rats emit short, high-frequency, ultrasonic vocalizations during rough-and-tumble play.
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NeocortexNeocortex•Visual, auditory,etc. - PERCEPTION• Memory, thinking, understanding • HUMOR
Brainstem, hypothalamus, Brainstem, hypothalamus, basal gangliabasal ganglia
Vocalization, respiration, gland excretion
Limbic systemLimbic systemPleasure, happiness, joy
Basic structures of the brainBasic structures of the brain
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A Brain Alight with Laughter…A Brain Alight with Laughter…
Visual cortexPrefrontalcortex
Motor cortex
Basal gangliaHypothalamus
Cerebellum
Pyramidal systemBrainstemLimbicsystem
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When something goes wrong with this complex system
Damage provoked in the neural circuitresponsible for the motor expression of laughter, may cause
a "desinhibition" of the laughtermechanism
Areas involved withlaughter expression
mechanism
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When laughter is not funny
Pathological laughter
Fits of abnormal laughter, producing an inappropriate, unrestrained, uncontrollable
laughter dissociated from any stimulus.
It is a disorder of emotional expression
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When something goes wrong with this complex system
Damage provoked in the neural circuitresponsible for the motor expression of laughter, may cause
a "desinhibition" of the laughtermechanism
Areas involved withlaughter expression
mechanism
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Pathological laughter occurs in:
• Tumors • Trauma • Vascular malformations• Strokes • Neural toxicity • Neural degeneration
All these conditions provoke an imbalance in the laughter expression mechanism
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Tickling and LaughterTickling and Laughter
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TicklingFascinating instance of the
Congenitally blindCongenitally blindchildchild
Normal Normal childchild
ChimpanzeeChimpanzee
• Connection between playfulness, laughter and social bonding
• Almost always produces laughter• Tickling and laughter evolved in part to help
us relate to others
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Skin
Sensory cortexSensory cortex
Axon Spinal cord
Thalamus
BrainBrain
Sensory ganglionNerve cellNerve cell
Touchreceptors
Anatomy of Tickling
Tickling stimulates touch receptors in the skin. These receptors, when stimulated carry information in sensory neurons that goes to the spinal cord.Then this information travels up to the sensory cortex via the thalamus.
The sensory cortex is involved in processing information from the skin.
(Area that registers touch)
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The big enigma of
We do not laugh when we tickle ourselves, only when other people tickle us.
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Why is it impossible to tickle ourselves?
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Predicts the sensory consequences of movements - supplying the brain with
information that reduces the sensation of touch information.
CerebellumCerebellumBrain region that helps to
control voluntary movement and balance
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Cerebellum
Somatosensorycortex
When you try to tickle yourself, your cerebellum sends to your somatosensory cortex precise informationprecise information on the
position of the tickling target and therefore what sensation to expect.
.
.