#1 - HPCI€¦ · • Naturally-derived ingredient to ISO 16128- 1:2016 ... anti-aging and...

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1 #1 JOURNAL

Transcript of #1 - HPCI€¦ · • Naturally-derived ingredient to ISO 16128- 1:2016 ... anti-aging and...

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#1

JOURNAL

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03COLD PROCESS EMULSIFIERThe next generation cold process emulsifi er presented by OMNOVA

21SOLUTION FOR AGELESS BEAUTYActive Beauty, Solutions for ageless beauty presented by Givaudan

42CELL COMMUNICATIONThe cell communication, the heart of well-beingpresented by Solabia

52EMULSIFIERS Emulsifi ers are the key to aesthetics presented by Grolman and Acqdot Ltd

Content

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Olivem® 2020

The next-generation cold process emulsifier

• Biomimetic• Based on olive oil chemistry• Provide hydration benefits• Sensorial modifier• High performance emulsifier for hot or cold processes• Thickener, stabilizer• Original, patent pending• Naturally-derived ingredient to ISO 16128-1:2016

Olivem® 2020: An Award-Winning Multi-functional Ingredient

Olivem® 2020 INCI: Ethylhexyl Olivate, Sodium Acrylates Copolymer, Polyglyceryl-4 Olivate

Olivem® 2020G INCI: Ethylhexyl Olivate, Sodium Acrylates Copolymer, Polyglyceryl-4 Oleate

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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Olivem® 2020 for Water Gels

Olivem® 2020: A Biomimetic Ingredient

CoconutOil

OliveOil

Healthy Skin Sebum

Short chain ≤C12; saturated >40% <5% <5%

Long chain C14-C18; saturated 25-35% 10-25% ≈40%

Long chain C14-C18; unsaturated 6.0-10% 60-85% ≈50%

Very few short chainsaturated fatty acidsunlike other naturaloils like in the Healthy skin sebum

Fatty acid compositions of triglycerides and free fatty acids in sebum depend on amount of triglycerides, and do not differ in presence or absence of acne vulgaris, Narifumi AKAZA,1,2 Hirohiko AKAMATSU,3 Shigeki NUMATA,2 Miyuki MATSUSUE,1

Yasuo MASHIMA,1 Masaaki MIYAWAKI,1 Shunji YAMADA,1 Akiko YAGAMI,2 Satoru NAKATA,1 Kayoko MATSUNAGA, THE JOURNAL OF DERMATOLOGY 2014; 41: 1069-1076

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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Internal test: 12 panelists – forearm MoistureMeterSC® - Delfin

All statistical differences are at least significant: p <0.05

Olivem® 2020: A Functional Naturals Ingredient Phase INCI Name [INN/USAN] (Other Information) Trade Name % Wt % Wt

Water (Aqua) (deionized) Up to 100 Up to 100Ethylhexyl Olivate, Sodium Acrylates Copolymer, Polyglyceryl- 4 Olivate

Olivem® 2020, Hallstar Italia 5,00 -

Glycerin 1,00 1,00

Other products - 5,00

A

significant: p <0.051,00 1,00

Other products - 5,00

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

Olivem® 2020: A High-performing Gel Cream

Phase INCI Name [INN/USAN] (Other Information) % Wt % Wt

A

Water (Aqua) (deionized) Up to 100 Up to 100

Olivem® 2020 5,00 -

Other Product - 5,00

Water Gel Performance

Up to 100

Water Gel Performance

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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0

10

20

30

40

50

60

70

80APPEARANCE

SPREADABILITY

NO GREASY

RICH

NO TACKCUSHIONING

FRESHNESS

SKIN SOFTNESS

HYDRATATIONSENSATION

OLIVEM 2020

PRODUCT 1

Skin Feel: Olivem® 2020 in comparison with a functional alternative product

Internal test: 12 panelists

Olivem® 2020: A Sensorial Modifier

Phase INCI Name % Wt % WtDemin. Water Up to 100 Up to 100

Olivem® 2020 5,00 -

Glycerin 1,00 1,00

Product 1 - 5,00

A

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

Olivem® 2020 Hydro Skin GelA simple water gel cream conceived to show Olivem ® 2020 sensorial properties and performance

Olivem® 2020viscosity builder,emulsifier and sensorial enhancer

soft and nice water

gel with a fresh and

rich skin feel

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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By applying Activating Serum, you enhance the authentic beauty and health of your skin...

DIAM Oléoactif® : minimizes the wrinkles and fills the signs of time

Olivem® 2020: Cold process emulsifier with unique texture

LIFE Oléobooster®:supplies strong energizing action

EPILOBIUM Oléoactif® :smooths the skin and moisturizes the skin

….and enjoy a refreshing light skin feel

Eurol® BT: Contrasts premature skin aging

Activating Serum

Phase INCI Name [INN/USAN] (Other Information) Trade Name % Wt Function

A

Water (Aqua) (deionized) up to 100 Volatile Carrier

Chamomilla Recutita (Matricaria) Flower Water 5,00 Active Ingredient

Propanediol 3,00 HumectantTrisodium Ethylenediamine Disuccinate (37% active) 0,60 Chelating Agent

B

Ethylhexyl Olivate, Sodium Acrylates Copolymer, Polyglyceryl-4 Olivate

Olivem® 2020, Hallstar Italia* 1,75 Multifunctional

Cold Emulsifier

Brassica Campestris Seed Oil, Polyglyceryl-3 Diisostearate, Stevia Rebaudania Extract, Cistus Monspeliensis Extract

LIFE Oléobooster®, Hallstar 0,50 Active Ingredient

Cocos Nucifera Oil, Oak Root Extract DIAM Oléoactif®, Hallstar 0,50 Active Ingredient

Helianthus Annuus Seed Oil, Epilobium Angustifolium Flower/Leaf/Stem Extract

EPILOBIUM Oléoactif®, Hallstar 0,50 Active Ingredient

Ethylhexyl IsononanoateHallStar® Octyl Isononanoate, Hallstar

0,75 Emollient / Slip Aid

Lecithin, Tocopherol, Ascorbyl Palmitate, Citric Acid 0,05 Antioxidant Agent

COlea Europaea (Olive) Leaf Extract, Water Eurol® BT, Hallstar

Italia 0,30 Multifunctional Active Ingredient

Parfum a.n. PerfumePreservative a.n. Preservative

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

Fight your spots with this magic sensory complexion with a subtle cushioning effect!

DIAM Oléoactif® : Anti-inflammatory properties to reduce skin redness

Olivem® 2020: Cold process emulsifier with uniquecushioning effect

BRIGHT Oléoactif® :Natural brightening, whitening and anti-dark spot active!

Eurol® WHT: Anti-dark spot and anti-inflammatory action for the water phase!

Phase INCI Name [INN/USAN] (Other Information) Trade Name % Wt Function

A Ethylhexyl Olivate, Sodium AcrylatesCopolymer, Polyglyceryl-4 Olivate

Olivem® 2020, Hallstar Italia 5,00 Emulsifier

B

Cocos Nucifera Oil, Oak Root Extract/ Cocos Nucifera Oil, Quercus Suber Bark Extract, OakRoot Extract

DIAM Oléoactif®, Hallstar 1,00 Active Ingredient

Brassica Campestris Seed Oil, GlycyrrhizaGlabra Root Extract, Polyglyceryl-3 Diisostearate, Althaea Officinalis Root Extract, Oryza Sativa Bran Extract

BRIGHT Oléoactif®, Hallstar

1,00 Active Ingredient

Glycerin, Water, Olea Europaea (Olive) Leaf Extract, Arctostaphylos Uva Ursi Leaf Extract

Eurol® WHT, Hallstar Italia 1,00 Active Ingredient

CGlycerin 1,00 HumectantWater (Aqua) (deionized) Water 90,00 Volatile CarrierPreservative a.n. Preservative

Spot Action Bouncy Gel

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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Olivem® 2020 for Oil in Water emulsions

Olivem® 2020: A High-Performing Emulsifier Performance 2% Olivem® 2020 with OilPerformance 2% Olivem® 2020 with Oil

Stability was evaluated using a centrifuge test

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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This light gel-cream formula works to delay all signs of aging caused by loss of moisture. It refreshes and cools the skin, reduces the appearance of fine lines, improves skin density and helps to increase moisture for deep hydration and skin elasticity.

Olivem® 2020 Cold process emulsifier with unique texture

Eurol® BT Multifunctional active ingredient: anti-irritating, anti-inflammatory, skin elasticizing and anti-acne

Sensolene ®

Natural elasticity restorer

LIFT ® Oléoactif, Biochemica® Camellia Tea Oil Brings a range of benefits to the skin includinganti-aging and rejuvenating

Lift Me Gel Cream

Phase INCI Name [INN/USAN] (Other Information) Trade Name % Wt Function

A

Water (Aqua) (deionized) up to 100 Volatile CarrierGlycerin 3,00 HumectantBetain 0,40 Active Ingredient

Olea Europaea (Olive) Leaf Extract, Water Eurol® BT, Hallstar Italia 0,25 Multifunctional Active Ingredient

Trisodium Ethylenediamine Disuccinate (37% active) 0,30 Chelating Agent

B

Camellia Oleifera Seed Oil Biochemica® Camellia Tea Oil, Hallstar 2,50 Emollient

Ethylhexyl Olivate Sensolene®, Hallstar Italia* 2,00 Multifunctional Lipid

Carthamus Tinctorius (Safflower) Seed Oil, Spilanthes Acmella Flower/ Leaf/ Stem Extract, Astragalus Membranaceus Root Extract, Ubiquinone, Tocopherol

LIFT Oléoactif®, Hallstar 1,00 Active Ingredient

Bisabolol 1,00 Active IngredientPreservative a.n. PreservativeLecithin, Tocopherol, Ascorbyl Palmitate, Citric Acid 0,05 Antioxidant Agent

Ethylhexyl Olivate, Sodium Acrylates Copolymer, Polyglyceryl-4 Olivate

Olivem® 2020, Hallstar Italia 2,00 Multifunctional

Cold Emulsifier

C

Cyclomethicone 8,00 Silicone OilCyclopentasiloxane, Dimethiconol 2,00 Silicone Oil

Dimethicone, Dimethicone/Vinyl Dimethicone Crosspolymer 1,00 Silicone Elastomer

Blend

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

Olivem® 2020 for SuncareApplications

COLD PROCESS EMULSIFIER

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Olivem® 2020 In Sun Care Formulations

• Olivem® 2020 can be used to create sun care creams with a gel texture thanks to its compatibility with major UV filters, solvents and stabilisers

• Compatible with HallBrite ® EZ-FLO TDX and HallBrite ® EZ-FLO TDX Plus

• Compatibility with ZnO is variable and depends on

• ZnO coating: Lipophilic coated ZnO (Triethoxycaprylylsilane) gives best results

• Particle size

• ZnO should be added to the water phase after obtaining a smooth gel with Olivem®

2020, possibly adding Xanthan Gum to improve stability and while controlling pH

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

Water Resistance: Olivem® 2020

1. Olivem® 2020 combined with Acrylates/DimethiconeCopolymer is a very good water resistance system.

2. Only 2%Olivem® 2020 is better than 5.80%PEG-100 Stearate + Glyceryl Stearate + Potassium CetylPhosphate and Hydrogenated Palm Glycerides + Xanthan gum

3. Olivem® 2020 compatible well with Acrylates/Dimethicone Copolymer, and 1% Acrylates/Dimethicone Copolymer has better water resistance than 2% VP/Eicosene Copolymer

Benefits from Olivem® 2020

• Use a co-polymer to provide electrostatic emulsion stabilization and to make oil film continuous and substantive on skin

• Provide a good hydrophobic lipid emulsifier to structure oil film, preventing re-emulsification

• Use very low number of emulsifier to reduce high HLB emulsifiers

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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This light and non-greasy sunscreen lotion applies to wet skin without whitening.

Olivem® 2020 Cold process self-emulsifier with a refreshing and unique texture

SolaStay® S1 Most effective photostabilizer for Avobenzone

HallBrite® BHBGood sunscreen solvent; it provides emolliency

Broad Spectrum SPF 50 Sunscreen Gel

PhaseINCI Name [INN/USAN] (Other Information)

Trade Name % Wt Function

A

Ethylhexyl Salicylate[Octisalate] 5.00 UV Filter / Sunscreen Agent

Octocrylene[Octocrilene] 10.00 UV Filter / Sunscreen Agent

Homosalate[Homosalate] 10.00 UV Filter / Sunscreen Agent

EthylhexylMethoxycrylene SolaStay® S1 3.00 Photostabilizer

Butyloctyl Salicylate HallBrite® BHB* 5.00 Sunscreen Solvent

BButylMethoxydibenzoylmethane [Avobenzone]

3.00 UV Filter / Sunscreen Agent

C

Ethylhexyl Olivate, Sodium AcrylatesCopolymer, Polyglyceryl-4 Olivate

Olivem® 2020 2.00 Multifunctional Cold Process Emulsifier

Acrylates/DimethiconeCopolymer 1.00 Film Former

DWater (Aqua) up to 100 Volatile CarrierGlycerin 8.00 Humectant

EPreservative a.n. PreservativeDisodium EDTA 0.05 Chelating Agent

F

Silica (spherical, 12 µm) 2.00 Deoiling Agent

Dimethicone (5 cSt) 3.00 Feel Modification / Enhancement

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

Olivem® 2020 G Cold process self-emulsifier with a refreshing and unique texture

HallBrite® BHBGood sunscreen solvent; it provides emolliency

This light and non-greasy sunscreen lotion applies to wet skin without whitening.

Phase INCI Name [INN/USAN] (Other Information) Trade Name % Wt Function

A

Ethylhexyl Salicylate [Octisalate] 5.00 UV Filter / Sunscreen

Agent

Octocrylene [Octocrilene] 10.00 UV Filter / Sunscreen Agent

Homosalate [Homosalate] 10.00 UV Filter / Sunscreen Agent

Butyloctyl Salicylate HallBrite® BHB 5.00 Sunscreen Solvent

Ethylhexyl Olivate Sensolene® 2.00 Multifunctional Emollient

Ethylhexyl Olivate, Sodium Acrylates Copolymer, Polyglyceryl-4 Oleate

Olivem® 2020 G 2.00 Multifunctional Cold Process Emulsifier

Acrylates/DimethiconeCopolymer 2.00 Film Former

BButyl Methoxydibenzoylmethane [Avobenzone]

3.00 UV Filter / Sunscreen Agent

C

Water (Aqua) up to 100 Volatile Carrier

Glycerin 8.00 Humectant

Preservative a.n Preservative

Disodium EDTA 0.05 Chelating Agent

Light and Non-Greasy Broad Spectrum SPF 50 Sunscreen Gel

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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Light and non-greasy sunscreen gel applies to wet skin without whitening, and protects the skin from burning and photo-ageing.

SolaStay® S1: Photostabilizer that improves sunscreen performance

HallBrite® BHB:Sunscreen polar solvent providing superior emolliency and improving filter’s stability

Phase INCI Name [INN/USAN] (Other Information) Trade Name % Wt Function

A

Ethylhexyl Salicylate [Octisalate] 5.00 UV Filter / Sunscreen AgentOctocrylene [Octocrilene] 10.00 UV Filter / Sunscreen AgentHomosalate [Homosalate] 10.00 UV Filter / Sunscreen AgentEthylhexyl Methoxycrylene SolaStay® S1 3.00 PhotostabilizerButyloctyl Salicylate HallBrite® BHB 5.00 Sunscreen Solvent

B Butyl Methoxydibenzoylmethane [Avobenzone] 3.00 UV Filter / Sunscreen Agent

CEthylhexyl Olivate, Sodium AcrylatesCopolymer, Polyglyceryl-4 Olivate Olivem® 2020 2.00 Multifunctional Cold Process

Emulsifier

Acrylates/Dimethicone Copolymer 1.00 Film Former

DWater (Aqua) up to 100 Volatile CarrierGlycerin 8.00 Humectant

EPreservative a.n. PreservativeDisodium EDTA 0.05 Chelating Agent

FSilica (spherical, 12 µm) 2.00 Deoiling Agent

Dimethicone (5 cSt) 3.00 Feel Modification / Enhancement

Olivem® 2020: Primary cold process emulsifier with no whitening upon application, evenon wet skin!

Sunscreen Gel SPF 50 PA++++ For Wet Skin

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

Cold Process Sunscreen Cream SPF 30

Polycrylene®

Can improve the substantiality of sunscreen formulations as measured by resistance to wash-off

HallBrite® EZ-FLO TDX PlusShows how mineral UV filters can be easy to work with and also provide nice feel, low whitening, high performance sunscreens for customers

Olivem® 2020: Primary cold process emulsifierdelivering skin hydration and sensorialbenefits to the final formulation

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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TIO2 Sunscreen Cream

Olivem® 2020 A naturally-derived cold process emulsifier based on olive oil chemistry for energy efficient operations

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

ZnO Sunscreen Cream

Olivem® 2020 A multifunctional biomimetic ingredient combining excellent emulsification performance and natural dermollience

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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Olivem® 2020 – tips to know

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

Base FormulaPhase INCI %

A Water Up to 100

BOlivem® 2020 3,00

Almond Oil 20,0

Into Oil Phase

Olivem® 2020: Use As You Like!Microscope Zeiss Primo Star 4000x

*

*

* Water Loss ≈ 3 – 5%

Different procedures, what’s the best?

Into Water Phase

Into Oil Phase Into Water Phase

Hot

Cold

There’s no significant differenceamong the procedures

*

*

* Water Loss ≈ 3 – 5%

procedures,

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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Olivem® 2020: Practical Aspects

The packaging has been chosen in order to facilitate the squeezing that will permit a re-mixing of the product. It is possible to squeeze the product inside the packaging or stir it outside.

Olivem® 2020 tends to settle like other similar materials.

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

Viscosity 10 RPMSamples

CoA Specs Olivem® 2020

max 50000 cPs(BT006-03/V01-17)

Viscosity 10 RPM Water gel 2%

CoA Water Gel Specs

10000-30000 cPs(BT006-04/V01-17)

Sample A 1400 cPs √ 19700 cPs √Sample B 7700 cPs √ 23000 cPs √Sample C 50000 cPs √ 23700 cPs √

OLIVEM® 2020 Standard Sample 20000 cPs √ 22000 cPs √

0 5000 10000 15000 20000

Sample A

Sample B

Sample C

OLIVEM® 2020

Viscosity 10 RPM WATER GEL 2% - QC ANALYSIS TEST

Olivem 2020 has been inaccurately homogenized and split in 3 parts

There are no significant differences in viscosity building properties.

Olivem® 2020: Practical Aspects

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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Olivem® 2020 –Anhydrous systems

2%Olivem® 2020 with Glycerin 90 / Oil 10

Clear gel with glycerine

Opaque gel with Octyldodecanol, Caprylic/Capric

Triglycerides, Octyl Isononanoate, Isododecane

Clear gel with Natural Oils

Clear Gel

2%Olivem® 2020 with Glycerin 90 / Oil 10

Clear gel with glycerine

Olivem® 2020: An Interesting Jellyfier For Anhydrous Applications

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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Olivem® 2020:Forms an oil in glycerin transparent holographic gel

An anhydrous holographic gel to restore the healthy feeling of incredibly soft and deeply nourished skin and smile again!

Phase INCI Name [INN/USAN] (Other Information) Trade Name % Wt Function

A Glycerin 89,90 Humectant

B

Ethylhexyl Olivate, Sodium AcrylatesCopolymer, Polyglyceryl-4 Olivate

Olivem® 2020, Hallstar Italia 1,00 Structuring

agent

Carthamus TinctoriusSeed Oil, AstragalusMembranaceus Root Extract, SpilanthesAcmella Flower/Leaf/StemExtract, Ubiquinone, Tocopherol

LIFT Oléoactif®, Hallstar 1,00 Active

Ingredient

Camellia Oleifera Seed OilBiochemica®

Camellia Tea Oil, Hallstar

8,00 Emollient

Tocopherol 0,10 AntioxidantAgent

LIFT® Oléoactif, Biochemica® Camellia Tea Oil Bring a range of benefits to the skin such as anti-aging and rejuvenating

Lift Diamond Mask

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

Take My Make-Up Off is a facial cleanser that leaves your skin soft and moisturized.

POMEGRANATE Oléoactif®

Restructures and purifies the skinOPUNTIA Oléoactif®

Relaxes and comforts damaged cells

Olivem® 2020: Cushioning effect and stabilizingagent

Florasolvs® Macadamia-16 Water -oluble oil leaving the skin velvety and hydrated

Massage this unique oil into your skin and then rinse it off with water

Take My Make-Up Off

Phase INCI Name [INN/USAN] (Other Information) Trade Name % Wt Function

A

Glycerin 49,00 Humectant

Ethylhexyl Olivate, Sodium AcrylatesCopolymer, Polyglyceryl-4 Olivate

Olivem® 2020, Hallstar Italia 0,50 Multifunctional

Cold Emulsifier

B

PEG-16 Macadamia Glycerides Florasolvs® Macadamia-16, Hallstar 5,00 Emollient

Brassica Campestris (Rapeseed) Seed Oil, Opuntia Ficus-Indica Flower Extract, Camelina Sativa Seed Oil

OPUNTIA Oléoactif®, Hallstar 1,00 Active Ingredient

Simmondsia Chinensis (Jojoba) Seed Oil, Punica Granatum Extract, Punica Granatum Flower Extract

POMEGRANATE Oléoactif®, Hallstar 1,00 Active Ingredient

Propylene Glycol 43,00 Humectant

CPreservative a.n PreservativePerfume a.n. Perfume

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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Olivem® 2020 – The formulation rescue for sensoriality and stability

Base Formula

INCI %

Water Up to 100

Carbomer 0,10

Ceteareth-20 0.25

Cetearyl Alcohol 0,50

Paraffin Oil 20

NaOH a.n.

100x Base Formula

100x1% Ceteareth-20/ Cetearyl Alcohol

100x1% Product 1

100x1% Olivem® 2020

0 5000 10000 15000 20000 25000 30000

+ 1% Olivem 2020

+ 0.50% Olivem 2020

+1% Product 1

+0.50% Product 1

+1.0 % Ceteareth -20 /Cetearyl Alcohol

Base Formula

Viscosity 10 rpm – mPa.s

Centrifuge 5000 rpm 60’ Stable

100x0,50% Olivem® 2020

100x0,50 % Product 1

Olivem® 2020 stabilizes a basic formulation starting to 0,5%

Olivem® 2020: An Efficient Stabilizer

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

COLD PROCESS EMULSIFIER

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Polarized light microscope

100x

40x

Polarized light microscope

Smooth and Hydrate Primer

Olivem® 2020: A Compatible Biomimetic Emulsifier

Phase INCI Name [INN/USAN] (Other Information) Trade Name % Wt Function

AWater (Aqua) (deionized) up to 100 Volatile CarrierTrisodium Ethylendiamine Disuccinate 0,30 Chelating Agent

B

BHT 0,10 Antioxidant Agent

Cetearyl Olivate, Sorbitan Olivate Olivem® 1000, Hallstar Italia* 3,00 Emulsifier

Sorbitan Olivate Olivem® 900, Hallstar Italia 1,00 Co-emulsifier

CMethyl Methacrylate Crosspolymer 2,00 Soft Focus agent

Silica, Titanium Dioxide, Iron Oxides 1,00 Soft Focus agent

D Acrylates Copolymer 3,00 Film Former

E

Preservative a.n. PreservativeBrassica Campestris Seed Oil, Zingiber Officinale Root Extract, Alpinia Officinarum Root Extract

YOUTH Oléobooster®, Hallstar

0,50 Active Ingredient

F Ethylhexyl Olivate, Sodium Acrylates Copolymer, Polyglyceryl-4 Olivate

Olivem® 2020, Hallstar Italia 1,00 Multifunctional

Cold Emulsifier

Olivem® and Olivem® 2020 are registered trademarks of Hallstar Innovations Corp.

Olivem® 2020: The Multi-Functional Ingredient

COLD PROCESS EMULSIFIER

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20 COLD PROCESS EMULSIFIER

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21

Confidential and proprietary business information of Givaudan 2

The Surprise effect

The need for the extra-ordinary turns into an attraction for unusual product experiences. Consumers are attracted by everything that is outstanding: unknown textures, exceptional colors and rule-breaking concepts. They want unique experiences and unforgettable services. They are highly experimental and fight monotony and their decisions are made on the spot depending on their moods and feelings. Versatile and flexible, they look for the same in the products they buy. New formats New textures New technologies New packaging ideas New routine steps New approaches New targets

Active Beauty New WOW, solutions for ageless beauty

1 Confidential and proprietary business information of Givaudan

2018

SOLUTION FOR AGELESS BEAUTY

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22

Confidential and proprietary business information of Givaudan 4

New Augmented Living

Augmented science

New Safety Brand communication needs to be honest and authentic to convince critical and aware consumers. Short and clear ingredient list, free-froms… are all valid approaches. Certifications are on the rise with also some touches of femininity, pleasure, fun and colors.

SOLUTION FOR AGELESS BEAUTY

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23 SOLUTION FOR AGELESS BEAUTY

New targets

Consumers today are in a perpetual change. In a so fast-moving context, expectations, needs and preferences keep evolving. Every target has its own codes and brands are trying to meet new emerging needs

Add date using "Insert" -> "Header & Footer" Add date using "Insert" -> "Header & Footer"

Confidential business and proprietary information of Givaudan, may not be copied or distributed to anyone without the express written permission of Givaudan

7 Confidential and proprietary business information of Givaudan

SKINFOOD LUNA

LAF

SORT OF COAL Barbecue-like shampoo

DREAMS COME TRUE Melted Cheese

cream

IT’S SKIN Cookie & ice cream

EVITA Beautiful rose -shaped foam

MEATY FRESH Bacon-like smell deodorant

SEPHORA Warming effect face care

WHOOSH Wobbly jelly

The need for the extra-ordinary turns into an attraction for ultra-sensorial

product experiences. #wow-Millennials are attracted by

everything that is outstanding!

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24

Confidential and proprietary business information of Givaudan 9

Sorbets :: jelly :: transforming textures :: powders in water :: bubbling :: with

true ingredients

CLINIQUE A refreshing gel-mask that instantly bubbles on skin

ERBORIAN Bamboo matte lotion with rice

powder

DIOR Hydra Life Fresh Hydration

Sorbet Crème

BOSCIA Charcoal Jelly Ball Cleanser

NEOGEN An innovative clay pore cleanser that transforms into a foam

DR. ROEBUCK’S Antioxidant potion

in mist for body

DR DREAM A powder essence that melts into a liquid form to absorb easily when lightly massaged onto dry skin.

ERBORIAN Spray to mask

SHISEIDO Jelly lotion

CHANEL Perfume in gel

FRESH An alcohol-free cleansing toner infused with real rose petals to remove residual impurities, refine the appearance of pores, and soften skin for a healthy-looking complexion.

Texture Pleasure

Consumers are now expecting to be moved and stimulated through multisensorial experiences. They want to feel alive, to be rooted in a sensorial reality that reenchants their life and daily environment.

SOLUTION FOR AGELESS BEAUTY

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25

Wow Technology

Consumers are attracted by everything that is outstanding: unknown textures, exceptional colors and rule-breaking concepts. They want unique experiences and unforgettable services.

Confidential and proprietary business information of Givaudan 11

Encapsulated actives :: concentrated formulations :: high potency :: boosters

:: changing color :: changing temperature

BOBBI BROWN Skin fortifier. Infused with natural lipids to rebuild and strengthen skin's barrier of defense against moisture loss and external aggressors.

CLINIQUE Supercharged concentrate. Liquid-sphere technology combines water-binding ingredients with encapsulated antioxidants to help break the cycle of dryness and environmental stress

SKIN INC. The powerful antioxidant, vitamin C, is encapsulated in its purest and freshest form to fight free radicals to address skin damage

TATCHA An ultra-hydrating concentrate of botanical oils and extracts that melt into skin for a youthful-looking glow in as little as one night.

DR. DENNIS GROSS Color smart cleanser & mask

DR. CI LABO Hot Peel Cleansing Gel

SOLUTION FOR AGELESS BEAUTY

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26

13

PrimalHyal™ Ultrafiller

A new generation of topical Hyaluronic acid for those who want a healthy skin with a flash ageless benefit.

INCI: Sodium Acetylated Hyaluronate

Confidential and proprietary business information of Givaudan

Confidential and proprietary business information of Givaudan 12

New techno concept n°1 PrimalHyal™ Ultrafiller ageless flash effect 2

SOLUTION FOR AGELESS BEAUTY

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27

Confidential and proprietary business information of Givaudan

I use products containing hyaluronic acids and always look for new innovation

Twisting the traditional technology

using grafting

Confidential and proprietary business information of Givaudan

►Acetylated Hyaluronic acid

►Very low molecular weight 20kDa

►Deeper skin penetration

►Dermal filler profile

PrimalHyal™ Ultrafiller

Confidential and proprietary business information of Givaudan Confidential and proprietary business information of Givaudan

Skin explant - Caucasian 44 yo donor Treated 8hrs with PrimalHyal 50 1%

Length Y (µm) Length Y (µm)

Leng

th X

(µm

)

Leng

th X

(µm

)

Antioxidant & antipollution

activities

Tight junctions reinforcement

Protection of Extracellular

matrix Water holding

Collagen I synthesis increase

Skin firmness Skin texture

Wrinkle depth reduction

Skin explant - Caucasian 37 yo donor Treated 8hrs with PrimalHyal™Ultrafiller 1%

I want more than a concentrated mix of HA. How can HAs be complementary?

SOLUTION FOR AGELESS BEAUTY

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28

► Reduction by -8.7%* of the length of furrows in 1 hour vs placebo.

► Reduction by -26.5%* of deeper wrinkles number in 6 hours.

*p<0.05 Student’s t-test vs placebo

I want a flash effect to get rid of my deepest wrinkles

21 volunteers Average age 63 yo Crow’s feet wrinkles PrimalHyal™Ultrafiller 0.2% T0 T1h

Confidential and proprietary business information of Givaudan

1

2

1

► Increase the enzyme TRXR1 by +34%** in pro oxidative stress. (**p<0.01 Student’s t-test vs untreated)

► Reduce free radicals production by -30%* in oxidative stress. ( *p<0.05 Student’s t-test vs untreated)

Antioxidant On NHEKs, PrimalHyal™ Ultrafiller 0.1%

► Sequestosome activation up to +40%* under heavy metals, hydro carbures and UV exposure.

► Reduce the MDA production on skin by -29%* (*p<0.05% Student’s t-test vs pollution + UV).

1 Antipollution On human skin explants

*p<0.05% Student’s t-test vs untreated

2 Protection of ECM On human skin explants

No

pol

luti

on

Pol

luti

on

+

UV

► Decrease the activity of MMP-1 and MMP-9 in the dermis by -18%** and -27%**. (**p<0.01 Student’s t-test vs untreated).

► Decrease MMP-1 and MMP-9 in dermis by -33%# and -203%x under heavy metals, hydrocarbures & UV exposure (#p<0.01, xp<0.05 Student’s t-test vs pollution+UV).

I want my skin to be healthy, detoxified and protected from photo pollution

SOLUTION FOR AGELESS BEAUTY

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29

-15

-10

-5

0

5

10

15

20

25

30

Crow's feet (lengthof furrows 0-0.5 mm)

after 1h

Crow's feet (numberof wrinkles 0.5-2

mm) after 6h

Del

ta D

0 (

%)

Placebo

PrimalHyal™ Ultrafiller

Crow’s feet wrinkles filling Flash filler effect in 1 to 6 hours

The wrinkles lengths and numbers were analysed by profilometry and VISIA®CR2.3 respectively after 1H and 6H.

Results:

PrimalHyal™Ultrafiller has a flash filler effect.

► Significant reduction of the length

of the crow’s feet down to -8.7% in 1 hour vs placebo.

► Significant reduction of deeper wrinkles number in 6 hours down to

-26.5%.

Confidential and proprietary business information of Givaudan 18

* p<0.05 Student’s t-test

-8.7%*

-26.5%*

Crow’s feet length and number reduction in 1 and 6H

Self assessment Flash filler effect in 1 to 6 hours

All the volunteers were asked to assess the efficacy of the product on their wrinkle appearances and the general aspect of their skin, 6 hours after application.

Confidential and proprietary business information of Givaudan 19

I see an improvement of

the appearance of my skin.

76%

My crow’s feet are smoother.

71%

6H

SOLUTION FOR AGELESS BEAUTY

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Reduction of nasogenian area wrinkles Mid and long term anti-ageing activity

Confidential and proprietary business information of Givaudan 21

Placebo

PrimalHyal™Ultrafiller 0.1%

*p<0.05 Student’s t-test

Confidential and proprietary business information of Givaudan 20 Confidential and proprietary business information of Givaudan

D0 D28

20 volunteers, average 56 yo Nasogenian wrinkles area Visia® Analysis PrimalHyal™Ultrafiller 0.1%

D0 D56

► Wrinkles number down to -9%* ► Wrinkled area down to -12% *

30 volunteers, average 57 yo Skin texture Visia® analysis PrimalHyal™Ultrafiller 0.1%

► Reduction of skin roughness by -9%*

I want a daily treatment making my skin healthier and smoother !

SOLUTION FOR AGELESS BEAUTY

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Confidential and proprietary business information of Givaudan 23

Self assessment Improvement of skin texture

All the volunteers were asked to assess the efficacy of the product on their skin appearances, after 56days of a twice daily application of a cream at 0.1% PrimalHyal™ Ultrafiller.

Confidential and proprietary business information of Givaudan 22

My skin looks healthier

70% My skin is smoother.

77%

My skin is more moisturised.

70%

SOLUTION FOR AGELESS BEAUTY

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32

The alternative to dermal filler!

Summary

Confidential and proprietary business information of Givaudan 25

PrimalHyal™ Ultrafiller - Xyliance S3D® Pro’Fill

03-2018 Confidential and proprietary business information of Givaudan. 24

Ref.: HAF 17-4

Phase INCI name Commercial name Supplier Dosage

A

Cetearyl wheat straw glycoside, Cetearyl alcohol Dimethicone Capric/caprylic triglyceride Phenoxyethanol, Ethylhexylglycerin

Xyliance Xiameter pmx-200 silicone Fluid 350cSt Miglyol 812N Euxyl PE 9010

Givaudan AB Dow corning Cremer oleo Schülke

4%

0.3%

4.5% 1%

B Aqua / Water Microcrystalline cellulose, Cellulose gum

Avicel PC 611

FMC corporate

SQ 100% 2%

C Aqua/Water Sodium acetylated hyaluronate

PrimalHyal™ Ultrafiller

Givaudan AB

2% 0.2%

D Polymethyl Methacrylate Covabed Velvet 20 Sensient 0.5%

E Fragrance, Geraniol, Citronellol, Linalool, D-Limonene

Lips anti age 05 EAF42861/00

Givaudan

0.2%

Process 1. Prepare A and heat under gentle stirring at 70°C in a Bain-Marie; 2. Prepare B under 5000 rpm for 30 minutes at room temperature; 3. Heat B under gentle stirring at 70°C in a Bain-Marie; 4. At 70°C, add B in A under high speed mixing at 3000 rpm for a few minutes; 5. At 35°C, add successively C, D and E in AB under gentle stirring for a few minutes until total

homogenization. Aspect: White lotion• Viscosity : 8000 mPa.s (Brookfield DVIII Ultra, Spindle E, Speed 12 at 20°C) • pH : 5.88

SOLUTION FOR AGELESS BEAUTY

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33

INCI

Origin

Preservation

Appearance

Solubility

Dosage

Processing

Compliance

Technical information PrimalHyal™ Ultrafiller

27

Sodium Acetylated Hyaluronate

Light yellow powder

Biotechnology

Water soluble

0.1%-0.2% Can be added at the end of the formulation process in a premix 0.1% PrimalHyal™Ultrafiller / 1.5% Water, or in the water phase at the end of heating if in an emulsion. Formulate at temperature < 80°C, and pH between 4 and 12.

Preservative free

Confidential and proprietary business information of Givaudan

(patent pending)

PrimalHyal™Ultrafiller behaves as a filler Stimulate skin dermis and epidermis metabolism

Confidential and proprietary business information of Givaudan 26

Plumping effect

SOLUTION FOR AGELESS BEAUTY

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34

29

Vetivyne™

Fragrance inspired skin youth booster for those who want to embrace their age with more comfort, firmness and tonicity.

Confidential and proprietary business information of Givaudan

INCI: Vetiveria Zizanoides Root Extract (and) Propanediol (and) Water

Confidential and proprietary business information of Givaudan 28

New techno concept n°2 Vetivyne™ from earth and upclycled 2

SOLUTION FOR AGELESS BEAUTY

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35

Upcycled exhausted Vetiver roots

Confidential and proprietary business information of Givaudan

I feel responsible for making the world a better place

Confidential and proprietary business information of Givaudan

► Boost the entire lipids synthesis in the skin

► Ongoing SOLSO program for Vetiver oil

► Ecocert Organic Standard and fair trade certification (ESR standard)

Fully natural Odour-free extract

Vetivyne™

► +31%*** lipids accumulation in sebocytes (in vitro, on sebocytes, Vetivyne 1%, ***p<0.001 Student’s t test vs lipogenic mix only)

► Up to +23%** antimicrobial lipids in sebum (in vitro, Lauric acid & Sapienic acid, Vetivyne 1%, **p<0.01 Student’s t-test vs lipogenic mix only)

► +42%** production of ceramides (in vitro, on RHE, Vetivyne 1%, **p<0.01 Student’s t test)

► +125%***expression of Ceramide Transport protein (in vitro, on NHEKs, Vetivyne 1%, ***p<0.001 Student’s t-test)

► +29.6%** lipid content in the cornified envelope (ex vivo, skin explant 69yo donor, Vetivyne 1%, **p<0.01 Student’s t-test)

► Up to +239%* expression of Dermokine, Involucrin, Loricrin in the Stratum Corneum (ex vivo, skin explants 69yo donor, Vetivyne 1%, *p<0.05 Student’s t-test)

I want my skin to feel supple and comfortable while replumped from the inside

1

2

1

2

Target +50 yo Dried & Wrinkled

Perfect Aged skin Wrinkles free

+

Confidential and proprietary business information of Givaudan

SOLUTION FOR AGELESS BEAUTY

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36

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in vitro/ex vivo Boosting adipocytes

33 Confidential and proprietary business information of Givaudan

Improving adipocytes differentiation In vitro

Pre-adipocytes were cultured for 13 days with or without Vetivyne™ at 3%.

Lipid droplets, a marker of adipocytes diferentiation, were then labelled using AdipoRed™ (a fluorescent lipid probe) to quantify the differentiation.

Results:

Vetivyne™ significantly

increases the adipocytes differentiation,

with an effect up to +3413%. *p<0.05 Student’s t-test

Confidential and proprietary business information of Givaudan 34

Unt

reat

ed

Vetiv

yne™

3%

+3413%*

SOLUTION FOR AGELESS BEAUTY

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37

Ex vivo Increasing adipocytes volume 1/2

Explants of full skin (epidermis, dermis and hypodermis) were treated or not with Vetivyne™ at 3%.

On D0, D1, D4 and D6, the product was topically applied.

On D8, explants were stained for microscopical analysis.

Adipocytes size determination was then performed by image analysis, by measuring their equivalent circular diameter. Results:

Vetivyne™ significantly

increases the average size of adipocytes in the hypodermis, as observed by microscopy.

Confidential and proprietary business information of Givaudan 35

Untreated

Vetivyne™ at 3%

Evolution of adipocytes size distribution and populations Increasing adipocytes volume 2/2

It is also noticeable that a shift in the population of adipocytes can be observed after the use of Vetivyne™.

*p<0.05 Student’s t-test

Confidential and proprietary business information of Givaudan 36

The number of « small » adipocytes increases by +26%, reflecting the differentiation boost

observed in vitro. (Appearance of new small adipocytes from pre-adipocytes)

The number of « large » adipocytes increases by +189%, as a consequence of the average

size increase and a better fat storage capacity. (Accumulation of lipids in the existing adipocytes)

20 – 60 µm 100 – 140 µm

SOLUTION FOR AGELESS BEAUTY

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I want a significant recovery of tonicity and firmness with an anti-fatigue effect

2 x 21 volunteers, average age 60 yo with sagging face and wrinkles. Vetivyne™ 2%

D0

D56

5.0 10.0 15.0 [mm]

After 56 days: ► +11.2%* in tonicity/firmness

► -17.8%* of skin fatigue *p<0.05 Student’s t-test vs placebo

► Down to -18%*** of Perilabial wrinkles area

► Significant effect for 100% of the volunteers vs placebo ***p<0.001 Student’s t-test vs placebo

D56 D0 D28

Confidential and proprietary business information of Givaudan

*p<0.05, #p<0.1 Student’s t-test vs placebo

20 volunteers 28 days of treatment

Vetivyne™ 2%

On the 29th day, a fine fragrance is applied: Boosting the fragrance olfactive intensity and long-lastingness by

+25%* after 2 hours and +21%# after 4 hours

I want a product that surprises me and delivers an additional value

« By emphasing fragrances heart and base notes over time, Vetivyne™ demonstrates a real interest as a fragrance sensuality booster. »

Professional Givaudan fragrance evaluator

Confidential and proprietary business information of Givaudan

SOLUTION FOR AGELESS BEAUTY

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39

Add date using "Insert" -> "Header & Footer" Add date using "Insert" -> "Header & Footer" 39 Confidential and proprietary business information of Givaudan Vetivyne™- Soligel™ - Uniprosyn® PS 18 - Syner-GX™ - Kendi oil – Nyamplung oil

Skin plump’

Process 1. Prepare A and B and heat under gentle stirring at 75°C in a Bain-Marie; 2. At 75°C, add B in A under high speed mixing at 3000 rpm for a few minutes; 3. Let it cool down at room temperature under gentle stirring; 4. At 35°C, add successively C and D under high speed mixing at 3000 rpm for a few minutes.

Aspect: White cream • Viscosity : 13000 mPa.s (Brookfield DVIII Ultra, Spindle E, Speed 12 at 20°C) • pH : 6.31

03-2018 Confidential and proprietary business information of Givaudan. 40

Ref.: SC 18-8

Phase INCI name Commercial name Supplier Dosage

A

Cetearyl wheat straw glycoside, Cetearyl alcohol Aleurites moluccanus seed oil Dimethicone Cyclopentasiloxane, Dimethiconol Isopropyl palmitate Mineral oil/Paraffinum liquidum Phenoxyethanol, Ethylhexylglycerin BHT

Xyliance Kendi oil Xiameter pmx-200 silicone Fluid 350cSt Xiameter PMX-1501 Fluid Dub IPP Marcol 82 Euxyl PE 9010 BHT

Givaudan AB Givaudan AB Dow corning Dow corning Stearinerie Dubois Exxonmobil Clariant Sigma

4% 3%

2.5%

3% 2% 1% 1%

0.05%

B

Aqua / Water Rhizobian gum Glycerin Cyamopsis tetragonoloba (guar) gum, Xanthan gum Sodium stearoyl glutamate Butylene Glycol, Hydrolyzed Oat Protein, Niacinamide, Adenosine Triphosphate

Soligel™ Vegetal glycerin rapeseed Syner-GX™ Amisoft HS11PF Uniprosyn® PS 18

Givaudan AB Oleon Givaudan AB Ajinomoto Givaudan AB

SQ 100% 0.1% 1%

0.1%

0.5% 3%

C Propanediol, Water, Vetiveria zizanoides root extract

Vetivyne™

Givaudan AB

2%

D Fragrance

Lips passion fruit 16 EAF42865/00

Givaudan

0.05%

SOLUTION FOR AGELESS BEAUTY

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40

Fragrance inspired skin youth booster!

Summary

Confidential and proprietary business information of Givaudan 41

Vetivyne™ acts on the three main lipids sources in the skin Mode of action

Confidential and proprietary business information of Givaudan 42

Before After

1. Improvement of skin hydration 2. Reduction of wrinkles and skin fatigue 3. Fragrance enhancing properties

1. Loss of Hydration 2. Less firmness and tonicity 3. Sagging skin and wrinkles

SOLUTION FOR AGELESS BEAUTY

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41

INCI

Origin

Preservation

Appearance

Solubility

Dosage

Processing

Compliance

Technical information Vetivyne™

43

Vetiveria Zizanoides Root Extract (and) Propanediol (and) Water

Amber liquid

Vegetal Extraction

Water soluble

1-3%

Can be added at the beginning or at the end of the formulation process into the water phase. Formulate at T° below 40°C, and pH between 4 and 10.

None

Confidential and proprietary business information of Givaudan

Approval pending

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Confidential business and proprietary information of Givaudan, may not be copied or distributed to anyone without the express written permission of Givaudan

Thank you

Marketing team [email protected]

44 Confidential and proprietary business information of Givaudan

SOLUTION FOR AGELESS BEAUTY

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42

Between Nature & Technology

By Solabia

The S.M.A.R.Tmultifunctional referencereference

THE CELL COMMUNICATION, THE HEART OF WELL-BEING

Between Nature & Technology

TO ACCESS WELL BEING

SCIENCE

POSITIVE COMMUNICATION

CELL COMMUNICATION

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43

Between Nature & Technology

KERATINOCYTE COMMUNICATION

SCIENCE

FORFOR BETTERBETTER AGINGAGING ANDRESTRUCTURINGRESTRUCTURINGRESTRUCTURING EFFECT

InfluencingInfluencing KERATINOCYTEKERATINOCYTE COMMUNICATIONallows to enhance

KERATINOCYTEKERATINOCYTE COMMUNICATIONCOMMUNICATIONenhanceenhance PROTEIN SYNTHESIS

Between Nature & Technology

SCIENCE

KEY EPIDERMAL PROTEINS

SIRTUINSIRTUIN-SIRTUIN-1

THE "youth proteins" or "proteins of longevity"

Essential role in physiological processes includingDNA repair, resistance to oxidative stress and celldeath

Promotes cell renewal

ZOOM ON… SIRTUIN-1

§

§

§

CELL COMMUNICATION

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44

Between Nature & Technology

SCIENCE

Restructuring Proteins

Produced during epidermal renewal,in the upper layers of the epidermis

Essential to skin barrier function

INVOLUCRININVOLUCRINLORICRIN

Stratum granulosum

Keratinocytes

Loricrin

Involucrin

EpidermaldifferentiationStratum corneum

KEY EPIDERMAL PROTEINS

ZOOM ON… INVOLUCRIN LORICRIN

§§

§

Between Nature & Technology

SCIENCE

TOTO GAINGAIN ININ COMFORTANDANDAND WELL

GAINGAIN INWELLWELL-WELLWELL-BEINGBEINGBEING SENSATION

InfluencingInfluencing NEURONNEURON COMMUNICATIONallows to regulate

NEURONNEURON COMMUNICATIONCOMMUNICATIONregulateregulate INFLAMMATION

and painful sensations

NEURON COMMUNICATION

CELL COMMUNICATION

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Transient Receptor Potential Vanilloid

Acid-Sensing Ion Channel

SCIENCE

Ca2+

Nerve membrane

TRPVor

ASIC

Activation of thereceptors of sensitivity

Irritant

Substance P

Neurogenicinflammation

TransientTRPVAcidASICS

Receptors activated by climate, pollution or chemicals

Release of inflammation mediators (Substance P)

Increase disconfort feeling and painfulsensation

ZOOM ON… TRPV & ASICSKEY RECEPTORS OF SENSITIVITY

§

§

§

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HOW TO POSITIVELY INFLUENCE ON

COMMUNICATION TO ACCESS WELL BEING?

POSITIVE COMMUNICATIONSCIENCE

CELL COMMUNICATION

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FUCOGEL®

ACTIVE

A UNIVERSAL AND MULTIFUNCTIONAL REFERENCE DEDICATEDUNIVERSAL AND MULTIFUNCTIONAL

TO SKIN MULTIFUNCTIONALMULTIFUNCTIONAL

TO SKIN WELLMULTIFUNCTIONAL

WELL-REFERENCE DEDICATEDREFERENCEMULTIFUNCTIONAL REFERENCE

WELL--BEINGFOR MORE THAN 20 YEARS

L-fucose

IS A POLYSACCHARIDE BASE ON FUCOSE, THE KEY FOR COMMUNICATIONIS A POLYSACCHARIDE BASE ON FUCOSE, THE KEY FOR COMMUNICATIONIS A POLYSACCHARIDE BASE ON FUCOSE, THE KEY FOR COMMUNICATIONIS A POLYSACCHARIDE BASE ON FUCOSE, THE KEY FOR COMMUNICA

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ACTIVE

THE FERMENTATION EXPERTISE

At the heart of SOLABIA’s fermentation expertise there

is an exclusive bacterial collection, in addition to

public collections

IDENTITY CARD§ High molecular weight (1.106 Da)§ Containing L-fucose, D-galactose and

galacturonic acid§ Obtained by bacterial fermentation from

non-GMO vegetable substrate

L-fucose

D-galactose

Galacturonic acid

CELL COMMUNICATION

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ACTIVE

S.M.A.R.T

Neuro-SOOTHING

MOISTURIZING

ANTI-AGING

RESTRUCTURING

TOUCH

WELLWELL-WELL-BEING

FUCOGELFUCOGEL®S.M.A.R.T PERFORMANCE TO ACCESS WELL-BEING

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0

5

10

15

Without lactic acid With lactic acid FUCOGEL® POWDER

Subs

tanc

e P

rele

ase

(A.U

)

FUCOGEL® 0.1% + lactic acid

PERFORMANCE

Inhibition of neurogenic inflammation through ASIC signaling pathway

*p<0.05*p<0.05

- 2 5 % *

v s C o n t r o l w i t h l a c t i c a c i d

In vitro study on keratinocytes/neurons co-culture treated in the medium with FUCOGEL® at 0.1% (or 0.01% FUCOGEL®POWDER) in water and lactic acid at 0.1%. Quantification of the Substance P released by ELISA kit.

FUCOGEL® relieves from neurogenic inflammation and stinging sensations

1. Neuro-SOOTHING

CELL COMMUNICATION

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PERFORMANCE

Immediate neuro-soothing activity

Only 5 minutes after application, FUCOGEL® has a soothing effect on irritated and hypersensitive skin by decreasing the tingling sensation

FUCOGEL® restores immediately well-being and comfort.

Clinical study on 19 volunteers with sensitive and reactive skin. One application of FUCOGEL® at 3% (or 0.3% FUCOGEL®POWDER) vs. Placebo on the nasolabial fold after lactic acid aggression. Soothing effect evaluation after 5 minutes (stinging test).

0,00,51,01,52,02,53,03,54,04,55,0

Placebo 3% FUCOGEL®

Reac

tivity

scor

e

T0 T5min

- 4 7 % *

v s T 0

- 2 4 % *

v s P l a c e b o

(or 0.3% FUCOGEL® POWDER)

* p<0.05

1. Neuro-SOOTHING

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PERFORMANCE

FUCOGEL® shows a progressive and prolonged moisturizing effect. Its effect complements that of hyaluronic acid.

In vivo study on volunteers. Application on the forearm of FUCOGEL® vs. hyaluronic acid (1% polysaccharide in water).Measurement of the hydration by N.M.R. before and after application (1h, 3h, 8h).

0

20

40

60

80

100

120

1 h 3 h 8 h

Valu

e of

hyd

ratio

nre

late

dto

T0

(%)

FUCOGEL® Hyaluronic acid

2. MOISTURIZING

CELL COMMUNICATION

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PERFORMANCE

Stimulation of epidermal renewal

Ex vivo study on explants treated topically with FUCOGEL® at 2% and 5% (or 0.2 and 0.5% FUCOGEL® POWDER) vs.Placebo. Quantization of the loricrin and involucrin by immunolabeling at D8.

Involucrin & Loricrin in pink

+ 8 8 % * * *

v s P l a c e b o

5% FUCOGEL®

(or 0.5% FUCOGEL® POWDER)

> Involucrin > Loricrin** p<0.05 *** p<0.01

+ 5 1 % *

v s P l a c e b o

5% FUCOGEL®

(or 0.5% FUCOGEL® POWDER)

* p<0.1 ** p<0.05

FUCOGEL® activates cell renewal and therefore the "young appearance" of the skin

FUCOGEL® Restore the quality of the skin barrier which is essential to reduce discomfort, even more in sensitive skin

4. RESTRUCTURING

CELL COMMUNICATION

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PERFORMANCE

FUCOGEL® fights against aging and promotes cell longevity

Stimulation of sirtuins-1, "youth proteins"

Ex vivo study on explants treated topically with FUCOGEL® at 5% (or 0.5% FUCOGEL® POWDER) vs. Placebo. Quantizationof sirtuins-1 by immunolabeling at D8.

* p<0.05

+ 4 7 5 % *

v s P l a c e b o

Sirtuin-1 in pink

Placebo5% FUCOGEL®

(or 0.5% FUCOGEL® POWDER)

3. ANTI-AGING

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PERFORMANCE

Increases Soft Touch

5. TouchImprovement of softness

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SoothingMoisturizingAnti-AgingRestructuringTouch

COMFORT AND WELL-BEING

FOR EVERYSKIN

THE ESSENTIAL

FUCOGELFUCOGEL®S.M.A.R.T PERFORMANCE TO ACCESS WELL-BEING

CELL COMMUNICATION

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ON the MARKET

Millennials CARE

MARKET PRODUCT

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Well-aging CARE

ON the MARKET

MARKET PRODUCT

CELL COMMUNICATION

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By Solabia

Meet us atAston Booth #301

THANK YOU

FOR YOUR ATTENTION !

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The information presented in this document cannot be copied or used at business ends without obtaining a written agreement of the SOLABIA Group and related entities. This information is provided in good faith and is based on our current knowledge. It is forinformation purpose only and does not commit SOLABIA Group liability. We hereby disclaim any warranty of suitability of the ingredient presented for any purpose. In particular, marketing claim ideas are only suggestions and required verification for commercialuse and advertising. The user of the ingredient presented is solely responsible for ensuring that the use made of the ingredient, the finished products including it and especially claims referring to it comply with all applicable laws and regulations.

CELL COMMUNICATION

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53 EMULSIFIERS

Introducing AqStarTM M1

Dr Andrew M Howe, FRSC

ü Naturally derived

ü High-performance emulsifier

ü Distinctive aesthetics

ü Formulation flexibility

Grolman Hall 4, Stand 330

Grolman, Hall 4 Booth 330

• What is AqStarTM M1?• How emulsifiers are the key to aesthetics

• Why choose AqStarTM M1?ü Naturally derivedü Distinctive aesthetics ü Formulation flexibilityü Simple processing steps

• Example Formulations

Content

© Aqdot Ltd

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54 EMULSIFIERS

Grolman, Hall 4 Booth 330

• A naturally-derived emulsifierü ISO16128ü GMO-free

• INCI: Sodium Starch Octenylsuccinate (and) Cucurbiturils*• A complex of lipophilic waxy maize starch and AqTMbit

ü Starch provides steric, charge and polymer microgel stabilisationü AqTMbit technology provides added stability by a combination of steric, charge

and interfacial-network interactions - “multi-mechanism” stability

AqStarTM M1 is…

© Aqdot Ltd 3

* REACH registered, No hazard labelling required.

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55 EMULSIFIERS

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56 EMULSIFIERS

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57 EMULSIFIERS

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58 EMULSIFIERS