1 Complement Pathways - bio.umass.edu · 1 Complement Pathways Complement Activation Proteins are...

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1 Complement Pathways Complement Activation Proteins are normally inactive - need to be activated (or transient) Activation - sequential proteolysis Covalent Attachment - become stably active after attaching to microbe (ab complexes) Regulation! - important to minimize complement mediated damage to host cells

Transcript of 1 Complement Pathways - bio.umass.edu · 1 Complement Pathways Complement Activation Proteins are...

Page 1: 1 Complement Pathways - bio.umass.edu · 1 Complement Pathways Complement Activation Proteins are normally inactive - need to be activated (or transient) ... DAF and CRI displace

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Complement Pathways

Complement Activation

Proteins are normally inactive -need to be activated (or transient)

Activation - sequential proteolysis

Covalent Attachment - becomestably active after attaching tomicrobe (ab complexes)

Regulation! - important tominimize complement mediateddamage to host cells

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C1 Inhibitor Regulation

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Inhibition of C3 Convertase Formation

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Factor I mediated cleavage of C3b


Eukaryotic Gene Control. Developmental pathways of multicellular organisms: All cells of a multicellular organism start with the same complement of DNA.

Eukaryotic Gene Control. Developmental pathways of multicellular organisms: All cells of a multicellular organism start with the same complement of DNA.

Cutaneous Immunology: Innate Immune Responses Advance... · 2015. 9. 3. · Complement System • Pathways can be activated through either innate (non- specific) or adaptive (specific)

Cutaneous Immunology: Innate Immune Responses Advance... · 2015. 9. 3. · Complement System • Pathways can be activated through either innate (non- specific) or adaptive (specific)

Complement Activation Contributes to Severe Acute ... · Multiple complement pathways contribute to SARS-CoV MA15-induced patho-genesis. To test the importance of the complement signaling

Complement Activation Contributes to Severe Acute ... · Multiple complement pathways contribute to SARS-CoV MA15-induced patho-genesis. To test the importance of the complement signaling

REVISAO GERAL ESTRUTURA. LISTENING - READING I´m (complement) Are you (complement)? I was (complement) Were you (complement)? I´ll be (complement) Will.

REVISAO GERAL ESTRUTURA. LISTENING - READING I´m (complement) Are you (complement)? I was (complement) Were you (complement)? I´ll be (complement) Will.

Complement. Complement pathways: Classical pathway Alternative pathway Lectin pathway.

Complement. Complement pathways: Classical pathway Alternative pathway Lectin pathway.

(Union, Intersection, Relative Complement(Difference), Universal … · 2021. 2. 21. · Union, Intersection, Relative Complement(Difference), Universal Set, Absolute Complement(Complement)

(Union, Intersection, Relative Complement(Difference), Universal … · 2021. 2. 21. · Union, Intersection, Relative Complement(Difference), Universal Set, Absolute Complement(Complement)

Novel Scabies Mite Serpins Inhibit the Three Pathways of the … · Novel Scabies Mite Serpins Inhibit the Three Pathways of the Human Complement System Angela Mika1, Simone L. Reynolds1,2,

Novel Scabies Mite Serpins Inhibit the Three Pathways of the … · Novel Scabies Mite Serpins Inhibit the Three Pathways of the Human Complement System Angela Mika1, Simone L. Reynolds1,2,

DLD03 Complement

DLD03 Complement

FY18 Q1 REPORT - Amazon S3 · and fluid dynamics, respectively. These complement two previous successful solicitations that the NSF has funded in ... solution pathways (a measure

FY18 Q1 REPORT - Amazon S3 · and fluid dynamics, respectively. These complement two previous successful solicitations that the NSF has funded in ... solution pathways (a measure

Complement 2

Complement 2

Computer Architecture - WordPress.com...- 9's complement of 835 10 is 164 10 - 1's complement of 1010 2 is 0101 2 (bit by bit complement operation) R's Complement R's complement of

Computer Architecture - WordPress.com...- 9's complement of 835 10 is 164 10 - 1's complement of 1010 2 is 0101 2 (bit by bit complement operation) R's Complement R's complement of

Tertiary Education Report · Ensure digital/online opportunities and tools like Tiro Whetū and MSD’s Pathways to Employment assessment tool complement each other. Share and promote

Tertiary Education Report · Ensure digital/online opportunities and tools like Tiro Whetū and MSD’s Pathways to Employment assessment tool complement each other. Share and promote

UvA-DARE (Digital Academic Repository) Complement in ...124 Chapter 5 Abstract The complement system is a key driver of neuroinflammation. Activation of complement by all pathways,

UvA-DARE (Digital Academic Repository) Complement in ...124 Chapter 5 Abstract The complement system is a key driver of neuroinflammation. Activation of complement by all pathways,

5 complement

5 complement

Novel Scabies Mite Serpins Inhibit the Three Pathways of ... · Novel Scabies Mite Serpins Inhibit the Three Pathways of the Human Complement System Angela Mika1, Simone L. Reynolds1,2,

Novel Scabies Mite Serpins Inhibit the Three Pathways of ... · Novel Scabies Mite Serpins Inhibit the Three Pathways of the Human Complement System Angela Mika1, Simone L. Reynolds1,2,

Complement Jan 25, 2006. Complement (C’) Complement Complement refers, historically, to fresh serum capable of lysing antibody (Ab)-coated cells. This.

Complement Jan 25, 2006. Complement (C’) Complement Complement refers, historically, to fresh serum capable of lysing antibody (Ab)-coated cells. This.

Biological activities of complement-derived peptidesComplement peptides are generated in body fluids during cascading activations via two trigger pathways, the classical or the laternative,

Biological activities of complement-derived peptidesComplement peptides are generated in body fluids during cascading activations via two trigger pathways, the classical or the laternative,

Complement cellularimmunity2

Complement cellularimmunity2

4 Yolk Proteins - bio.umass.edu · analysis are providing cloned cDNA and genomic- ... By virtue of its central location in the egg the yolk ... lipids, vitamins, ...

4 Yolk Proteins - bio.umass.edu · analysis are providing cloned cDNA and genomic- ... By virtue of its central location in the egg the yolk ... lipids, vitamins, ...

Complement system

Complement system