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Centre for Medical Image Computing (CMIC)

University College London

David Atkinson

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UCL Hospital

Centre for Advanced Biomedical Imaging

Inst. HepatologyQueen SquareInst Neurology,

National Hospital Neuro. Functional Imaging lab,

Dementia Research CentreAdvanced MRI lab.

Inst. Child HealthGreat Ormond Street

London Centre for Nanotechnology

Centre for Medical Image Computing

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Centre for Medical Image Computing

• 6 academic staff• ~ 50 PostDocs and PhD students.• Majority with backgrounds in Computing,

Maths, Engineering, Physics, Biomedicine.

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Research Highlights• Image Registration• Image Segmentation• MRI Motion Correction• MRI Flow measurements• High Resolution Diffusion• MRI Guided Prostatectomy

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Image Registration• Non-rigid registration

– Fast Free-Form Deformation– Parallelized for NVidia Graphics card.– <1 minute for 3D registration– Nifty Reg http://sourceforge.net/projects/niftyreg/

M. Modat, et al., Fast free-form deformation using graphics processing units, Comput. Methods Programs Biomed. (in press)

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Image Registration• Alignment of DCE-MRI liver images.

– PPCR algorithm aligns successive breath-hold images in the presence of contrast changes.

No correction Fluid-based registration PPCRMelbourne et al Phys Med Biol, 2007, 52:4805-4826

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Image Segmentation• Whole heart segmentation using atlas and

free-form deformation registration

Zhuang et al. FUNCTIONAL IMAGING AND MODELING OF THE HEART, PROCEEDINGS   5528  p303-311

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MRI Motion Correction• Training phase gives motion model• Enables motion correction of higher

resolution data.

White et al Magn. Reson. Med. 62 p440 (2009)

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MRI Motion Correction• Cardiac cine without ECG or breath-

holding.• Uses ky=0 navigator and 32 channel coil.

Odille et al. Magn. Reson. Med. (in press)

CorrectedNo correction

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Real-time flow

Steeden et al. ISMRM Workshop Sintra 2009

Undersampled real-time spiral acq.Reconstruction on console

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High Resolution Diffusion MRI• Multi-shot sequences and reconstruction.

trace-weighted MD FA FA

Porter et al. ISMRM 2008

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MR Guided Endoscopic Prostatectomy

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Overlay of MRI on Endoscopic view

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and more …• Breast supine MRI to prone operation.• Image directed prostate ablation.• Motion modelling for lung radiotherapy.• Tissue biomechanical modelling.• Inverse Problems.• Tissue microstructure from MRI.

– axonal radius and density from DTI-type acq.• Interactive MRI reconstructions using graphics

cards.– trading spatial and temporal resolution.