1 Blank to maintain numbering. 2 Midterm There will be one Periodic Table, Hemoglobin, DNA,...
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Transcript of 1 Blank to maintain numbering. 2 Midterm There will be one Periodic Table, Hemoglobin, DNA,...
2Midterm• There will be one
• Periodic Table, Hemoglobin, DNA, Anfinsen, Tamiflu will feature
• Study TOPIC guide will appear
• Syllabus says Oct. 18; I’m thinking 25 may be more likely. Will inform next week or by e-mail
3Anfinsen
A1) each molecule more or less instantly goes to fully correct form. It’s a ‘snowball rolling down hill’ model, where each correct association greatly enhances the subsequent. So my 2nd bond is quicker than your 1st. Predicts precise tracking of disulfides formed vs. achieved activity
4Anfinsen A1
A1) each molecule more or less instantly goes to fully correct form. It’s a ‘snowball rolling down hill’ model, where each correct association greatly enhances the subsequent. So my 2nd bond is quicker than your 1st. Predicts precise tracking of disulfides formed vs. achieved activity
5Anfinsen A2
A2) Only correct bonds form, but with different rates for different bonds--so there is an order and timing of bond formation that is the same for all molecules. So A-A’ might form quickly; B-B’ slowly, etc.
6Deadline = line + dead
deadline |ˈdedˌlīn|noun1 this definition not relevant2 historical a line drawn around a prison beyond which prisoners were liable to be shot.
think about it
Does it really make sense to designate that period at the end as the target as opposed to that at the
beginning?
Is it really the case that your schedule is such that all available times just happen to fall at the last minute?
77
Beating TamifluBeating TamifluThemes:
Evolution: then and nowamino acids, mutations, folding: they
matter
Themes: Evolution: then and now
amino acids, mutations, folding: they matter
8How evolution happens
• Good ideas are rewarded not sought/planned
• There’s no mechanism for foresight, so it cannot be that way
9How the flu happens
http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif
10
Just passin’ through
http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif
11
Just passin’ through
http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif
12
Just passin’ through
http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif
13
Tamiflu: you shall not pass!
http://en.wikipedia.org/wiki/File:Oseltamivir-3D-balls.png
a.k.a. oseltamivir